当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CANCER期刊下所有文献 > Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction.

Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction.

Abstract：

:The aim of this prospective study was to assess the uptake of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC) and its associations with sociodemographic and other factors, and long-term satisfaction with taking the test. The test was offered to all high-risk members (n = 446) of 36 Finnish HNPCC families in which the mutation was known. The procedure comprised an educational counselling session, a period for reflection, and a test disclosure session. Data were collected by questionnaires sent before the educational counselling and 1 month and 1 year after the test disclosure. Of those eligible, 85% (n = 381) completed the first questionnaire study. Non-participation was more common among men living alone who had not participated in the clinical cancer surveillance programme. Of the 347 subjects who attended counselling, 334 (75% of all subjects) were actually tested. After logistic-regression analysis, the only significant factor predicting test acceptance proved to be employment status: those employed were more likely than others to accept the test (odds ratio = 2.25; 95% confidence intervals, 1.09 to 4.6 1). At follow-up, over 90% of the subjects were fully satisfied with the decision to take the test. In conclusion, acceptance of the test was considerably higher than in previously reported studies. We attribute this to our careful face-to-face individualized counselling, our health care system, and to attitudes of the Finnish population, which are generally favourable towards health care and disease prevention.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Aktan-Collan K,Mecklin JP,Järvinen H,Nyström-Lahti M,Peltomäki P,Söderling I,Uutela A,de la Chapelle A,Kääriäinen H

keywords:

subject

Has Abstract

pub_date

2000-01-20 00:00:00

pages

44-50

issue

1

eissn

0020-7136

issn

1097-0215

pii

10.1002/(SICI)1097-0215(20000120)89:1<44::AID-IJC8

journal_volume

89

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CANCER文献大全
  • Socioeconomic inequality and short-term outcome in Hodgkin's lymphoma.

    abstract：:Socioeconomic status (SES) is a determinant of outcome in various types of cancer. The aim of this study is to analyze the impact of the SES in Hodgkin's lymphoma (HL). From 2001 to 2005, 194 consecutive patients were prospectively followed in 5 institutions. Patients answered a questionnaire with a set of items used ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.22417

    authors： Soares A,Biasoli I,Scheliga A,Luiz RR,Costa MA,Land M,Romano S,Morais JC,Spector N

    更新日期：2007-02-15 00:00:00

  • Expression of cholecystokinin forms by medullary thyroid cancer.

    abstract：:We have studied the production and release of cholecystokinin (CCK) forms by rat medullary thyroid cancer (MTC) in vivo. MTC cells were inoculated s.c. into 8 Wag-Rij rats. One month later, after i.v. injection of calcium plasma levels of CCK, calcitonin and tissue contents of gastrin and calcitonin were determined by...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910480510

    authors： Poston GJ,Draviam EJ,Seitz PK,Rajaraman S,Alexander RW,Cooper CW,Townsend CM Jr,Thompson JC

    更新日期：1991-07-09 00:00:00

  • A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens.

    abstract：:Increasing evidence indicates that breast cancer pathogenesis is linked with DNA double-strand break (DSB) repair dysfunction. This conclusion is based on advances in the study of functions of breast cancer susceptibility genes such as BRCA1 and BRCA2, on the identification of breast cancer-associated changes regardin...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.23551

    authors： Keimling M,Kaur J,Bagadi SA,Kreienberg R,Wiesmüller L,Ralhan R

    更新日期：2008-08-01 00:00:00

  • Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinoma.

    abstract：:Epigenetic alterations play an important role in carcinogenesis. Recent studies suggested that global histone modifications are predictors of cancer recurrence in various tumor entities. Our study was performed to evaluate histone H3 lysine 4 mono-methyl (H3K4me1), -di-methyl (H3K4me2) and -trimethyl (H3K4me3) pattern...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.25250

    authors： Ellinger J,Kahl P,Mertens C,Rogenhofer S,Hauser S,Hartmann W,Bastian PJ,Büttner R,Müller SC,von Ruecker A

    更新日期：2010-11-15 00:00:00

  • MKK7 transcription positively or negatively regulated by SP1 and KLF5 depends on HDAC4 activity in glioma.

    abstract：:JNK activity has been implicated in the malignant proliferation, invasion and drug-resistance of glioma cells (GCs), but the molecular mechanisms underlying JNK activation are currently unknown. Here, we reported that MKK7, not MKK4, directly activates JNK in GCs and exerts oncogenic effects on tumor formation. Notabl...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32321

    authors： Wang Y,Xia Y,Hu K,Zeng M,Zhi C,Lai M,Wu L,Liu S,Zeng S,Huang Z,Ma S,Yuan Z

