Estimates of the worldwide frequency of sixteen major cancers in 1980.

abstract：:Several lines of evidence suggest that long-term treatment with non-steroidal anti-inflammatory drugs may reduce the risk of colon cancer and the size and number of colonic polyps in patients with familial adenomatous polyposis. Aspirin has also been shown to inhibit cell proliferation in human tumor cell lines and to...

journal_title：International journal of cancer

authors： Ricchi P,Pignata S,Di Popolo A,Memoli A,Apicella A,Zarrilli R,Acquaviva AM

更新日期：1997-12-10 00:00:00

abstract：:Chimeric bcr/abl fusion proteins are thought to be the molecular 'pathogen' of chronic myelogenous leukaemia (CML). Expression levels of the respective fusion RNAs reflect disease progression as well as remission upon therapeutic intervention in CML patients. However, there is no quick and reliable method that would a...

journal_title：International journal of cancer

authors： Kreuzer KA,Lass U,Nagel S,Ellerbrok H,Pauli G,Pawlaczyk-Peter B,Siegert W,Huhn D,Schmidt CA

更新日期：2000-06-01 00:00:00

abstract：:We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and up-regulated E-cadherin, an epi...

journal_title：International journal of cancer

authors： Kabashima A,Higuchi H,Takaishi H,Matsuzaki Y,Suzuki S,Izumiya M,Iizuka H,Sakai G,Hozawa S,Azuma T,Hibi T

更新日期：2009-06-15 00:00:00

abstract：:The relationship between the strength of the estrogenic and progestational components of combined oral contraceptives and risk of endometrial carcinoma was examined in a multinational hospital-based case-control study comparing 220 cases from 7 countries with 1,537 age- and hospital-matched controls. Oral contraceptiv...

journal_title：International journal of cancer

authors： Rosenblatt KA,Thomas DB

更新日期：1991-12-02 00:00:00

abstract：:Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone EO9 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase may be involved in the metabolic activation of EO9 and mitomycin C in...

journal_title：International journal of cancer

authors： Plumb JA,Workman P

更新日期：1994-01-02 00:00:00

abstract：:We have quantified the expression of all 4 isoforms of vascular endothelial growth factor (VEGF) mRNA in non-small-cell lung cancer (NSCLC) using a new kinetic quantitative PCR method, real-time quantitative (RTQ) RT-PCR, and investigated the association between VEGF expression at the mRNA and protein levels and the c...

journal_title：International journal of cancer

authors： Yuan A,Yu CJ,Chen WJ,Lin FY,Kuo SH,Luh KT,Yang PC

更新日期：2000-11-20 00:00:00

abstract：:Germline variation in the TP53 network genes PRKAG2, PPP2R2B, CCNG1, PIAS1 and YWHAQ was previously suggested to have an impact on drug response in vitro. Here, we investigated the effect on breast cancer survival of germline variation in these genes in 925 Finnish breast cancer patients and further analyzed five sing...

journal_title：International journal of cancer

authors： Jamshidi M,Schmidt MK,Dörk T,Garcia-Closas M,Heikkinen T,Cornelissen S,van den Broek AJ,Schürmann P,Meyer A,Park-Simon TW,Figueroa J,Sherman M,Lissowska J,Keong GT,Irwanto A,Laakso M,Hautaniemi S,Aittomäki K,Blomqvist

更新日期：2013-05-01 00:00:00

abstract：:Interleukin-12 (IL-12) has potent antitumor activities via natural killer cells and cytotoxic T lymphocytes. However, the molecular mechanisms whereby IL-12 induces tumoricidal activities are poorly understood. Here, we report the genome-wide analysis of gene expression in a primary murine mammary carcinoma model that...

journal_title：International journal of cancer

authors： Shi X,Liu J,Xiang Z,Mitsuhashi M,Wu RS,Ma X

更新日期：2004-07-01 00:00:00

abstract：:The aim of this study was to determine whether the skin-sensitizing agent 2,4-dinitrofluorobenzene (DNFB) would elicit the same morphological and biochemical events that are characteristic of 12-O-tetradecanoylphorbol-13-acetate (TPA). While single applications of 0.1% or 0.2% DNFB produced only mild epidermal hyperpl...

journal_title：International journal of cancer

authors： Maldve RE,Fischer SM

更新日期：1995-02-08 00:00:00

abstract：:Daphnane-type diterpene gnidimacrin isolated from the Chinese plant Stellera chamaejasme L. is an antitumor agent that activates protein kinase C (PKC). The mechanism of antitumor action of gnidimacrin and the possible involvement of PKC were examined using sensitive K562 and refractory HLE cells. Gnidimacrin did bind...

journal_title：International journal of cancer

authors： Yoshida M,Yokokura H,Hidaka H,Ikekawa T,Saijo N

更新日期：1998-07-17 00:00:00

abstract：:Data from immunocytochemical assessment of estrogen receptor (ER) regulation in MCF-7 cells under estrogenic and anti-estrogenic stimulation were compared with those obtained by enzyme immunoassay (Abbott ER-EIA). Similar trends were observed, although ER level variations were less marked when assessed immunocytochemi...

