Abstract:
:Pesticide exposure has been associated with non-Hodgkin lymphoma (NHL) risk in a number of studies, and two recent studies suggest that the increased risk may be confined to those with a history of asthma. We examined the interaction between occupational pesticide exposure and atopy on risk of NHL in an Australian population-based case-control study. Incident cases (n = 694) were diagnosed in New South Wales or the Australian Capital Territory between 2000 and 2001 and controls (n = 694) were randomly selected from electoral rolls and frequency-matched to cases by age, sex and state of residence. Occupational pesticide exposure was determined by an expert occupational hygienist's assessment of job-specific questionnaires administered by telephone. History of atopy (asthma, hay fever, eczema and food allergy) was self-reported. Logistic regression models included the three matching variables, ethnicity and sun exposure. The OR for NHL with substantial pesticide exposure and any history of asthma was 3.07 (95% CI 0.55-17.10) and with substantial pesticide exposure and no asthma history it was 4.23 (95% CI 1.76-10.16). The p-value for interaction was 0.29. A similar pattern of risk was observed for each of the pesticide subtypes; for asthma at various times of life; for hay fever, eczema, food allergy and any atopy, in men only and for follicular lymphomas only. Although this study had limited power, the findings do not suggest modification of the association between pesticide exposure and NHL risk by asthma or atopic disease more generally.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Vajdic CM,Fritschi L,Grulich AE,Kaldor JM,Benke G,Kricker A,Hughes AM,Turner JJ,Milliken S,Goumas C,Armstrong BKdoi
10.1002/ijc.22602subject
Has Abstractpub_date
2007-05-15 00:00:00pages
2271-4issue
10eissn
0020-7136issn
1097-0215journal_volume
120pub_type
杂志文章abstract::Leukoplakia is an asymptomatic, potentially malignant change in the oral mucosa. Previous studies have reported that smoking and betel quid chewing are associated with increased risk of leukoplakia; few studies have reported on these associations in populations where betel quid does not contain tobacco. We conducted a...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1002/ijc.23739
更新日期:2008-10-15 00:00:00
abstract::The mouse anti-id MAb MK2-23 bears the internal image of the antigenic determinant defined by anti-HMW-MAA MAb 763.74. Active specific immunotherapy with anti-id MAb MK2-23 is associated with a statistically significant prolongation of survival in patients with malignant melanoma. Characterization of the immune respon...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600310
更新日期:1995-01-27 00:00:00
abstract::Nitrogen-containing bisphosphonates (N-BPs) are effective antiosteolytic agents in patients with multiple myeloma. Preclinical studies have also demonstrated that these agents have direct antitumor effects in vitro and can reduce tumor burden in a variety of animal models, although it is not clear whether such effects...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24758
更新日期:2010-01-01 00:00:00
abstract::A human revertant cell line, derived from non-producer human osteosarcoma cells (NP/KHOS) induced by Kirsten murine sarcoma virus, was treated in vitro with various levels of polycyclic aromatic hydrocarbons (3-methylcholanthrene, 7,12-dimethylbenz(alpha)anthracene, and benzo(alpha)pyrene [BP] or dimethyl sulfoxide (c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210106
更新日期:1978-01-15 00:00:00
abstract::The light microscopic distinction between complex atypical hyperplasia (CAH) and invasive endometrioid carcinoma (UEC) on endometrial sampling is problematic and often has significant clinical implications. Using mouse models of endometrial tumorigenesis based on two of the most common molecular alterations found in p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24022
更新日期:2009-03-15 00:00:00
abstract::Transfer of the herpes simplex virus type I thymidine kinase (HSV-TK) gene into tumor cells using virus-based vectors in conjunction with ganciclovir (GCV) exposure provides a potential gene therapy strategy for the treatment of cancer. The possibility of using a novel targetable Sindbis virus expression vector contai...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990105)80:1<110::aid-ijc
更新日期:1999-01-05 00:00:00
abstract::Chromosome 17 is a frequent target during breast-cancer formation and progression. It has been shown to be affected by allele losses at multiple sites, as well as by DNA amplification. Our aim was to delineate a map of the genetic alterations on chromosome 17 in a given set of breast tumors. To this end we analyzed 15...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560208
