Abstract:
:The antigen-induced leukocyte adherence inhibition (LAI) test is an assay of cellular immune reactivity which was expected to offer a promising adjunct to currently available diagnostic and monitoring procedures in cancer patients. We have applied this assay to (1) 83 inpatients clinically suspected of having breast cancer, (2) 50 out-patients before mammography, and (3) 37 healthy women. In order to account for the known heterogenicity of breast cancer, we performed LAI assays with extracts from 15 primary tumors of known and 14 primary tumors of initially unknown histology. Thus, the problem of tumor specificity in the LAI assay was tackled in a double-blind fashion. The results obtained clearly show that breast-tissue-specific rather than tumor-specific responses were detected by LAI testing. The LAI assay failed to discriminate between high-risk patients with and without cancer and between extracts from breast tumors with and without carcinoma. The results are discussed with regard to the many claims for the detection of specific tumor immunity in the literature.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Fritze D,Fedra G,Kaufmann Mdoi
10.1002/ijc.2910290306subject
Has Abstractpub_date
1982-03-15 00:00:00pages
261-4issue
3eissn
0020-7136issn
1097-0215journal_volume
29pub_type
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journal_title:International journal of cancer
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abstract::The morphology of rat liver cells containing alpha-feto-protein (AFP) during early stages of carcinogenesis induced by 3'methyl-4-dimethylaminoazobenzene and 2-acetylaminofluorene was investigated. Indirect immunofluorescence was used to detect AFP. AFP was not found in the cells of hyperplastic nodules but was presen...
journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
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更新日期:2008-10-15 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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doi:
更新日期:2000-09-20 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
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更新日期:2015-03-15 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/(sici)1097-0215(19980130)75:3<396::aid-ijc
更新日期:1998-01-30 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.11080
更新日期:2003-06-20 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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abstract::The androgen receptor (AR) gene is a transcription factor responsible for mediating the physiological effects of androgens. Evidence suggests that androgens and the androgen receptor are involved in uterine cell proliferation. A polymorphic CAG repeat in exon 1 of the AR gene encodes a polyglutamine tract that is inve...
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