Modulation of viability and maturation of human monocyte-derived dendritic cells by oncolytic adenoviruses.

abstract：:Numerous reports suggest that interleukin-6 (IL-6) promotes survival and proliferation of tumor cells through the phosphorylation of a cell-signaling protein, signal-transducer-and-activator-of-transcription-3 (STAT3). Constitutive activation of STAT3 in head and neck squamous cell carcinoma (HNSCC) and its role in pr...

journal_title：International journal of cancer

authors： Chakravarti N,Myers JN,Aggarwal BB

更新日期：2006-09-15 00:00:00

abstract：:The annual incidence of non-Hodgkin's lymphomas is increasing by 3 to 4% in different parts of the developed world, while rates for Hodgkin's disease, myelomas and leukemias are more stable. In the case of this group of malignancies, hypothesis generation on risk factors has been limited by the use of the ICD classifi...

journal_title：International journal of cancer

authors： Masala G,Di Lollo S,Picoco C,Crosignani P,Demicheli V,Fontana A,Funtó I,Miligi L,Nanni O,Papucci A,Ramazzotti V,Rodella S,Stagnaro E,Tumino R,Viganó C,Vindigni C,Seniori Costantini A,Vineis P

更新日期：1996-10-09 00:00:00

abstract：:We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...

journal_title：International journal of cancer

authors： Merlo A,Jermann E,Hausmann O,Chiquet-Ehrismann R,Probst A,Landolt H,Maecke HR,Mueller-Brand J,Gratzl O

更新日期：1997-05-29 00:00:00

abstract：:We describe 2-step and 3-step strategies for intraperitoneal tumor radio-localization by means of monoclonal antibodies (MAbs). Nude mice bearing intraperitoneal human colon carcinoma tumors were injected i.p. with biotinylated MAb AUAI, followed 24 hr later by radioiodinated streptavidin (2-step). The uptake of radio...

journal_title：International journal of cancer

authors： Paganelli G,Pervez S,Siccardi AG,Rowlinson G,Deleide G,Chiolerio F,Malcovati M,Scassellati GA,Epenetos AA

更新日期：1990-06-15 00:00:00

abstract：:Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly...

journal_title：International journal of cancer

authors： Hou X,Tao Y,Pang Y,Li X,Jiang G,Liu Y

更新日期：2018-12-15 00:00:00

abstract：:As part of a collaborative study of risk factors for childhood brain tumours, the effects of the mother's smoking and her potential for passive smoking exposure during the pregnancy were assessed in a case-control study. Parents of 91 cases and 321 population controls from Northern Italy, matched for age, sex and resi...

journal_title：International journal of cancer

authors： Filippini G,Farinotti M,Lovicu G,Maisonneuve P,Boyle P

更新日期：1994-06-15 00:00:00

abstract：:Current ovarian cancer maintenance therapy is limited by toxicity and no proven impact on overall survival. To study a maintenance strategy targeted at missense mutant p53, we hypothesized that the release of mutant p53 from mortalin inhibition by the SHetA2 drug combined with reactivation of mutant p53 with the PRIMA...

journal_title：International journal of cancer

authors： Ramraj SK,Elayapillai SP,Pelikan RC,Zhao YD,Isingizwe ZR,Kennedy AL,Lightfoot SA,Benbrook DM

更新日期：2020-08-15 00:00:00

abstract：:India has the highest burden of cervical cancer in the world. To estimate the consequences of delaying implementation of organized cervical cancer screening, we projected the avertable burden of disease under different implementation scenarios of a screening program. We used an individual-based microsimulation model o...

journal_title：International journal of cancer

authors： Campos NG,Tsu V,Jeronimo J,Regan C,Resch S,Clark A,Sy S,Kim JJ

更新日期：2019-02-15 00:00:00

abstract：:Medulloblastoma is a primitive neuroectodermal tumor of the cerebellum with poorly understood pathogenesis. Previous studies have reported loss of heterozygosity (LOH) on chromosome arms 17p, 11p and 9q and cytogenetic abnormalities of chromosome 1 in medulloblastoma. We have used the polymerase chain reaction to ampl...

