Abstract:
:Estrogen signaling plays an important role in breast carcinogenesis. An increased understanding of estrogen gene targets and their effects will allow for more directed and effective therapies for individuals with breast cancer, particularly those with estrogen receptor positive tumors resistant to tamoxifen therapy. Here, we identify YPEL3 as a growth suppressive protein downregulated by estrogen in estrogen receptor positive breast cancer cell lines. Estrogen repression of YPEL3 expression was found to be independent of p53 but dependent on estrogen receptor alpha expression. Importantly, YPEL3 expression, which is induced by the removal of estrogen or treatment with tamoxifen triggers cellular senescence in MCF-7 cells while loss of YPEL3 increases the growth rate of MCF-7 cells. Taken together these findings suggest that YPEL3 may represent a potential target for directed hormonal therapy for estrogen receptor positive breast cancer patients.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Tuttle R,Miller KR,Maiorano JN,Termuhlen PM,Gao Y,Berberich SJdoi
10.1002/ijc.26239subject
Has Abstractpub_date
2012-05-15 00:00:00pages
2291-9issue
10eissn
0020-7136issn
1097-0215journal_volume
130pub_type
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