Hormonal content of combined oral contraceptives in relation to the reduced risk of endometrial carcinoma. The WHO Collaborative Study of Neoplasia and Steroid Contraceptives.

abstract：:In advanced prostate cancer, cellular changes occur leading to a transition from androgen-dependent to androgen-independent growth. During this transition, proliferation of androgen-dependent prostate cancer cells becomes more and more dependent on growth factors, like the epidermal growth factor (EGF). Endocytosis of...

journal_title：International journal of cancer

authors： Oosterhoff JK,Kühne LC,Grootegoed JA,Blok LJ

更新日期：2005-02-10 00:00:00

abstract：:Previous studies have been inconsistent with respect to the reported associations between phospho-Akt (p-Akt) overexpression and lung cancer prognosis. In this study, we conducted a systematic review and meta-analysis to assess the prognostic value of p-Akt in patients with non-small cell lung carcinoma (NSCLC). Relev...

journal_title：International journal of cancer

authors： Yang Y,Luo J,Zhai X,Fu Z,Tang Z,Liu L,Chen M,Zhu Y

更新日期：2014-09-15 00:00:00

abstract：:A mammographic breast cancer screening programme has been ongoing in the Florence District (Italy) since 1970 and a favourable impact of screening on breast cancer mortality of women aged 50-70 has been shown by means of a case-control study. Two hundred and eleven screen- and 116 interval-detected cancers in the peri...

journal_title：International journal of cancer

authors： Paci E,Ciatto S,Buiatti E,Cecchini S,Palli D,Rosselli del Turco M

更新日期：1990-08-15 00:00:00

abstract：:Although adult obesity is known to increase endometrial cancer risk, evidence for childhood obesity is limited. We prospectively examined the association between body fatness throughout life and endometrial cancer risk. 47,289 participants in the Nurses' Health Study (NHS) and 105,386 of the Nurses' Health Study II (N...

journal_title：International journal of cancer

authors： Dougan MM,Hankinson SE,Vivo ID,Tworoger SS,Glynn RJ,Michels KB

更新日期：2015-08-01 00:00:00

abstract：:The SIL gene expression is increased in multiple cancers and correlates with the expression of mitotic spindle checkpoint genes and with increased metastatic potential. SIL regulates mitotic entry, organization of the mitotic spindle and cell survival. The E2F transcription factors regulate cell cycle progression by c...

journal_title：International journal of cancer

authors： Erez A,Chaussepied M,Castiel A,Colaizzo-Anas T,Aplan PD,Ginsberg D,Izraeli S

更新日期：2008-10-01 00:00:00

abstract：:Intestinal mucositis is a common side effect of chemotherapy leading to diarrhea, abdominal pain and increased risk of infections. The intestinal microbiota has been recognized as a key regulator of mucosal immune responses. Therefore, we hypothesized that intestinal microbial changes would be associated with enterocy...

journal_title：International journal of cancer

authors： De Pietri S,Ingham AC,Frandsen TL,Rathe M,Krych L,Castro-Mejía JL,Nielsen DS,Nersting J,Wehner PS,Schmiegelow K,Hasle H,Pamp SJ,Müller K

更新日期：2020-10-01 00:00:00

abstract：:Primary breast diffuse large B-cell lymphoma (DLBCL) is an extremely rare presentation of non-Hodgkin's lymphoma that has been associated with poorer clinical outcomes compared with nodal DLBCL in the pre-rituximab era. The aim of this study was to investigate the impact of rituximab on clinical outcomes in patients w...

journal_title：International journal of cancer

authors： Yhim HY,Kim JS,Kang HJ,Kim SJ,Kim WS,Choi CW,Eom HS,Kim JA,Lee JH,Won JH,Shim H,Huh J,Lee DH,Suh C,Kwak JY

更新日期：2012-07-01 00:00:00

abstract：:Hereditary non-polyposis colorectal cancer, HNPCC, is an autosomal dominant condition predisposing to cancers of primarily the colorectum and the endometrium. The aim of our study was to identify persons at a high risk of hereditary colorectal cancer and to estimate their risk of colon and other HNPCC-associated tumou...

journal_title：International journal of cancer

authors： Cederquist K,Golovleva I,Emanuelsson M,Stenling R,Grönberg H

更新日期：2001-02-15 00:00:00

abstract：:Lymphatic leukemia developed in C57BL/6 mice following inoculation of normal thymocytes that and been co-cultured on leukemic thymus epithelial reticulum monolayer cells. Using thymocytes genetically marked in Ly membrane antigens, we showed that the thymomas which developed were produced by the co-cultured thymocytes...

journal_title：International journal of cancer

authors： Haas M

更新日期：1978-01-15 00:00:00

abstract：:The effect of linoleic acid (LA) on growth and transformation of IEC6 intestinal cells was examined. IEC6 cells expressed mRNAs of 15-lipooxygenase (LOX15) and peroxisome proliferator-activated receptor (PPAR)gamma but not COX-2. Cell growth was suppressed by LA in a dose-dependent manner in IEC6 cells. Three-week tre...

