Tumor-antigen-specific humoral immune response of animals to anti-idiotypic antibodies and comparative serological analysis of patients with small-cell lung carcinoma.

abstract：:The factors associated with risk of lung cancer among nonsmokers have not been fully elucidated, but dietary factors have consistently been shown to play a role. Chinese women are unique in having a high incidence of lung cancer despite a low smoking prevalence. This population is also known to have a high intake of s...

journal_title：International journal of cancer

authors： Seow A,Poh WT,Teh M,Eng P,Wang YT,Tan WC,Chia KS,Yu MC,Lee HP

更新日期：2002-01-20 00:00:00

abstract：:The tumor-suppressor genes p14(ARF), p16(INK4a) and Tp53 are commonly inactivated in many tumors. We investigated their role in the pathogenesis of 9 bile tract cancer cell lines and 21 primary sporadic extrahepatic bile duct carcinomas. p53 and p16 protein expression was examined by Western blot analysis and immunohi...

journal_title：International journal of cancer

authors： Caca K,Feisthammel J,Klee K,Tannapfel A,Witzigmann H,Wittekind C,Mössner J,Berr F

更新日期：2002-02-01 00:00:00

abstract：:Esophageal cancer is a leading cause of cancer death, especially in developing countries. In high-risk regions, squamous cell carcinoma is the most common type of esophageal cancer, and its etiology remains poorly understood. The purpose of this study was to evaluate the association between human papillomavirus (HPV) ...

journal_title：International journal of cancer

authors： Gao GF,Roth MJ,Wei WQ,Abnet CC,Chen F,Lu N,Zhao FH,Li XQ,Wang GQ,Taylor PR,Pan QJ,Chen W,Dawsey SM,Qiao YL

更新日期：2006-09-15 00:00:00

abstract：:In 1979, a hypothesis-generating, population-based case-control study was undertaken in Montreal, Canada, to explore the association between occupational exposure to 294 substances, 130 occupations and industries, and various cancers. Interviews were carried out with 3, 630 histologically confirmed cancer cases, of wh...

journal_title：International journal of cancer

authors： Dumas S,Parent ME,Siemiatycki J,Brisson J

更新日期：2000-09-15 00:00:00

abstract：:The activity of systemic and in situ natural killer (NK) cells was measured in 3- to 5-week-old CBA mice with progressively growing murine sarcoma virus (MSV)-induced tumors. Splenic NK activity was depressed in tumor-bearing mice. NK activity was quite low or not detectable in unfractionated cell suspensions from the...

journal_title：International journal of cancer

authors： Gerson J,Varesio L,Herberman RB

更新日期：1981-02-15 00:00:00

abstract：:As the most abundant noncoding RNA in cells, tRNA plays an important role in tumorigenesis and development. The report of tRNA on the pathogenesis of lung adenocarcinoma is rare. It is of great clinical significance to explore the relationship between tRNA expression and prognosis of lung adenocarcinoma. The expressio...

journal_title：International journal of cancer

authors： Kuang M,Zheng D,Tao X,Peng Y,Pan Y,Zheng S,Zhang Y,Li H,Yuan C,Zhang Y,Xiang J,Li Y,Chen H,Sun Y

更新日期：2019-10-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor-suppressor and other genes related to cell differentiation, cell-cycle arrest or apoptosis of tumor cells. The...

journal_title：International journal of cancer

authors： Biran A,Brownstein M,Haklai R,Kloog Y

更新日期：2011-02-01 00:00:00

abstract：:There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer...

journal_title：International journal of cancer

authors： Solans M,Benavente Y,Saez M,Agudo A,Naudin S,Hosnijeh FS,Noh H,Freisling H,Ferrari P,Besson C,Mahamat-Saleh Y,Boutron-Ruault MC,Kühn T,Kaaks R,Boeing H,Lasheras C,Rodríguez-Barranco M,Amiano P,Huerta JM,Barricarte A

更新日期：2019-07-01 00:00:00

abstract：:Adhesion molecules involved in attachment between human pancreatic carcinoma and activated endothelial cells in vitro were investigated. Basal adhesion occurred between 6 pancreatic carcinoma cell lines and unstimulated human umbilical vein endothelial cells (HUVEC), and augmented basal adhesion to activated HUVEC was...

journal_title：International journal of cancer

authors： Iwai K,Ishikura H,Kaji M,Sugiura H,Ishizu A,Takahashi C,Kato H,Tanabe T,Yoshiki T

更新日期：1993-07-30 00:00:00

abstract：:This population-based cohort study investigated the occurrence of familial astrocytoma among first-degree relatives of patients with astrocytoma diagnosed between 1985 and 1993 in the northern region of Sweden. The 432 cases received a questionnaire. They were asked to provide names and cancer diagnoses of first-degre...

journal_title：International journal of cancer

authors： Malmer B,Grönberg H,Bergenheim AT,Lenner P,Henriksson R

更新日期：1999-05-05 00:00:00

abstract：:Risk of Hodgkin's disease (HD) in young adults has frequently been associated with limited access to social contact in childhood and related correlates of childhood social class. In addition, case clustering has sometimes been associated with influxes of population into relatively isolated communities. To investigate ...

