Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance.

abstract：:Human non-small cell lung cancer (NSCLC) cells were transfected with recombinant prodrug herpes simplex virus type I thymidine kinase (HSV-tk) cDNA, and the selected clones underwent apoptosis in response to induction by antiviral ganciclovir (GCV). The efficiency of GCV-induced growth inhibition and the extent of the...

journal_title：International journal of cancer

authors： Chiu CC,Kang YL,Yang TH,Huang CH,Fang K

更新日期：2002-12-01 00:00:00

abstract：:Tumors need to acquire an angiogenic phenotype for outgrowth and metastasis formation. Limited information on the angiogenic potential of specific tissues, especially human breast tissues is available. Here we describe an in vivo model, using the dorsal skin fold chamber in immunodeficient nude mice, where various tis...

journal_title：International journal of cancer

authors： Lichtenbeld HC,Barendsz-Janson AF,van Essen H,Struijker Boudier H,Griffioen AW,Hillen HF

更新日期：1998-07-29 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a molecular chaperone that promotes the conformational maturation of numerous client proteins, many of which play critical roles in tumor cell growth and survival. The ansamycin-based Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) is currently in Phase III clinical tes...

journal_title：International journal of cancer

authors： Yin X,Zhang H,Lundgren K,Wilson L,Burrows F,Shores CG

更新日期：2010-03-01 00:00:00

abstract：:We conducted a population-based case-control study of 1,447 incident rectal cancer cases and 3,106 population controls aged 20-76 years to assess the effect of recreational physical activity, energy intake and obesity on rectal cancer risk in 7 of 10 Canadian provinces in 1994-97. After adjustment for the effect of va...

journal_title：International journal of cancer

authors： Mao Y,Pan S,Wen SW,Johnson KC,Canadian Cancer Registries Epidemiology Research Group.

更新日期：2003-07-20 00:00:00

abstract：:Limited and inefficient treatment options exist for metastatic relapsed cervical cancer (MRCC), and there are currently no reliable indicators to guide therapeutic selection. We performed deep sequencing analyses targeting 322 cancer-related genes in plasma cell-free DNA and matched white blood cells in 173 serial blo...

journal_title：International journal of cancer

authors： Tian X,Ge D,Zhang F,Zhang B,Bai W,Xu X,Li Z,Cao Y,Li P,Zou K,Zou L

更新日期：2021-02-15 00:00:00

abstract：:Active, structurally unrelated tumor promoters (12-0-tetradecanoyl-phorbol-13-acetate (TPA), teleocidin and aplysiatoxin) inhibit growth of mammary carcinoma cells (MCF7- greater than BT-20 greater than MDA-MB-231 greater than = ZR-75-1 greater than HBL-100). This efficiency in inhibiting cell growth correlates with t...

journal_title：International journal of cancer

authors： Regazzi R,Fabbro D,Costa SD,Borner C,Eppenberger U

更新日期：1986-05-15 00:00:00

abstract：:Anti-estrogen toremifene inhibits growth of the 7,12-dimethylbenz(a)anthracene(DMBA)-induced rat mammary carcinoma. The changes in proliferation and cell death were studied in detail. Proliferation was measured by counting mitotic figures in histologic sections, expressed by volume-corrected mitotic index (M/V INDEX)....

journal_title：International journal of cancer

authors： Huovinen R,Wärri A,Collan Y

更新日期：1993-10-21 00:00:00

abstract：:A variety of analytical approaches have indicated that melanoma cell line UCLA-SO-M14 (M14) and breast carcinoma cell line MDA-MB-435 originate from a common donor. This indicates that at some point in the past, one of these cell lines became misidentified, meaning that it ceased to correspond to the reported donor an...

journal_title：International journal of cancer

authors： Korch C,Hall EM,Dirks WG,Ewing M,Faries M,Varella-Garcia M,Robinson S,Storts D,Turner JA,Wang Y,Burnett EC,Healy L,Kniss D,Neve RM,Nims RW,Reid YA,Robinson WA,Capes-Davis A

更新日期：2018-02-01 00:00:00

abstract：:Hybridomas producing syngeneic monoclonal antibodies (MAbs) were prepared by fusion of spleen cells of BALB/c mice, which were immunized with sublethal doses of RMB-I cells. This cell line originates from a Rauscher virus (R-MuLV)-induced myeloid leukemia and forms tumors when re-inoculated into mice. MAbs were charac...

journal_title：International journal of cancer

authors： Berends D,Rhijnsburger EH,van Gaalen JL,van Houwelingen G,Zondervan PE,de Both NJ

更新日期：1988-07-15 00:00:00

abstract：:The expression of fibronectin (FN) isoforms containing the extradomains A and B (ED-A+ and ED-B+ FNs) as well as a differentially O-glycosylated oncofetal form of the protein (onf-FN) was investigated in 6 normal human anterior pituitaries and 25 human pituitary adenomas. In normal tissue, immunohistochemical experime...

