Abstract:
:Recombinant human interferon beta (rIFN-beta) inhibited in a time- and dose-dependent manner the proliferation of 18/18 human colon carcinoma cell lines in monolayer culture and 8/9 lines in a soft agar assay but had no effect on 4 human fibroblast cell lines. Maximal inhibition of cell proliferation by rIFN-beta required repetitive treatment (every 2 days) with lymphokine (50 units/ml). Furthermore, the inhibitory activity of rIFN-beta was neutralized by polyclonal antibodies against natural IFN-beta. In contrast to rIFN-beta, rIFN-alpha was inactive against all colon cell lines tested, and rIFN-gamma, with the exception of HT-29 cells, was similarly ineffective. These data demonstrate that rIFN-beta is a potent growth inhibitor of colon carcinoma cells in vitro, and suggest that studies on its mechanism of action may lead to a better understanding of the regulation of colon tumor cell proliferation.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Wong VL,Rieman DJ,Aronson L,Dalton BJ,Greig R,Anzano MAdoi
10.1002/ijc.2910430331subject
Has Abstractpub_date
1989-03-15 00:00:00pages
526-30issue
3eissn
0020-7136issn
1097-0215journal_volume
43pub_type
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