Progress against cancer in the Netherlands since the late 1980s: an epidemiological evaluation.

abstract：:In 1984 the GBSG started a multicenter randomized trial to compare the effectiveness of 6 cycles of cyclophosphamide, methotrexate and fluorouracil (CMF) with or without radiotherapy (RT) as adjuvant treatment in node-positive breast-cancer patients treated by mastectomy. During 5 years, 199 patients were randomized. ...

journal_title：International journal of cancer

authors： Schmoor C,Bastert G,Dunst J,Bojar H,Christmann D,Unbehaun V,Tümmers G,Bauer W,Sauerbrei W,Schumacher M

更新日期：2000-05-01 00:00:00

abstract：:Fecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all FOBT-positive persons have screen-detected adenomas. Despite removal of these, patients with large/multiple adenomas have increased risk of later developing new advanced adenomas and CRC....

journal_title：International journal of cancer

authors： Bjerrum A,Lindebjerg J,Andersen O,Fischer A,Lynge E

更新日期：2020-08-15 00:00:00

abstract：:Fischer rat thyroid epithelial cella (FRT) growing continuously in culture were infected with the Kirsten murine sarcoma virus KiMSV(KiMuLV) and found to produce this virus constitutively. Although the morphology of the FRT cells did not change appreciably, the cells became malignant after infection with KiMSV(KiMuLV)...

journal_title：International journal of cancer

authors： Fusco A,Pinto A,Ambesi-Impiombato FS,Vecchio G,Tsuchida N

更新日期：1981-11-15 00:00:00

abstract：:In a previous study, human ZNF312b was identified as a cell proliferation-associated oncogene via the K-ras/extracellular signal-regulated kinase cascade in gastric cancer. However, the mechanism concerning its transcriptional activation remains unknown. Here, we show that DNA methylation and histone acetylation of th...

journal_title：International journal of cancer

authors： Song IS,Ha GH,Kim JM,Jeong SY,Lee HC,Kim YS,Kim YJ,Kwon TK,Kim NS

更新日期：2011-11-01 00:00:00

abstract：:An experiment in which rats were injected intrapleurally with asbestos, the injection taking place at an age of either 2 or 10 months, is reported. In the former group 19 out of 48 rats developed a mesothelioma compared with 17 out of 90 in the latter group. However, by considering the two groups at equal times after ...

journal_title：International journal of cancer

authors： Berry G,Wagner JC

更新日期：1976-04-15 00:00:00

abstract：:Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well-documented clinical correlation between platelet coun...

journal_title：International journal of cancer

authors： Buergy D,Wenz F,Groden C,Brockmann MA

更新日期：2012-06-15 00:00:00

abstract：:Telomerase activity is involved in the maintenance of telomere length and is thought to be required for cellular immortality and oncogenesis. Three major subunits composing telomerase, human telomerase RNA (hTR), telomerase-associated protein (TPI) and human telomerase catalytic subunit (hTERT), have been identified. ...

journal_title：International journal of cancer

authors： Kyo S,Kanaya T,Takakura M,Tanaka M,Yamashita A,Inoue H,Inoue M

更新日期：1999-03-15 00:00:00

abstract：:Suramin is an experimental anti-neoplastic agent which has shown promising activity against prostatic carcinoma and lymphoma in clinical trials. To elucidate its mechanism of action, suramin was examined for an effect on the transport of folate compounds by tumor cells. Influx of the anti-folate methotrexate via the r...

journal_title：International journal of cancer

authors： Rideout DC,Bustamante A,Patel R,Henderson GB

更新日期：1995-06-09 00:00:00

abstract：:In previous reports, systemic administration of a stimulatory monoclonal antibody directed against the 4-1BB receptor had no effect on survival or tumor burden in mice inoculated with the poorly immunogenic B16-F10 melanoma. We combined IL-12 gene transfer with 4-1BB costimulation to explore a previously noted coopera...

journal_title：International journal of cancer

authors： Xu D,Gu P,Pan PY,Li Q,Sato AI,Chen SH

更新日期：2004-04-20 00:00:00

abstract：:Galunisertib (LY2157299), a promising small-molecule inhibitor of the transforming growth factor-beta (TGF-β) receptor, is currently in mono- and combination therapy trials for various cancers including glioblastoma, hepatocellular carcinoma and breast cancer. Using genetically modified mouse models, we investigated t...

journal_title：International journal of cancer

authors： Li W,Tibben M,Wang Y,Lebre MC,Rosing H,Beijnen JH,Schinkel AH

更新日期：2020-03-15 00:00:00

abstract：:Oxaliplatin, which is widely used as chemotherapy for certain solid cancers, frequently causes peripheral neuropathy. Commonly described neuropathic symptoms include aberrant sensations such as mechanical allodynia (hypersensitivity to normally innocuous stimuli). Although oxaliplatin neuropathy is a dose-limiting tox...

journal_title：International journal of cancer

authors： Yamamoto S,Yamashita T,Ito M,Caaveiro JMM,Egashira N,Tozaki-Saitoh H,Tsuda M

