Cotargeting BET proteins overcomes resistance arising from PI3K/mTOR blockade-induced protumorigenic senescence in colorectal cancer.

abstract：:Biliary glycoprotein I (BGP I) is a member of carcinoembryonic antigen (CEA) gene family consisting of at least 11 related genes. The transcription of BGP I gene was analysed in malignant and non-malignant human liver tissues with a 396-bp 3'-untranslated region probe from a cDNA clone 4-13 which was newly isolated fr...

journal_title：International journal of cancer

authors： Hinoda Y,Imai K,Nakagawa N,Ibayashi Y,Nakano T,Paxton RJ,Shively JE,Yachi A

更新日期：1990-05-15 00:00:00

abstract：:Anti-idiotypic antibodies that mimic tumour-associated antigens can stimulate anti-tumour T-cell responses. In this article, we have studied the role of Fc in the presentation of T-cell epitopes by 2 anti-idiotypic antibodies, 105AD7 and 708. The human monoclonal antibody 105AD7, which mimics CD55, stimulated strong i...

journal_title：International journal of cancer

authors： Durrant LG,Parsons T,Moss R,Spendlove I,Carter G,Carr F

更新日期：2001-05-01 00:00:00

abstract：:gamma-L-glutaminyl-4-hydroxy-3-iodobenzene (I-GHB), a novel iodinated analog of gamma-L-glutaminyl-4-hydroxybenzene (GHB), demonstrates greater anti-tumor activity in human and in murine melanoma cell lines. These phenolic amides are substrates for gamma-glutamyltranspeptidase (GGTP; E.C. 2.3.2.2), a cell-membrane-ass...

journal_title：International journal of cancer

authors： Prezioso JA,Hughey RP,Wang N,Damodaran KM,Bloomer WD

更新日期：1994-03-15 00:00:00

abstract：:From an assessment of the presence of a junctional component in 8,380 pigmented naevi, and histological review of its extent and the presence of inflammation and regression in a sample of 216 junctional and compound naevi, it was determined that naevi excised in summer were more likely to have a junctional component a...

journal_title：International journal of cancer

authors： Holman CD,Heenan PJ,Caruso V,Glancy RJ,Armstrong BK

更新日期：1983-02-15 00:00:00

abstract：:The red bone marrow (BM) is an important indicator organ of hematogenous micrometastatic spread of carcinomas. Characterization of biological properties specific for BM micrometastatic cells, however, is technically challenging due to the limited number of target cells usually available for the purpose. This report pr...

journal_title：International journal of cancer

authors： Ree AH,Engebraaten O,Hovig E,Fodstad Ø

更新日期：2002-01-01 00:00:00

abstract：:Many tumors are impervious to anticancer agents. Resistance due to lack of cytotoxic penetration into the tumor is often overlooked but can play a significant role in undermining therapy. Insufficient and irregular vascularization of tumors is a possible barrier to drug delivery, but there are others, e.g., impaired v...

journal_title：International journal of cancer

authors： Wildiers H,Guetens G,de Boeck G,Landuyt W,Verbeken E,Highley M,de Bruijn EA,van Oosterom AT

更新日期：2002-06-01 00:00:00

abstract：:The prognostic role of inflammation index like neutrophil-to-lymphocyte ratio (NLR) in colorectal cancer (CRC) remains controversial. We conduct a meta-analysis to determine the predictable value of NLR in the clinical outcome of CRC patients. The analysis was carried out based on the data from 16 studies (19 cohorts)...

journal_title：International journal of cancer

authors： Li MX,Liu XM,Zhang XF,Zhang JF,Wang WL,Zhu Y,Dong J,Cheng JW,Liu ZW,Ma L,Lv Y

更新日期：2014-05-15 00:00:00

abstract：:The modifying effects of a Kunitz trypsin inhibitor (KTI) and a Bowman-Birk trypsin inhibitor (BBI), purified from soybean trypsin inhibitor, as dietary supplements on experimental and spontaneous pulmonary metastasis of murine Lewis lung carcinoma 3LL cells as well as peritoneal disseminated metastasis model in human...

