Reduced expression of transforming growth factor-beta receptors is an unfavorable prognostic factor in human esophageal squamous cell carcinoma.

abstract：:We studied if bladder cancers respond to HAMLET (human alpha-lactalbumin made lethal to tumor cells) to establish if intravesical HAMLET application might be used to selectively remove cancer cells in vivo. Patients with nonmuscle invasive transitional cell carcinomas were included. Nine patients received 5 daily intr...

journal_title：International journal of cancer

authors： Mossberg AK,Wullt B,Gustafsson L,Månsson W,Ljunggren E,Svanborg C

更新日期：2007-09-15 00:00:00

abstract：:Anthropometric measures have been related to risk of several cancers. For bladder cancer, however, evidence is sparse. Comparability of existing studies is hampered by use of different obesity-measures, inadequate control for smoking, and few female cases. This study examined associations between height, weight, waist...

journal_title：International journal of cancer

authors： Roswall N,Freisling H,Bueno-de-Mesquita HB,Ros M,Christensen J,Overvad K,Boutron-Ruault MC,Severi G,Fagherazzi G,Chang-Claude J,Kaaks R,Steffen A,Boeing H,Argüelles M,Agudo A,Sánchez MJ,Chirlaque MD,Barricarte Gurrea A

更新日期：2014-12-15 00:00:00

abstract：:We used a cross-sectional survey to examine short-term anxiety and distress in women receiving different results following routine human papillomavirus (HPV) primary testing at cervical screening. Participants were women aged 24-65 (n = 1,127) who had attended screening at one of five sites piloting HPV primary screen...

journal_title：International journal of cancer

authors： McBride E,Marlow LAV,Forster AS,Ridout D,Kitchener H,Patnick J,Waller J

更新日期：2020-04-15 00:00:00

abstract：:Gene silencing by DNA hypermethylation of CpG islands is a well-characterized phenomenon in cancer. The effect of hypomethylation in particular of non-CpG island genes is much less well described. By genome-wide screening, we identified 105 genes in microsatellite stable (MSS) colorectal adenocarcinomas with an invers...

journal_title：International journal of cancer

authors： Øster B,Linnet L,Christensen LL,Thorsen K,Ongen H,Dermitzakis ET,Sandoval J,Moran S,Esteller M,Hansen TF,Lamy P,COLOFOL steering group.,Laurberg S,Ørntoft TF,Andersen CL

更新日期：2013-05-15 00:00:00

abstract：:Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genome-wide methylation analysis of five sporadic breast carcinomas we identified a hypermethylated CpG island within the first in...

journal_title：International journal of cancer

authors： Versmold B,Felsberg J,Mikeska T,Ehrentraut D,Köhler J,Hampl JA,Röhn G,Niederacher D,Betz B,Hellmich M,Pietsch T,Schmutzler RK,Waha A

更新日期：2007-08-01 00:00:00

abstract：:Although surgical resection is considered the adequate treatment in early stages of nonsmall cell lung cancer, long-term survival is not satisfactory and recurrence rate is high. We previously showed that postoperative chemotherapy at stage IB reduces recurrences and prolongs overall survival. We extended size and obs...

journal_title：International journal of cancer

authors： Roselli M,Mariotti S,Ferroni P,Laudisi A,Mineo D,Pompeo E,Ambrogi V,Mineo TC

更新日期：2006-08-15 00:00:00

abstract：:We have shown that modulation of intracellular calcium in EBV latently infected cells could induce the expression of viral antigens, and suggested that a protein kinase-C (PKC) may play a major role in the EBV genome activation. We now report further investigations on the role of PKC using 2 selective enzymatic inhibi...

journal_title：International journal of cancer

authors： Lazdins J,Zompetta C,Grimaldi S,Barile G,Venanzoni M,Frati L,Faggioni A

更新日期：1987-12-15 00:00:00

abstract：:Murine macrophages from different anatomical sites were compared for their ability to become tumoricidal and to secrete interleukin-1 (IL-1) and tumor necrosis factor (TNF) following stimulation in vitro by several biological response modifiers (BRM). Peritoneal macrophages (PM), alveolar macrophages (AM), and tumor-i...

journal_title：International journal of cancer

authors： Brunda MJ,Sulich V,Wright RB,Palleroni AV

更新日期：1991-07-09 00:00:00

abstract：:Histone deacetylases (HDAC) extensively contribute to the c-Myc oncogenic program, pointing to their inhibition as an effective strategy against c-Myc-overexpressing cancers. We, thus, studied the therapeutic activity of the new-generation pan-HDAC inhibitor ITF2357 (Givinostat®) against c-Myc-overexpressing human B-c...

journal_title：International journal of cancer

authors： Zappasodi R,Cavanè A,Iorio MV,Tortoreto M,Guarnotta C,Ruggiero G,Piovan C,Magni M,Zaffaroni N,Tagliabue E,Croce CM,Zunino F,Gianni AM,Di Nicola M