更新日期：2019-10-15 00:00:00

abstract：:A case of epidermodysplasia verruciformis in a patient from Upper-Volta is described. Slightly elevated, flat warts were observed on hands, feet, arms and legs, and pityriasis versicolor-like lesions were found mainly on the trunk. The patient showed no malignant tumors. Histological examination revealed hyperkeratosi...

journal_title：International journal of cancer

authors： Pfister H,Nürnberger F,Gissmann L,zur Hausen H

更新日期：1981-05-15 00:00:00

abstract：:Cancer vaccines directed against tumor associate antigen (TAA) have produced encouraging results in preclinical models but not in cancer patients. A major limitation of this strategy is the relative degree of tolerance to these antigens and the low and heterogeneous tumor cell expression of TAA and major histocompatib...

journal_title：International journal of cancer

authors： Correale P,Aquino A,Giuliani A,Pellegrini M,Micheli L,Cusi MG,Nencini C,Petrioli R,Prete SP,De Vecchis L,Turriziani M,Giorgi G,Bonmassar E,Francini G

更新日期：2003-04-20 00:00:00

abstract：:Monocytes from the peripheral blood of 10 normal adult human donors were tested for their cytolytic activity on untransformed or SV40-transformed, early passage, human fibroblasts. Two pairs of human fibroblast lines (2303 and SV40-2303, 2931 and SV40-2931) were used and lysis was assessed in terms of release of [3H]t...

journal_title：International journal of cancer

authors： Mantovani A,Tagliabue A,Dean JH,Jerrells TR,Herberman RB

更新日期：1979-01-15 00:00:00

abstract：:Bladder cancer-associated protein (BLCAP) is a highly conserved protein among species, and it is considered a novel candidate tumor suppressor gene originally identified from human bladder carcinoma. However, little is known about the regulation or the function of this protein. Here, we show that the human BLCAP trans...

journal_title：International journal of cancer

authors： Galeano F,Leroy A,Rossetti C,Gromova I,Gautier P,Keegan LP,Massimi L,Di Rocco C,O'Connell MA,Gallo A

更新日期：2010-07-01 00:00:00

abstract：:Hereditary non-polyposis colorectal cancer, HNPCC, is an autosomal dominant condition predisposing to cancers of primarily the colorectum and the endometrium. The aim of our study was to identify persons at a high risk of hereditary colorectal cancer and to estimate their risk of colon and other HNPCC-associated tumou...

journal_title：International journal of cancer

authors： Cederquist K,Golovleva I,Emanuelsson M,Stenling R,Grönberg H

更新日期：2001-02-15 00:00:00

abstract：:A glutamine analogue, L-glutamic acid gamma-monohydroxamate (GAH) demonstrated complete cytotoxicity against L1210 cells in culture and marked anti-tumoral activity in vivo against L1210 leukemia and B16 melanoma. In vitro, GAH caused concentration-dependent inhibition of L1210 cell growth, with complete cell death be...

journal_title：International journal of cancer

authors： Vila J,Thomasset N,Navarro C,Doré JF

更新日期：1990-04-15 00:00:00

abstract：:Targeting the GA733 antigen (also known as CO17-1A, EGP, KS1-4, KSA, Ep-CAM) by monoclonal antibody CO17-1A or anti-idiotypic antibodies mimicking the CO17-1A or GA733 epitope has induced prolonged survival and specific immune responses to the antigen, respectively, in colorectal cancer (CRC) patients. In pre-clinical...

journal_title：International journal of cancer

authors： Staib L,Birebent B,Somasundaram R,Purev E,Braumüller H,Leeser C,Küttner N,Li W,Zhu D,Diao J,Wunner W,Speicher D,Beger HG,Song H,Herlyn D

更新日期：2001-04-01 00:00:00

abstract：:MicroRNA (miRNA) expression is frequently altered in human cancers. To search for epigenetically silenced miRNAs in non-small-cell lung cancer (NSCLC), we mapped human miRNAs on autosomal chromosomes and selected 55 miRNAs in silico. We treated six NSCLC cell lines with the DNA methylation inhibitor 5-aza-2'-deoxycyti...

journal_title：International journal of cancer

authors： Watanabe K,Emoto N,Hamano E,Sunohara M,Kawakami M,Kage H,Kitano K,Nakajima J,Goto A,Fukayama M,Nagase T,Yatomi Y,Ohishi N,Takai D

更新日期：2012-06-01 00:00:00

abstract：:Chemotherapy is a well-established risk factor for acute myeloid leukemia (AML) but little is known about other prescription drugs and AML risk. We report data from a population-based Los Angeles County study in which 299 matched case-control pairs had complete data on prescription drug use and 88% of cases were subty...

