Effects of the farnesyltransferase inhibitor UCF-1C/manumycin on growth and p21-ras post-translational processing in NIH3T3 cells.


:Examination of the effect of the farnesylprotein transferase (FPTase) inhibitor UCF1-C/manumycin on NIH3T3 cells transfected with a normal N-ras gene and expressing high levels of the corresponding p21-ras protein showed that 10 microm UCF1-C immediately and reversibly inhibited growth in these cells, without modifying cell-death rate, thus acting as a cytostatic. There was also a 98% reduction of p21-ras neofarnesylation and a 3-fold decrease in total content in p21-ras products, yet without gross modification of the relative content in the post-translational products and without accumulation of the native protein to detectable levels. UCF1-C likewise reversibly inhibited growth in parental NIH3T3 cells, as well as in sub-strains expressing a transfected normal or mutated H-ras gene. Together with the fact that the well-developed network of actin stress fibers present in the NIH3T3 (N-ras) cells was not affected by the FPTase inhibitor, these data indicate that its growth-inhibitory effect is not necessarily in direct relation with that exerted on p21-ras processing. Alternatively, it might be causally related to the decreased prenylation of other cellular proteins, perhaps included among the 13 proteins, unrelated to p21-ras, of which the farnesylation was also reduced under UCF1-C treatment. Some cells transformed by a ras or non-ras oncogene might exhibit higher susceptibility towards FPTase inhibitors than normal cells, but this might then be attributable to differences in the pattern of expression and/or in the functional importance of non-ras farnesylated proteins.


Int J Cancer


Servais P,Gulbis B,Fokan D,Galand P




Has Abstract


1998-05-18 00:00:00














  • A re-examination of the Epstein-Barr virus carrier state in healthy seropositive individuals.

    abstract::A panel of 24 healthy seropositive donors have been followed prospectively over a period of 15 months and monitored (1) for the level of EB virus shedding in the throat by means of a sensitive cord-blood transformation assay; (2) for the level of virus-infected B cells in the blood via a new in vitro protocol where "s...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yao QY,Rickinson AB,Epstein MA

    更新日期:1985-01-15 00:00:00

  • Ovarian cancer-derived copy number alterations signatures are prognostic in chemoradiotherapy-treated head and neck squamous cell carcinoma.

    abstract::DNA copy number alterations (CNAs) are frequent in cancer, and recently developed CNA signatures revealed their value in molecular tumor stratification for patient prognosis and platinum resistance prediction in ovarian cancer. Head and neck squamous cell carcinoma (HNSCC) is also characterized by high CNAs. In this s...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Essers PBM,van der Heijden M,Vossen D,de Roest RH,Leemans CR,Brakenhoff RH,van den Brekel MWM,Bartelink H,Verheij M,Vens C

    更新日期:2020-09-15 00:00:00

  • Expression of urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in benign, borderline, malignant primary and metastatic ovarian tumors.

    abstract::Elevated levels of expression of the urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 have shown to be related to poor prognosis in a variety of cancer types. In the present study, cytosolic levels of uPA and PAI-1 were determined with enzyme-linked immunosorbent assays in cytosols prepared from 244 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van der Burg ME,Henzen-Logmans SC,Berns EM,van Putten WL,Klijn JG,Foekens JA

    更新日期:1996-12-20 00:00:00

  • Beta-galactoside alpha2,6 sialyltransferase in human colon cancer: contribution of multiple transcripts to regulation of enzyme activity and reactivity with Sambucus nigra agglutinin.

    abstract::Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dall'Olio F,Chiricolo M,Ceccarelli C,Minni F,Marrano D,Santini D

    更新日期:2000-10-01 00:00:00

  • Apc10.1: an ApcMin/+ intestinal cell line with retention of heterozygosity.

    abstract::APC10.1 is a new intestinal cell line derived from ApcMin/+ mice that retains both the heterozygous Apc genotype and a nonactivated Wnt signaling pathway and displays an early neoplastic phenotype. Although tumorigenic both in immunodepressed and in immunocompetent syngeneic mice, it requires a high cell dose and a lo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: De Giovanni C,Landuzzi L,Nicoletti G,Astolfi A,Croci S,Micaroni M,Nanni P,Lollini PL

    更新日期:2004-03-20 00:00:00

  • Biodistribution of 111In-labelled SCN-bz-DTPA-BC-2 MAb following loco-regional injection into glioblastomas.

    abstract::We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Merlo A,Jermann E,Hausmann O,Chiquet-Ehrismann R,Probst A,Landolt H,Maecke HR,Mueller-Brand J,Gratzl O