    更新日期：2019-11-01 00:00:00

  • Dietary factors and risk of pancreatic cancer: results of a Canadian population-based case-control study.

    abstract：:Dietary information from a case-control study of pancreatic cancer conducted in Metropolitan Toronto between 1983 and 1986 is reported. A total of 249 cases and 505 population-based controls completed quantitative diet histories from which total caloric intake and the intake of a number of nutrients were estimated. A ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910450405

    authors： Howe GR,Jain M,Miller AB

    更新日期：1990-04-15 00:00:00

  • Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer.

    abstract：:Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer mortality worldwide. Emerging evidence indicates that tumour cells release substantial amounts of RNA into the bloodstream, in which RNA strongly resists RNases and is present at sufficient levels for quantitative analyses. ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32747

    authors： Xu W,Zhou G,Wang H,Liu Y,Chen B,Chen W,Lin C,Wu S,Gong A,Xu M

    更新日期：2020-05-15 00:00:00

  • Mouse mammary tumor virus production stimulated by hormones and polyamines in cells grown in semi-synthetic in vitro conditions.

    abstract：:Hormonal regulation of mouse mammary tumor virus (MMTV) synthesis was studied in the CCL-51-SF cell subline derived from the Sykes' mammary tumor cell line CCL-51 and adapted to grow in semi-synthetic in vitro conditions. The virus was quantitated by measuring the supernatant reverse transcriptase activity in exogenou...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910190215

    authors： Svec J,Links J

    更新日期：1977-02-15 00:00:00

  • Burden of disease from breast cancer attributable to smoking and second-hand smoke exposure in Europe.

    abstract：:Smoking and second-hand smoke (SHS) exposure have been recently linked to a higher risk of breast cancer in women. The aim of this work is to estimate the number of deaths and disability-adjusted life years (DALYs) from breast cancer attributable to these two risk factors in the European Union (EU-28) in 2017. The com...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.33021

    authors： Carreras G,Lachi A,Boffi R,Clancy L,Gallus S,Fernández E,López MJ,Soriano JB,López Nicolás Á,Semple S,Behrakis P,Gorini G,TackSHS Project Investigators.

    更新日期：2020-11-01 00:00:00

  • HER2/neu over-expression induces endothelial cell retraction.

    abstract：:Over-expression of the HER2/neu (HER2) proto-oncogene in breast carcinoma imparts an enhanced metastatic potential. Metastasis requires escape of the tumor cell from the vasculature into subjacent tissue, a transmigration event across an endothelial cell (EC) monolayer. EC retraction has been reported to precede trans...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0215(200002)9999:9999<::aid-ijc1061>3

    authors： Carter WB,Hoying JB,Boswell C,Williams SK

    更新日期：2001-02-01 00:00:00

  • Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol.

    abstract：:Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras e...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.31152

    authors： Unver N,Delgado O,Zeleke K,Cumpian A,Tang X,Caetano MS,Wang H,Katayama H,Yu H,Szabo E,Wistuba II,Moghaddam SJ,Hanash SM,Ostrin EJ

    更新日期：2018-04-01 00:00:00

  • CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo.

    abstract：:The suppressive activity of regulatory T cells (Treg) has been implicated as an important factor limiting immune mediated destruction of tumor cells. However, not much is known about the presence and function of Treg within tumors. Here we show in a syngeneic murine glioma model a time-dependent accumulation of CD4+Fo...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.22607

    authors： Grauer OM,Nierkens S,Bennink E,Toonen LW,Boon L,Wesseling P,Sutmuller RP,Adema GJ

    更新日期：2007-07-01 00:00:00

  • Differences in antitumor effects of various statins on human pancreatic cancer.

    abstract：:Statins are widely used for the treatment of hypercholesterolemia. However, their inhibitory action on HMG-CoA reductase also results in the depletion of intermediate biosynthetic products, which importantly contribute to cell proliferation. The aim of the present study was to compare the effects of the individual com...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.23242

    authors： Gbelcová H,Lenícek M,Zelenka J,Knejzlík Z,Dvoráková G,Zadinová M,Poucková P,Kudla M,Balaz P,Ruml T,Vítek L

    更新日期：2008-03-15 00:00:00

  • Cross-sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high-risk area in northeast Thailand.

    abstract：:We describe an innovative strategy to quantify risk of cancer associated with varying levels of exposure to chronic parasitic infection through the identification of asymptomatic cases of cholangiocarcinoma within a population-based survey of Opisthorchis viverrini infection. Stool samples from 12,311 adults over age ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910590412

    authors： Haswell-Elkins MR,Mairiang E,Mairiang P,Chaiyakum J,Chamadol N,Loapaiboon V,Sithithaworn P,Elkins DB

