In vivo induction of endogenous retroviruses in BALB/c mouse hepatocytes by successive treatments with carbon tetrachloride and bromodeoxyuridine.

Abstract:

:The effects of bromodeoxyuridine (BrdUrd) incorporation into hepatocytes of carbon tetrachloride (CCl4)-induced regenerating liver of BALB/c mice on the induction of endogenous retroviruses was examined. From the nucliec acid hybridization studies, the maximum levels of hybridization were obtained for both N- and X-tropic BALB/c endogenous retrovirus specific [3H]-cDNAs with liver RNA from animals receiving BrdUrd at 40 and 44 h post-CCl4 treatment, and killed on the fourth day following BrdUrd injection. Media from NIH-3T3 (Swiss mouse) and mink cell cultures, infected with liver homogenates from animals treated as above, gave significant levels of reverse transcriptase activity. The observations made in the present study show that BrdUrd incorporation into cell DNA can cause induction of both N- and X-tropic endogenous retroviruses in BALB/c mouse hepatocytes in vivo, and such induction is probably a transient event.

journal_name

Int J Cancer

authors

Ayukawa HM,Saltzburg D,Mukherjee BB

doi

10.1002/ijc.2910240419

subject

Has Abstract

pub_date

1979-10-15 00:00:00

pages

498-503

issue

4

eissn

0020-7136

issn

1097-0215

journal_volume

24

pub_type

杂志文章
  • Population differences in immune marker profiles associated with human T-lymphotropic virus type I infection in Japan and Jamaica.

    abstract::The natural history of human T-lymphotropic virus type I (HTLV-I) has been shown to differ markedly by geographic area. The differences include contrasting patterns of risk of adult T-cell lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which may be due in part to differences in...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.24012

    authors: Birmann BM,Breen EC,Stuver S,Cranston B,Martínez-Maza O,Falk KI,Okayama A,Hanchard B,Mueller N,Hisada M

    更新日期:2009-02-01 00:00:00

  • Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer.

    abstract::Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer mortality worldwide. Emerging evidence indicates that tumour cells release substantial amounts of RNA into the bloodstream, in which RNA strongly resists RNases and is present at sufficient levels for quantitative analyses. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.32747

    authors: Xu W,Zhou G,Wang H,Liu Y,Chen B,Chen W,Lin C,Wu S,Gong A,Xu M

    更新日期:2020-05-15 00:00:00

  • Inverse regulation of neuronal cellular adhesion molecule (NCAM) by IFN-gamma in melanoma cell cultures established from CNS lesions.

    abstract::In advanced stages of malignant melanoma (MM), metastases to the CNS are frequently observed. Few results are available on trophic factors and immunological features involved in the process of invasion and adhesion of circulating metastatic cells into the CNS. A direct comparison of remote metastases found in differen...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19990924)83:1<135::aid-ijc

    authors: Geertsen R,Zenklusen R,Kamarashev J,Burg G,Dummer R

    更新日期:1999-09-24 00:00:00

  • Establishment of L1210 leukemia cells resistant to the distamycin-A derivative (FCE 24517): characterization and cross-resistance studies.

    abstract::N-deformyl-N-[4-N,N-bis(2-chloroethylamino)benzoyl] distamycin-A (FCE 24517) is a new cytotoxic anti-tumor agent in phase-1 clinical trials. We have isolated stable FCE-24517-resistant cell sublines from murine leukemia L1210 cells by in vitro exposure to the drug. FCE 24517 selects a mixed population of resistant cel...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910530223

    authors: Geroni C,Pesenti E,Tagliabue G,Ballinari D,Mongelli N,Broggini M,Erba E,D'Incalci M,Spreafico F,Grandi M

    更新日期:1993-01-21 00:00:00

  • Treatment of multi-focal colorectal carcinoma metastatic to the liver of immune-competent and syngeneic rats by hepatic artery infusion of oncolytic vesicular stomatitis virus.

    abstract::Viruses that replicate selectively in cancer cells hold considerable promise as novel therapeutic agents for the treatment of malignancy. We report an orthotopic model of multi-focal colorectal cancer (CRC) metastases in the livers of syngeneic and immune-competent rats, which permitted rigorous testing of oncolytic v...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.20772

    authors: Shinozaki K,Ebert O,Woo SL

    更新日期:2005-04-20 00:00:00

  • Eurogin Roadmap 2015: How has HPV knowledge changed our practice: Vaccines.

