High level of messenger RNA for BRMS1 in primary breast carcinomas is associated with poor prognosis.


:BRMS1 is regarded as a metastasis suppressor gene for its ability to reduce metastatic potential of human and murine breast cancer cells as well as human melanoma cells. However, BRMS1 association to human tumor progression is not clearly understood. In the present study we analyzed BRMS1 mRNA expression in tumor progression and its potential prognostic value for breast carcinoma. BRMS1 mRNA expression level was quantified by real-time PCR in 47 tumoral, in 14 peritumoral and in 15 metastatic microdissected cellular populations from 47 breast cancer patients with 10-year follow up. We found BRMS1 expression to be higher in carcinoma cells than in matching normal epithelial cell populations in 10 out of 14 cases (p = 0.0005), while lymph-nodal carcinoma cells showed lower BRMS1 expression in 9 out of 15 cases (p = 0.001). Using both in vivo (human mammary breast carcinomas) and in vitro systems (breast cancer cell lines) we were able to demonstrate that BRMS1 overexpression was not a bias effect induced by cell proliferation rate. BRMS1 expression levels did not correlate with standard breast cancer prognostic factors but BRMS1 higher expression was associated with patient shorter disease-free and overall survival. Our findings are apparently inconsistent with the concept of BRMS1 as a metastasis suppressor gene. One possible explanation is that epithelial cells increase their BRMS1 expression as a compensatory response to tumor formation or metastasis progression, which is elevated in proportion to tumor aggressiveness, whereas those cells of the primary tumor that cannot upregulate BRMS1 escape to form metastasis.


Int J Cancer


Lombardi G,Di Cristofano C,Capodanno A,Iorio MC,Aretini P,Isola P,Tancredi M,Collecchi P,Naccarato AG,Porta RP,Bevilacqua G,Caligo MA




Has Abstract


2007-03-15 00:00:00












  • In vitro transformation by avian erythroblastosis virus recruits cells of erythroid lineage with varying degree of differentiation.

    abstract::We have previously shown that AEV infection of leukosis-free chickens provokes an erythroleukemia in the infected birds, and that the target cell for virus transformation is most likely an early pro-erythroblast comparable to the BFU-E. The virus infection correlates with a block in differentiation which was studied a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Therwath A,Scherrer K

    更新日期:1982-05-15 00:00:00

  • Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women.

    abstract::Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model-insulin resistance (HOMA-IR...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Kabat GC,Kim MY,Stefanick M,Ho GYF,Lane DS,Odegaard AO,Simon MS,Bea JW,Luo J,Wassertheil-Smoller S,Rohan TE

    更新日期:2018-08-01 00:00:00

  • An immunohistological study of leukocyte localization in benign and malignant breast tissue.

    abstract::Using morphometric and immunohistological techniques, we investigated the distribution of T lymphocytes and subsets, B lymphocytes, macrophages and plasma cells in sections of human breast tissue. In normal lobules and ducts, leukocytes were found in greater density in the epithelium than in the stroma. The intra-epit...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lwin KY,Zuccarini O,Sloane JP,Beverley PC

    更新日期:1985-10-15 00:00:00

  • Resistance-associated factors in human small-cell lung-carcinoma GLC4 sub-lines with increasing adriamycin resistance.

    abstract::Previous studies have shown that the in vitro-selected adriamycin-resistant human small-cell lung-carcinoma cell line GLC4-ADR150 displays multidrug resistance as the result of 3-fold decreased DNA-topoisomerase II (topo II) activity and a 6-fold reduction in adriamycin accumulation. Not the MDR1 gene, but the MRP gen...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Versantvoort CH,Withoff S,Broxterman HJ,Kuiper CM,Scheper RJ,Mulder NH,de Vries EG

    更新日期:1995-05-04 00:00:00

  • In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma.