    更新日期：1994-11-15 00:00:00

  • Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan.

    abstract：:Incidence rates of Wilms' tumor (WT) markedly differ in East Asian and Caucasian children. In the present study, we examined WT1 deletions/mutations and loss of heterozygosity (LOH) on 11p and 11q in a large number of WTs and compared our findings with those from 4 series of Caucasian WTs. Incidence rates of the subtl...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.1475

    authors： Nakadate H,Yokomori K,Watanabe N,Tsuchiya T,Namiki T,Kobayshi H,Suita S,Tsunematsu Y,Horikoshi Y,Hatae Y,Endo M,Komada Y,Eguchi H,Toyoda Y,Kikuta A,Kobayashi R,Kaneko Y

    更新日期：2001-11-01 00:00:00

  • Oncogenesis and classification of mixed-type liposarcoma: a radiological, histopathological and molecular biological analysis.

    abstract：:Liposarcomas are separated into clinicopathological entities with a characteristic morphological spectrum and mutually exclusive genetic alterations. Therefore, the rare occurrence of cases with combined patterns of well-differentiated liposarcoma and myxoid liposarcoma designated as mixed-type liposarcoma pose a conc...

    journal_title：International journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1002/ijc.25390

    authors： de Vreeze RS,de Jong D,Koops W,Nederlof PM,Ariaens A,Haas RL,van Coevorden F

    更新日期：2011-02-15 00:00:00

  • Increased LDL receptor mRNA expression in colon cancer is correlated with a rise in plasma cholesterol levels after curative surgery.

    abstract：:It is currently under debate whether the low serum cholesterol levels that are frequently observed in cancer patients represent a risk factor for/or, rather, are a consequence of the tumour. We postulate that malignant tumours are directly involved in an increased catabolism of cholesterol-rich low-density lipoprotein...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910610405

    authors： Niendorf A,Nägele H,Gerding D,Meyer-Pannwitt U,Gebhardt A

    更新日期：1995-05-16 00:00:00

  • Parental smoking and risk of childhood brain tumors.

    abstract：:Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. Tobacco smoke contains 61 known carcinogens and increases the risk of several adult cancers. This study investigated associations between parental smoking and risk of CBT in a population-based ca...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.28004

    authors： Milne E,Greenop KR,Scott RJ,Ashton LJ,Cohn RJ,de Klerk NH,Armstrong BK

    更新日期：2013-07-01 00:00:00

  • Abrogation of tumor-inhibitory MRC-OX8+ (CD8+) effector T-cell generation in rats by selective depletion of neutrophils in vivo using a monoclonal antibody.

    abstract：:These studies were designed to examine the role of neutrophils in transplantation immunity to syngeneic rat tumors. We have earlier reported that specific transplantation immunity to syngeneic transplanted tumors is abrogated by selective depletion of peripheral-blood neutrophils by administration of a monoclonal anti...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910540121

    authors： Tanaka E,Sendo F

    更新日期：1993-04-22 00:00:00

  • Decrease of human pancreatic cancer cell tumorigenicity by alpha1,3galactosyltransferase gene transfer.

    abstract：:The enzyme alpha1,3galactosyltransferase synthesizes the alphaGal epitope, a carbohydrate structure (Galalpha1,3Galbeta1,4GlcNAc-R), on glycoconjugates in lower mammals. The enzyme is absent in humans but large amounts of natural antibodies that recognize alphaGal epitopes are present in human serum. It is likely that...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.11470

    authors： Aubert M,Crotte C,Bernard JP,Lombardo D,Sadoulet MO,Mas E

    更新日期：2003-12-20 00:00:00

  • Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation-free hypoxia response element of S100A4 gene.

    abstract：:Hypoxia is known to play important roles in the development and progression of tumors. We previously demonstrated that S100A4, a critical molecule for metastasis, was upregulated in ovarian cancer cells. Therefore, we examined the mechanisms of the upregulation of S100A4 expression in ovarian carcinoma cells, with par...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.27448

    authors： Horiuchi A,Hayashi T,Kikuchi N,Hayashi A,Fuseya C,Shiozawa T,Konishi I

    更新日期：2012-10-15 00:00:00

  • Treatment of melanoma of unknown primary in the era of immunotherapy and targeted therapy: A Dutch population-based study.