    abstract::This review is one of two complementary reviews that have been prepared in the framework of the Eurogin Roadmap 2015 to evaluate how knowledge about HPV is changing practices in HPV infection and disease control through vaccination and screening. In this review of HPV vaccine knowledge, we present the most significant...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1002/ijc.30063

    authors: Brotherton JM,Jit M,Gravitt PE,Brisson M,Kreimer AR,Pai SI,Fakhry C,Monsonego J,Franceschi S

    更新日期:2016-08-01 00:00:00

  • Tumour angiogenesis factor (TAF) in human and animal tumours.

    abstract::Extracts were made from Walker 256 carcinoma, spontaneous rat mammary adenocarcinoma, Wilms' tumour, human neuroblastoma and human haemangioma. Chromatography of the extracts on Sephadex G-100 yielded four fractions, A, B, C and D. Injection of fractions B and C resulted in the growth of new capillaries in the subcuta...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910170502

    authors: Phillips P,Steward JK,Kumar S

    更新日期:1976-05-15 00:00:00

  • Interferon receptor expression regulates the antiproliferative effects of interferons on cancer cells and solid tumors.

    abstract::In addition to antiviral effects, Type I interferons (IFN) have potent antiproliferative and immunomodulatory activities. Because of these properties IFNs have been evaluated as therapeutics for the treatment of a number of human diseases, including cancer. Currently, IFNs have been shown to be efficacious for the tre...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.20236

    authors: Wagner TC,Velichko S,Chesney SK,Biroc S,Harde D,Vogel D,Croze E

    更新日期:2004-08-10 00:00:00

  • The mutational landscape and prognostic indicators of pseudomyxoma peritonei originating from the ovary.

    abstract::Pseudomyxoma peritonei (PMP) is a rare disorder with unique pathological and genetic changes. Although several studies have reported the clinical features and mutational changes of PMP that originates from the appendix, few studies on PMP originating from the ovary have been reported due to its extreme rarity. In orde...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.33460

    authors: Wang B,Yao J,Ma R,Liu D,Lu Y,Shi G,An L,Xia A,Chen F,Pang S,Zhai X,Liu G,Chen S,Xu M,Song L,Xu H

    更新日期:2021-01-05 00:00:00

  • Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan.

    abstract::Seventy to 40% of K-RAS wild type colorectal tumors does not seem to benefit from treatment with antiepidermal growth factor receptor (anti-EGFR) monoclonal antibodies. Recent data suggested that in presence of IGF-1 system, altered activation colorectal cancer cells may escape anti-EGFR mediated cell death. The inter...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.25193

    authors: Scartozzi M,Mandolesi A,Giampieri R,Pierantoni C,Loupakis F,Zaniboni A,Galizia E,Giustini L,Silva RR,Bisonni R,Berardi R,Biagetti S,Menzo S,Falcone A,Bearzi I,Cascinu S

    更新日期:2010-10-15 00:00:00

  • Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion.

    abstract::We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and up-regulated E-cadherin, an epi...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.24349

    authors: Kabashima A,Higuchi H,Takaishi H,Matsuzaki Y,Suzuki S,Izumiya M,Iizuka H,Sakai G,Hozawa S,Azuma T,Hibi T

    更新日期:2009-06-15 00:00:00

  • Prognostic value of phospho-Akt in patients with non-small cell lung carcinoma: a meta-analysis.

    abstract::Previous studies have been inconsistent with respect to the reported associations between phospho-Akt (p-Akt) overexpression and lung cancer prognosis. In this study, we conducted a systematic review and meta-analysis to assess the prognostic value of p-Akt in patients with non-small cell lung carcinoma (NSCLC). Relev...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/ijc.28788

    authors: Yang Y,Luo J,Zhai X,Fu Z,Tang Z,Liu L,Chen M,Zhu Y

    更新日期:2014-09-15 00:00:00

  • Mortality and incidence trends from esophagus cancer in selected geographic areas of China circa 1970-90.

    abstract::China was one of the countries with the highest esophagus cancer risk in the world during the 1970s. This report provides data on time trends of esophagus cancer incidence and mortality during the 1970s-90s in selected geographic areas of China. Information on newly diagnosed cancer cases and cancer deaths is based on...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.10706

    authors: Ke L

    更新日期:2002-11-20 00:00:00

  • Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11.

    abstract::Anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (HPVs), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of "low-risk" HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV-related anogenital ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.28228

    authors: Cornall AM,Roberts JM,Garland SM,Hillman RJ,Grulich AE,Tabrizi SN

    更新日期:2013-11-01 00:00:00

  • The ability of normal mouse cells to reduce the malignant potential of transformed mouse bladder epithelial cells depends on their somatic origin.