    更新日期:1997-05-29 00:00:00

  • Modulation of cellular gene expression in B lymphoma cells following in vitro infection by Epstein-Barr virus (EBV).

    abstract::In vitro infection of EBV-negative lymphoma cell lines with immortalizing strains of Epstein-Barr virus induces the cell-surface expression of B-cell markers, such as the EBV receptor/CR2 (CD21) and the CD23 antigen. The non-immortalizing EBV variant, P3HRI, which carries a deletion encompassing the EBV nuclear antige...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Calender A,Cordier M,Billaud M,Lenoir GM

    更新日期:1990-10-15 00:00:00

  • Imbalances of chemokines, chemokine receptors and cytokines in Hodgkin lymphoma: classical Hodgkin lymphoma vs. Hodgkin-like ATLL.

    abstract::Classical Hodgkin lymphoma (HL) is characterized by the presence of Hodgkin and Reed-Sternberg cells (H&RS) and a prominent lymphocytic infiltration. We previously reported Hodgkin-like adult T-cell leukemia/lymphoma (HL-like ATLL) (new WHO classification). Various CXC and CC chemokines are expressed on H&RS cells and...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ohshima K,Karube K,Hamasaki M,Suefuji H,Tutiya T,Yamaguchi T,Suzumiya J,Kikuchi M

    更新日期:2003-09-20 00:00:00

  • Hormone replacement therapy and the risk of breast cancer. Nested case-control study in a cohort of Swedish women attending mammography screening.

    abstract::There is concern that hormone replacement therapy (HRT) increases the risk of breast cancer. We undertook a case-control study of this risk relationship within a cohort of 40- to 74-year-old women in Uppsala County, Sweden, who participated in mammography screening. Incident cases of breast cancer were ascertained dur...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Persson I,Thurfjell E,Bergstrom R,Holmberg L

    更新日期:1997-09-04 00:00:00

  • Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells.

    abstract::Our study explored the drug interaction of all-trans retinoic acid (ATRA) and RAD001 (everolimus), the inhibitor of mammalian target of rapamycin complex 1 (mTORC1), in acute myelogenous leukemia (AML) NB4 and HL60 cells. RAD001 (10 nM) significantly enhanced the ATRA-induced growth arrest and differentiation of these...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nishioka C,Ikezoe T,Yang J,Gery S,Koeffler HP,Yokoyama A

    更新日期:2009-10-01 00:00:00

  • Anti-idiotype vaccine against Hodgkin's lymphoma: induction of B- and T-cell immunity across species barriers against CD30 antigen by murine monoclonal internal image antibodies.

    abstract::Murine monoclonal antibody HRS-4 (Ab1), which defines the cell-bound and soluble CD30 antigen associated with Hodgkin's lymphoma, was used to generate monoclonal anti-idiotypic antibodies (Ab2) in syngeneic BALB/c mice. Murine monoclonal Ab2 14G9 and Ab2 9G10 directed against HRS-4 were shown to be anti-idiotypic Ab2 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pohl C,Renner C,Schwonzen M,Sieber M,Lorenz P,Pfreundschuh M,Diehl V

    更新日期:1992-04-01 00:00:00

  • Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer.

    abstract::Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer mortality worldwide. Emerging evidence indicates that tumour cells release substantial amounts of RNA into the bloodstream, in which RNA strongly resists RNases and is present at sufficient levels for quantitative analyses. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Xu W,Zhou G,Wang H,Liu Y,Chen B,Chen W,Lin C,Wu S,Gong A,Xu M

    更新日期:2020-05-15 00:00:00

  • A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues.

    abstract::A new murine monoclonal antibody (MAb), E-9, has been raised using tissue-cultured human umbilical vein endothelial cells. The antigen recognized by this MAb is a peptide of 170 kDa under non-reducing conditions and 96 kDa under reducing conditions. MAb E-9 showed marked heterogeneity in its distribution in various ti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wang JM,Kumar S,Pye D,van Agthoven AJ,Krupinski J,Hunter RD

    更新日期:1993-05-28 00:00:00

  • Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle-invasive bladder cancer.

    abstract::The aim of this study was to test the utility of AIMP3, an upstream regulator of DNA damage response following genotoxic stress, as a clinical biomarker in muscle-invasive bladder cancer (MIBC). AIMP3 was identified from a meta-analysis of a global gene-expression dataset. AIMP3 protein expression was determined by im...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Gurung PM,Veerakumarasivam A,Williamson M,Counsell N,Douglas J,Tan WS,Feber A,Crabb SJ,Short SC,Freeman A,Powles T,Hoskin PJ,West CM,Kelly JD