journal_title：International journal of cancer

authors： Farnoud MR,Farhadian F,Samuel JL,Derome P,Peillon F,Li JY

更新日期：1995-03-29 00:00:00

abstract：:To elucidate the relationship, if any, of p53 gene expression according to smoking and drinking habits, 135 subjects with cancer of the upper aero-digestive tract were sampled from a case-control investigation conducted in Pordenone province, Northeast Italy, between 1986 and 1991. Adequate pathological material for i...

journal_title：International journal of cancer

authors： Franceschi S,Gloghini A,Maestro R,Barzan L,Bidoli E,Talamini R,Vukosavljevic T,Carbone A,Boiocchi M

更新日期：1995-03-16 00:00:00

abstract：:The effect of all-trans-retinoic acid (RA) was examined on (1) transformation induced in C127 cells by transfection with plasmid pdBPV-1 (142-6), which contains DNA of bovine papillomavirus (BPV), (2) the capacity of transformed BPV DNA-containing clones to form colonies with transformed properties (e.g., piling up in...

journal_title：International journal of cancer

authors： Tsang SS,Li G,Stich HF

更新日期：1988-07-15 00:00:00

abstract：:Several observational epidemiological studies have reported inconsistent results on the association between the use of benzodiazepine and the risk of cancer. We investigated the association by using a meta-analysis. We searched PubMed, EMBASE, and the bibliographies of relevant articles to locate additional publicatio...

journal_title：International journal of cancer

authors： Kim HB,Myung SK,Park YC,Park B

更新日期：2017-02-01 00:00:00

abstract：:Trifluorothymidine (TFT) is part of the oral drug formulation TAS-102. Both 5-fluorouracil (5-FU) and TFT can inhibit thymidylate synthase and be incorporated into DNA. TFT shows only moderate cross-resistance to 5-FU. Therefore, we examined whether mechanistic differences in cell death could underlie their different ...

journal_title：International journal of cancer

authors： Bijnsdorp IV,Peters GJ,Temmink OH,Fukushima M,Kruyt FA

更新日期：2010-05-15 00:00:00

abstract：:We screened 29 human esophageal squamous cell carcinoma (ESC) cell lines for mutations of the p53 gene through all coding exons and exon-intron junctions. Mutations were found in 22 cell lines (76%), consisting of 20 single-base substitutions, 2 small deletions and 1 single-base insertion. Out of 20 single-base substi...

journal_title：International journal of cancer

authors： Tanaka H,Shibagaki I,Shimada Y,Wagata T,Imamura M,Ishizaki K

更新日期：1996-01-26 00:00:00

abstract：:XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in normal urothelium and TCC. We also examined the therapeutic effect of xiap AS PODN on the cell cycle and apoptosis of multidrug-resistant T24 bladder cancer cells. XI...

journal_title：International journal of cancer

authors： Bilim V,Kasahara T,Hara N,Takahashi K,Tomita Y

更新日期：2003-01-01 00:00:00

abstract：:Anthropometric measures have been related to risk of several cancers. For bladder cancer, however, evidence is sparse. Comparability of existing studies is hampered by use of different obesity-measures, inadequate control for smoking, and few female cases. This study examined associations between height, weight, waist...

journal_title：International journal of cancer

authors： Roswall N,Freisling H,Bueno-de-Mesquita HB,Ros M,Christensen J,Overvad K,Boutron-Ruault MC,Severi G,Fagherazzi G,Chang-Claude J,Kaaks R,Steffen A,Boeing H,Argüelles M,Agudo A,Sánchez MJ,Chirlaque MD,Barricarte Gurrea A

更新日期：2014-12-15 00:00:00

abstract：:Lymphatic leukemia developed in C57BL/6 mice following inoculation of normal thymocytes that and been co-cultured on leukemic thymus epithelial reticulum monolayer cells. Using thymocytes genetically marked in Ly membrane antigens, we showed that the thymomas which developed were produced by the co-cultured thymocytes...

journal_title：International journal of cancer

authors： Haas M

更新日期：1978-01-15 00:00:00

abstract：:Emerging reports now implicate alterations of arachidonic acid (AA) metabolism with prostate carcinogenesis. To test this hypothesis, androgen-primed benign hyperplastic (BHC) and malignant tumorigenic (MTC) cells derived from the Lobund-Wistar rat model of autochthonous prostate adenocarcinoma were incubated with (14...

journal_title：International journal of cancer

authors： Pham H,Banerjee T,Ziboh VA

更新日期：2004-08-20 00:00:00

abstract：:In our previous study on hepatocellular carcinoma (HCC) susceptibility genes in chronic hepatitis patients, we identified the MHC class I polypeptide-related sequence A (MICA). Natural killer cells eliminate various cancer cells, including HCC, by suppressing MICA shedding. Therefore, we investigated MICA sheddases an...

journal_title：International journal of cancer

authors： Arai J,Goto K,Tanoue Y,Ito S,Muroyama R,Matsubara Y,Nakagawa R,Kaise Y,Lim LA,Yoshida H,Kato N

更新日期：2018-11-15 00:00:00

abstract：:Caveolae have been indicated as a center of cytoskeleton regulation for Src kinase/Rho GTPase signaling. In addition, Src recruitment on intact cortical actin cytoskeleton appears to be required for bFGF/FGFR signal activation. Recently, we established a relationship between caveolin-1 (Cav-1) expression and cell migr...