journal_title：International journal of cancer

authors： Pogoda JM,Katz J,McKean-Cowdin R,Nichols PW,Ross RK,Preston-Martin S

更新日期：2005-04-20 00:00:00

abstract：:Prostate cancer (PC) has the highest degree of genetic transmission of any form of malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal dominance trait. We reviewed the known predisposing genetic markers to assess possible strategies for screening of families at risk. We carried o...

journal_title：International journal of cancer

authors： Lynch HT,Kosoko-Lasaki O,Leslie SW,Rendell M,Shaw T,Snyder C,D'Amico AV,Buxbaum S,Isaacs WB,Loeb S,Moul JW,Powell I

更新日期：2016-06-01 00:00:00

abstract：:Data from a large, multicenter, population-based case-control study were analyzed to investigate the relation between multiple birth pregnancies and subsequent breast-cancer risk in the gravidas. Women less than 75 years old who had breast cancer were identified from statewide tumor registries in Wisconsin, western Ma...

journal_title：International journal of cancer

authors： Dietz AT,Newcomb PA,Storer BE,Longnecker MP,Mittendorf R

更新日期：1995-07-17 00:00:00

abstract：:Tumor toxins are recombinant, bifunctional proteins which comprise a tumor-cell-specific recognition domain and an enzymatic toxin domain. We have evaluated the in vivo effects of a tumor toxin that specifically recognizes the erbB-3 and erbB-4 receptors (HRG beta 1-ETA). High doses of HRG beta 1-ETA administered syst...

journal_title：International journal of cancer

authors： Groner B,Wick B,Jeschke M,Fiebig HH,Dengler W,Runau T,Mihatsch M,Kahl R,Schmidt M,Wels W,Stöcklin E

更新日期：1997-03-17 00:00:00

abstract：:Evidence has accumulated that, in addition to the MDR1 gene-coded P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP) also mediates the multidrug resistance (MDR) of various human tumors. In the case of gastric cancer, there is little or no involvement of P-glycoprotein, and the mechanisms of MDR remai...

journal_title：International journal of cancer

authors： Endo K,Maehara Y,Kusumoto T,Ichiyoshi Y,Kuwano M,Sugimachi K

更新日期：1996-11-04 00:00:00

abstract：:Benzo(a)pyrene and benz(a) anthrancene which, in contrast to the K-region epoxides benzo(a)pyrene 4,5-oxide and benz(a)anthracene 5,6-oxide, are not mutagenic to Salmonella typhimurium TA 1537 in the absence of mammalian enzyme preparations, were activated by liver microsomes from C3H mice, which had not received any ...

journal_title：International journal of cancer

authors： Oesch F,Bentley P,Glatt HR

更新日期：1976-10-15 00:00:00

abstract：:Peripheral blood mononuclear cells of most normal adults and patients with breast or lung cancer were found to inhibit [3H] thymidine uptake by lymphoid cell lines in a growth inhibition assay. At effector:target cell ratios between 5:1 and 20:1, lung cancer patients and breast cancer patients, when compared to normal...

journal_title：International journal of cancer

authors： Jerrells TR,Dean JH,Richardson G,Cannon GB,Herberman RB

更新日期：1979-06-15 00:00:00

abstract：:Epstein-Barr virus (EBV) can be detected in Hodgkin and Reed-Sternberg (HRS) cells in about one-half of cases of Hodgkin's disease (HD) in Western countries. To determine whether EBV is also associated with HD in a developing country such as China, we studied paraffin sections from 28 Chinese cases of HD for expressio...

journal_title：International journal of cancer

authors： Zhou XG,Hamilton-Dutoit SJ,Yan QH,Pallesen G

更新日期：1993-09-30 00:00:00

abstract：:Risk factors for prostate cancer could differ for various sub-groups, such as for "aggressive" and "non-aggressive" cancers or by grade or stage. Determinants of mortality could differ from those for incidence. Using data from the Health Professionals Follow-Up Study, we re-examined 10 factors (cigarette smoking histo...

journal_title：International journal of cancer

authors： Giovannucci E,Liu Y,Platz EA,Stampfer MJ,Willett WC

更新日期：2007-10-01 00:00:00

abstract：:An important feature of cytochrome P450 (CYP) 2B1 is its high ability to convert the prodrug cyclophosphamide (CPA) to therapeutically cytotoxic metabolites, resulting in interstrand DNA-cross-linking and cell death. We have examined whether and how the phosphorylation of CYP2B1 influences CPA metabolic activation in ...

journal_title：International journal of cancer

authors： Oesch-Bartlomowicz B,Richter B,Becker R,Vogel S,Padma PR,Hengstler JG,Oesch F

更新日期：2001-12-01 00:00:00

abstract：:The influence of 4 murine monoclonal antibodies (MAbs) directed against surface determinants of a metastasizing rat adenocarcinoma (BSp73ASML) on metastatic spread was evaluated and compared to their in vivo binding as well as to the induction of a humoral anti-MAb response, especially with respect to the development ...

journal_title：International journal of cancer

authors： Reber S,Matzku S,Günthert U,Ponta H,Herrlich P,Zöller M

更新日期：1990-11-15 00:00:00