journal_title：International journal of cancer

authors： Sasaki T,Yoshida K,Shimura H,Ichiba M,Sasahira T,Shimomoto T,Denda A,Kuniyasu H

更新日期：2006-02-01 00:00:00

abstract：:The clinical pathological findings of eight cases of ovarian endodermal sinus tumour (yolk sac tumour) are presented. Histological exmination in all eight cases showed a typical endodermal sinus tumour pattern, and in six of the patients other tumour elements such as dysgerminoma, choriocarcinoma, malignant teratoma, ...

journal_title：International journal of cancer

authors： Sell A,Sogaard H,Norgaard-Pedersen B

更新日期：1976-11-15 00:00:00

abstract：:Inhibitors of matrix metalloproteinases (MMPs) were developed as anticancer agents based on the observation that MMPs facilitate local tumor spread and metastasis by promoting matrix degradation and cell migration. Unfortunately, these inhibitors were unsuccessful in the clinical treatment of several cancers, includin...

journal_title：International journal of cancer

authors： Chen X,Su Y,Fingleton B,Acuff H,Matrisian LM,Zent R,Pozzi A

更新日期：2005-08-10 00:00:00

abstract：:Interest has increased in the potential role of circulating tumour cells in cancer management. Most cell-based studies have been designed to determine the number of circulating tumour cells in a given volume of blood. Ability to understand the biology of the cancer cells would increase the clinical potential. The purp...

journal_title：International journal of cancer

authors： Dent BM,Ogle LF,O'Donnell RL,Hayes N,Malik U,Curtin NJ,Boddy AV,Plummer ER,Edmondson RJ,Reeves HL,May FE,Jamieson D

更新日期：2016-01-01 00:00:00

abstract：:We used a cross-sectional survey to examine short-term anxiety and distress in women receiving different results following routine human papillomavirus (HPV) primary testing at cervical screening. Participants were women aged 24-65 (n = 1,127) who had attended screening at one of five sites piloting HPV primary screen...

journal_title：International journal of cancer

authors： McBride E,Marlow LAV,Forster AS,Ridout D,Kitchener H,Patnick J,Waller J

更新日期：2020-04-15 00:00:00

abstract：:The role of STAT2 in mediating the antigrowth effects of type I interferon (IFN) is well-documented in vitro. Yet evidence of IFN-activated STAT2 as having tumor suppressor function in vivo and participation in antitumor immunity is lacking. Here we show in a syngeneic tumor transplantation model that STAT2 reduces tu...

journal_title：International journal of cancer

authors： Yue C,Xu J,Tan Estioko MD,Kotredes KP,Lopez-Otalora Y,Hilliard BA,Baker DP,Gallucci S,Gamero AM

更新日期：2015-01-01 00:00:00

abstract：:We analyzed the role of reproductive factors on the risk of endometrial cancer using data from a case-control study conducted in Italy. Cases were 752 women with histologically confirmed endometrial cancer < 75 years of age. Controls were 2,606 patients < 75 years of age admitted for acute, non-gynecological non-hormo...

journal_title：International journal of cancer

authors： Parazzini F,Negri E,La Vecchia C,Benzi G,Chiaffarino F,Polatti A,Francheschi S

更新日期：1998-06-10 00:00:00

abstract：:Cryopreserved tumour cells obtained from the ascitic fluid of a patient with an ovarian carcinoma were employed to determine the effect on in vitro drug cytotoxicities of varying both drug concentration and exposure time. Four antitumour drugs, in common clinical usage, were selected for study. Tumour-cell survival fo...

journal_title：International journal of cancer

authors： Rupniak HT,Whelan RD,Hill BT

更新日期：1983-07-15 00:00:00

abstract：:Barrett's esophagus (BE) is a metaplastic condition caused by chronic gastroesophageal reflux which represents an early step in the development of esophageal adenocarcinoma (EAC). Single-nucleotide polymorphism microarray (SNP-chip) analysis is a novel, precise, high-throughput approach to examine genomic alterations ...

journal_title：International journal of cancer

authors： Akagi T,Ito T,Kato M,Jin Z,Cheng Y,Kan T,Yamamoto G,Olaru A,Kawamata N,Boult J,Soukiasian HJ,Miller CW,Ogawa S,Meltzer SJ,Koeffler HP

更新日期：2009-11-15 00:00:00

abstract：:We investigated whether variants in sex steroid hormone metabolism genes modify the effect of hormone therapy (HT) on endometrial cancer risk in postmenopausal non-Hispanic white women. A nested case-control study was conducted within the California Teachers Study (CTS). We genotyped htSNPs in six genes involved in th...

journal_title：International journal of cancer

authors： Razavi P,Lee E,Bernstein L,Van Den Berg D,Horn-Ross PL,Ursin G

更新日期：2012-04-01 00:00:00

abstract：:Leukocyte migration inhibition (LMI) assays were performed using 3 M KCI extracts to detect cell-mediated immune reactions against tumor-associated antigens (TAA) of swine melanoma. Positive LMI reactivity was 70% or greater in melanoma-bearing swine compared to 10% reactivity or less in normal swine tested with extra...