journal_title：International journal of cancer

authors： Fecchi K,Travaglione S,Spadaro F,Quattrini A,Parolini I,Piccaro G,Raggi C,Fabbri A,Felicetti F,Carè A,Fiorentini C,Sargiacomo M

更新日期：2012-03-15 00:00:00

abstract：:The acyclic nucleoside phosphonate analogue cidofovir is a broad-spectrum anti-DNA virus agent, which also possesses potent inhibitory activity against various tumors associated with papillomaviruses in animal models and patients. Moreover, we recently described the potent inhibition of polyomavirus (PyV)-induced hema...

journal_title：International journal of cancer

authors： Liekens S,Verbeken E,De Clercq E,Neyts J

更新日期：2001-04-15 00:00:00

abstract：:Cancer Procoagulant (CP), a cysteine proteinase which triggers blood coagulation by directly activating Factor X (FX) in the absence of Factor VII (F VII), has recently been isolated from rabbit V2 carcinoma and biochemically characterized. We have studied the procoagulant activity of tissue extracts from 4 murine exp...

journal_title：International journal of cancer

authors： Falanga A,Bolognese Dalessandro AP,Casali B,Roncaglioni MC,Donati MB

更新日期：1987-06-15 00:00:00

abstract：:Immunotherapy targeting programmed cell death-1 (PD-1) has become a standard pharmacological therapy. Although tumor mutation burden level was reported to depend on the tumor location in nonsmall cell lung cancer (NSCLC), predictive impact of the tumor location on the response to anti-PD-1 therapy is unknown. Two hund...

journal_title：International journal of cancer

authors： Takamori S,Takada K,Shimokawa M,Matsubara T,Haratake N,Miura N,Toyozawa R,Yamaguchi M,Takenoyama M,Yoneshima Y,Tanaka K,Okamoto I,Tagawa T,Mori M

更新日期：2020-10-15 00:00:00

abstract：:Deletions on chromosomes 1p and 19q are associated with favorable prognosis in patients with oligodendroglial tumors. The aim of our study was to identify additional genomic aberrations linked to patient survival. We performed a genome-wide screen for genomic imbalances by comparative genomic hybridization on tumors f...

journal_title：International journal of cancer

authors： Trost D,Ehrler M,Fimmers R,Felsberg J,Sabel MC,Kirsch L,Schramm J,Wiestler OD,Reifenberger G,Weber RG

更新日期：2007-06-01 00:00:00

abstract：:The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV-IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell-to-...

journal_title：International journal of cancer

authors： Peluso G,Marchese M,Furgi A,Ranieri M,Russo Spena S,Ravagnan G,Fuggetta MP,Porta R,Metafora V,Metafora S

更新日期：1997-07-17 00:00:00

abstract：:Progression from an androgen-dependent to an androgen-independent state often occurs in patients with prostate cancer (PCa) who undergo hormonal therapy. We have investigated whether inhibition of the epidermal growth factor receptor (EGFR) signaling pathway affects the antitumor effect of a nonsteroidal antiandrogen....

journal_title：International journal of cancer

authors： Festuccia C,Gravina GL,Angelucci A,Millimaggi D,Muzi P,Vicentini C,Bologna M

更新日期：2005-07-01 00:00:00

abstract：:In an attempt to understand the underlying cellular/biochemical factors of sensitivity/resistance in human small-cell lung cancer (SCLC), 2 SCLC tumor lines were compared with respect to tumor responsiveness to drug treatment, cell sensitivity, cellular doxorubicin accumulation, and DNA topoisomerase-II-mediated DNA c...

journal_title：International journal of cancer

authors： Pratesi G,Capranico G,Binaschi M,De Isabella P,Pilotti S,Supino R,Zunino F

更新日期：1990-10-15 00:00:00

abstract：:We conducted a case-control study of adenocarcinoma of the lung and exposure to environmental tobacco smoke (ETS) in 7 countries. We interviewed 70 cases of adenocarcinoma of the lung and 178 population or hospital controls. All subjects had smoked fewer than 400 cigarettes in their lifetimes. Ever exposure to ETS fro...

journal_title：International journal of cancer

authors： Boffetta P,Ahrens W,Nyberg F,Mukeria A,Brüske-Hohlfeld I,Fortes C,Constantinescu V,Simonato L,Batura-Gabryel H,Lea S,Gaborieau V,Benhamou S

更新日期：1999-11-26 00:00:00

abstract：:We aimed to identify risk factors for Kaposi's sarcoma (KS) among HIV-positive patients and behaviors associated with human Herpesvirus 8 (HHV-8) infection, as well as to assess KS incidence and mortality rates longitudinally. To fulfill the first objective, a European case-control study was designed in the early 1990...

journal_title：International journal of cancer

authors： Martró E,Esteve A,Schulz TF,Sheldon J,Gambús G,Muñoz R,Whitby D,Casabona J,Euro-Shaks study group.

更新日期：2007-03-01 00:00:00