Abstract:
:Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly killing tumor cells through heat and reactive oxygen species, PTT and PDT can also induce various antitumor effects. In particular, the resultant massive tumor cell death after PTT and PDT triggers immune responses, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines and the transformation of memory T lymphocytes. The antitumor effects can be enhanced by immune checkpoint blockage therapy. This article reviewed the recent advances of nanoparticle-based PTT and PDT, summarized the studies on nanoparticle-based photothermal and photodynamic immunotherapies in vitro and in vivo, and discussed challenges and future research directions.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Hou X,Tao Y,Pang Y,Li X,Jiang G,Liu Ydoi
10.1002/ijc.31717subject
Has Abstractpub_date
2018-12-15 00:00:00pages
3050-3060issue
12eissn
0020-7136issn
1097-0215journal_volume
143pub_type
杂志文章,评审abstract::High-grade serous epithelial ovarian cancer (HGS-EOC) is a systemic disease, with marked intra and interpatient tumor heterogeneity. The issue of spatial and temporal heterogeneity has long been overlooked, hampering the possibility to identify those genomic alterations that persist, before and after therapy, in the g...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32288
更新日期:2019-11-15 00:00:00
abstract::To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy spec...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19981005)78:2<135::aid-ijc
更新日期:1998-10-05 00:00:00
abstract::Apc gene-deficient Min and Apc(1309) mice feature a hyperlipidemic state with a markedly low expression level of lipoprotein lipase (LPL) compared to their wild-type counterparts. We previously showed that induction of LPL mRNA by peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonists or an LPL sel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22872
更新日期:2007-10-15 00:00:00
abstract::In a formal prospective-retrospective analysis of the phase III SBG0102 clinical trial randomizing metastatic breast cancer patients to gemcitabine-docetaxel or to single agent docetaxel, patients with basal-like tumors by PAM50 gene expression had significantly better overall survival in the gemcitabine arm. By immun...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31969
更新日期:2019-05-15 00:00:00
abstract::Angiogenesis, a critical driver of tumor development, is controlled by interconnected signaling pathways. Vascular endothelial growth factor receptor (VEGFR) 2 and tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 play crucial roles in the biology of normal and tumor vasculature. Regora...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25864
更新日期:2011-07-01 00:00:00
abstract::The p16INK4 gene is a candidate tumour-suppressor gene which maps to the genomic locus 9p21, and mutations of this gene are associated with melanoma and other cancers. Biochemical studies suggest that p16INK4 mediates its effects by specifically inhibiting the G1 cyclin-dependent kinases CDK4 and CDK6, thereby regulat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960410)66:2<249::AID-IJC
更新日期:1996-04-10 00:00:00
abstract::Hybridoma CE7 produces a murine antibody (gamma 1/kappa) which binds to a 190-kDa cell-surface glycoprotein of human neuroblastoma. Because of its tumor specificity, it has been used routinely in clinical pathology to confirm diagnosis of neuroblastoma. We have isolated the gene segments coding for the variable region...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530127
更新日期:1993-01-02 00:00:00
abstract::Cervical cancer screening test performance has been hampered by either lack of sensitivity of Pap cytology or lack of specificity of Human Papillomavirus (HPV) testing. This uncertainty can lead to unnecessary referral and treatment, which is disturbing for patients and increases costs for health care providers. The i...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28900
更新日期:2015-06-15 00:00:00
abstract::Angiogenesis in pancreatic ductal adenocarcinomas depends on the presence of angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and is thought to be stimulated by hypoxia. We tested the angiogenic potential of 9 cell lines of pancreatic ductal carcinoma origi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10753
更新日期:2002-12-20 00:00:00
abstract::Data on human T-cell lymphotropic-virus-type-I (HTLV-I) status and hematology from 528 individuals were analyzed for associations with low reactivity to the purified protein derivative (PPD) of Mycobacterium tuberculosis recall antigen. Subjects were classified as HTLV-I carriers with abnormal lymphocytes (Ably), carr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560307
更新日期:1994-02-01 00:00:00
abstract::To further examine the association between oral hygiene and esophageal squamous cell carcinoma (ESCC) risk and the effect modification of other exposures, we conducted a population-based case-control study between 2010 and 2012 in Taixing, China, a high-risk area for ESCC. Cases were primarily recruited from endoscopy...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30484
更新日期:2017-02-01 00:00:00
abstract::There is little long-term follow-up information about how the number of melanoma deaths and case fatality vary over time according to the measured thickness of melanoma at diagnosis. This population-based longitudinal cohort study examines patterns and trends in case fatality among 44,531 people in Queensland (Austral...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32930
更新日期:2020-09-01 00:00:00
abstract::In this report, we quantified HTLV-I provirus load using the AmpliSensor system, which utilizes fluorescence to measure PCR products. With this method, provirus loads could be measured within 6 hr, and the results obtained correlated well with those obtained by other methods. Samples from 256 blood donors, who were po...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990611)81:6<859::aid-ijc
更新日期:1999-06-11 00:00:00
abstract::In a prospective study with a median follow-up of 13 months on a series of 71 breast cancer patients, 9 developed haematogenous metastases. The neu protein was found on the cell membranes in 27 of the 71 carcinomas (38%) by an immunohistochemical technique using a monoclonal antibody (MAb). Eight of the 9 patients wit...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450112
