Abstract:
:XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in normal urothelium and TCC. We also examined the therapeutic effect of xiap AS PODN on the cell cycle and apoptosis of multidrug-resistant T24 bladder cancer cells. XIAP was moderately expressed in normal transitional epithelium with prominent expression on the superficial layer cells. Seventy-nine of 108 (73.15%) tumor samples were positive for XIAP protein, but XIAP positivity was not correlated with tumor stage or grade. Moreover, 4 bladder cancer cell lines (SCaBER, HT1376, T24 and RT4) expressed similar levels of XIAP. xiap AS PODN dose-dependently reduced the XIAP protein level and induced apoptosis, leading to decreased cell viability by 87%. Combined administration with doxorubicin resulted in marked cytotoxicity due to escalation of apoptosis. Overexpression of XIAP in T24 cells resulted in a modest but statistically significant (p < 0.01) survival advantage compared to parental cells. Thus, XIAP expression may be critical for maintaining the viability and drug resistance of TCC, and endogenous XIAP levels are sufficient to protect cells from apoptosis. Our results suggest that XIAP may play an important role early in human TCC carcinogenesis. xiap AS may be a candidate for use as a cancer therapy for overcoming drug resistance in highly malignant TCC.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Bilim V,Kasahara T,Hara N,Takahashi K,Tomita Ydoi
10.1002/ijc.10776keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
29-37issue
1eissn
0020-7136issn
1097-0215journal_volume
103pub_type
杂志文章abstract::Recombinant human (rhu) macrophage colony-stimulating factor (M-CSF) was evaluated for efficacy, either alone or in combination with local X-irradiation (LR), in mice inoculated subcutaneously (s.c.) with Lewis lung carcinoma (LLC) cells. The size of the primary tumor and numbers of lung metastases, 21 days after tumo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470125
更新日期:1991-01-02 00:00:00
abstract::The purpose of this study is to help clarify the use of prostate size as a selection factor for prostate brachytherapy. From 1997 to 1998, 33 patients with a TRUS-based prostate volume greater than 50 cc were treated at the University of Washington by I-125 (144 Gy) or Pd-103 (115 Gy) implantation for prostatic carcin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-08-20 00:00:00
abstract::Hooded rats bearing a syngeneic methylcholanthrene-induced tumour were evaluated for extent of in vivo host immunity and this was correlated by in vitro techniques with the levels of circulating tumour antigen and specific antibody. Early tumour growth was associated with detectable immunity, as measured by the capaci...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150619
更新日期:1975-06-15 00:00:00
abstract::Microarray analysis of paired cultures of normal and cancerous urothelial cells revealed differences in cytokeratin and adhesion gene expression. Normal cells expressed autocrine growth factor genes more strongly whereas carcinoma cells were distinguished by concomitant expression of urothelial and epidermal different...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23893
更新日期:2008-12-15 00:00:00
abstract::In order to understand the expression and modulation of adhesion molecules (AMs) on the surface of different gastric cancers, we studied 4 gastric-cancer cell lines including SC-M1, KATO-III, AGS and AZ-521. The expression of E-cadherin, integrins (beta1, beta2 and beta3), ICAMs (1 and 2), and CD11 (a, b and c) on the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960904)67:5<690::AID-IJC
更新日期:1996-09-04 00:00:00
abstract::In order to update the findings of relative risk associated with cigarette smoking for lung cancer by histologic type in Japan, the data from a population-based cohort study of 91,738 men and women were analyzed. During 1990-1999, 422 lung cancer incident cases were identified. The relative risk for all incident cases...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10308
更新日期:2002-05-10 00:00:00
abstract::ATL is a fatal malignancy of T lymphocytes caused by HTLV-I infection and remains incurable. Galectins are a family of animal lectins that function both extracellularly (by interacting with cell surface and extracellular matrix glycoproteins and glycolipids) and intracellularly (by interacting with cytoplasmic and nuc...