更新日期：2014-11-01 00:00:00

abstract：:Highly differentiated, spontaneous hepatomas occurring in 13- to 15-month-old CBA mice were unable to produce embryo-specific serum protein alpha-fetoprotein (AFP). AFP synthesis, however, was induced in such tumors by minimal mechanical damage (small incisions of the tumors). On the 3rd day following surgery, AFP-pos...

journal_title：International journal of cancer

authors： Shipova LY,Gleiberman AS

更新日期：1985-01-15 00:00:00

abstract：:Heat shock protein (HSP) gp96/grp94 contains a signal peptide at the amino terminus and a -KDEL sequence at the carboxy terminus and is a major component of the lumen of the mammalian endoplasmic reticulum (ER). We show, by a number of immunolocalization methods using light and electron microscopy, that a significant ...

journal_title：International journal of cancer

authors： Altmeyer A,Maki RG,Feldweg AM,Heike M,Protopopov VP,Masur SK,Srivastava PK

更新日期：1996-08-22 00:00:00

abstract：:Diet is the primary source of cadmium-a proven Group 1 human carcinogen-for non-smokers. Observational studies investigating the effect of cadmium from food sources on breast cancer risk have produced inconsistent results. We examined the association between dietary cadmium and risk of breast cancer defined by estroge...

journal_title：International journal of cancer

authors： Grioni S,Agnoli C,Krogh V,Pala V,Rinaldi S,Vinceti M,Contiero P,Vescovi L,Malavolti M,Sieri S

更新日期：2019-05-01 00:00:00

abstract：:Fibroblast-like cells (F-cells) and epithelial-like (E-cells) derived from cultures of rabbit VX-2 carcinoma released collagenase in both active and latent forms in serum-free medium at a level higher than that of normal rabbit fibroblast cultures. The enhanced capacity of the F-cells to release the enzyme, however, c...

journal_title：International journal of cancer

authors： Dabbous MK,El-Torky M,Haney L,Brinkley SB,Sobhy N

更新日期：1983-03-15 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a cell plasticity process required for metastasis and chemoresistance of carcinoma cells. We report a crucial role of the signal adaptor proteins CRK and CRKL in promoting EMT and tumor aggressiveness, as well as resistance against chemotherapy in colorectal and pancreatic ca...

journal_title：International journal of cancer

authors： Franke FC,Slusarenko BO,Engleitner T,Johannes W,Laschinger M,Rad R,Nitsche U,Janssen KP

更新日期：2020-09-15 00:00:00

abstract：:To better inform the next clinical trials of vascular disrupting agent combretastatin-A4-phosphate (CA4P) in patients with hepatic malignancies, this preclinical study aimed at evaluating CA4P therapeutic efficacy in rats with primary hepatocellular carcinomas (HCCs) of a full spectrum of differentiation and vasculari...

journal_title：International journal of cancer

authors： Liu Y,De Keyzer F,Wang Y,Wang F,Feng Y,Chen F,Yu J,Liu J,Song S,Swinnen J,Bormans G,Oyen R,Huang G,Ni Y

更新日期：2018-10-01 00:00:00

abstract：:We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to differe...

journal_title：International journal of cancer

authors： Eriksson M,Hardell L,Carlberg M,Akerman M

更新日期：2008-10-01 00:00:00

abstract：:A human ovarian adenocarcinoma cell line (PE04) has been established as a xenograft in nude mice. In vitro, this cell line is estrogen receptor (ER)-positive and its growth is stimulated by 17 beta-estradiol at concentrations between 10(-12) and 10(-6) M. When xenografted, PE04 cells remain ER-positive and also posses...

journal_title：International journal of cancer

authors： Langdon SP,Ritchie A,Young K,Crew AJ,Sweeting V,Bramley T,Hillier S,Hawkins RA,Tesdale AL,Smyth JF

更新日期：1993-09-30 00:00:00

abstract：:An inverse association between smoking and endometrial cancer has generally been observed, primarily among current smokers. To assess this association, we analyzed data from the prospective Nurses' Health Study. From 1976 to 2000, 702 cases of invasive endometrial cancer were identified during 1.8 million person-years...

journal_title：International journal of cancer

authors： Viswanathan AN,Feskanich D,De Vivo I,Hunter DJ,Barbieri RL,Rosner B,Colditz GA,Hankinson SE

更新日期：2005-05-10 00:00:00

abstract：:Although tumor heterogeneity is widely accepted, the existence of cancer stem cells (CSCs) and their proposed role in tumor maintenance has always been challenged and remains a matter of debate. Recently, a path-breaking chapter was added to this saga when three independent groups reported the in vivo existence of CSC...

journal_title：International journal of cancer

authors： Singh AK,Arya RK,Maheshwari S,Singh A,Meena S,Pandey P,Dormond O,Datta D

更新日期：2015-05-01 00:00:00

abstract：:The molecular mechanisms underlying the genesis and progression of oligodendroglial tumors are poorly understood, since only restricted information on loss of heterozygosity from isolated cases is available. The commonest alterations appear to involve deletion of 1p and 19q, while loss of heterozygosity for 9p, chromo...