journal_title：International journal of cancer

authors： Seo HS,Larsimont D,Querton G,El Khissiin A,Laios I,Legros N,Leclercq G

更新日期：1998-12-09 00:00:00

abstract：:Permanent cell lines have been established in vitro from lymphoid tumors induced in C57BH/Ka mice by fractionated X-irradiation or by inoculation of the radiation leukemia virus (RadOV). The cultured cells are lymphoblastic, replicate rapidly in vitro, and are tumorigenic in vivo. The cell surface markers Thy 1, Ly 1,...

journal_title：International journal of cancer

authors： Lieberman M,Declève A,Ricciardi-Castagnoli P,Boniver J,Finn OJ,Kaplan HS

更新日期：1979-08-01 00:00:00

abstract：:KLF5 is a transcription factor that plays important roles in multiple physical and pathological processes, including cell growth, cell cycle regulation, and angiogenesis. To better characterize KLF5 function in bladder carcinogenesis, we established stable TSU-Pr1 cell clones expressing different levels of KLF5. These...

journal_title：International journal of cancer

authors： Chen C,Benjamin MS,Sun X,Otto KB,Guo P,Dong XY,Bao Y,Zhou Z,Cheng X,Simons JW,Dong JT

更新日期：2006-03-15 00:00:00

abstract：:A deficit in colorectal cancer survival in Denmark and in the UK compared to Sweden, Norway and Finland was found in the EUROCARE studies. We set out to explore if these differences still exist. Patients diagnosed with colorectal cancer as their first invasive cancer at age 15-89 in the period 1994-2000 were identifie...

journal_title：International journal of cancer

authors： Engholm G,Kejs AM,Brewster DH,Gaard M,Holmberg L,Hartley R,Iddenden R,Møller H,Sankila R,Thomson CS,Storm HH

更新日期：2007-09-01 00:00:00

abstract：:While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by poolin...

journal_title：International journal of cancer

authors： Jochems SHJ,Reulen RC,van Osch FHM,Witlox WJA,Goossens ME,Brinkman M,Giles GG,Milne RL,van den Brandt PA,White E,Weiderpass E,Huybrechts I,Hémon B,Agudo A,Bueno-de-Mesquita B,Cheng KK,van Schooten FJ,Bryan RT,Wesseliu

更新日期：2020-10-15 00:00:00

abstract：:We show that siRNA-mediated suppression of protein tyrosine phosphatase alpha (PTP alpha) reduces Src activity 2 to 4-fold in breast, colon and other human cancer cell lines. Src and PTP alpha RNAi induced apoptosis in estrogen receptor (ER)-negative breast cancer and colon cancer cells, but not in immortalized noncan...

journal_title：International journal of cancer

authors： Zheng X,Resnick RJ,Shalloway D

更新日期：2008-05-01 00:00:00

abstract：:CA 50 is a new tumor marker based on a monoclonal antibody (MAb) against a human colorectal carcinoma cell line. The CA 50 antigen is similar, but not identical, to the tumor marker CA 19-9. The serum concentrations of CA 50 were measured by an immunoradiometric assay (CA 50 IRMA) in 95 patients with pancreatic cancer...

journal_title：International journal of cancer

authors： Haglund C,Kuusela P,Jalanko H,Roberts PJ

更新日期：1987-04-15 00:00:00

abstract：:The physiological stress response to surgery promotes wound healing and functional recovery and includes the activation of neural, inflammatory and proangiogenic signaling pathways. Paradoxically, the same pathways also promote metastatic spread and growth of residual cancer. Human and animal studies show that cancer ...

journal_title：International journal of cancer

authors： Raskov H,Orhan A,Salanti A,Gögenur I

更新日期：2020-06-15 00:00:00

abstract：:Occupational X-ray examination programs have been conducted in many countries to screen for occupational and nonoccupational respiratory diseases, resulting in widespread exposure to X-radiation. We conducted a multicentre case-control study of lung cancer in the Czech Republic, Hungary, Poland, Romania, Russia and Sl...

journal_title：International journal of cancer

authors： Boffetta P,Mannetje A,Zaridze D,Szeszenia-Dabrowska N,Rudnai P,Lissowska J,Fabiánová E,Mates D,Bencko V,Navratilova M,Janout V,Cardis E,Fevotte J,Fletcher T,Brennan P

更新日期：2005-06-10 00:00:00

abstract：:In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were ana...

journal_title：International journal of cancer

authors： Bellini A,Bessoltane-Bentahar N,Bhalshankar J,Clement N,Raynal V,Baulande S,Bernard V,Danzon A,Chicard M,Colmet-Daage L,Pierron G,Le Roux L,Planchon JM,Combaret V,Lapouble E,Corradini N,Thebaud E,Gambart M,Valteau-Cou

更新日期：2019-11-15 00:00:00

abstract：:Although preliminary evidence suggests that germline variation in genes involved in steroid hormone metabolism may alter breast cancer prognosis, this has not been systematically evaluated. We examined associations between germline polymorphisms in 6 genes involved in the steroid hormone metabolism and signaling pathw...