journal_title：International journal of cancer

authors： Kraus JA,Koch A,Albrecht S,Von Deimling A,Wiestler OD,Pietsch T

更新日期：1996-07-03 00:00:00

abstract：:Although some authorities consider smoking to be an established risk factor for colorectal cancer, the international literature is not entirely consistent. Further, only 1 study has addressed the association with smokeless tobacco and none with Scandinavian moist snuff (snus). This retrospective cohort study included ...

journal_title：International journal of cancer

authors： Nordenvall C,Nilsson PJ,Ye W,Nyrén O

更新日期：2011-01-01 00:00:00

abstract：:The lung retention patterns of B16 melanoma cells were determined after intravenous injection of [125l]dUrd-labelled tumor cells into B16 melanomabearing mice. Experiments were performed with mice undergoing acute or chronic reactions to bacterial endotoxin or zymosan, both of which were shown to modify the activity o...

journal_title：International journal of cancer

authors： Glaves D

更新日期：1980-07-15 00:00:00

abstract：:Oxaliplatin, which is widely used as chemotherapy for certain solid cancers, frequently causes peripheral neuropathy. Commonly described neuropathic symptoms include aberrant sensations such as mechanical allodynia (hypersensitivity to normally innocuous stimuli). Although oxaliplatin neuropathy is a dose-limiting tox...

journal_title：International journal of cancer

authors： Yamamoto S,Yamashita T,Ito M,Caaveiro JMM,Egashira N,Tozaki-Saitoh H,Tsuda M

更新日期：2019-10-15 00:00:00

abstract：:Microsatellite instability (MSI) has been reported to occur in a wide variety of sporadic tumours, such as colorectal and gastric cancers. MSI positivity has been associated with a particular clinico-pathologic profile, including the presence of abundant lymphoid infiltration, poor differentiation and a relatively goo...

journal_title：International journal of cancer

authors： Schmitt FC,Soares R,Gobbi H,Milanezzi F,Santos-Silva F,Cirnes L,Costa C,Seruca R

更新日期：1999-08-27 00:00:00

abstract：:The radiosensitivity of three forms of response to injection of C. parvum in mice has been investigated. The increase in phagocytin index evoked by IP or IV injection of 0.7 mg C. parvum (but not that evoked by 1.4 mg) was reduced but not abolished in mice given 350-500 rad whole-body irradiation 4 days before C. parv...

journal_title：International journal of cancer

authors： Woodruff MF,Ghaffar A,Whitehead VL

更新日期：1976-05-15 00:00:00

abstract：:NY-ESO-1 antigen is a prototype of a class of cancer/testis antigens. We carried out a clinical trial using NY-ESO-1 whole protein as a cancer vaccine for 13 advanced cancer patients. We have recently reported that vaccine elicited humoral and cellular immune responses in 9 cancer patients including 4 esophageal cance...

journal_title：International journal of cancer

authors： Wada H,Sato E,Uenaka A,Isobe M,Kawabata R,Nakamura Y,Iwae S,Yonezawa K,Yamasaki M,Miyata H,Doki Y,Shiku H,Jungbluth AA,Ritter G,Murphy R,Hoffman EW,Old LJ,Monden M,Nakayama E

更新日期：2008-11-15 00:00:00

abstract：:Conjugates (immunotoxins) comprising ricin A-chain and monoclonal antibody 96.5, which is specific for human melanoma-associated antigen p97, inhibited protein synthesis and colony formation of cultured human melanoma cells that expressed more than 80,000 molecules of p97 per cell. Cells expressing fewer than 5,000 mo...

