Abstract：
:The mRNA levels of the ras-related human rhoA, rhoB and rhoC genes were studied in human breast-cancer cell lines (HBCal), and in normal and immortalized mammary epithelial cells (HMEC) by Northern blot analysis and in situ hybridization. In contrast to the ubiquitous rhoA and rhoC gene expression, dramatic variations in the mRNA level of the rhoB gene were evidenced. The rhoB mRNA level appeared to be inversely correlated to the amounts of the epidermal-growth-factor(EGF) receptors in these cells. The rhoB transcripts were detected at high levels in ZR75-1, MCF7, HSL 53, HSL 59, HSL 90, T47D and SKBR3 HBCal, at hardly detectable levels in BT 20, MDA-MB 231 and H466B HBCal and at intermediate levels in normal and immortalized breast epithelial cells. Rapid and transient induction of the rhoB transcription was observed after EGF treatment in serum-deprived MDA-MB231, T47D and immortalized epithelial cells. In contrast, no modulation of rhoB expression by EGF could be objectified in the MCF7 and ZR75-1 cell lines. Yet a normal function of EGF receptors was evidenced, since the immediate early gene c-fos was rapidly induced, suggesting a constitutive expression of rhoB in these cell lines bypassing the regulation by EGF. In human mammary epithelial cells, rhoB mRNA is rapidly and transiently induced with EGF concentrations known to stimulate cell proliferation. This suggests that the rhoB product might be involved in a cascade that initiates or promotes cell proliferation, and plays an important role in EGF-stimulated growth of breast normal and cancer cells.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
de Cremoux P,Gauville C,Closson V,Linares G,Calvo F,Tavitian A,Olofsson Bdoi
10.1002/ijc.2910590320subject
Has Abstractpub_date
1994-11-01 00:00:00pages
408-15issue
3eissn
0020-7136issn
1097-0215journal_volume
59pub_type
杂志文章abstract：:History of diabetes may be associated with decreased prostate cancer (PCa) risk. Published studies have not always accounted for time since diabetes diagnosis or confounding and effect modification by lifestyle factors. The authors investigated the relationship between diabetes and PCa risk in men in the Health Profes...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24044
更新日期：2009-03-15 00:00:00
abstract：:We tested the efficacy of gefitinib in the prevention of HER2/neu-mediated breast cancer development in BALB-NeuT transgenic mice. Oral administration of gefitinib to female transgenic mice from 5 to 14 weeks of age reduced tumor multiplicity from 9.6 +/- 0.82 to 0.58 +/- 1.1 (83%). We observed a decrease in the numbe...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23231
更新日期：2008-04-15 00:00:00
abstract：:The results from the population-based cancer registry for the city of Ho Chi Minh in 1995-1996 represent the first information on the incidence of cancer in southern Viet Nam. A total of 4,080 cancer cases in males and 4,338 in females were registered, corresponding to age-standardized incidence rates (ASRs) of 130.9 ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980518)76:4<472::aid-ijc
更新日期：1998-05-18 00:00:00
abstract：:Our aim was to determine the long-term outcome and the possible role of neoadjuvant (preoperative) radiation therapy for breast cancers unsuitable for primary conservative surgery. From 1977 to 1992, 75 unifocal non-inflammatory and non-metastatic T2 and T3 breast cancers were treated in our department. All these pati...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.1024
更新日期：2001-08-20 00:00:00
abstract：:Resistance to anticancer drugs is the major problem in the treatment of many advanced cancers, including androgen-independent prostate cancer. Recently, increased expression of Id-1, a basic helix-loop-helix protein, is reported in several types of advanced cancer. It is suggested that high expression of Id-1 may prov...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21592
更新日期：2006-04-15 00:00:00
abstract：:The p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and cancer-derived cell lines as a result of infection by human papillomavirus (HPV). The HPV E6 oncoprotein forms complexes with p53 and promotes its degradation via ubiquitin-dependent mechanism. In our study, we attempted to improve t...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.26013
更新日期：2012-01-15 00:00:00
abstract：:The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV-IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell-to-...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970717)72:2<321::aid-ijc
更新日期：1997-07-17 00:00:00
abstract：:We have investigated the effect of interferon-gamma (IFN-gamma) treatment of neuroblastoma cells on the susceptibility to lysis by lymphokine-activated killer (LAK) cells and examined the participation of cell-adhesion molecules on the target cells in LAK cell lysis. Untreated neuroblastoma cells expressed lymphocyte-...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910470410
更新日期：1991-02-20 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980729)77:3<455::aid-ijc
更新日期：1998-07-29 00:00:00
abstract：:The present study was undertaken to determine the role of the metalloproteinase MMP-9 in the invasive phenotype of squamous-cell carcinoma of the oral cavity and the regulation of its expression. Zymographic analysis of conditioned medium from 2 highly invasive squamous-cell-carcinoma cell lines indicated large amount...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910550104
更新日期：1993-08-19 00:00:00
abstract：:There are no reliable serologic tumor markers for transitional cell carcinoma (TCC) of the urinary bladder and noninvasive urine investigations are inadequate. We used fluorescent microsatellite analysis (MSA) to detect serum DNA and urine-sediment DNA alterations in patients with bladder cancer and prospectively coll...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.1434
更新日期：2001-10-01 00:00:00
abstract：:Interest has increased in the potential role of circulating tumour cells in cancer management. Most cell-based studies have been designed to determine the number of circulating tumour cells in a given volume of blood. Ability to understand the biology of the cancer cells would increase the clinical potential. The purp...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29680
更新日期：2016-01-01 00:00:00
