New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats.

abstract：:The c-KIT protooncogene encodes a tyrosine kinase receptor, KIT, that is expressed in many normal and cancerous tissues. In this study, we have examined the expression of c-KIT and its ligand, stem cell factor (SCF), in human epithelial ovarian tumors, in normal ovaries and in cultured ovarian surface epithelium (OSE)...

journal_title：International journal of cancer

authors： Tonary AM,Macdonald EA,Faught W,Senterman MK,Vanderhyden BC

更新日期：2000-05-20 00:00:00

abstract：:GC-binding factor 2 (GCF2), a transcriptional repressor that decreases the activity of several genes is capable of binding directly to the GC-rich sequence of the EGFR promoter and repressing the transcriptional activity of EGFR. In addition to its function as a transcriptional repressor, GCF2 can directly interact wi...

journal_title：International journal of cancer

authors： Ohtsuka H,Oikawa M,Ariake K,Rikiyama T,Motoi F,Katayose Y,Unno M,Johnson AC

更新日期：2011-10-01 00:00:00

abstract：:Lymphatic leukemia developed in C57BL/6 mice following inoculation of normal thymocytes that and been co-cultured on leukemic thymus epithelial reticulum monolayer cells. Using thymocytes genetically marked in Ly membrane antigens, we showed that the thymomas which developed were produced by the co-cultured thymocytes...

journal_title：International journal of cancer

authors： Haas M

更新日期：1978-01-15 00:00:00

abstract：:The aim of our study was to investigate the protection afforded to the bone marrow by Goralatide (AcSDKP), an inhibitor of hemopoietic stem cell proliferation, when administered alone or in combination with a growth factor (granulocyte/macrophage colony-stimulating factor [GM-CSF]) during iterative cycles of Ara-C (cy...

journal_title：International journal of cancer

authors： Bogden AE,Moreau JP,Gamba-Vitalo C,Deschamps de Paillette E,Tubiana M,Frindel E,Carde P

更新日期：1998-03-30 00:00:00

abstract：:Hyaluronan (HA) has been shown to play important roles in the growth, invasion and metastasis of malignant tumors. Our previous study showing that high HA expression in malignant peripheral nerve sheath tumors (MPNST) is predictive of poor patient prognosis, prompted us to speculate that inhibition of HA synthesis in ...

journal_title：International journal of cancer

authors： Ikuta K,Ota T,Zhuo L,Urakawa H,Kozawa E,Hamada S,Kimata K,Ishiguro N,Nishida Y

更新日期：2017-01-15 00:00:00

abstract：:The distance of nerve invasion is an important prognostic factor in pancreatic cancer. The extracellular matrix (ECM) of nerve, mainly composed of laminin, collagen IV and anchoring fibrils, might affect nerve invasion. However, this relationship has not been demonstrated. Our study aimed at discovering the promoting ...

journal_title：International journal of cancer

authors： Mitsunaga S,Fujii S,Ishii G,Kinoshita T,Hasebe T,Aoyagi K,Sasaki H,Ochiai A

更新日期：2010-08-15 00:00:00

abstract：:The expression of two discrete cell properties related to the host natural effector mechanisms, i.e., resistance to damage by H2O2, a cytotoxic product of activated macrophages, and the ability to secrete PGE, which inhibits NK-cell cytotoxicity, has been examined in parental Syrian hamster embryo cells spontaneously ...

journal_title：International journal of cancer

authors： Deichman GI,Kluchareva TE,Matveeva VA,Kushlinsky NE,Bassalyk LS,Vendrov EL

更新日期：1989-11-15 00:00:00

abstract：:Stem cell-like cells have recently been identified in melanoma cell lines, but their relevance for melanoma pathogenesis is controversial. To characterize the stem cell signature of melanoma, expression of stem cell markers BMI-1 and nestin was studied in 64 cutaneous melanomas, 165 melanoma metastases as well as 53 m...

journal_title：International journal of cancer

authors： Mihic-Probst D,Kuster A,Kilgus S,Bode-Lesniewska B,Ingold-Heppner B,Leung C,Storz M,Seifert B,Marino S,Schraml P,Dummer R,Moch H

更新日期：2007-10-15 00:00:00

abstract：:Murine SCC-VII squamous carcinoma cells have the capacity to penetrate reconstituted basement membranes (Matrigel) in vitro. The invasion of Matrigel layers by SCC-VII cells was significantly reduced by E-64, a specific inhibitor of lysosomal cysteine proteinases. The cathepsin-B-selective E-64 derivative, CA-074, inh...

journal_title：International journal of cancer

authors： Coulibaly S,Schwihla H,Abrahamson M,Albini A,Cerni C,Clark JL,Ng KM,Katunuma N,Schlappack O,Glössl J,Mach L

更新日期：1999-11-12 00:00:00

abstract：:Murine macrophages from different anatomical sites were compared for their ability to become tumoricidal and to secrete interleukin-1 (IL-1) and tumor necrosis factor (TNF) following stimulation in vitro by several biological response modifiers (BRM). Peritoneal macrophages (PM), alveolar macrophages (AM), and tumor-i...

