Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi.


:We show that siRNA-mediated suppression of protein tyrosine phosphatase alpha (PTP alpha) reduces Src activity 2 to 4-fold in breast, colon and other human cancer cell lines. Src and PTP alpha RNAi induced apoptosis in estrogen receptor (ER)-negative breast cancer and colon cancer cells, but not in immortalized noncancerous breast cells, ER-positive breast cancer cells or other cancer cell types tested. RNAi of other Src family members (Fyn and Yes) or of PTP1B, a phosphatase previously suggested to be an activator of Src in breast cancer, had no effect. Although further tests with primary tumor tissues are required, the unexpected correlation between ER status and Src/PTP alpha dependence in breast cancer cell lines may be important for planning therapeutic strategies, and the insensitivity of normal breast cells to the RNAi highlights the potential of PTP alpha, which may be easier to target than Src, as a therapeutic target in ER-negative breast cancer.


Int J Cancer


Zheng X,Resnick RJ,Shalloway D




Has Abstract


2008-05-01 00:00:00












  • Human tumor cells synthesize and secrete alpha-2-macroglobulin in vitro.

    abstract::In previous studies we showed that human sarcoma and melanoma cell lines synthesize and secrete into culture medium a glycoprotein, migrating in urea sodium dodecyl sulfate-polyacrylamide gel electrophoresis at Mr 140,000. It is not detected in cultures of the corresponding normal cells. Conditioned medium of the mela...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bízik J,Vaheri A,Saksela O,Kalkkinen N,Meri S,Grófóva M

    更新日期:1986-01-15 00:00:00

  • Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53.

    abstract::Current ovarian cancer maintenance therapy is limited by toxicity and no proven impact on overall survival. To study a maintenance strategy targeted at missense mutant p53, we hypothesized that the release of mutant p53 from mortalin inhibition by the SHetA2 drug combined with reactivation of mutant p53 with the PRIMA...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ramraj SK,Elayapillai SP,Pelikan RC,Zhao YD,Isingizwe ZR,Kennedy AL,Lightfoot SA,Benbrook DM

    更新日期:2020-08-15 00:00:00

  • No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency.

    abstract::Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vajdic CM,van Leeuwen MT,Turner JJ,McDonald AM,Webster AC,McDonald SP,Chapman JR,Kaldor JM,Grulich AE

    更新日期:2010-12-01 00:00:00

  • Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome.

    abstract::Routine pathological examination cannot distinctively predict the clinical course of meningiomas because even histologically benign tumors may recur after gross total resection. Numerous efforts have been made for the evaluation of different immunohistochemical assays in meningioma prognosis. We investigated the progn...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Korshunov A,Shishkina L,Golanov A

    更新日期:2003-05-10 00:00:00

  • The mechanism of hepatic uptake of a radiolabelled monoclonal antibody.

    abstract::Clinical and experimental scintigraphic studies have found that radiolabelled antibodies are not only taken up by tumour(s) but also by normal liver. The accumulation of radionuclides in this organ poses a major problem to the use of radiolabelled antibodies as diagnostic and therapeutic tools. In an attempt to unders...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Boyle CC,Paine AJ,Mather SJ

    更新日期:1992-04-01 00:00:00

  • Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism.

    abstract::Malignant activation of oncogenes ras or trk is implicated in a number of solid tumors and leukemias. We determined the chemosensitivity profile of wild-type mouse NIH-3T3 fibroblasts, and that of NIH-3T3 lines transformed by the H-ras (S2-721) and trk (106-632) oncogenes, against 11 different drugs from various class...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Peters GJ,Wets M,Keepers YP,Oskam R,van Ark-Otte J,Noordhuis P,Smid K,Pinedo HM

    更新日期:1993-05-28 00:00:00

  • Inhibitory effect of linoleic acid on transformation of IEC6 intestinal cells by in vitro azoxymethane treatment.

    abstract::The effect of linoleic acid (LA) on growth and transformation of IEC6 intestinal cells was examined. IEC6 cells expressed mRNAs of 15-lipooxygenase (LOX15) and peroxisome proliferator-activated receptor (PPAR)gamma but not COX-2. Cell growth was suppressed by LA in a dose-dependent manner in IEC6 cells. Three-week tre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sasaki T,Yoshida K,Shimura H,Ichiba M,Sasahira T,Shimomoto T,Denda A,Kuniyasu H