    abstract：:Melanoma of unknown primary (MUP) may have a different biology to melanoma of known primary, but clinical trials of novel therapies (e.g., immune checkpoint or BRAF/MEK inhibitors) have not reported the outcomes in this population. We therefore evaluated the overall survival (OS) among patients with MUP in the era of ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32229

    authors： Verver D,van der Veldt A,van Akkooi A,Verhoef C,Grünhagen DJ,Louwman WJ

    更新日期：2020-01-01 00:00:00

  • Patterns of seminoma tissue markers and deletions.

    abstract：:Seminomas and control tissues were analyzed for several tumor markers. Very high levels of placental alkaline phosphatase (PLAP)-like enzyme levels were found in all 18 seminomas studied. The majority of the seminomas were of phenotype I, thus differing from palcental PLAP. The mean amount of enzyme protein as measure...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910400507

    authors： Yamamoto H,Rudén U,Ljungdahl-Ståhle E,Brehmer-Andersson E,Hirano K,Hisazumi H,Stigbrand T,Wahren B

    更新日期：1987-11-15 00:00:00

  • Production of P-glycoprotein from the MDR1 upstream promoter is insufficient to affect the response to first-line chemotherapy in advanced breast cancer.

    abstract：:Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.23149

    authors： Raguz S,Randle RA,Sharpe ER,Foekens JA,Sieuwerts AM,Meijer-van Gelder ME,Melo JV,Higgins CF,Yagüe E

    更新日期：2008-03-01 00:00:00

  • Quantitative proteomics to study a small molecule targeting the loss of von Hippel-Lindau in renal cell carcinomas.

    abstract：:Inactivation of the tumor suppressor gene, von Hippel-Lindau (VHL), is known to play an important role in the development of sporadic clear cell renal cell carcinomas (ccRCCs). Even if available targeted therapies for metastatic RCCs (mRCCs) have helped to improve progression-free survival rates, they have no durable ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.30774

    authors： Bouhamdani N,Joy A,Barnett D,Cormier K,Léger D,Chute IC,Lamarre S,Ouellette R,Turcotte S

    更新日期：2017-08-15 00:00:00

  • Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies.

    abstract：:Multifocal occurrence and frequent recurrence are characteristic features of urothelial carcinomas of both the urinary bladder and the upper urinary tract. To describe the clonal nature of these tumors, 2 theories have been proposed. The monoclonality hypothesis describes the multiple tumors as descendants of a single...

    journal_title：International journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1002/ijc.10544

    authors： Hafner C,Knuechel R,Stoehr R,Hartmann A

    更新日期：2002-09-01 00:00:00

  • Characteristics of membrane and cytosol forms of the mammary tumor glycoprotein molecule MTGP in human breast carcinoma cell cultures and tumors.

    abstract：:The presence, concentration and selected molecular characteristics of the human mammary carcinoma glycoprotein molecule set MTGP, a trace and apparently tumor-specific molecule, were examined in fifteen cell cultures established from mammary carcinomas, tissue from seven mammary carcinomas and control cultures. Both c...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910280107

    authors： Leung JP,Nelson-Rees WA,Moore GE,Cailleau R,Edgington TS

    更新日期：1981-07-15 00:00:00

  • p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.

    abstract：:Combretastatin A4 (CA4) is a novel vascular disrupting agent that has promising clinical efficacy because of its ability to inhibit microtubule assembly and subsequently disrupt tumor blood flow. In this study, we demonstrate that mitogen-activated protein kinases (MAPKs) are critically involved in the cytotoxicity of...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.23262

    authors： Quan H,Xu Y,Lou L

    更新日期：2008-04-15 00:00:00

  • Immunodetection of cathepsins B and L present in and secreted from human pre-malignant and malignant colorectal tumour cell lines.

    abstract：:Pre-malignant and malignant human colorectal tumour epithelial cell lines both secreted precursor forms of the 2 cysteine proteinases, cathepsins B and L. The amount of proteinases secreted by these cell lines varied according to the cell density. Comparison at similar cell densities showed that the pre-malignant, ade...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910430323

    authors： Maciewicz RA,Wardale RJ,Etherington DJ,Paraskeva C

    更新日期：1989-03-15 00:00:00

  • Parity and breast cancer risk: possible effect on age at diagnosis.

    abstract：:We examined the effect of parity on breast cancer risk on the basis of information from 107,146 married female nurses followed prospectively between 1976-1980. For everparous women, a significant protective effect against breast cancer was observed with increasing parity (chi 12 for trend = 14.2, p less than 0.001). A...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910370105

    authors： Pathak DR,Speizer FE,Willett WC,Rosner B,Lipnick RJ

    更新日期：1986-01-15 00:00:00