journal_title：International journal of cancer

authors： Alexander FE,Ricketts TJ,McKinney PA,Cartwright RA

更新日期：1991-04-22 00:00:00

abstract：:Studies have shown an increased risk of malignancies in women with endometriosis. Little is known about the impact of endometriosis on cancer survival. We investigated whether the survival after a diagnosis of a malignancy differs in women with a previously diagnosed endometriosis compared to other women. Women with a...

journal_title：International journal of cancer

authors： Melin A,Lundholm C,Malki N,Swahn ML,Sparen P,Bergqvist A

更新日期：2011-08-15 00:00:00

abstract：:Beta-lapachone and camptothecin are structurally unrelated agents thought to inhibit topoisomerase-I activity through distinct mechanisms. We find that beta-lapachone is much more potent than camptothecin in inducing acute cytotoxic effects on human malignant glioma cells. Acute cytotoxicity induced by both drugs is a...

journal_title：International journal of cancer

authors： Weller M,Winter S,Schmidt C,Esser P,Fontana A,Dichgans J,Groscurth P

更新日期：1997-11-27 00:00:00

abstract：:Cultured tumor cell lines, tumor xenografts grown in athymic nude mice, and a murine experimental metastasis model were used to assess the in vitro and in vivo anti-tumor activity of the potent IMP dehydrogenase (IMPDH) inhibitor, mycophenolic acid (MPA), and its morpholinoethyl ester pro-drug, mycophenolate mofetil (...

journal_title：International journal of cancer

authors： Tressler RJ,Garvin LJ,Slate DL

更新日期：1994-05-15 00:00:00

abstract：:The Ontario Cancer Registry (OCR) and the Surveillance, Epidemiology and End Results (SEER) databases were used to describe temporal trends in the incidence and survival of squamous cancers of the upper aerodigestive tract (UADT) in Ontario and the US between 1984 and 2001. Between the 1984-86 and 1999-01 periods, the...

journal_title：International journal of cancer

authors： Gupta S,Kong W,Peng Y,Miao Q,Mackillop WJ

更新日期：2009-11-01 00:00:00

abstract：:Conversion of solid sarcomas and carcinomas into ascites tumors depends on the in vivo selection of phenotypically altered tumor cell variants that can grow in the dissociated form. Once selected, they retain this property even after prolonged s.c. growth as solid tumors. From an s.c.-passaged subline of an ascites-co...

journal_title：International journal of cancer

authors： Minarovits J,Steinitz M,Boldog F,Imreh S,Wirschubsky Z,Ingvarsson S,Hedenskog M,Minarovits-Kormuta S,Klein G

更新日期：1990-03-15 00:00:00

abstract：:Fatty acid ester surfactants, e.g., Cremophor EL and Solutol HS 15, that modulate multi-drug resistance (MDR) have been described; however, the drug potential of these preparations is unclear because of the molecular heterogeneity of these and other commercial surfactants. In previous experiments, an active but still ...

journal_title：International journal of cancer

authors： Buckingham LE,Balasubramanian M,Safa AR,Shah H,Komarov P,Emanuele RM,Coon JS

更新日期：1996-01-03 00:00:00

abstract：:Cancer vaccines directed against tumor associate antigen (TAA) have produced encouraging results in preclinical models but not in cancer patients. A major limitation of this strategy is the relative degree of tolerance to these antigens and the low and heterogeneous tumor cell expression of TAA and major histocompatib...

journal_title：International journal of cancer

authors： Correale P,Aquino A,Giuliani A,Pellegrini M,Micheli L,Cusi MG,Nencini C,Petrioli R,Prete SP,De Vecchis L,Turriziani M,Giorgi G,Bonmassar E,Francini G

更新日期：2003-04-20 00:00:00

abstract：:Human papillomavirus-induced cervical carcinomas often show impaired expression of MHC class I molecules resulting in the inability of tumor cells to directly present viral peptides to cytotoxic T lymphocytes. Loss of MHC class I expression combined with the expression of activating NK cell receptor ligands renders tu...

journal_title：International journal of cancer

authors： Textor S,Dürst M,Jansen L,Accardi R,Tommasino M,Trunk MJ,Porgador A,Watzl C,Gissmann L,Cerwenka A

更新日期：2008-11-15 00:00:00

abstract：:The role of plasma oxidant-antioxidant status in survival after breast cancer surgery was investigated in a cohort of patients (n = 363) hospitalized in Southern France between 1989 and 1992. The median follow-up was 8 years after surgery for histologically confirmed breast cancer. Plasma analyses were performed after...

journal_title：International journal of cancer

authors： Saintot M,Mathieu-Daude H,Astre C,Grenier J,Simony-Lafontaine J,Gerber M

更新日期：2002-02-10 00:00:00

abstract：:Sexual behavior has been consistently identified as a major risk factor for cervical cancer. Population-based studies have demonstrated that risk related to sexual activity is mediated by human papillomavirus (HPV) infection. We conducted a case-control study of 199 cases with low-grade squamous intraepithelial lesion...