更新日期:1990-01-15 00:00:00
abstract::The hedgehog (Hh) signaling pathway is essential for the development of tissues and organs. Hyperactive Hh signaling has been implicated in many gastric cancers, including esophageal cancer. However, the interaction between the Hh pathway and other potential signaling pathways in primary esophageal tumorigenesis has n...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25673
更新日期:2011-07-15 00:00:00
abstract::Survivin protein is an attractive candidate for cancer immunotherapy since it is abundantly expressed in most common human cancers and mostly absent in normal adult tissues. Malignant mesothelioma (MM) is a deadly cancer associated with asbestos or erionite exposure for which no successful therapies are currently avai...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28048
更新日期:2013-08-01 00:00:00
abstract::Experimental studies have suggested that the biosynthesis of arachidonic acid-derived eicosanoids such as prostaglandin E2 via the cyclo-oxygenase pathway may play a significant role in supporting cell proliferation in human prostate cancer cell lines. However, the aetiological significance of this for clinical prosta...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980812)77:4<511::aid-ijc
更新日期:1998-08-12 00:00:00
abstract::Hybridomas producing syngeneic monoclonal antibodies (MAbs) were prepared by fusion of spleen cells of BALB/c mice, which were immunized with sublethal doses of RMB-I cells. This cell line originates from a Rauscher virus (R-MuLV)-induced myeloid leukemia and forms tumors when re-inoculated into mice. MAbs were charac...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420121
更新日期:1988-07-15 00:00:00
abstract::The absolute risk reduction by prophylaxis in chemotherapy-induced febrile neutropenia (FN) is largest in patients at highest underlying risk. Therefore, reliable predictive models are needed. Here, we develop and validate such a model for risk of FN during chemotherapy cycles 2-6. A prediction score for risk of FN du...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32249
更新日期:2020-01-15 00:00:00
abstract::Surveillance guidelines for the management of familial colorectal cancer (FCC), a dominant family history of colorectal cancer in which the polyposis syndromes and Lynch syndrome have been excluded, are not firmly established. The outcome of colonoscopic surveillance is studied using data from six centers. DNA mismatc...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.28397
更新日期:2014-02-15 00:00:00
abstract::Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33206
更新日期:2021-01-15 00:00:00
abstract::As many patients with mammary carcinoma are now treated by conservative forms of surgery, there is a need for prognostic information obtainable from the primary tumour alone. One possible source is the antigenic profile of tumour cells. Using an indirect immunoperoxidase technique, we stained histological sections of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330304
更新日期:1984-03-15 00:00:00
abstract::Protein phosphatase 2A (PP2A) consists of 3 subunits: the catalytic subunit, C, and the regulatory subunits, A and B. The A and C subunits both exist as 2 isoforms (alpha and beta) and the B subunit as multiple forms subdivided into 3 families, B, B' and B". It has been reported that the genes encoding the Aalpha and ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1423
更新日期:2001-09-01 00:00:00
abstract::The cell-cycle regulator p16 inhibits the complex cdk4-cyclin D1 and controls G1-S transition. In human tumors, p16 inactivation is often accomplished by homozygous deletion (HD) of its encoding gene, CDKN2A. Methylation of the 5' CpG island promoter has been proposed as an alternative mechanism of inactivation. Expre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20001115)88:4<554::aid-ijc6>3.0.
更新日期:2000-11-15 00:00:00
abstract::Serum and tumor tissue from breast cancer patients were evaluated for the presence of alpha subunit of hCG, by means of the specific radioimmunoassay. Elevated serum levels occurred in 0/50 (0%) of normal female controls, 1/17 (6%) of patients with benign breast disease, 3/53 (6%) of patients with primary breast cance...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250508
更新日期:1980-05-15 00:00:00
abstract::Our aim was to compare the occurrence and prognostic significance over 14-20 years of immunocytochemically detected S100A4 and other tumour variables in primary tumours from 349 patients with operable breast cancer. For a cut-off of 1% staining of the malignant cells, the antibody to S100A4 stains positively 56% of th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-20 00:00:00
abstract::Macrophages were isolated from 22 human ascitic ovarian epithelial tumors and their growth-inhibitory capacity was tested using as targets the following in vitro tumor cell lines: murine TLX9 lymphoma and FS6 sarcoma; human myeloid K562 leukemia and human E cell line derived from an ovarian carcinoma. Macrophage prepa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230204
更新日期:1979-02-01 00:00:00
abstract::Syrian-hamster-derived lymphotoxin inhibits benzo(a)pyrene and ultraviolet carcinogen-induced in vitro morphologic transformation of diploid secondary passage hamster embryo cells. When lymphotoxin is added up to 4 days post carcinogen, the reduction in the frequency of morphologic transformation 6 days after carcinog...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270108
更新日期:1981-01-15 00:00:00
abstract::While platelet-derived growth factor, PDGF, is not regularly expressed in mesenchymal tissues, PDGF B mRNA is often found in tumors derived from these tissues. PDGF B protein is also present, but the protein levels in individual tumors do not appear to correlate well with those of the mRNA. PDGF B is homologous to the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-01-15 00:00:00
abstract::Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone EO9 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase may be involved in the metabolic activation of EO9 and mitomycin C in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560124
更新日期:1994-01-02 00:00:00