Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling.

abstract：:In this study we investigated the effect of Tax on nucleotide excision repair (NER) in human T-cell lines by using the host cell repair analysis of UVC-irradiated reporter plasmid. This analysis revealed a p53-dependent NER activity in wild type (w.t.) p53-containing T-cells and p53-independent NER in w.t. p53-lacking...

journal_title：International journal of cancer

authors： Schavinsky-Khrapunsky Y,Priel E,Aboud M

更新日期：2008-01-15 00:00:00

abstract：:Suppressor of cytokine signaling 3 (SOCS3), as a key regulator of cytokine signaling, has the potential to modulate numerous cellular processes. Its involvement in inflammatory disease is well established, and there is increasing evidence for a role in breast cancer as a regulator of signal transducers and activators ...

journal_title：International journal of cancer

authors： Barclay JL,Anderson ST,Waters MJ,Curlewis JD

更新日期：2009-04-15 00:00:00

abstract：:In a series of consecutive 51chromium (51Cr) assays, 21 melanoma and 14 colo-rectal carcinoma patients were tested for their in vitro cell-mediated immune reactions to melanoma, rectal adenocarcinoma, and normal fibroblast target cells. Blood lymphocytes (BL) from four individuals were included in each experiment. In ...

journal_title：International journal of cancer

authors： Steele G Jr,Sjögren HO,Stadenberg I

更新日期：1976-01-15 00:00:00

abstract：:Chemokine receptors are known to regulate homing of lymphocytes into secondary lymphoid organs and may also be involved in the lymphatic spread of solid tumors. Therefore, the assessment of chemokine receptor expression on colorectal carcinomas could potentially improve the prediction of lymph node spread. This is of ...

journal_title：International journal of cancer

authors： Günther K,Leier J,Henning G,Dimmler A,Weissbach R,Hohenberger W,Förster R

更新日期：2005-09-20 00:00:00

abstract：:Mammalian LIM kinase 1 (LIMK1) phosphorylates and inactivates the actin-binding and -depolymerizing factor cofilin and induces actin cytoskeletal changes. LIMK1 is reported to play an important role in cell motility, but the mechanism of induction of cell motility and the role of LIMK1 in tumor growth, angiogenesis an...

journal_title：International journal of cancer

authors： Bagheri-Yarmand R,Mazumdar A,Sahin AA,Kumar R

更新日期：2006-06-01 00:00:00

abstract：:Progress against cancer through prevention and treatment is often measured by survival statistics only instead of analyzing trends in incidence, survival and mortality simultaneously because of interactive influences. This study combines these parameters of major cancers to provide an overview of the progress achieved...

journal_title：International journal of cancer

authors： Karim-Kos HE,Kiemeney LA,Louwman MW,Coebergh JW,de Vries E

更新日期：2012-06-15 00:00:00

abstract：:We report that the Rhesus (Rh)-negative phenotype is more prevalent in patients with small-cell lung cancer (SCLC) than in the normal Caucasian population (SCLC: 25% Rh-negative vs. 15% expected, p less than 0.0001). This finding has been validated for a Central and a Northern European population (Switzerland and UK)....

journal_title：International journal of cancer

authors： Cerny T,Fey MF,Oppliger R,Castiglione M,Nachbur B,Gertsch M,Gasser A,Joss RA,Thatcher N,Lind M

更新日期：1992-09-30 00:00:00

abstract：:Cervical cancer screening will rely, increasingly, on HPV testing as a primary screen. The requirement for triage tests which can delineate clinically significant infection is thus prescient. In this EUROGIN 2017 roadmap, justification behind the most evidenced triages is outlined, as are challenges for implementation...

journal_title：International journal of cancer

authors： Cuschieri K,Ronco G,Lorincz A,Smith L,Ogilvie G,Mirabello L,Carozzi F,Cubie H,Wentzensen N,Snijders P,Arbyn M,Monsonego J,Franceschi S

更新日期：2018-08-15 00:00:00

abstract：:Therapy-induced senescence (TIS) as a permanent growth arrest can be induced by various stimuli, including anticancer compounds. TIS emerged as a promising strategy to overcome resistance phenomena. However, senescent cancer cells might regain proliferation activity in vivo or even secrete tumor-promoting cytokines. T...

journal_title：International journal of cancer

authors： Weiland T,Lampe J,Essmann F,Venturelli S,Berger A,Bossow S,Berchtold S,Schulze-Osthoff K,Lauer UM,Bitzer M

更新日期：2014-01-01 00:00:00

abstract：:IL-21 is a member of the IL-2 cytokine family, produced by CD4+ T cells. We previously showed that immunotherapy (IT) with IL-21-transduced neuroblastoma cells (Neuro2a/IL-21) cured 33% of syngeneic mice bearing systemic NB. Here, we studied whether the removal of Treg cells could potentiate the therapeutic efficacy o...