journal_title：International journal of cancer

authors： Brunda MJ,Sulich V,Wright RB,Palleroni AV

更新日期：1991-07-09 00:00:00

abstract：:Although in the normal healthy organism angiogenesis is a tightly regulated process, under a variety of circumstances it may contribute to disease states. These include the growth of solid tumors, the hematogenous spread of tumor cells and the growth of metastasis. Our aim was to measure the levels of 5 angiogenic cyt...

journal_title：International journal of cancer

authors： Fuhrmann-Benzakein E,Ma MN,Rubbia-Brandt L,Mentha G,Ruefenacht D,Sappino AP,Pepper MS

更新日期：2000-01-01 00:00:00

abstract：:Like the majority of tumor cells, ovarian cancer cell growth is critically dependent on their neovascularization. Adhesion molecules and cellular events that lead to ovarian tumor cell interactions with endothelial extracellular matrix surrounding the vasculature are poorly identified. To understand the role of alphav...

journal_title：International journal of cancer

authors： Carreiras F,Thiébot B,Leroy-Dudal J,Maubant S,Breton MF,Darbeida H

更新日期：2002-06-20 00:00:00

abstract：:Serum alkaline DNase activity (SADA) was investigated in rats receiving s.c. transplants of tumor cells sensitive or resistant to chemotherapy. Serum samples from each animal were collected before transplantation, during the development of tumors and after therapy. Within a few days after transplantation of both tumor...

journal_title：International journal of cancer

authors： Economidou-Karaoglou A,Brasseur F,Lans M,Taper HS,Roberfroid MB

更新日期：1989-05-15 00:00:00

abstract：:While dietary antioxidants are emerging as potentially modifiable risk factors for esophageal adenocarcinoma (EAC), studies on dietary antioxidants and its precursor Barrett's esophagus (BE) are limited. The present study extends previous work on BE by investigating risks of nondysplastic BE, dysplastic BE and EAC ass...

journal_title：International journal of cancer

authors： Ibiebele TI,Hughes MC,Nagle CM,Bain CJ,Whiteman DC,Webb PM,Study of Digestive Health and Australian Cancer Study.

更新日期：2013-07-01 00:00:00

abstract：:We have shown that the loss of p53 function contributed to resistance of tumor cells to TNF-induced cytotoxicity. In the present study, we evaluated the effect of wild-type p53 (wt-p53) expression on TNF sensitivity, by introducing wt-p53 into MCF7/Adr cells in which p53 was deleted, via a recombinant adenovirus encod...

journal_title：International journal of cancer

authors： Shatrov VA,Ameyar M,Bouquet C,Cai Z,Stancou R,Haddada H,Chouaib S

更新日期：2000-01-01 00:00:00

abstract：:The mRNA levels of the ras-related human rhoA, rhoB and rhoC genes were studied in human breast-cancer cell lines (HBCal), and in normal and immortalized mammary epithelial cells (HMEC) by Northern blot analysis and in situ hybridization. In contrast to the ubiquitous rhoA and rhoC gene expression, dramatic variations...

journal_title：International journal of cancer

authors： de Cremoux P,Gauville C,Closson V,Linares G,Calvo F,Tavitian A,Olofsson B

更新日期：1994-11-01 00:00:00

abstract：:Sera samples from 111 women, including 73 breast cancer patients and 38 patients with benign diseases of the breast, were examined. These were compared with samples from healthy women or from patients carrying tumors of origin other than breast as controls. This was done to determine whether antibodies against GCDFP-1...

journal_title：International journal of cancer

authors： Pasquinelli R,Barba P,Capasso I,D'Aiuto M,D'Aiuto G,Anzisi AM,De Berardinis P,Guardiola J

更新日期：1999-12-22 00:00:00

abstract：:Receptor status and gene amplification were studied in advanced human ovarian adenocarcinoma tissues, borderline and benign ovarian tumours and normal ovarian tissues. Sixty-five percent (53/82) of ovarian adenocarcinomas, 57% (8/14) of benign/borderline tumours and only 31% (5/16) of normal ovarian tissues studied sh...

journal_title：International journal of cancer

authors： Berns EM,Klijn JG,Henzen-Logmans SC,Rodenburg CJ,van der Burg ME,Foekens JA

更新日期：1992-09-09 00:00:00

abstract：:Experimental studies have suggested that the biosynthesis of arachidonic acid-derived eicosanoids such as prostaglandin E2 via the cyclo-oxygenase pathway may play a significant role in supporting cell proliferation in human prostate cancer cell lines. However, the aetiological significance of this for clinical prosta...

journal_title：International journal of cancer

authors： Norrish AE,Jackson RT,McRae CU

更新日期：1998-08-12 00:00:00

abstract：:IL-21 is a member of the IL-2 cytokine family, produced by CD4+ T cells. We previously showed that immunotherapy (IT) with IL-21-transduced neuroblastoma cells (Neuro2a/IL-21) cured 33% of syngeneic mice bearing systemic NB. Here, we studied whether the removal of Treg cells could potentiate the therapeutic efficacy o...