    更新日期:2006-02-01 00:00:00

  • Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development.

    abstract::Mitotic and meiotic cell cycle regulation is essential for normal development and tumor prevention. The underlying molecular mechanisms are not completely characterized. The aim of our analysis was to derive a global expression map of cell cycle regulators in mitosis and meiosis. First, the expression of cyclins, CDKs...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Diederichs S,Bäumer N,Schultz N,Hamra FK,Schrader MG,Sandstede ML,Berdel WE,Serve H,Müller-Tidow C

    更新日期:2005-08-20 00:00:00

  • Examination of POU homeobox gene expression in human breast cancer cells.

    abstract::Abnormal expression of homeobox genes may lead to the development of leukemias, lymphomas, and solid tumors. Expression of homeobox genes in mammary glands, however, has not been studied actively until recently. We have examined the expression of POU homeobox genes in human breast cancer cell lines and human breast ti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jin T,Branch DR,Zhang X,Qi S,Youngson B,Goss PE

    更新日期:1999-03-31 00:00:00

  • Development and validation of a cycle-specific risk score for febrile neutropenia during chemotherapy cycles 2-6 in patients with solid cancers: The CSR FENCE score.

    abstract::The absolute risk reduction by prophylaxis in chemotherapy-induced febrile neutropenia (FN) is largest in patients at highest underlying risk. Therefore, reliable predictive models are needed. Here, we develop and validate such a model for risk of FN during chemotherapy cycles 2-6. A prediction score for risk of FN du...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Aagaard T,Reekie J,Roen A,Daugaard G,Specht L,Sengeløv H,Mocroft A,Lundgren J,Helleberg M

    更新日期:2020-01-15 00:00:00

  • Induction of carcinoembryonic antigen (CEA)-specific cytotoxic T-lymphocyte responses in vitro using autologous dendritic cells loaded with CEA peptide or CEA RNA in patients with metastatic malignancies expressing CEA.

    abstract::The application of dendritic cells (DC) to the active immunotherapy of cancer currently relies on the generation of potent DC capable of presenting tumor antigens such as carcinoembryonic antigen (CEA). It is unknown whether the T cells of patients with advanced malignancies can be reliably stimulated against tumor an...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nair SK,Hull S,Coleman D,Gilboa E,Lyerly HK,Morse MA

    更新日期:1999-07-02 00:00:00

  • Anti-CD30-IL-12 antibody-cytokine fusion protein that induces IFN-gamma secretion of T cells and NK cell-mediated lysis of Hodgkin's lymphoma-derived tumor cells.

    abstract::Interleukin-12 (IL-12) is a disulfide-linked p40-p35 heterodimeric cytokine and plays a key role in linking innate cellular immunity to an adaptive Th1 response against pathogens and tumor cells and in counteracting a Th2 immune response. The pathogenesis of Hodgkin's disease (HD) is partially attributed to a Th2 domi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Heuser C,Diehl V,Abken H,Hombach A

    更新日期:2003-09-10 00:00:00

  • The importance of 5-HT for tumor cell lodgement in the liver.

    abstract::Arrest and lodgement of circulating tumor cells in the microvasculature is a prerequisite for metastasis formation. Aggregation of activated platelets and subsequent release of bioactive substances seem to influence the lodgement process. Since thrombocytopenia has been shown to reduce lodgement and since 5-HT is one ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Skolnik G,Bagge U,Dahlström A,Ahlman H

    更新日期:1984-04-15 00:00:00

  • The ability of normal mouse cells to reduce the malignant potential of transformed mouse bladder epithelial cells depends on their somatic origin.

    abstract::Somatic cell hybrids have been made between a transformed mouse bladder carcinoma cell line and normal mouse bladder epithelium and mesenchyme. In the epithelial tumour/mesenchyme hybrids the malignant phenotype was expressed dominantly whereas in the carcinoma/normal epithelium hybrids the malignant potential was gre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cowell JK,Franks LM

    更新日期:1984-05-15 00:00:00

  • Meta-iodobenzylguanidine induces growth inhibition and apoptosis of neuroendocrine gastrointestinal tumor cells.

    abstract::Neuroendocrine gastrointestinal tumors take up, decarboxylate and store large amounts of monoamines. Radioactive-labeled monoamines like the norepinephrine analogue meta-iodobenzylguanidine (MIBG) have been used for the imaging of neuroendocrine tumors for many years. MIBG is selectively taken up via norepinephrine tr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Höpfner M,Sutter AP,Beck NI,Barthel B,Maaser K,Jockers-Scherübl MC,Zeitz M,Scherübl H