journal_title：International journal of cancer

authors： Bello MJ,Leone PE,Vaquero J,de Campos JM,Kusak ME,Sarasa JL,Pestaña A,Rey JA

更新日期：1995-06-22 00:00:00

abstract：:An important goal in prostate cancer research is to define specific molecular and cellular alterations that are associated with malignant progression. The mouse prostate reconstitution model is a relevant and useful system as it allows the study of early events in cancer progression under conditions where oncogene-ini...

journal_title：International journal of cancer

authors： Greene DR,Taylor SR,Aihara M,Yoshida K,Egawa S,Park SH,Timme TL,Yang G,Scardino PT,Thompson TC

更新日期：1995-01-27 00:00:00

abstract：:Chemotherapy-induced gastrointestinal toxicity (CIGT) occurs in up to 80% of all patients undergoing cancer treatment, and leads to symptoms such as diarrhoea, abdominal bleeding and pain. There is currently limited understanding of how to predict an individual patient's risk of CIGT. It is believed the gut microbiome...

journal_title：International journal of cancer

authors： Secombe KR,Coller JK,Gibson RJ,Wardill HR,Bowen JM

更新日期：2019-05-15 00:00:00

abstract：:Anti-estrogen toremifene inhibits growth of the 7,12-dimethylbenz(a)anthracene(DMBA)-induced rat mammary carcinoma. The changes in proliferation and cell death were studied in detail. Proliferation was measured by counting mitotic figures in histologic sections, expressed by volume-corrected mitotic index (M/V INDEX)....

journal_title：International journal of cancer

authors： Huovinen R,Wärri A,Collan Y

更新日期：1993-10-21 00:00:00

abstract：:The role of alcoholic beverages in the etiology of gastric cancer is unclear. Recent summaries showed a positive association between higher alcohol intake and gastric cancer risk, but the magnitude of association is small, there is moderate heterogeneity among studies, and most cases were from Asian populations. We pr...

journal_title：International journal of cancer

authors： Wang S,Freedman ND,Loftfield E,Hua X,Abnet CC

更新日期：2018-12-01 00:00:00

abstract：:Progress in the systemic control of osteosarcoma has been limited over the past decades thus indicating the urgent clinical need for the development of novel treatment strategies. Therefore, we have recently developed new preclinical models to study promising novel agents for the treatment of pediatric osteosarcoma. T...

journal_title：International journal of cancer

authors： Heidler CL,Roth EK,Thiemann M,Blattmann C,Perez RL,Huber PE,Kovac M,Amthor B,Neu-Yilik G,Kulozik AE

更新日期：2020-08-15 00:00:00

abstract：:Although viral sequences closely related to feline leukaemia virus are represented in multiple copies in cellular DNA of all domestic cats, a specific fraction was present only in the virus-infected cells. This fraction was detected by viral cDNA enriched by a prior absorption of a total complementary DNA (cDNA) trans...

journal_title：International journal of cancer

authors： Okabe H,DuBuy J,Gilden RV,Gardner MB

更新日期：1978-07-15 00:00:00

abstract：:Cutaneous T-Cell lymphoma (CTCL) is a non-Hodgkin's lymphoma of unknown pathogenesis. Mycosis fungoides (MF) is a clinically determined subset of CTCL with intensive infiltration of lymphoma cells into the epidermis. To determine whether Epstein-Barr virus (EBV) is associated with these lymphoma cells, we performed mR...

journal_title：International journal of cancer

authors： Shimakage M,Sasagawa T,Kawahara K,Yutsudo M,Kusuoka H,Kozuka T

更新日期：2001-04-15 00:00:00

abstract：:CD4(+) T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor rejection. Therefore, the anticancer therapeutic efficacy of peptide-based vaccines may be improved by addition of HLA class II epitopes to stimulate T helper c...

journal_title：International journal of cancer

authors： Widenmeyer M,Griesemann H,Stevanović S,Feyerabend S,Klein R,Attig S,Hennenlotter J,Wernet D,Kuprash DV,Sazykin AY,Pascolo S,Stenzl A,Gouttefangeas C,Rammensee HG

更新日期：2012-07-01 00:00:00

abstract：:In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis. In our study, we de...

journal_title：International journal of cancer

authors： Chen B,Liu X,Savell VH,Dilday BR,Johnson MW,Jenkins JJ,Parham DM

更新日期：1999-09-24 00:00:00

abstract：:Our study demonstrates that synthetic sialyl Lewis X (SLex) as a ligand for selectins and fibronectin-derived RGDS peptide analogue [Ar(DRGDS)3] inhibits lung metastases produced by i.v. co-injection of B16-BL6 melanoma cells. To investigate the inhibitory mechanisms in a living animal, we performed positron-emission ...

journal_title：International journal of cancer

authors： Saiki I,Koike C,Obata A,Fujii H,Murata J,Kiso M,Hasegawa A,Komazawa H,Tsukada H,Azuma I,Okada S,Oku N

更新日期：1996-03-15 00:00:00