    更新日期:2015-02-01 00:00:00

  • Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells.

    abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit proliferation and angiogenesis in colorectal cancer. We examined a possible involvement of store-operated calcium (SOC) entry in human colon carcinoma cells (HRT-18), which require calcium for proliferation. Acetyl-salicylic-acid (ASA), mefenamic acid (MEF) and su...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Weiss H,Amberger A,Widschwendter M,Margreiter R,Ofner D,Dietl P

    更新日期:2001-06-15 00:00:00

  • Transient immunological and clinical effectiveness of treating mice bearing premalignant oral lesions with PD-1 antibodies.

    abstract::A carcinogen-induced premalignant oral lesion model that progresses to oral cancer was used to examine the impact of blocking PD-1 on cytokine expression and on progression of lesions to cancer. The results of this study show increased production of IL-2 and the inflammatory cytokines IL-6, IL-17 and TNF-α by spleen c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Levingston CA,Young MR

    更新日期:2017-04-01 00:00:00

  • Antitumor effects of 4-methylumbelliferone, a hyaluronan synthesis inhibitor, on malignant peripheral nerve sheath tumor.

    abstract::Hyaluronan (HA) has been shown to play important roles in the growth, invasion and metastasis of malignant tumors. Our previous study showing that high HA expression in malignant peripheral nerve sheath tumors (MPNST) is predictive of poor patient prognosis, prompted us to speculate that inhibition of HA synthesis in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ikuta K,Ota T,Zhuo L,Urakawa H,Kozawa E,Hamada S,Kimata K,Ishiguro N,Nishida Y

    更新日期:2017-01-15 00:00:00

  • Treatment of Burkitt's lymphoma: randomized clinical trial of single-agent versus combination chemotherapy.

    abstract::A randomized clinical trial designed to compare the effectiveness of cytoxan (CTX) alone versus a combination consisting of CTX, vincristine (Oncovin) and methotrexate (COM) in the treatment of Burkitt's lymphoma (BL) was carried out. Nineteen patients were selected at random to receive CTX alone while 21 received COM...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Olweny CL,Katongole-Mbidde E,Kaddu-Mukasa A,Atine I,Owor R,Lwanga S,Carswell W,Magrath IT

    更新日期:1976-04-15 00:00:00

  • Sex-specificity in lung cancer risk.

    abstract::Smoking is indisputably linked to lung cancer, yet only a small fraction of smokers develops this disease. Although previously tobacco-derived carcinogens and enzyme polymorphisms have been identified to increase the risk for smokers, recent epidemiological data suggest even sex-specificity as a new and additional fac...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Stapelfeld C,Dammann C,Maser E

    更新日期:2020-05-01 00:00:00

  • Associations between autoimmune conditions and hepatobiliary cancer risk among elderly US adults.

    abstract::Growing evidence suggests that people with autoimmune conditions may be at increased risk of hepatobiliary tumors. In the present study, we evaluated associations between autoimmune conditions and hepatobiliary cancers among adults aged ≥66 in the United States. We used Surveillance, Epidemiology, and End Results (SEE...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: McGee EE,Castro FA,Engels EA,Freedman ND,Pfeiffer RM,Nogueira L,Stolzenberg-Solomon R,McGlynn KA,Hemminki K,Koshiol J

    更新日期:2019-02-15 00:00:00

  • Age- and sex-specific cumulative rate and risk of ATLL for HTLV-I carriers.

    abstract::We have surveyed the incidence of adult T-cell leukemia/lymphoma (ATLL) in an endemic area of 290,464 inhabitants for 7 years. We now revise our previous results on the basis of additional findings and estimate the age- and sex-specific cumulative rate for HTLV-I carriers, the adoption of which is recommended by curre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kondo T,Kono H,Miyamoto N,Yoshida R,Toki H,Matsumoto I,Hara M,Inoue H,Inatsuki A,Funatsu T

    更新日期:1989-06-15 00:00:00

  • Effect of tunicamycin on synthesis and secretion of carcinoembryonic antigen by human colonic adenocarcinoma cells.

    abstract::The effect of the glycosylation inhibitor, tunicamycin, on synthesis and secretion of the membrane-associated glycoprotein carcinoembryonic antigen (CEA), was studied in the LS174T human colon cancer cell line. Tunicamycin treatment inhibited total cellular glycoprotein synthesis but did not affect CEA levels of cellu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Miura S,Kim YS