    更新日期:2002-09-20 00:00:00

  • Tumor progression in human malignant melanoma is associated with changes in alpha 6/beta 1 laminin receptor.

    abstract::Cells of the melanocytic lineage have been shown to be capable of producing laminin and to lose this property during transformation. In the present study, we have evaluated immunohistochemically whether these changes are paralleled by an altered expression of the alpha 6/beta 1 laminin receptor. Results of this analys...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Natali PG,Nicotra MR,Cavaliere R,Giannarelli D,Bigotti A

    更新日期:1991-09-09 00:00:00

  • Role of the stromal microenvironment in carcinogenesis of the prostate.

    abstract::The topic of this review is the role of stromal-epithelial interactions in normal and malignant prostatic growth. Because cell-cell interactions and androgens play such key roles in the prostate, the goal of this review will be to apply endocrinologic and developmental concepts to the understanding of normal and malig...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Cunha GR,Hayward SW,Wang YZ,Ricke WA

    更新日期:2003-10-20 00:00:00

  • Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy.

    abstract::The purpose of this study was to assess the relationship between progression-free survival (PFS) in patients treated with DFMO + PCV (procarbazine, CCNU, vincristine) chemotherapy for malignant gliomas with tumor cell ornithine decarboxylase (ODC) activity. Formalin-fixed slides were obtained for study patients with a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Levin VA,Jochec JL,Shantz LM,Aldape KD

    更新日期:2007-11-15 00:00:00

  • A recombinant vaccinia virus expressing human prostate-specific antigen (PSA): safety and immunogenicity in a non-human primate.

    abstract::Prostate-specific antigen (PSA) is a serine protease secreted by prostatic epithelial cells and is widely used as a marker for prostate cancer. The tissue specificity of PSA makes it a potential target for active specific immunotherapy, especially in prostate cancer patients who have undergone prostatectomy and in who...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hodge JW,Schlom J,Donohue SJ,Tomaszewski JE,Wheeler CW,Levine BS,Gritz L,Panicali D,Kantor JA

    更新日期:1995-10-09 00:00:00

  • Interferon receptor expression regulates the antiproliferative effects of interferons on cancer cells and solid tumors.

    abstract::In addition to antiviral effects, Type I interferons (IFN) have potent antiproliferative and immunomodulatory activities. Because of these properties IFNs have been evaluated as therapeutics for the treatment of a number of human diseases, including cancer. Currently, IFNs have been shown to be efficacious for the tre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wagner TC,Velichko S,Chesney SK,Biroc S,Harde D,Vogel D,Croze E

    更新日期:2004-08-10 00:00:00

  • Autocrine growth stimulation of human renal Wilms' tumour G401 cells by a gastrin-like peptide.

    abstract::The role of gastrin in the control of growth of renal G401 cells isolated from a human nephroblastoma (Wilms' tumour) was investigated. G401 cell growth was enhanced in the presence of exogenous gastrin. Addition of anti-gastrin antibodies to serum-free medium significantly inhibited the growth of G401 cells. G401 cel...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Blackmore M,Doherty E,Manning JE,Hirst BH

    更新日期:1994-05-01 00:00:00

  • Increased ether lipid cytotoxicity by reducing membrane cholesterol content.

    abstract::Ether-linked glycerophospholipids (ether lipids, EL) are selectively toxic and anti-proliferative agents against cancer cells in vitro. The reason for such selectivity is not completely clear. Their mechanism of action is mediated through an interaction with the plasma membrane and the membrane lipid composition may m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Diomede L,Piovani B,Modest EJ,Noseda A,Salmona M

    更新日期:1991-09-30 00:00:00

  • IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines.

    abstract::Cytokines play a crucial role in tumor initiation and progression. Here, we demonstrate that interleukin (IL)-6 is a key factor by driving tumor progression from benign to malignant, invasive tumors in the HaCaT-model of human skin carcinoma. IL-6 activates STAT3 and directly stimulates proliferation and migration of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lederle W,Depner S,Schnur S,Obermueller E,Catone N,Just A,Fusenig NE,Mueller MM