journal_title:International journal of cancer
pub_type: 杂志文章,收录出版
doi:10.1002/ijc.22534
更新日期:2007-05-15 00:00:00
abstract::Adenoviral oncolysis is a promising new modality for treatment of cancer based on selective viral replication in tumor cells. However, tumor cell killing by adenoviral oncolysis needs to be improved to achieve therapeutic benefit in the clinic. Towards this end, the activation of anti-tumor immunity by adenoviral onco...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23074
更新日期:2008-01-01 00:00:00
abstract::Eleven population-based cancer registries tabulated second cancers among 133,411 patients diagnosed with testicular cancer, ovarian cancer or Hodgkin's disease between 1945 and 1984. Overall, 3,157 second cancers were observed, as compared with 2,420 expected at least one year after the first cancer. Survivors of test...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390506
更新日期:1987-05-15 00:00:00
abstract::Evidence of the association between chronic inflammation and the risk of colorectal cancer (CRC) and other obesity-related cancers (OBRC) remains inconsistent, possibly due to a paucity of studies examining repeated measures of inflammation. In the Health ABC prospective study of 2,490 adults aged 70-79 years at basel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29868
更新日期:2016-03-01 00:00:00
abstract::Previous literature, although not consistent, suggests that moderate alcohol consumption might be associated with decreased risk of renal cell carcinoma (RCC) in women. Thus, we examined the association between alcohol intake and the incidence of RCC by analyzing data from the Swedish Mammography Cohort, a population-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21231
更新日期:2005-12-10 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Little is known about its molecular pathogenesis and the relevance of DNA methylation for disease initiation and progression. Nevertheless, promoter methylation of some genes has been implicated as potential marker for HCC. Thirty-four HCC, 34...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23433
更新日期:2008-06-15 00:00:00
abstract::Malignant mesothelioma (MM) is an aggressive tumor associated with environmental or occupational exposure to asbestos fibers. Erionite is a fibrous zeolite, morphologically similar to asbestos and it is assumed to be even more carcinogenic. Onset and progression of MM has been suggested as the result of the cooperatio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22687
更新日期:2007-07-01 00:00:00
abstract::Experimental studies have suggested that the biosynthesis of arachidonic acid-derived eicosanoids such as prostaglandin E2 via the cyclo-oxygenase pathway may play a significant role in supporting cell proliferation in human prostate cancer cell lines. However, the aetiological significance of this for clinical prosta...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980812)77:4<511::aid-ijc
更新日期:1998-08-12 00:00:00
abstract::Abnormal survivin expression has been reported to be involved in many types of cancer. A single-nucleotide polymorphism (SNP), C-31G, located in the promoter region of survivin reportedly may alter the mRNA level, while the significance of the nonsynonymous SNP A9194G in exon 4 has not yet been clarified. Here, the as...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25850
更新日期:2011-10-15 00:00:00
abstract::Human mammary tumours which are histologically well differentiated are more likely to synthesize receptors for estrogen (ER) and progesterone (PR) and to respond to systemic endocrine therapy. The aim of this study was to explore the relationship between differentiation, receptors and endocrine responsiveness in more ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420203
更新日期:1988-08-15 00:00:00
abstract::Statins are widely used for the treatment of hypercholesterolemia. However, their inhibitory action on HMG-CoA reductase also results in the depletion of intermediate biosynthetic products, which importantly contribute to cell proliferation. The aim of the present study was to compare the effects of the individual com...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23242
更新日期:2008-03-15 00:00:00
abstract::The relationship between the biomarker of vitamin D status, 25(OH)D, and the risk for colorectal neoplasia is suggestive but equivocal. Questions remain regarding whether there are differential associations between 25(OH)D and colorectal adenoma by gender, colorectal subsite or features of baseline and recurrent adeno...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28316
更新日期:2013-12-15 00:00:00
