Abstract:
:Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12ql3-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified 12q sequences. In a series of 228 cytogenetically analyzed and histopathologically reexamined ordinary lipomas and ALT, 10 tumors showed unbalanced chromosome-12 aberrations. All 4 tumors with loss of segments from 12q were classified as ordinary lipomas, whereas 5 of the 6 tumors showing gain of 12q material were diagnosed as ALT. One or three extra copies of 12q15-q24 were present in all 5 ALT. We conclude that duplication of 12q sequences may be a sufficient level of amplification for development of the microscopic appearance that characterizes ALT.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Mandahl N,Akerman M,Aman P,Dal Cin P,De Wever I,Fletcher CD,Mertens F,Mitelman F,Rosai J,Rydholm A,Sciot R,Tallini G,Van den Berghe H,Van de Ven W,Vanni R,Willén Hdoi
10.1002/(SICI)1097-0215(19960904)67:5<632::AID-IJCsubject
Has Abstractpub_date
1996-09-04 00:00:00pages
632-5issue
5eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19960904)67:5<632::AID-IJCjournal_volume
67pub_type
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