journal_title：International journal of cancer

authors： Casellas P,Brown JP,Gros O,Gros P,Hellström I,Jansen FK,Poncelet P,Roncucci R,Vidal H,Hellström KE

更新日期：1982-10-15 00:00:00

abstract：:Salvicine is a diterpenoid quinone derived from a traditional Chinese medication that has been shown to possess potent in vitro and in vivo antitumor effects. This compound, which inhibits the activity of Topoisomerase II, was found to equipotently kill various multidrug-resistant tumor cells and their corresponding p...

journal_title：International journal of cancer

authors： Miao ZH,Tong LJ,Zhang JS,Han JX,Ding J

更新日期：2004-07-10 00:00:00

abstract：:Cell kinetics is a predictive parameter of breast-cancer aggressiveness, and mutations occurring in mammary tumorigenesis may favor uncontrolled cell proliferation. In this study, cell kinetics, clinico-pathological characteristics and genetic alterations at the int-2, bcl-1, c-myc, c-erbB-2, and DF3 loci were analyze...

journal_title：International journal of cancer

authors： Contegiacomo A,Pizzi C,De Marchis L,Alimandi M,Delrio P,Di Palma E,Petrella G,Ottini L,French D,Frati L

更新日期：1995-03-29 00:00:00

abstract：:The occurrence of metastasis severely affects prognosis and survival of breast cancer patients. In order to metastasize, breast cancer cells need to cross the basement membrane (BM) tissue boundaries. Matrix metalloproteases (MMPs) are enzymes with proteolytic activity towards extracellular matrix components (ECM) of ...

journal_title：International journal of cancer

authors： Giannelli G,Erriquez R,Fransvea E,Daniele A,Trerotoli P,Schittulli F,Grano M,Quaranta M,Antonaci S

更新日期：2004-05-01 00:00:00

abstract：:Despite recent advances in targeted and immune-based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the genes and cellular processes that drive progression and metastasis is critical for identifying new therapeutic strategies. Here, we found that the GTPase RAB27A ...

journal_title：International journal of cancer

authors： Guo D,Lui GYL,Lai SL,Wilmott JS,Tikoo S,Jackett LA,Quek C,Brown DL,Sharp DM,Kwan RYQ,Chacon D,Wong JH,Beck D,van Geldermalsen M,Holst J,Thompson JF,Mann GJ,Scolyer RA,Stow JL,Weninger W,Haass NK,Beaumont KA

更新日期：2019-06-15 00:00:00

abstract：:Genome-wide association studies (GWAS) have identified several loci contributing to lung cancer and COPD risk independently; however, inflammation-related pathways likely harbor additional lung cancer risk-associated variants in biologically relevant immune genes that differ dependent on COPD. We selected single nucle...

journal_title：International journal of cancer

authors： Watza D,Lusk CM,Dyson G,Purrington KS,Wenzlaff AS,Neslund-Dudas C,Soubani AO,Gadgeel SM,Schwartz AG

更新日期：2020-08-01 00:00:00

abstract：:The application of dendritic cells (DC) to the active immunotherapy of cancer currently relies on the generation of potent DC capable of presenting tumor antigens such as carcinoembryonic antigen (CEA). It is unknown whether the T cells of patients with advanced malignancies can be reliably stimulated against tumor an...

journal_title：International journal of cancer

authors： Nair SK,Hull S,Coleman D,Gilboa E,Lyerly HK,Morse MA

更新日期：1999-07-02 00:00:00

abstract：:Recent analyses have suggested decreases over time in colorectal cancer incidence at older ages (≥55 years) but increases at younger ages (20-54 years). Understanding the geographic heterogeneity of incidence facilitates resource allocation for potential interventions and advances our knowledge of differential etiolog...

journal_title：International journal of cancer

authors： Chernyavskiy P,Kennerley VM,Jemal A,Little MP,Rosenberg PS

更新日期：2019-04-15 00:00:00

abstract：:A variety of analytical approaches have indicated that melanoma cell line UCLA-SO-M14 (M14) and breast carcinoma cell line MDA-MB-435 originate from a common donor. This indicates that at some point in the past, one of these cell lines became misidentified, meaning that it ceased to correspond to the reported donor an...