    abstract::A glutamine analogue, L-glutamic acid gamma-monohydroxamate (GAH) demonstrated complete cytotoxicity against L1210 cells in culture and marked anti-tumoral activity in vivo against L1210 leukemia and B16 melanoma. In vitro, GAH caused concentration-dependent inhibition of L1210 cell growth, with complete cell death be...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vila J,Thomasset N,Navarro C,Doré JF

    更新日期:1990-04-15 00:00:00

  • Increased phosphorylation of nuclear phosphoproteins in human lung-cancer cells resistant to cis-diamminedichloroplatinum (II).

    abstract::A novel non-phorbol-ester-like tumor promoter, okadaic acid (OA) has been shown to be an inhibitor of protein phosphatase I and IIA and, thus, to cause an "apparent activation" of protein kinase C (PKC). We previously showed that cis-diamminedichloroplatinum(II) (CDDP)-resistant cells, PC-9/CDDP, were cross-resistant ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nishio K,Sugimoto Y,Kasahara K,Fujiwara Y,Nishiwaki S,Fujiki H,Ohata M,Saijo N

    更新日期:1992-02-01 00:00:00

  • Risk factors for prostate cancer incidence and progression in the health professionals follow-up study.

    abstract::Risk factors for prostate cancer could differ for various sub-groups, such as for "aggressive" and "non-aggressive" cancers or by grade or stage. Determinants of mortality could differ from those for incidence. Using data from the Health Professionals Follow-Up Study, we re-examined 10 factors (cigarette smoking histo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Giovannucci E,Liu Y,Platz EA,Stampfer MJ,Willett WC

    更新日期:2007-10-01 00:00:00

  • Human papillomavirus, herpes simplex virus and cervical cancer incidence in Greenland and Denmark. A population-based cross-sectional study.

    abstract::In Greenland, the incidence of cervical cancer is 5.7 times higher than in Denmark among women aged 20-39. From Nuuk (Greenland) and Nykøbing Falster (Denmark) a sample of 800 women aged 20-39 years was drawn at random. A total of 586 and 661 women were investigated in Greenland and Denmark respectively. All women had...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kjaer SK,de Villiers EM,Haugaard BJ,Christensen RB,Teisen C,Møller KA,Poll P,Jensen H,Vestergaard BF,Lynge E

    更新日期:1988-04-15 00:00:00

  • Involvement of alphavbeta 3 integrin and disruption of endothelial fibronectin network during the adhesion of the human ovarian adenocarcinoma cell line IGROV1 on the human umbilical vein cell extracellular matrix.

    abstract::Like the majority of tumor cells, ovarian cancer cell growth is critically dependent on their neovascularization. Adhesion molecules and cellular events that lead to ovarian tumor cell interactions with endothelial extracellular matrix surrounding the vasculature are poorly identified. To understand the role of alphav...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Carreiras F,Thiébot B,Leroy-Dudal J,Maubant S,Breton MF,Darbeida H

    更新日期:2002-06-20 00:00:00

  • Occupational radiation exposure and thyroid cancer incidence in a cohort of U.S. radiologic technologists, 1983-2013.

    abstract::Although childhood exposure to ionizing radiation is a well-established risk factor for thyroid cancer, the risk associated with adulthood exposure remains unclear. We prospectively examined the association between cumulative, low-to-moderate dose occupational radiation exposure to the thyroid and thyroid cancer incid...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kitahara CM,Preston DL,Neta G,Little MP,Doody MM,Simon SL,Sigurdson AJ,Alexander BH,Linet MS

    更新日期:2018-11-01 00:00:00

  • Deficiency of natural killer cell activity in patients with chronic lymphocytic leukemia.

    abstract::Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that f...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ziegler HW,Kay NE,Zarling JM

    更新日期:1981-03-15 00:00:00

  • Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan.