journal_title：International journal of cancer

authors： Kobayashi H,Fukuda Y,Yoshida R,Kanada Y,Nishiyama S,Suzuki M,Kanayama N,Terao T

更新日期：2004-11-10 00:00:00

abstract：:When Fc receptors (FcR) on normal human peripheral blood lymphocytes were induced to modulate by overnight (18 h) incubation in the presence of soluble or particulate immune complexes, the natural killer (NK) activity of the effector lymphocyte suspension, as measured against the K562 erythroleukemia cell line, was si...

journal_title：International journal of cancer

authors： Kay HD,Fagnani R,Bonnard GD

更新日期：1979-08-01 00:00:00

abstract：:Hyaluronan (HA) has been shown to play crucial roles in the tumorigenicity of malignant tumors. Previous studies demonstrated that inhibition of HA suppressed the tumorigenicity of various malignant tumors including breast cancer. 4-methylumbelliferone (MU) has been reported to inhibit HA synthesis in several cell typ...

journal_title：International journal of cancer

authors： Urakawa H,Nishida Y,Wasa J,Arai E,Zhuo L,Kimata K,Kozawa E,Futamura N,Ishiguro N

更新日期：2012-01-15 00:00:00

abstract：:Active, structurally unrelated tumor promoters (12-0-tetradecanoyl-phorbol-13-acetate (TPA), teleocidin and aplysiatoxin) inhibit growth of mammary carcinoma cells (MCF7- greater than BT-20 greater than MDA-MB-231 greater than = ZR-75-1 greater than HBL-100). This efficiency in inhibiting cell growth correlates with t...

journal_title：International journal of cancer

authors： Regazzi R,Fabbro D,Costa SD,Borner C,Eppenberger U

更新日期：1986-05-15 00:00:00

abstract：:Oncogenes of the myc family c-raf-1 and K-ras have been reported to modulate radiosensitivity. We examined the possible relationship between in vivo radiosensitivity to single-dose irradiation with 3-10 Gy, and activity of these proto-oncogenes in 2 sets of small-cell lung cancer (SCLC) xenografts, the CPH and the GLC...

journal_title：International journal of cancer

authors： Rygaard K,Slebos RJ,Spang-Thomsen M

更新日期：1991-09-09 00:00:00

abstract：:Emerging evidence suggests that the transcription factor Forkhead Box M1 (FoxM1) is associated with aggressive human carcinomas, including breast cancer. Because elevated expression of FoxM1 has been observed in human breast cancers, FoxM1 has attracted much attention in recent years as a potential target for the prev...

journal_title：International journal of cancer

authors： Ahmad A,Ali S,Wang Z,Ali AS,Sethi S,Sakr WA,Raz A,Rahman KM

更新日期：2011-10-01 00:00:00

abstract：:In light of recent, strong inverse findings between lifetime red wine consumption and prostate cancer among younger men, we revisited our previous cohort analysis to more thoroughly investigate red wine consumption and prostate cancer in the Health Professionals Follow-up Study (HPFS). In 1986, HPFS participants repor...

journal_title：International journal of cancer

authors： Sutcliffe S,Giovannucci E,Leitzmann MF,Rimm EB,Stampfer MJ,Willett WC,Platz EA

更新日期：2007-04-01 00:00:00

abstract：:Knowledge about the prevalence of human papillomavirus (HPV) on a population level is important. We conducted a large population-based study in Denmark to determine the overall and age-specific HPV prevalence, and HPV type distribution in women. Liquid-based cytology samples (SurePath) were collected consecutively. HP...

journal_title：International journal of cancer

authors： Kjaer SK,Breugelmans G,Munk C,Junge J,Watson M,Iftner T

更新日期：2008-10-15 00:00:00

abstract：:Limited penetration of anticancer drugs through tumour tissue is an important factor that may limit therapeutic effects against solid tumours. Here we report studies of the penetration of radiolabelled methotrexate through multicellular layers (MCL) of murine EMT-6 and human MCF-7 cells grown on semiporous teflon memb...