    abstract::Somatic cell hybrids have been made between a transformed mouse bladder carcinoma cell line and normal mouse bladder epithelium and mesenchyme. In the epithelial tumour/mesenchyme hybrids the malignant phenotype was expressed dominantly whereas in the carcinoma/normal epithelium hybrids the malignant potential was gre...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910330517

    authors: Cowell JK,Franks LM

    更新日期:1984-05-15 00:00:00

  • Up-regulation of alpha 2 beta 1 integrin cell-surface expression protects A431 cells from epidermal growth factor-induced apoptosis.

    abstract::High epidermal growth factor (EGF) concentration (10(-8) M) induces inhibition of A431 cell proliferation, resulting in part from an apoptotic process. For some cells escaping this process, proliferation was associated with a decrease in apoptosis. Moreover, these surviving cells displayed marked morphological changes...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0215(20000801)87:3<360::aid-ijc8>3.0.

    authors: Smida Rezgui S,Honore S,Rognoni JB,Martin PM,Penel C

    更新日期:2000-08-01 00:00:00

  • Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathway enzymes.

    abstract::TK is a pyrimidine metabolic pathway enzyme involved in salvage DNA synthesis. What roles TK may play in epithelial ovarian cancer and the relationships between TK and the other pyrimidine pathway enzymes remain unclear. We examined TK1 gene expression by RT-PCR and related it to gene expression of TS, TP and DPD in 6...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.10319

    authors: Fujiwaki R,Hata K,Nakayama K,Moriyama M,Iwanari O,Katabuchi H,Okamura H,Sakai E,Miyazaki K

    更新日期:2002-05-20 00:00:00

  • Oncogenicity of Friend-virus-infected cells: determination of origin of spleen colonies by the H-2 antigens as genetic markers.

    abstract::Spleen cells from mice infected with Friend leukemia virus (FLV) inoculated by the intravenous route give rise to macroscopically visible colonies in the spleens of normal F1 histocompatible hybrid hosts. A study of H-2 antigens as generic markers for identification of strains of origin of cells constituting the splee...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910220418

    authors: Wendling F,Tambourin PE

    更新日期:1978-10-15 00:00:00

  • Risk factors for prostate cancer incidence and progression in the health professionals follow-up study.

    abstract::Risk factors for prostate cancer could differ for various sub-groups, such as for "aggressive" and "non-aggressive" cancers or by grade or stage. Determinants of mortality could differ from those for incidence. Using data from the Health Professionals Follow-Up Study, we re-examined 10 factors (cigarette smoking histo...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.22788

    authors: Giovannucci E,Liu Y,Platz EA,Stampfer MJ,Willett WC

    更新日期:2007-10-01 00:00:00

  • Glycated hemoglobin and cancer incidence and mortality in the Atherosclerosis in Communities (ARIC) Study, 1990-2006.

    abstract::Diabetes is a risk factor for many cancers; chronic hyperglycemia is hypothesized to be, in part, explanatory. We evaluated the association between glycated hemoglobin, a time-integrated glycemia measure, and cancer incidence and mortality in nondiabetic and diabetic men and women. We conducted a prospective study of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.27394

    authors: Joshu CE,Prizment AE,Dluzniewski PJ,Menke A,Folsom AR,Coresh J,Yeh HC,Brancati FL,Platz EA,Selvin E

    更新日期:2012-10-01 00:00:00

  • Analysis of the polymorphic CAG repeat length in the androgen receptor gene in patients with testicular germ cell cancer.

    abstract::Changes in the length of a polymorphic trinucleotide (CAG) repeat in the androgen receptor (AR) gene, which may lead to altered transactivation of the AR gene, have been implicated to play a role in the pathogenesis of several forms of endocrine cancer and certain reproductive disorders. Subjects with reproductive dis...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.10680

    authors: Rajpert-De Meyts E,Leffers H,Daugaard G,Andersen CB,Petersen PM,Hinrichsen J,Pedersen LG,Skakkebaek NE

    更新日期:2002-11-10 00:00:00

  • Glutamate receptor, ionotropic, kainate 2 silencing by DNA hypermethylation possesses tumor suppressor function in gastric cancer.

    abstract::Aberrant DNA methylation is considered a major mechanism for silencing tumor suppressor genes in gastric cancer. We used CpG microarray and differential methylation hybridization strategies to identify potential tumor suppressor genes and recovered glutamate receptor, ionotropic, kainate 2 (GRIK2) as a novel epigeneti...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.24958

    authors: Wu CS,Lu YJ,Li HP,Hsueh C,Lu CY,Leu YW,Liu HP,Lin KH,Hui-Ming Huang T,Chang YS

    更新日期:2010-06-01 00:00:00

  • Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.