    abstract::Incidence rates of Wilms' tumor (WT) markedly differ in East Asian and Caucasian children. In the present study, we examined WT1 deletions/mutations and loss of heterozygosity (LOH) on 11p and 11q in a large number of WTs and compared our findings with those from 4 series of Caucasian WTs. Incidence rates of the subtl...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nakadate H,Yokomori K,Watanabe N,Tsuchiya T,Namiki T,Kobayshi H,Suita S,Tsunematsu Y,Horikoshi Y,Hatae Y,Endo M,Komada Y,Eguchi H,Toyoda Y,Kikuta A,Kobayashi R,Kaneko Y

    更新日期:2001-11-01 00:00:00

  • Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the most common type of primary tumor in the liver and is a leading cause of cancer-related death worldwide. Activated hepatic stellate cells (HSCs) are key components of the HCC microenvironment and play an important role in the onset and progression of HCC through the secretion of g...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Ruan Q,Wang H,Burke LJ,Bridle KR,Li X,Zhao CX,Crawford DHG,Roberts MS,Liang X

    更新日期:2020-09-15 00:00:00

  • The role of vegetable and fruit consumption in the aetiology of squamous cell carcinoma of the oesophagus: a case-control study in Uruguay.

    abstract::There is strong evidence of a protection of high consumption of plant foods against squamous cell carcinoma of the oesophagus, but the respective role of fruits and vegetables is not well elucidated. In the time period 1996-2003, a case-control study designed in order to address this question was conducted in Uruguay....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: De Stefani E,Boffetta P,Deneo-Pellegrini H,Ronco AL,Correa P,Mendilaharsu M

    更新日期:2005-08-10 00:00:00

  • Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor.

    abstract::The effects of a new metalloproteinase inhibitor, BE16627B [L-N-(N-hydroxy-2-isobutylsuccinynamoyl)-seryl-L-valine, MW: 375.2] isolated from microbial cultures, on human tumor cell growth in nude mice were investigated. BE16627B inhibited metalloproteinases in enzyme assays, as well as gelatinolysis and collagenolysis...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Naito K,Kanbayashi N,Nakajima S,Murai T,Arakawa K,Nishimura S,Okuyama A

    更新日期:1994-09-01 00:00:00

  • Fowlpox-based survivin vaccination for malignant mesothelioma therapy.

    abstract::Survivin protein is an attractive candidate for cancer immunotherapy since it is abundantly expressed in most common human cancers and mostly absent in normal adult tissues. Malignant mesothelioma (MM) is a deadly cancer associated with asbestos or erionite exposure for which no successful therapies are currently avai...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bertino P,Panigada M,Soprana E,Bianchi V,Bertilaccio S,Sanvito F,Rose AH,Yang H,Gaudino G,Hoffmann PR,Siccardi A,Carbone M

    更新日期:2013-08-01 00:00:00

  • Spatiotemporal homogeneity and distinctness of the T-cell receptor β-chain repertoires in Epstein-Barr virus-associated primary and metastatic nasopharyngeal carcinomas.

    abstract::Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated lymphoepithelioma. The aim of this study was to characterize the homogeneity and distinctness of the T-cell repertoires within and between primary and metastatic NPCs. We used ultra-deep sequencing of the hypervariably rearranged antigen-binding ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chung YL,Wu ML

    更新日期:2018-08-01 00:00:00

  • Genetic analysis of sorted Hodgkin and Reed-Sternberg cells using comparative genomic hybridization.

    abstract::Hodgkin and Reed-Sternberg (H and RS) cells are generally considered to be the neoplastic cells of Hodgkin's disease (HD); however, such cells are found only in a minority of HD lesions. Very few data have so far been published on the cytogenetic abnormalities in HD. An analysis of unknown genetic aberrations has only...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ohshima K,Ishiguro M,Ohgami A,Sugihara M,Haraoka S,Suzumiya J,Kikuchi M

    更新日期:1999-07-19 00:00:00

  • Endoscopic screening for synchronous esophageal neoplasia among patients with incident head and neck cancer: Prevalence, risk factors, and outcomes.