journal_title：International journal of cancer

authors： Udler MS,Azzato EM,Healey CS,Ahmed S,Pooley KA,Greenberg D,Shah M,Teschendorff AE,Caldas C,Dunning AM,Ostrander EA,Caporaso NE,Easton D,Pharoah PD

更新日期：2009-12-01 00:00:00

abstract：:The relative expression of estrogen receptor (ER) and progesterone receptor (PR) mRNA transcripts was measured in 71 primary breast-cancer biopsies. ER and PR binding activity were estimated in parallel by the dextran-coated-charcoal method. There was a close correlation between the amount of ER mRNA and estradiol bin...

journal_title：International journal of cancer

authors： Nagai MA,Marques LA,Yamamoto L,Fujiyama CT,Brentani MM

更新日期：1994-11-01 00:00:00

abstract：:gamma-L-glutaminyl-4-hydroxy-3-iodobenzene (I-GHB), a novel iodinated analog of gamma-L-glutaminyl-4-hydroxybenzene (GHB), demonstrates greater anti-tumor activity in human and in murine melanoma cell lines. These phenolic amides are substrates for gamma-glutamyltranspeptidase (GGTP; E.C. 2.3.2.2), a cell-membrane-ass...

journal_title：International journal of cancer

authors： Prezioso JA,Hughey RP,Wang N,Damodaran KM,Bloomer WD

更新日期：1994-03-15 00:00:00

abstract：:A "divergent pathway" model for the development of cutaneous melanoma has been proposed. The model hypothesizes that melanomas occurring in people with a low tendency to develop nevi will, on average, arise more commonly on habitually sun-exposed body sites such as the head and neck. In contrast, people with an inhere...

journal_title：International journal of cancer

authors： Olsen CM,Zens MS,Stukel TA,Sacerdote C,Chang YM,Armstrong BK,Bataille V,Berwick M,Elwood JM,Holly EA,Kirkpatrick C,Mack T,Bishop JN,Østerlind A,Swerdlow AJ,Zanetti R,Green AC,Karagas MR,Whiteman DC

更新日期：2009-02-15 00:00:00

abstract：:Telomerase activity is involved in the maintenance of telomere length and is thought to be required for cellular immortality and oncogenesis. Three major subunits composing telomerase, human telomerase RNA (hTR), telomerase-associated protein (TPI) and human telomerase catalytic subunit (hTERT), have been identified. ...

journal_title：International journal of cancer

authors： Kyo S,Kanaya T,Takakura M,Tanaka M,Yamashita A,Inoue H,Inoue M

更新日期：1999-03-15 00:00:00

abstract：:Genetic and epigenetic alterations during development of pancreatic ductal adenocarcinomas (PDACs) are well known. This study investigates genetic and epigenetic data together with tumor biology to find specific alterations responsible for metastasis formation. Using 16 human PDAC cell lines in a murine orthotopic PDA...

journal_title：International journal of cancer

authors： Mees ST,Mardin WA,Wendel C,Baeumer N,Willscher E,Senninger N,Schleicher C,Colombo-Benkmann M,Haier J

更新日期：2010-01-01 00:00:00

abstract：:A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) nega...

journal_title：International journal of cancer

authors： Rudolph A,Milne RL,Truong T,Knight JA,Seibold P,Flesch-Janys D,Behrens S,Eilber U,Bolla MK,Wang Q,Dennis J,Dunning AM,Shah M,Munday HR,Darabi H,Eriksson M,Brand JS,Olson J,Vachon CM,Hallberg E,Castelao JE,Carrac

更新日期：2015-03-15 00:00:00

abstract：:The identification of high-risk patients with thyroid cancer and the preoperative differentiation between follicular adenoma and carcinoma remain clinically challenging. Our study was conducted to analyze whether the quantification of matrix metalloproteinases (MMPs) and urokinase-type plasminogen activator receptor (...

journal_title：International journal of cancer

authors： Buergy D,Weber T,Maurer GD,Mudduluru G,Medved F,Leupold JH,Brauckhoff M,Post S,Dralle H,Allgayer H

更新日期：2009-08-15 00:00:00

abstract：:Macrophages were isolated from 22 human ascitic ovarian epithelial tumors and their growth-inhibitory capacity was tested using as targets the following in vitro tumor cell lines: murine TLX9 lymphoma and FS6 sarcoma; human myeloid K562 leukemia and human E cell line derived from an ovarian carcinoma. Macrophage prepa...

journal_title：International journal of cancer

authors： Mantovani A,Peri G,Polentarutti N,Bolis G,Mangioni C,Spreafico F

更新日期：1979-02-01 00:00:00

abstract：:We have previously identified a region containing 16 CpGs within the MGMT CpG islands which is critical for the transcriptional control of MGMT (Malley, Acta Neuropathol 2011). To investigate the patterns and incidence of MGMT methylation in astrocytic and oligodendroglial tumors, we quantitatively assessed methylatio...

journal_title：International journal of cancer

authors： Mulholland S,Pearson DM,Hamoudi RA,Malley DS,Smith CM,Weaver JM,Jones DT,Kocialkowski S,Bäcklund LM,Collins VP,Ichimura K

更新日期：2012-09-01 00:00:00