abstract：:The importance of tumor associated neutrophils (TANs) in cancer development is in the meantime well established. Numerous of clinical data document the adverse prognostic effects of neutrophil infiltration in solid tumors. However, certain tumor therapies need functional neutrophils to be effective, suggesting altered...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29945
更新日期：2016-04-15 00:00:00
abstract：:The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cance...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.1319
更新日期：2001-07-15 00:00:00
abstract：:Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to assess the associa...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25628
更新日期：2011-06-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23595
更新日期：2008-09-01 00:00:00
abstract：:Mouse IFN gamma preparations purified 30-fold were found to have direct cytolytic activity against a number of tumor and normal cells. Cell killing was determined using a sensitive, rapid and accurate assay which employed very low numbers of cells and very small quantities of interferon. The cytolytic activity of IFN ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910300111
更新日期：1982-07-15 00:00:00
abstract：:The mode of transmission of human herpesvirus 8 (HHV8) was investigated in two seroepidemiological studies of Swedish women who completed a questionnaire about sexual behavior. Seropositivity for HHV8 antibodies, measured using an indirect immunofluorescence assay, was linked to a high number (>10) of sexual partners ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：
更新日期：2000-07-15 00:00:00
abstract：:We have recently shown in the BDII rat model of human endometrial adenocarcinoma (EAC), rat chromosome 10 (RNO10) is frequently involved in chromosomal aberrations. In the present study, we investigated the association between RNO10 deletions, allelic imbalance (AI) at RNO10q24 and Tp53 mutation in 27 rat EAC tumors. ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22533
更新日期：2007-04-01 00:00:00
abstract：:Transferrin is required for proliferation of most cells in culture. This effect is presumably mediated by the binding of transferrin to its receptor, a surface glycoprotein which is preferentially expressed by actively growing cells. Here we show that normal human fibroblasts cultured in serum, and other media contain...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910310118
更新日期：1983-01-15 00:00:00
abstract：:The question of whether squamous cell carcinomas (SCCs) arising in different sites of lung are caused by different etiological factors is of obvious importance for prevention, early detection and effective treatment. We here subclassified a large series of resected SCCs (74 cases) into 3 tumor-sites, central (main to ...
journal_title：International journal of cancer
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doi：10.1002/ijc.21877
更新日期：2006-08-01 00:00:00
abstract：:Data from 1,916 cases of oral neoplasms occurring in the Sudan in a 16-year period, from January 1970 to December 1985, were retrieved and analysed. The study revealed a relatively high frequency of oral neoplasms in comparison with neighbouring countries. In this study, squamous-cell carcinoma was the most common ora...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910610202
更新日期：1995-04-10 00:00:00
abstract：:A human tumor clonogenic assay has been used to test the antiproliferative effect of recombinant human leukocyte interferon alpha 2 alone and in combination with each of 8 cytotoxic agents. Cell lines derived from 6 human tumors and primary tumor cells from 13 patients have been used in these clonogenic assay studies....
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910350605
更新日期：1985-06-15 00:00:00
abstract：:The metastatic spread of tumor cells is the most lethal aspect of cancer and can occur via various routes, including the lymphatic vasculature. Studies of tumor models in animals and clinicopathological data have indicated that growth of lymphatic vessels (lymphangiogenesis) in the vicinity of solid tumors may contrib...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.21899
更新日期：2006-10-15 00:00:00
abstract：:Leukocyte adherence inhibition (LAI) reactivity of various lymphoid tissues of dogs with canine transmissible venereal sarcoma (CTVS) at different stages of growth was determined by the tube LAI test. Tumors were classified at the time of excision into progressor, steady state, and regressor stages of growth. The LAI ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910270314
更新日期：1981-03-15 00:00:00
abstract：:Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras e...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31152
更新日期：2018-04-01 00:00:00
abstract：:Immune cells in tumor microenvironment play a prominent role in tumor progression and metastasis. MicroRNA-155 (miR-155) represents an important player in innate and adaptive immunity by regulating differentiation, maturation and activation of macrophages, dendritic cells, B cells and T cells. However, the role of miR...
journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2015-03-15 00:00:00
abstract：:Apoptin is a chicken anemia virus-derived, p53-independent, bcl-2-insensitive apoptotic protein with the ability to specifically induce apoptosis in tumor cells. To explore the use of the Apoptin gene in cancer gene therapy, we constructed a recombinant fowlpox virus expressing the Apoptin protein (vFV-Apoptin) and co...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22215
更新日期：2006-12-15 00:00:00
abstract：:Murine macrophages from different anatomical sites were compared for their ability to become tumoricidal and to secrete interleukin-1 (IL-1) and tumor necrosis factor (TNF) following stimulation in vitro by several biological response modifiers (BRM). Peritoneal macrophages (PM), alveolar macrophages (AM), and tumor-i...
journal_title：International journal of cancer
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更新日期：1991-07-09 00:00:00
abstract：:Human malignant glioma cell lines and clones were incubated with various concentrations of recombinant human TNF-alpha, either alone or in combination with recombinant human IFN-gamma. The surface expression of HLA-ABC (class I) antigens and beta 2-microglobulin, was significantly enhanced by TNF-alpha alone on every ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910420525
更新日期：1988-11-15 00:00:00