journal_title：International journal of cancer

authors： Kjaer SK,van den Brule AJ,Bock JE,Poll PA,Engholm G,Sherman ME,Walboomers JM,Meijer CJ

更新日期：1996-03-01 00:00:00

abstract：:Interleukin-12 (IL-12) is a disulfide-linked p40-p35 heterodimeric cytokine and plays a key role in linking innate cellular immunity to an adaptive Th1 response against pathogens and tumor cells and in counteracting a Th2 immune response. The pathogenesis of Hodgkin's disease (HD) is partially attributed to a Th2 domi...

journal_title：International journal of cancer

authors： Heuser C,Diehl V,Abken H,Hombach A

更新日期：2003-09-10 00:00:00

abstract：:Smoking and second-hand smoke (SHS) exposure have been recently linked to a higher risk of breast cancer in women. The aim of this work is to estimate the number of deaths and disability-adjusted life years (DALYs) from breast cancer attributable to these two risk factors in the European Union (EU-28) in 2017. The com...

journal_title：International journal of cancer

authors： Carreras G,Lachi A,Boffi R,Clancy L,Gallus S,Fernández E,López MJ,Soriano JB,López Nicolás Á,Semple S,Behrakis P,Gorini G,TackSHS Project Investigators.

更新日期：2020-11-01 00:00:00

abstract：:The assessment of tumor molecular features in combination with the detection of occult malignant cells may provide important clinical information, beyond the standard staging of breast cancer. Using a nested RT-PCR technique, we assessed prospectively the presence of cytokeratin-19 (CK19) mRNA positive cells in the bl...

journal_title：International journal of cancer

authors： Giatromanolaki A,Koukourakis MI,Kakolyris S,Mavroudis D,Kouroussis C,Mavroudi C,Perraki M,Sivridis E,Georgoulias V

更新日期：2004-02-10 00:00:00

abstract：:Homeobox-containing genes are a network of genes encoding DNA-binding proteins highly conserved throughout evolution. They are involved in the control of normal development as well as in the regulation of gene expression in adult differentiating systems, including hematopoiesis. Aberrant expression of homeobox-contain...

journal_title：International journal of cancer

authors： Celetti A,Barba P,Cillo C,Rotoli B,Boncinelli E,Magli MC

更新日期：1993-01-21 00:00:00

abstract：:Histone deacetylases (HDAC) extensively contribute to the c-Myc oncogenic program, pointing to their inhibition as an effective strategy against c-Myc-overexpressing cancers. We, thus, studied the therapeutic activity of the new-generation pan-HDAC inhibitor ITF2357 (Givinostat®) against c-Myc-overexpressing human B-c...

journal_title：International journal of cancer

authors： Zappasodi R,Cavanè A,Iorio MV,Tortoreto M,Guarnotta C,Ruggiero G,Piovan C,Magni M,Zaffaroni N,Tagliabue E,Croce CM,Zunino F,Gianni AM,Di Nicola M

更新日期：2014-11-01 00:00:00

abstract：:Cell kinetics is a predictive parameter of breast-cancer aggressiveness, and mutations occurring in mammary tumorigenesis may favor uncontrolled cell proliferation. In this study, cell kinetics, clinico-pathological characteristics and genetic alterations at the int-2, bcl-1, c-myc, c-erbB-2, and DF3 loci were analyze...

journal_title：International journal of cancer

authors： Contegiacomo A,Pizzi C,De Marchis L,Alimandi M,Delrio P,Di Palma E,Petrella G,Ottini L,French D,Frati L

更新日期：1995-03-29 00:00:00

abstract：:While chrysotile has been commonly used by Chinese textile industry for many years, investigations on the association of chrysotile exposure with risk of mesothelioma in China are scarce. We conducted a case-control study in a county located at Southeastern China, including 46 cases and 230 individually matched contro...

journal_title：International journal of cancer

authors： Jiang Z,Chen T,Chen J,Ying S,Gao Z,He X,Miao C,Yu M,Feng L,Xia H,Wu W,Chen R,Morinaga K,Lou J,Zhang X

更新日期：2018-02-01 00:00:00

abstract：:We previously produced evidence that the human mammary-carcinoma cell line 8701-BC expresses several metalloproteinases (MMP-1, -2, -9, and -10) and their tissue inhibitors). In order to obtain a better understanding of the environmental control over gelatinolytic activities, we have tested the enzyme production of 87...

journal_title：International journal of cancer

authors： Minafra S,Giambelluca C,Andriolo M,Pucci-Minafra I

更新日期：1995-09-15 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) inhibits epithelial cell proliferation. Inactivation of the TGF-beta signaling pathway is thought to play a role in tumorigenesis. Our purpose was to clarify the correlation between TGF-beta receptors or TGF-beta 1 expression and the clinicopathologic characteristics of patie...

journal_title：International journal of cancer

authors： Fukai Y,Fukuchi M,Masuda N,Osawa H,Kato H,Nakajima T,Kuwano H

更新日期：2003-03-20 00:00:00