journal_title：International journal of cancer

authors： Croce M,Corrias MV,Orengo AM,Brizzolara A,Carlini B,Borghi M,Rigo V,Pistoia V,Ferrini S

更新日期：2010-09-01 00:00:00

abstract：:The effects of prolonged administration of genistein, a tyrosine-kinase inhibitor, on sodium-chloride-enhanced induction of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine, and the labeling and apoptotic indices and vessel counts in the gastric mucosa and gastric cancers, were investigated in Wi...

journal_title：International journal of cancer

authors： Tatsuta M,Iishi H,Baba M,Yano H,Uehara H,Nakaizumi A

更新日期：1999-01-29 00:00:00

abstract：:In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis. In our study, we de...

journal_title：International journal of cancer

authors： Chen B,Liu X,Savell VH,Dilday BR,Johnson MW,Jenkins JJ,Parham DM

更新日期：1999-09-24 00:00:00

abstract：:Extracts were made from Walker 256 carcinoma, spontaneous rat mammary adenocarcinoma, Wilms' tumour, human neuroblastoma and human haemangioma. Chromatography of the extracts on Sephadex G-100 yielded four fractions, A, B, C and D. Injection of fractions B and C resulted in the growth of new capillaries in the subcuta...

journal_title：International journal of cancer

authors： Phillips P,Steward JK,Kumar S

更新日期：1976-05-15 00:00:00

abstract：:Modulation of cytoplasmic Ca++ concentration is a mechanism common to signal transduction pathways regulating many cellular phenomena, including the interactions of tumors with the hemostatic system. We have investigated the pro-aggregating and pro-coagulant activities of human tumor cell lines cultured in vitro and t...

journal_title：International journal of cancer

authors： Saporiti A,Brocchieri A,Porta C,Moroni M,Grignani G

更新日期：1995-07-28 00:00:00

abstract：:We transduced a human gastric carcinoma cell line, HR, with the interleukin 2 (IL-2) gene. Stable HR transfectants secreted nanogram quantities of biologically active IL-2 and had significantly increased expression of IL-2 mRNA relative to that in parental cells. Expression of intracellular IL-2 protein was not quanti...

journal_title：International journal of cancer

authors： Nagashima S,Kashii Y,Reichert TE,Suminami Y,Suzuki T,Whiteside TL

更新日期：1997-07-03 00:00:00

abstract：:p27Kip1, one of the cyclin-dependent kinase (CDK) inhibitors (CDKIs), blocks progression from G1 to S phase by binding cyclin D1-CDK4 and/or cyclin E-CDK2 and inhibiting their activities. Reflecting the function of p27 as a CDKI in vitro, a reduced expression of protein p27 has recently been reported to be associated ...

journal_title：International journal of cancer

authors： Anayama T,Furihata M,Ishikawa T,Ohtsuki Y,Ogoshi S

更新日期：1998-08-21 00:00:00

abstract：:An antiserum to SF antigen was shown to be selectively cytotoxic to two human fibroblast lines, while two tumor cell lines (one melanoma and one Hela cell line) were resistant. The selective cytotoxicity was also demonstrable in mixtures of fibroblasts and tumor cells. The cytotoxic effect was abrogated by admixture o...

journal_title：International journal of cancer

authors： Ruoslahti E,Sjögren HO

更新日期：1976-09-15 00:00:00

abstract：:Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004,...

journal_title：International journal of cancer

authors： Marinaccio A,Binazzi A,Marzio DD,Scarselli A,Verardo M,Mirabelli D,Gennaro V,Mensi C,Riboldi L,Merler E,Zotti RD,Romanelli A,Chellini E,Silvestri S,Pascucci C,Romeo E,Menegozzo S,Musti M,Cavone D,Cauzillo G,Tumino

更新日期：2012-05-01 00:00:00

abstract：:The aim of this prospective study was to assess the uptake of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC) and its associations with sociodemographic and other factors, and long-term satisfaction with taking the test. The test was offered to all high-risk members (n = 446) of 36 Fi...

journal_title：International journal of cancer

authors： Aktan-Collan K,Mecklin JP,Järvinen H,Nyström-Lahti M,Peltomäki P,Söderling I,Uutela A,de la Chapelle A,Kääriäinen H

更新日期：2000-01-20 00:00:00

abstract：:Others have argued that as many as a third of women treated for high-grade cervical intraepithelial neoplasia (CIN) would have developed cervical cancer in the absence of screening and treatment. Under various assumptions and using past data on CIN grade 3 (CIN3) registrations in England and Scotland, we estimate what...

journal_title：International journal of cancer

authors： Sasieni P,Castanon A,Parkin DM

更新日期：2009-01-15 00:00:00

abstract：:Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in 5-year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is...

journal_title：International journal of cancer

authors： Garwicz S,Anderson H,Olsen JH,Winther JF,Sankila R,Langmark F,Tryggvadóttir L,Möller TR,Association of the Nordic Cancer Registries.,Nordic Society for Pediatric Hematology Oncology.