abstract::A novel intra-operative chemotherapy nude mouse model for human hepatocellular carcinoma (HCC) has been developed. Intra-peritoneal (i.p.) administration of 5-fluorouracil (5-FU) was begun 2 hr before hepatic resection of HCC and then continued post-operatively for 4 consecutive days. This regime, termed intra-hepatec...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(200002)9999:9999<::aid-ijc1042>3
更新日期:2001-01-15 00:00:00
abstract::Expression of the macrophage antigen CD163 in breast cancer cells is recently shown to be related to early distant recurrence and shortened survival. In this study, 163 patients with rectal cancer, included in the Swedish rectal cancer trial and followed up for a median of 71 months, were examined for the expression o...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.24506
更新日期:2009-10-15 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is a cell plasticity process required for metastasis and chemoresistance of carcinoma cells. We report a crucial role of the signal adaptor proteins CRK and CRKL in promoting EMT and tumor aggressiveness, as well as resistance against chemotherapy in colorectal and pancreatic ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32955
更新日期:2020-09-15 00:00:00
abstract::Cytogenetic analysis of short-term cultures from 26 primary bronchial large cell carcinomas and 1 metastasis from a primary large cell carcinoma revealed clonal chromosome abnormalities in 20 tumors and a normal karyotype in 6. No outgrowth was obtained in 1 case. Simple aberrations were present in 3 tumors; in 1, the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570404
更新日期:1994-05-15 00:00:00
abstract::Oncogene-transformed fibroblasts which expressed IL-1, spontaneously or after activation with conditioned medium (CM) and lipopolysaccharide (LPS), regressed in the syngeneic host. Since regression was significantly influenced by the immune competence of the host (see companion report), we speculated that regression w...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500321
更新日期:1992-02-01 00:00:00
abstract::Frequently, the number of circulating tumor cells (CTC) isolated in 7.5 mL of blood is too small to reliably determine tumor heterogeneity and to be representative as a "liquid biopsy". In the EU FP7 program CTCTrap, we aimed to validate and optimize the recently introduced Diagnostic LeukApheresis (DLA) to screen lit...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.31752
更新日期:2018-11-15 00:00:00
abstract::Our study investigated the association of breast cancer risk as assessed by mammographic density with insulin-like growth factor I (IGF-I) and one of its binding proteins (IGFBP-3) in healthy premenopausal women with different ethnic backgrounds. In a cross-sectional design, we analyzed the baseline mammograms and fas...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11505
更新日期:2003-12-20 00:00:00
abstract::Human non-small cell lung cancer (NSCLC) cells were transfected with recombinant prodrug herpes simplex virus type I thymidine kinase (HSV-tk) cDNA, and the selected clones underwent apoptosis in response to induction by antiviral ganciclovir (GCV). The efficiency of GCV-induced growth inhibition and the extent of the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10701
更新日期:2002-12-01 00:00:00
abstract::Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor-suppressor and other genes related to cell differentiation, cell-cycle arrest or apoptosis of tumor cells. The...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25367
更新日期:2011-02-01 00:00:00
abstract::We have investigated the effect of interferon-gamma (IFN-gamma) treatment of neuroblastoma cells on the susceptibility to lysis by lymphokine-activated killer (LAK) cells and examined the participation of cell-adhesion molecules on the target cells in LAK cell lysis. Untreated neuroblastoma cells expressed lymphocyte-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470410
更新日期:1991-02-20 00:00:00
abstract::The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954) to a potent cytotoxic species that generates interstrand crosslinks in DNA. Nitroreductase therefore has potential as a "suicide enzyme" for cancer gene therapy, as cells that ex...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000615)86:6<848::aid-ijc
更新日期:2000-06-15 00:00:00
abstract::Ciclopirox olamine (CPX) is a synthetic antifungal agent clinically used to treat mycoses of the skin and nails. Here, we show that CPX inhibited tumor growth in human breast cancer MDA-MB-231 xenografts. To unveil the underlying mechanism, we further studied the antitumor activity of CPX in cell culture. The results ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25255
更新日期:2010-11-15 00:00:00