journal_title：International journal of cancer

authors： Cowan DS,Tannock IF

更新日期：2001-01-01 00:00:00

abstract：:Oncogenic activation of MYC occurs often in breast carcinoma and is associated with poor prognosis. Loss or inactivation of mechanisms that restrain MYC may therefore be involved in tumor progression. In this study, we show that the MYC-interacting adaptor protein BIN1 is frequently missing in malignant breast cells a...

journal_title：International journal of cancer

authors： Ge K,Duhadaway J,Sakamuro D,Wechsler-Reya R,Reynolds C,Prendergast GC

更新日期：2000-02-01 00:00:00

abstract：:Socioeconomic status (SES) is a determinant of outcome in various types of cancer. The aim of this study is to analyze the impact of the SES in Hodgkin's lymphoma (HL). From 2001 to 2005, 194 consecutive patients were prospectively followed in 5 institutions. Patients answered a questionnaire with a set of items used ...

journal_title：International journal of cancer

authors： Soares A,Biasoli I,Scheliga A,Luiz RR,Costa MA,Land M,Romano S,Morais JC,Spector N

更新日期：2007-02-15 00:00:00

abstract：:The diagnostic specificity of the detection of disseminated prostatic cells by reverse-transcriptase polymerase chain reaction (RT-PCR) of PSA mRNA was investigated. A sensitive nested PCR was developed. In blood samples from 10 healthy female and 10 healthy male persons examined by RT-PCR, mRNA of PSA was detected 3 ...

journal_title：International journal of cancer

authors： Henke W,Jung M,Jung K,Lein M,Schlechte H,Berndt C,Rudolph B,Schnorr D,Loening SA

更新日期：1997-01-06 00:00:00

abstract：:We transduced a human gastric carcinoma cell line, HR, with the interleukin 2 (IL-2) gene. Stable HR transfectants secreted nanogram quantities of biologically active IL-2 and had significantly increased expression of IL-2 mRNA relative to that in parental cells. Expression of intracellular IL-2 protein was not quanti...

journal_title：International journal of cancer

authors： Nagashima S,Kashii Y,Reichert TE,Suminami Y,Suzuki T,Whiteside TL

更新日期：1997-07-03 00:00:00

abstract：:Hodgkin and Reed-Sternberg (H and RS) cells are generally considered to be the neoplastic cells of Hodgkin's disease (HD); however, such cells are found only in a minority of HD lesions. Very few data have so far been published on the cytogenetic abnormalities in HD. An analysis of unknown genetic aberrations has only...

journal_title：International journal of cancer

authors： Ohshima K,Ishiguro M,Ohgami A,Sugihara M,Haraoka S,Suzumiya J,Kikuchi M

更新日期：1999-07-19 00:00:00

abstract：:Apigenin is a plant flavonoid that is thought to play a role in the prevention of carcinogenesis. However, its mechanism of action has not yet been elucidated. Because of the importance of angiogenesis in tumor growth, we investigated the effect of apigenin on endothelial and smooth-muscle cells in an in vitro model. ...

journal_title：International journal of cancer

authors： Trochon V,Blot E,Cymbalista F,Engelmann C,Tang RP,Thomaïdis A,Vasse M,Soria J,Lu H,Soria C

更新日期：2000-03-01 00:00:00

abstract：:MAGE genes encoding tumor-rejection antigens recognized by cytotoxic T lymphocytes are expressed at the mRNA level in various malignant tumors. We have investigated the expression of genes MAGE-1, -2, -3/-6 and -4a/-4b at the mRNA level in malignant and non-malignant ovarian tumors as well as in normal ovaries by reve...