journal_title：International journal of cancer

authors： Korch C,Hall EM,Dirks WG,Ewing M,Faries M,Varella-Garcia M,Robinson S,Storts D,Turner JA,Wang Y,Burnett EC,Healy L,Kniss D,Neve RM,Nims RW,Reid YA,Robinson WA,Capes-Davis A

更新日期：2018-02-01 00:00:00

abstract：:To provide an up-to-date overview of recent trends in mortality from oral and pharyngeal cancer, we analyzed death certification data for 61 countries worldwide provided by the World Health Organization in 2010-2015, and, for selected most populous countries, over the period 1970-2016. For 12 largest countries, we ana...

journal_title：International journal of cancer

authors： Bosetti C,Carioli G,Santucci C,Bertuccio P,Gallus S,Garavello W,Negri E,La Vecchia C

更新日期：2020-08-15 00:00:00

abstract：:The influence of prolonged treatment with antilymphocyte globulin on tumour incidence in BN/a and BN/b mice was studied. One ALG sample appeared to be highly leukaemogenic in two independent experiments. All treated mice developed, after a short latency period, non-thymic lymphomas with involvement of abdominal lymph ...

journal_title：International journal of cancer

authors： Szkudlarek J,Radzikowski C,Czarnomska A,Dux K,Bartoszewicz W

更新日期：1976-12-15 00:00:00

abstract：:HPV35 has been found in only ∼2% of invasive cervical cancers (ICC) worldwide but up to 10% in Sub-Saharan Africa, warranting further investigation and consideration of impact on preventive strategies. We studied HPV35 and ethnicity, in relation to the known steps in cervical carcinogenesis, using multiple large epide...

journal_title：International journal of cancer

authors： Pinheiro M,Gage JC,Clifford GM,Demarco M,Cheung LC,Chen Z,Yeager M,Cullen M,Boland JF,Chen X,Raine-Bennett T,Steinberg M,Bass S,Befano B,Xiao Y,Tenet V,Walker J,Zuna R,Poitras NE,Gold MA,Dunn T,Yu K,Zhu B,Bu

更新日期：2020-11-15 00:00:00

abstract：:In order to understand the expression and modulation of adhesion molecules (AMs) on the surface of different gastric cancers, we studied 4 gastric-cancer cell lines including SC-M1, KATO-III, AGS and AZ-521. The expression of E-cadherin, integrins (beta1, beta2 and beta3), ICAMs (1 and 2), and CD11 (a, b and c) on the...

journal_title：International journal of cancer

authors： Hsieh MC,Wu CW,Wu LH,Lui WY,P'eng FK,Yu CL

更新日期：1996-09-04 00:00:00

abstract：:Fibronectin in human solid tumors was studied by indirect immunofluorescence staining of biopsy material. Altogether 73 tumors were examined, comprising 12 sarcomas, 3 melanomas 1 reticulum cell sarcoma, 39 carcinomas, 6 benign soft-tissue tumors and 12 benign epithelial tumors. In all sarcomas the individual tumor ce...

journal_title：International journal of cancer

authors： Stenman S,Vaheri A

更新日期：1981-01-01 00:00:00

abstract：:High circulating glucose, insulin resistance and obesity appear to be associated with increased risk of breast cancer (BC). We sought further insight into the relation of these variables to BC. We assessed associations of BC risk with serum fasting glucose, insulin, homeostasis model assessment-insulin resistance (HOM...

journal_title：International journal of cancer

authors： Sieri S,Muti P,Claudia A,Berrino F,Pala V,Grioni S,Abagnato CA,Blandino G,Contiero P,Schunemann HJ,Krogh V

更新日期：2012-02-15 00:00:00