更新日期:1994-01-15 00:00:00
abstract::We report on pigmentary characteristics, sun sensitivity and some other possible risk factors for non-Hodgkin lymphoma (NHL) in people 20-74 years of age. A statewide case-control study was conducted in New South Wales, Australia, with population-based sampling of cases (n = 704) and controls (n = 694). Risk of NHL wa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20128
更新日期:2004-06-20 00:00:00
abstract::Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor-suppressor and other genes related to cell differentiation, cell-cycle arrest or apoptosis of tumor cells. The...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25367
更新日期:2011-02-01 00:00:00
abstract::Seven-day-old mouse embryos were transplanted under the kidney capsule of adult syngeneic recipients which were either X-irradiated, treated with cyclophosphamide, splenectomized or immunized with teratocarcinoma cell lines prior to embryonic transplantation. The yield of malignant tumors was decreased in preirradiate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300613
更新日期:1982-12-15 00:00:00
abstract::Human alpha interferon (IFN-alpha) and beta interferon (IFN-beta) showed antiviral and anticellular effects on human lymphoblastoid Daudi and P3HR-1 cells, but up to 1,000 units/ ml of gamma interferon (IFN-gamma) showed no such effect. Though a fairly high level of dsRNA-dependent 2'-5'-oligoadenylate synthetase (2-5...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300206
更新日期:1982-08-15 00:00:00
abstract::We previously demonstrated that leptin, an adipose-derived hormone, induces cell proliferation in a model of preneoplastic (IMCE (Apc(Min/+)), but not normal (YAMC (Apc(+/+)), colon epithelial cells by inducing autocrine IL-6 production and trans-IL-6 signaling. Low serum adiponectin is associated with colon, prostate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23436
更新日期:2008-06-01 00:00:00
abstract::In order to identify regulatory genes involved in the development of an apoptosis-resistant phenotype in patients with chemotherapy refractory B-cell chronic lymphocytic leukemia (B-CLL) expression of apoptosis-regulating genes in B-CLL cells was quantified using cDNA arrays and RT-PCR. Data were obtained from and com...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20614
更新日期:2005-02-20 00:00:00
abstract::Data from immunocytochemical assessment of estrogen receptor (ER) regulation in MCF-7 cells under estrogenic and anti-estrogenic stimulation were compared with those obtained by enzyme immunoassay (Abbott ER-EIA). Similar trends were observed, although ER level variations were less marked when assessed immunocytochemi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19981209)78:6<760::aid-ijc
更新日期:1998-12-09 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, seem to have chemopreventive properties against several types of cancer, particularly colon cancer. Persons with rheumatoid arthritis, an autoimmune disease for which NSAIDs are used commonly, have been reported to be at lower risk of colon cancer but ...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ijc.11311
更新日期:2003-09-20 00:00:00
abstract::This study reports the induction of interferon (IFN) in human mononuclear cells (MNC) by hematopoietic tumor cells. Only 3 out of 15 cell lines were capable of inducing IFN in the mixed leukocyte/tumor-cell reaction (MLTR). K562, a pluripotent stem cell line and DUTKO-I, a hybrid between K562 and Daudi (Burkitt lympho...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340108
更新日期:1984-07-15 00:00:00
abstract::The c-met oncogene encodes the receptor for hepatocyte growth factor/scatter factor (HGF/SF), a multifunctional cytokine able to mediate morphogenesis as well as mitogenesis, motogenesis and invasiveness of epithelial cells. HGF/SF has been implicated in branching tubulogenesis of the developing kidney and in regenera...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960621)69:3<212::AID-IJC
更新日期:1996-06-21 00:00:00
abstract::Survivin protein is an attractive candidate for cancer immunotherapy since it is abundantly expressed in most common human cancers and mostly absent in normal adult tissues. Malignant mesothelioma (MM) is a deadly cancer associated with asbestos or erionite exposure for which no successful therapies are currently avai...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28048
更新日期:2013-08-01 00:00:00