    abstract::A glucuronide doxorubicin prodrug N-[4-doxorubicin-N-carbonyl (oxymethyl) phenyl] O-beta-glucuronyl carbamate (DOX-GA3) has been developed to improve the antitumor effects of doxorubicin (DOX). The prodrug was originally designed to be activated into drug by human beta-glucuronidase (GUS) released from tumor cells in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0215(200002)9999:9999<::aid-ijc1075>3

    authors: Houba PH,Boven E,van der Meulen-Muileman IH,Leenders RG,Scheeren JW,Pinedo HM,Haisma HJ

    更新日期:2001-02-15 00:00:00

  • Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human.

    abstract::The importance of tumor associated neutrophils (TANs) in cancer development is in the meantime well established. Numerous of clinical data document the adverse prognostic effects of neutrophil infiltration in solid tumors. However, certain tumor therapies need functional neutrophils to be effective, suggesting altered...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.29945

    authors: Andzinski L,Kasnitz N,Stahnke S,Wu CF,Gereke M,von Köckritz-Blickwede M,Schilling B,Brandau S,Weiss S,Jablonska J

    更新日期:2016-04-15 00:00:00

  • Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas.

    abstract::Aberrant activation of wingless (Wnt) signaling is involved in the pathogenesis of various cancers. Recent studies suggested a role of Wnt signaling in gliomas, the most common primary brain tumors. We investigated 70 gliomas of different malignancy grades for promoter hypermethylation in 8 genes encoding members of t...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.24981

    authors: Götze S,Wolter M,Reifenberger G,Müller O,Sievers S

    更新日期:2010-06-01 00:00:00

  • Estrogen and progesterone receptor mRNA levels in primary breast cancer: association with patient survival and other clinical and tumor features.

    abstract::The relative expression of estrogen receptor (ER) and progesterone receptor (PR) mRNA transcripts was measured in 71 primary breast-cancer biopsies. ER and PR binding activity were estimated in parallel by the dextran-coated-charcoal method. There was a close correlation between the amount of ER mRNA and estradiol bin...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910590310

    authors: Nagai MA,Marques LA,Yamamoto L,Fujiyama CT,Brentani MM

    更新日期:1994-11-01 00:00:00

  • Inherited variation at MC1R and ASIP and association with melanoma-specific survival.

    abstract::Melanocortin-1 receptor (MC1R) is a marker of melanoma risk in populations of European ancestry. However, MC1R effects on survival are much less studied. We investigated associations between variation at MC1R and survival in an international, population-based series of single primary melanoma patients enrolled into th...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.29317

    authors: Taylor NJ,Reiner AS,Begg CB,Cust AE,Busam KJ,Anton-Culver H,Dwyer T,From L,Gallagher RP,Gruber SB,Rosso S,White KA,Zanetti R,Orlow I,Thomas NE,Rebbeck TR,Berwick M,Kanetsky PA,GEM Study Group.

    更新日期:2015-06-01 00:00:00

  • DNA methylation patterns in blood of patients with colorectal cancer and adenomatous colorectal polyps.

    abstract::Colorectal cancer (CRC) screening rates are currently suboptimal. Blood-based screening could improve rates of earlier detection for CRC and adenomatous colorectal polyps. In this study, we evaluated the feasibility of plasma-based detection of early CRC and adenomatous polyps using array-mediated analysis methylation...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.26484

    authors: Cassinotti E,Melson J,Liggett T,Melnikov A,Yi Q,Replogle C,Mobarhan S,Boni L,Segato S,Levenson V

    更新日期:2012-09-01 00:00:00

  • Regulation of natural killer activity in vivo. II. The effect of alcohol consumption on human peripheral blood natural killer activity.

    abstract::Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32 alcoholics and 15 control subjects in a 4-h chromium release assay using K562 tumor target cells. The natural killer activity of human peripheral blood lymphocytes in alcoholics was significantly higher than the level found in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910260405

    authors: Saxena QB,Mezey E,Adler WH

    更新日期:1980-10-15 00:00:00

  • Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

    abstract::It is considered that fruit and vegetable (F&V) protect against oesophagus and gastric cancer (GC). However, 2 recent meta-analyses suggest that the strength of association on GC seems to be weaker for vegetables than for fruit and weaker in cohort than in case-control studies. No evidence exists from cohort studies a...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ijc.21678

    authors: González CA,Pera G,Agudo A,Bueno-de-Mesquita HB,Ceroti M,Boeing H,Schulz M,Del Giudice G,Plebani M,Carneiro F,Berrino F,Sacerdote C,Tumino R,Panico S,Berglund G,Simán H,Hallmans G,Stenling R,Martinez C,Dorronsoro M

    更新日期:2006-05-15 00:00:00