更新日期：2012-10-01 00:00:00

abstract：:The in vitro sponge-gel-supported three-dimensional histoculture chemosensitivity assay (Hoffman assay) allows the in vivo-like culture of human tumors. In this study, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H tetrazolium bromide (MTT) end point was applied to the Hoffman assay in an attempt to increase in vitr...

journal_title：International journal of cancer

authors： Furukawa T,Kubota T,Watanabe M,Takahara T,Yamaguchi H,Takeuchi T,Kase S,Kodaira S,Ishibiki K,Kitajima M

更新日期：1992-05-28 00:00:00

abstract：:Recombinant human interferon beta (rIFN-beta) inhibited in a time- and dose-dependent manner the proliferation of 18/18 human colon carcinoma cell lines in monolayer culture and 8/9 lines in a soft agar assay but had no effect on 4 human fibroblast cell lines. Maximal inhibition of cell proliferation by rIFN-beta requ...

journal_title：International journal of cancer

authors： Wong VL,Rieman DJ,Aronson L,Dalton BJ,Greig R,Anzano MA

更新日期：1989-03-15 00:00:00

abstract：:Paraffin sections (n = 168, 27 benign, 16 low malignant potential [LMP] and 125 malignant tumours) from epithelial ovarian tumours were evaluated immunohistochemically for expression of retinoblastoma gene product (pRB) and p53 protein, and the relationship among pRB, p53 and cyclin-dependent kinase inhibitor 2 (CDKN2...

journal_title：International journal of cancer

authors： Dong Y,Walsh MD,McGuckin MA,Cummings MC,Gabrielli BG,Wright GR,Hurst T,Khoo SK,Parsons PG

更新日期：1997-08-22 00:00:00

abstract：:Although the net benefits of tamoxifen in adjuvant breast cancer therapy have been proven, the recurrence of the cancer in an aggressive and hormone independent form has been highly problematic. We previously demonstrated the important role mitochondrial DNA (mtDNA) plays in hormone-independence in prostate cancer. He...

journal_title：International journal of cancer

authors： Naito A,Carcel-Trullols J,Xie CH,Evans TT,Mizumachi T,Higuchi M

更新日期：2008-04-01 00:00:00

abstract：:Hybridoma CE7 produces a murine antibody (gamma 1/kappa) which binds to a 190-kDa cell-surface glycoprotein of human neuroblastoma. Because of its tumor specificity, it has been used routinely in clinical pathology to confirm diagnosis of neuroblastoma. We have isolated the gene segments coding for the variable region...

journal_title：International journal of cancer

authors： Amstutz H,Rytz C,Novak-Hofer I,Spycher M,Schubiger PA,Blaser K,Morgenthaler JJ

更新日期：1993-01-02 00:00:00

abstract：:Several lines of evidence have demonstrated that IFNs could be relevant in the treatment of certain neoplastic diseases such as carcinomas. In particular, IFN-alpha, in addition to the anti-proliferative and cytostatic effects, was demonstrated to be capable of inducing cell death by apoptosis both in vivo and in vitr...

journal_title：International journal of cancer

authors： Matarrese P,Giandomenico V,Fiorucci G,Rivabene R,Straface E,Romeo G,Affabris E,Malorni W

更新日期：1998-05-18 00:00:00

abstract：:The mouse anti-id MAb MK2-23 bears the internal image of the antigenic determinant defined by anti-HMW-MAA MAb 763.74. Active specific immunotherapy with anti-id MAb MK2-23 is associated with a statistically significant prolongation of survival in patients with malignant melanoma. Characterization of the immune respon...

journal_title：International journal of cancer

authors： Kageshita T,Hirai S,Ono T,Ferrone S

更新日期：1995-01-27 00:00:00

abstract：:Liposarcomas are separated into clinicopathological entities with a characteristic morphological spectrum and mutually exclusive genetic alterations. Therefore, the rare occurrence of cases with combined patterns of well-differentiated liposarcoma and myxoid liposarcoma designated as mixed-type liposarcoma pose a conc...

journal_title：International journal of cancer

authors： de Vreeze RS,de Jong D,Koops W,Nederlof PM,Ariaens A,Haas RL,van Coevorden F

更新日期：2011-02-15 00:00:00

abstract：:Lysine-specific demethylase-1 (LSD1) removes the methyl groups from mono- and di-methylated lysine 4 of histone H3. Previous studies have linked LSD1 to malignancy in several human tumors, and LSD1 is considered to epigenetically regulate the energy metabolism genes in adipocytes and hepatocellular carcinoma. This stu...

journal_title：International journal of cancer

authors： Kosumi K,Baba Y,Sakamoto A,Ishimoto T,Harada K,Nakamura K,Kurashige J,Hiyoshi Y,Iwatsuki M,Iwagami S,Sakamoto Y,Miyamoto Y,Yoshida N,Oki E,Watanabe M,Hino S,Nakao M,Baba H

更新日期：2016-01-15 00:00:00