    更新日期:2011-06-15 00:00:00

  • Cell death induced by N-(4-hydroxyphenyl)retinamide in human epidermal keratinocytes is modulated by TGF-beta and diminishes during the progression of squamous cell carcinoma.

    abstract::It has been demonstrated that the chemopreventive agent N-(4-hydroxyphenyl)retinamide (4-HPR) induces apoptotic cell death, but recent data has suggested that late stage/recurrent tumours lose their response to 4-HPR-induced cell death by mechanisms that are unknown. Our study investigated the ability of 4-HPR to indu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Davies M,Paterson IC,Ganapathy A,Prime SS

    更新日期:2006-12-15 00:00:00

  • Intraperitoneal radio-localization of tumors pre-targeted by biotinylated monoclonal antibodies.

    abstract::We describe 2-step and 3-step strategies for intraperitoneal tumor radio-localization by means of monoclonal antibodies (MAbs). Nude mice bearing intraperitoneal human colon carcinoma tumors were injected i.p. with biotinylated MAb AUAI, followed 24 hr later by radioiodinated streptavidin (2-step). The uptake of radio...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Paganelli G,Pervez S,Siccardi AG,Rowlinson G,Deleide G,Chiolerio F,Malcovati M,Scassellati GA,Epenetos AA

    更新日期:1990-06-15 00:00:00

  • High levels of nm23-H1 and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages.

    abstract::Expression of the candidate metastasis-suppressor gene nm23-H1 has been shown to correlate inversely with metastatic potential in some human tumors, but not in all. Until now, few studies have been carried out on the activity of the homologous nm23-H2 gene in human cancer. No nm23 transcription studies exist for human...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Engel M,Theisinger B,Seib T,Seitz G,Huwer H,Zang KD,Welter C,Dooley S

    更新日期:1993-09-30 00:00:00

  • Dietary sources of N-nitroso compounds and bladder cancer risk: findings from the Los Angeles bladder cancer study.

    abstract::N-Nitroso compounds (NOCs) have been proposed as possible bladder carcinogens. The main sources of exogenous exposure to NOCs are cigarette smoke and diet, particularly processed (i.e., nitrite-treated) meats. Perhaps more importantly, NOCs can be formed endogenously from dietary precursors such as nitrate, nitrite an...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Catsburg CE,Gago-Dominguez M,Yuan JM,Castelao JE,Cortessis VK,Pike MC,Stern MC

    更新日期:2014-01-01 00:00:00

  • Equivalent chemotherapy efficacy against leukemia in mice treated with topical vasoconstrictors to prevent cancer therapy side effects.

    abstract::Topically applied vasoconstrictor is a new strategy to prevent oral mucositis and alopecia, two complications of chemotherapy and stem-cell transplant. We sought to determine whether mice treated with topical vasoconstrictor minutes before chemotherapy to suppress L1210 leukemia would develop a vasoconstrictor-induced...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Graul-Conroy A,Hicks EJ,Fahl WE

    更新日期:2016-06-15 00:00:00

  • Sister chromatid exchange in lymphoma line and lymphoblastoid cell lines before and after heterotransplantation into nude mice.

    abstract::The sister chromatid exchange (SCE) rates of cell lines derived from patients with different malignant and premalignant disease were studied before and after intracerebral inoculation into nude mice and were compared to the SCE frequencies of cell lines from healthy controls. Lymphoma lines characterized by chromosoma...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fonatsch C,Kirchner HH,Schaadt M,Günzel M,Diehl V

    更新日期:1981-10-15 00:00:00

  • Large-scale randomized prostate cancer screening trials: program performances in the European Randomized Screening for Prostate Cancer trial and the Prostate, Lung, Colorectal and Ovary cancer trial.

    abstract::Two large-scale randomized screening trials, the Prostate, Lung, Colorectal and Ovary (PLCO) cancer trial in the USA and the European Randomized Screening for Prostate Cancer (ERSPC) trial in Europe are currently under way, aimed at assessing whether screening reduces prostate cancer mortality. Up to the end of 1998, ...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: de Koning HJ,Auvinen A,Berenguer Sanchez A,Calais da Silva F,Ciatto S,Denis L,Gohagan JK,Hakama M,Hugosson J,Kranse R,Nelen V,Prorok PC,Schröder FH,European Randomized Screening for Prostate Cancer (ERSPC) Trial.,Internationa

    更新日期:2002-01-10 00:00:00