journal_title：International journal of cancer

authors： Hook RR Jr,Hamby CV,Millikan LE,Berkelhammer J,Stills HF Jr,Oxenhandler RW

更新日期：1983-05-15 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is activated in a variety of human cancers, including ovarian cancer. The molecular mechanism by which the STAT3 is activated in cancer cells is poorly understood. We observed that human ovarian xenograft tumors (A2780) in mice were severely hypoxic (pO(2) app...

journal_title：International journal of cancer

authors： Selvendiran K,Bratasz A,Kuppusamy ML,Tazi MF,Rivera BK,Kuppusamy P

更新日期：2009-11-01 00:00:00

abstract：:Recent genome-wide scans identified several novel breast cancer risk alleles, including variants of the FGFR2, MAP3K1 and LSP1 genes, and a study of associations between these alleles and characteristics of breast cancer patients reported a borderline significant correlation between the number of FGFR2 minor alleles a...

journal_title：International journal of cancer

authors： Gates MA,Tworoger SS,Terry KL,De Vivo I,Hunter DJ,Hankinson SE,Cramer DW

更新日期：2009-02-01 00:00:00

abstract：:We examined the effect of parity on breast cancer risk on the basis of information from 107,146 married female nurses followed prospectively between 1976-1980. For everparous women, a significant protective effect against breast cancer was observed with increasing parity (chi 12 for trend = 14.2, p less than 0.001). A...

journal_title：International journal of cancer

authors： Pathak DR,Speizer FE,Willett WC,Rosner B,Lipnick RJ

更新日期：1986-01-15 00:00:00

abstract：:Estrogen signaling plays an important role in breast carcinogenesis. An increased understanding of estrogen gene targets and their effects will allow for more directed and effective therapies for individuals with breast cancer, particularly those with estrogen receptor positive tumors resistant to tamoxifen therapy. H...

journal_title：International journal of cancer

authors： Tuttle R,Miller KR,Maiorano JN,Termuhlen PM,Gao Y,Berberich SJ

更新日期：2012-05-15 00:00:00

abstract：:Second-line ipilimumab has been publicly funded in Ontario for metastatic melanoma (MM) since September 2012. We examined real-world toxicity of second-line ipilimumab compared to standard second-line treatments prior to funding. MM patients who received systemic treatment from April 2005 to March 2015 were included. ...

journal_title：International journal of cancer

authors： Dai WF,Beca J,Croxford R,Isaranuwatchai W,Menjak IB,Petrella TM,Mittmann N,Earle CC,Gavura S,Mercer RE,Hanna TP,Chan KKW

更新日期：2020-10-26 00:00:00

abstract：:We examined cancer-associated fibroblasts (CAFs) and a panel of immunohistochemical markers of epithelial-mesenchymal transition (EMT) in 19 pair-matched oral tongue squamous cell carcinoma (SCC) and metastatic tumors to regional lymph nodes (RLNs). alpha-Smooth muscle actin (alpha-SMA) was studied to identify CAFs. E...

journal_title：International journal of cancer

authors： Vered M,Dayan D,Yahalom R,Dobriyan A,Barshack I,Bello IO,Kantola S,Salo T

更新日期：2010-09-01 00:00:00

abstract：:Metastasis-associated protein MTA1 and histone deacetylase form a protein complex with histone deacetylase activity that plays an important role in histone deacetylation, alteration of chromatin structure and transcriptional control. The precise role of the MTA1 protein in the malignant progression of human cancers re...

journal_title：International journal of cancer

authors： Toh Y,Ohga T,Endo K,Adachi E,Kusumoto H,Haraguchi M,Okamura T,Nicolson GL

更新日期：2004-06-20 00:00:00

abstract：:Previous work from this laboratory established a large bank of human colon carcinoma cell lines in culture and classified them with respect to growth regulatory phenotypes based on several biological and biochemical characteristics. In the present report, Northern analysis indicates that addition of the maturational a...

journal_title：International journal of cancer

authors： Mulder KM,Brattain MG

更新日期：1988-07-15 00:00:00

abstract：:Endostatin, the proteolytic fragment of collagen XVIII, is an inhibitor of angiogenesis and tumor growth. Interestingly, elevated circulating endostatin levels have been found to correlate with poor patients' prognosis in several cancers. The aim of this study was to assess the prognostic value of endostatin in bladde...

journal_title：International journal of cancer

authors： Szarvas T,László V,Vom Dorp F,Reis H,Szendröi A,Romics I,Tilki D,Rübben H,Ergün S

更新日期：2012-06-15 00:00:00

abstract：:Conjugates (immunotoxins) comprising ricin A-chain and monoclonal antibody 96.5, which is specific for human melanoma-associated antigen p97, inhibited protein synthesis and colony formation of cultured human melanoma cells that expressed more than 80,000 molecules of p97 per cell. Cells expressing fewer than 5,000 mo...

journal_title：International journal of cancer

authors： Casellas P,Brown JP,Gros O,Gros P,Hellström I,Jansen FK,Poncelet P,Roncucci R,Vidal H,Hellström KE

更新日期：1982-10-15 00:00:00