abstract::Lymphatic leukemia developed in C57BL/6 mice following inoculation of normal thymocytes that and been co-cultured on leukemic thymus epithelial reticulum monolayer cells. Using thymocytes genetically marked in Ly membrane antigens, we showed that the thymomas which developed were produced by the co-cultured thymocytes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210119
更新日期:1978-01-15 00:00:00
abstract::Previous literature, although not consistent, suggests that moderate alcohol consumption might be associated with decreased risk of renal cell carcinoma (RCC) in women. Thus, we examined the association between alcohol intake and the incidence of RCC by analyzing data from the Swedish Mammography Cohort, a population-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21231
更新日期:2005-12-10 00:00:00
abstract::We previously produced evidence that the human mammary-carcinoma cell line 8701-BC expresses several metalloproteinases (MMP-1, -2, -9, and -10) and their tissue inhibitors). In order to obtain a better understanding of the environmental control over gelatinolytic activities, we have tested the enzyme production of 87...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620622
更新日期:1995-09-15 00:00:00
abstract::The International Classification of Childhood Cancer (ICCC) updates the widely used Birch and Marsden classification scheme. ICCC is based on the second edition of the International Classification of Diseases for Oncology (ICD-O-2). The purpose of the new classification is to accommodate important changes in recogniti...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0215(19961211)68:6<759::AID-IJC
更新日期:1996-12-11 00:00:00
abstract::A high molecular weight RNA-reverse transcriptase complex in the culture media of peripheral leukocytes obtained from two Japanese patients with myeloma-leukemia was detected by demonstration of a 3H-uridine peak and a peak of DNA polymerizing activity banding at a density of 1.15-1.19g/ml. The enzyme in the complex w...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910200105
更新日期:1977-07-15 00:00:00
abstract::BRMS1 is regarded as a metastasis suppressor gene for its ability to reduce metastatic potential of human and murine breast cancer cells as well as human melanoma cells. However, BRMS1 association to human tumor progression is not clearly understood. In the present study we analyzed BRMS1 mRNA expression in tumor prog...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22379
更新日期:2007-03-15 00:00:00
abstract::The purpose of this study was to induce in postnatal life the selective growth of altered hepatocytic populations which had been induced in utero by various chemicals. Pregnant rats of a Wistar strain were given a single dose of various chemical carcinogens on the 18th gestational day. From two months postpartum, both...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290317
更新日期:1982-03-15 00:00:00
abstract::Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.31717
更新日期:2018-12-15 00:00:00
abstract::Using immunohistochemical methods, we analyzed the association between nuclear p53 overexpression and various clinicopathological parameters in patients with endometrial cancers. Formalin-fixed and paraffin-embedded tissue sections from 139 cases of endometrial cancer (endometrioid type, 126; serous papillary type, 12...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580104
更新日期:1994-07-01 00:00:00
abstract::Mesothelin is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed on the cell surface of mesothelioma, ovarian cancer and other malignant tumors. The interaction between mesothelin and CA125 (also called MUC16) may facilitate the implantation and metastasis of tumors in the peritoneal cavity....
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25557
更新日期:2011-05-01 00:00:00
abstract::An orang-utan (Pongo pygmaeus) suspension line, CP81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic N-alkaline phosphatase activity, and to release a B-cell-tropic herpesvirus. This herpesvirus, termed Herpesvirus pongo, had 30--40% DNA homology with EBV an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210614
更新日期:1978-06-15 00:00:00
abstract::The promoter variants of TNF-α, a major regulator of immune and inflammation responses, have been implicated in cancer development and prognosis. Thus, we investigated associations between four TNF-α promoter variants and risk of recurrence of squamous cell carcinoma of the oropharynx (SCCOP). We evaluated association...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28512
更新日期:2014-04-15 00:00:00