journal_title：International journal of cancer

authors： Yamada A,Kataoka A,Shichijo S,Kamura T,Imai Y,Nishida T,Itoh K

更新日期：1995-12-20 00:00:00

abstract：:The incidence of esophageal cancer is extremely high in Linxian County and certain other regions of the People's Republic of China. Epidemiologic and laboratory studies suggest that N-nitroso carcinogens and other environmental factors play a causative role. In the present study, employing over 100 DNA samples obtaine...

journal_title：International journal of cancer

authors： Lu SH,Hsieh LL,Luo FC,Weinstein IB

更新日期：1988-10-15 00:00:00

abstract：:Cancer cells have the capacity to lyse erythrocytes by a cell-contact-requiring phenomenon. Subcellular fractionation procedures have revealed that the hemolytic principle resides in the cancer cell plasma membrane. In this study we report the detergent extraction of a potent hemolytic factor from the plasma membranes...

journal_title：International journal of cancer

authors： Zucker S,DiMassimo BI,Lysik RM,Vuaridel-Bonanomi E

更新日期：1991-01-21 00:00:00

abstract：:Breast cancer is one of the most common and feared cancers faced by women. The prognosis of patients with advanced or recurrent breast cancer remains poor despite refinements in multimodality therapies involving chemotherapeutic and hormonal agents. Multimodal therapy with more specific and effective strategy is urgen...

journal_title：International journal of cancer

authors： Tan G,Kasuya H,Sahin TT,Yamamura K,Wu Z,Koide Y,Hotta Y,Shikano T,Yamada S,Kanzaki A,Fujii T,Sugimoto H,Nomoto S,Nishikawa Y,Tanaka M,Tsurumaru N,Kuwahara T,Fukuda S,Ichinose T,Kikumori T,Takeda S,Nakao A,Kode

更新日期：2015-04-01 00:00:00

abstract：:T24 human bladder carcinoma cells reveal a high locomotor activity (70% locomoting cells) within a 3-dimensional collagen matrix. This high migratory activity is induced by an autocrine engagement of the interleukin-8 receptor A, as was shown by antibodies neutralizing the secreted interleukin-8. Treatment of the cell...

journal_title：International journal of cancer

authors： Lang K,Niggemann B,Zanker KS,Entschladen F

更新日期：2002-06-10 00:00:00

abstract：:The causes of childhood cancers are largely unknown. Birth order has been used as a proxy for prenatal and postnatal exposures, such as frequency of infections and in utero hormone exposures. We investigated the association between birth order and childhood cancers in a pooled case-control dataset. The subjects were d...

journal_title：International journal of cancer

authors： Von Behren J,Spector LG,Mueller BA,Carozza SE,Chow EJ,Fox EE,Horel S,Johnson KJ,McLaughlin C,Puumala SE,Ross JA,Reynolds P

更新日期：2011-06-01 00:00:00

abstract：:The selective targets for HTLV-III/LAV, the causal infectious agent of AIDS and AIDS-related complex (ARC), are T4 cells, apparently because the virus receptor is associated with T4 antigen determinants. This accounts for T4 cell depletion in AIDS and for a decrease of IL-2 production by AIDS peripheral blood lymphocy...

journal_title：International journal of cancer

authors： Fouchard M,Reveil B,Mbayo K,Lurhuma A,Sarin PS,Gallo RC,Zagury D

更新日期：1986-11-15 00:00:00

abstract：:Bromodomain and extraterminal domain (BET) inhibitors are broadly active against distinct types of cancer, including nonsmall cell lung cancer (NSCLC). Previous studies have addressed the effect of BET-inhibiting drugs on the expression of oncogenes such as c-Myc, but DNA damage repair pathways have also been reported...

journal_title：International journal of cancer

authors： Takashima Y,Kikuchi E,Kikuchi J,Suzuki M,Kikuchi H,Maeda M,Shoji T,Furuta M,Kinoshita I,Dosaka-Akita H,Sakakibara-Konishi J,Konno S

更新日期：2020-02-15 00:00:00