    更新日期:1986-08-15 00:00:00

  • Distribution of the transferrin receptor in normal human fibroblasts and fibrosarcoma cells.

    abstract::Transferrin is required for proliferation of most cells in culture. This effect is presumably mediated by the binding of transferrin to its receptor, a surface glycoprotein which is preferentially expressed by actively growing cells. Here we show that normal human fibroblasts cultured in serum, and other media contain...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ekblom P,Thesleff I,Lehto VP,Virtanen I

    更新日期:1983-01-15 00:00:00

  • Enhanced expression of LFA-3 on human T-cell lines and leukemic cells carrying human T-cell-leukemia virus type 1.

    abstract::Previously, we studied the surface expression of LFA-1 (CD11a/CD18) and ICAM-1 (CD54) in a panel of 16 human T-cell lines and found that those carrying HTLV-1 pro-viruses expressed high levels of ICAM-1. Enhanced expression of ICAM-1 was also seen in fresh leukemic cells from ATL patients. In the present study, we sys...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Imai T,Tanaka Y,Fukudome K,Takagi S,Araki K,Yoshie O

    更新日期:1993-11-11 00:00:00

  • Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma.

    abstract::Pancreatic ductal adenocarcinoma is among the top 10 causes of death from cancer in industrialized countries. In comparison with other gastrointestinal malignancies, pancreatic cancer is one of the tumors most resistant to chemotherapy. An important mechanism of tumor multidrug resistance is increased drug efflux medi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: König J,Hartel M,Nies AT,Martignoni ME,Guo J,Büchler MW,Friess H,Keppler D

    更新日期:2005-06-20 00:00:00

  • A potential role for aspirin in the prevention and treatment of cholangiocarcinoma.

    abstract::Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide. Owing to late diagnosis and limited treatment options, the prognosis for cholangiocarcinoma remains dismal, compelling a search for new treatments. As aspirin exhibits a well-supported chemopreventive effect on comm...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Shen X,Shen X

    更新日期:2021-03-15 00:00:00

  • Intraperitoneal radio-localization of tumors pre-targeted by biotinylated monoclonal antibodies.

    abstract::We describe 2-step and 3-step strategies for intraperitoneal tumor radio-localization by means of monoclonal antibodies (MAbs). Nude mice bearing intraperitoneal human colon carcinoma tumors were injected i.p. with biotinylated MAb AUAI, followed 24 hr later by radioiodinated streptavidin (2-step). The uptake of radio...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Paganelli G,Pervez S,Siccardi AG,Rowlinson G,Deleide G,Chiolerio F,Malcovati M,Scassellati GA,Epenetos AA

    更新日期:1990-06-15 00:00:00

  • A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis.

    abstract::Individuals differ in their ability to repair DNA damage induced by carcinogens. Studies have shown that polymorphisms in DNA repair genes contribute to individual variation in DNA repair capacity and cancer risk. In a hospital-based case-control study, we tested the hypothesis that a C to T variant (Thr241Met) of DNA...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shen H,Sturgis EM,Dahlstrom KR,Zheng Y,Spitz MR,Wei Q

    更新日期:2002-06-20 00:00:00

  • Antibodies to HTLV-I in Nigerian blood-donors, their relatives and patients with leukaemias, lymphomas and other diseases.

    abstract::Antibodies to HTLV-I have been detected in sera from 15 (2.0%) of 736 adult blood-donors in Nigeria, in 4 (20.0%) of 20 patients with chronic lymphatic leukaemia, 3 (10.0%) of 30 with non-Hodgkin's lymphoma, one of 12 with Burkitt's lymphoma and one of 7 with acute lymphoblastic leukaemia. The frequency of positivity ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fleming AF,Maharajan R,Abraham M,Kulkarni AG,Bhusnurmath SR,Okpara RA,Williams E,Akinsete I,Schneider J,Bayer H

    更新日期:1986-12-15 00:00:00

  • Genome-wide profiling of normal gastric mucosa identifies Helicobacter pylori- and cancer-associated DNA methylome changes.

    abstract::The large geographic variations in the incidence of gastric cancer (GC) are likely due to differential environmental exposures, in particular to Helicobacter pylori (H. pylori) infection. We aimed to investigate the impact of H. pylori on the epigenome in normal gastric mucosa and methylation changes associated with c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Woo HD,Fernandez-Jimenez N,Ghantous A,Degli Esposti D,Cuenin C,Cahais V,Choi IJ,Kim YI,Kim J,Herceg Z

    更新日期:2018-08-01 00:00:00