journal_title：International journal of cancer

authors： Croce M,Corrias MV,Orengo AM,Brizzolara A,Carlini B,Borghi M,Rigo V,Pistoia V,Ferrini S

更新日期：2010-09-01 00:00:00

abstract：:A triazene-xenogenized tumor sub-line was derived from the mouse mastocytoma cell line P815 following several transplant generations in vivo on DTIC. The highly immunogenic P815/DTIC variant line expressed new CTL-defined antigens. Novel antigens were also detected by antibodies in immunoprecipitation and by Western b...

journal_title：International journal of cancer

authors： Grohmann U,Fioretti MC,Binaglia L,Belladonna ML,Bianchi R,Puccetti P

更新日期：1993-09-09 00:00:00

abstract：:Increasing evidence indicates that breast cancer pathogenesis is linked with DNA double-strand break (DSB) repair dysfunction. This conclusion is based on advances in the study of functions of breast cancer susceptibility genes such as BRCA1 and BRCA2, on the identification of breast cancer-associated changes regardin...

journal_title：International journal of cancer

authors： Keimling M,Kaur J,Bagadi SA,Kreienberg R,Wiesmüller L,Ralhan R

更新日期：2008-08-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a common neoplasm in Southeastern Asia, and cisplatin-containing regimens for combinational chemotherapy are widely used for treating locally recurrent or metastatic diseases. However, resistance to cisplatin is not infrequently seen and its associated side effects may be life-threate...

journal_title：International journal of cancer

authors： To YF,Sun RW,Chen Y,Chan VS,Yu WY,Tam PK,Che CM,Lin CL

更新日期：2009-04-15 00:00:00

abstract：:Using radioiodinated Staphylococcus aureus protein A [125I]SPA to measure syngeneic, allogeneic and heterogeneic IgG bound to murine tumor cells, we performed a serological analysis of surface antigens of 8 solid tumors and 2 leukemias of BALB/c mice (3 chemically-induced colon carcinomas, 3 chemically-induced sarcoma...

journal_title：International journal of cancer

authors： Cleveland PH,Belnap LP,Knotts FB,Nayak SK,Baird SM,Pilch YH

更新日期：1979-03-15 00:00:00

abstract：:Loss of heterozygosity (LOH) is an important event of tumorigenesis. In gastric cancer, we found a novel region of LOH in chromosome 9q having about 800 kb deletions at 9q31.1. The microsatellite marker D9S938 in that region exhibiting the highest LOH frequency, 56.5%. In addition, the LOH at 9q31.1 did not show any r...

journal_title：International journal of cancer

authors： Kakinuma N,Kohu K,Sato M,Yamada T,Nakajima M,Akiyama T,Ohwada S,Shibanaka Y

更新日期：2004-03-01 00:00:00

abstract：:Protein phosphatase 2A (PP2A) consists of 3 subunits: the catalytic subunit, C, and the regulatory subunits, A and B. The A and C subunits both exist as 2 isoforms (alpha and beta) and the B subunit as multiple forms subdivided into 3 families, B, B' and B". It has been reported that the genes encoding the Aalpha and ...

journal_title：International journal of cancer

authors： Colella S,Ohgaki H,Ruediger R,Yang F,Nakamura M,Fujisawa H,Kleihues P,Walter G

更新日期：2001-09-01 00:00:00

abstract：:We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...

journal_title：International journal of cancer

authors： Merlo A,Jermann E,Hausmann O,Chiquet-Ehrismann R,Probst A,Landolt H,Maecke HR,Mueller-Brand J,Gratzl O

更新日期：1997-05-29 00:00:00

abstract：:In vivo TSTA induction in Syrian hamsters was studied with the use of SV40 ts mutants (A, B, C, BC and D). The ts A30, TS A239 and possibly also the ts BC210 mutants were defective in resistance-inducing activity in hamsters in contrast to wild type SV40 and other ts mutnats. At the permissive temperature ts A30 and t...

journal_title：International journal of cancer

authors： Deichman GI,Kluchareva TE,Kashkina LM

更新日期：1977-10-15 00:00:00

abstract：:Colorectal cancer is a heterogeneous disease at the histomorphological, clinical and molecular level. Approximately 20% of cases may progress through the "serrated" pathway characterized by BRAF mutation and high-level CpG Island Methylator Phenotype (CIMP). A large subgroup are additionally microsatellite instable (M...

journal_title：International journal of cancer

authors： Dawson H,Galván JA,Helbling M,Muller DE,Karamitopoulou E,Koelzer VH,Economou M,Hammer C,Lugli A,Zlobec I

更新日期：2014-05-15 00:00:00

abstract：:It has been debated whether the reported increased risk of Hodgkin's lymphoma (HL) after tonsillectomy could be due to some underlying factor rather than the surgery itself. We studied whether not only tonsillectomy but also tonsillitis was associated with HL. This nationwide cohort study included all Danish residents...

journal_title：International journal of cancer

authors： Vestergaard H,Westergaard T,Wohlfahrt J,Hjalgrim H,Melbye M

更新日期：2010-08-01 00:00:00