    abstract::Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients we...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wang YK,Chuang YS,Wu TS,Lee KW,Wu CW,Wang HC,Kuo CT,Lee CH,Kuo WR,Chen CH,Wu DC,Wu IC

    更新日期:2017-11-15 00:00:00

  • Humanization and characterization of the anti-HLA-DR antibody 1D10.

    abstract::1D10 is a previously described antibody that binds to cells from a majority of B-cell malignancies. The current studies were designed to further evaluate the antigen specificity of 1D10 and its potential as an immunotherapeutic agent. Studies with transfectants and immunoprecipitation demonstrated that 1D10 recognizes...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kostelny SA,Link BK,Tso JY,Vasquez M,Jorgensen BH,Wang H,Hall WC,Weiner GJ

    更新日期:2001-08-15 00:00:00

  • Serum folate receptor alpha as a biomarker for ovarian cancer: Implications for diagnosis, prognosis and predicting its local tumor expression.

    abstract::Folate receptor alpha (FRA) is a GPI-anchored glycoprotein and encoded by the FOLR1 gene. High expression of FRA is observed in specific malignant tumors of epithelial origin, including ovarian cancer, but exhibits very limited normal tissue expression, making it as an attractive target for the ovarian cancer therapy....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kurosaki A,Hasegawa K,Kato T,Abe K,Hanaoka T,Miyara A,O'Shannessy DJ,Somers EB,Yasuda M,Sekino T,Fujiwara K

    更新日期:2016-04-15 00:00:00

  • MHC imbalance and metastatic spread in Lewis lung carcinoma clones.

    abstract::Imbalance in the Kb and Db region encoded molecules is observed in Lewis lung carcinoma clones. The uncloned metastatic population and the D122 high-metastatic clone show no expression of H-2Kb products, while the nonmetastatic A9 clone expresses Kb products. Twenty-nine new subclones of 3LL and A9 were analyzed for D...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Eisenbach L,Segal S,Feldman M

    更新日期:1983-07-15 00:00:00

  • Occupational sun exposure and risk of melanoma according to anatomical site.

    abstract::Although sunburn and intermittent sun exposures are associated with increased melanoma risk, most studies have found null or inverse associations between occupational (more continuous pattern) sun exposure and melanoma risk. The association of melanoma with occupational sun exposure may differ according to anatomical ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vuong K,McGeechan K,Armstrong BK,AMFS Investigators.,GEM Investigators.,Cust AE

    更新日期:2014-06-01 00:00:00

  • Prescription drug use and risk of acute myeloid leukemia by French-American-British subtype: results from a Los Angeles County case-control study.

    abstract::Chemotherapy is a well-established risk factor for acute myeloid leukemia (AML) but little is known about other prescription drugs and AML risk. We report data from a population-based Los Angeles County study in which 299 matched case-control pairs had complete data on prescription drug use and 88% of cases were subty...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pogoda JM,Katz J,McKean-Cowdin R,Nichols PW,Ross RK,Preston-Martin S

    更新日期:2005-04-20 00:00:00

  • Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism.

    abstract::Malignant activation of oncogenes ras or trk is implicated in a number of solid tumors and leukemias. We determined the chemosensitivity profile of wild-type mouse NIH-3T3 fibroblasts, and that of NIH-3T3 lines transformed by the H-ras (S2-721) and trk (106-632) oncogenes, against 11 different drugs from various class...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Peters GJ,Wets M,Keepers YP,Oskam R,van Ark-Otte J,Noordhuis P,Smid K,Pinedo HM

    更新日期:1993-05-28 00:00:00

  • High-grade tumor-specific immunity induced by L1210 leukemia variants obtained from the culture of L1210 cells fused with Lesch-Nyhan fibroblasts.

    abstract::A highly immunogenic variant of the murine L1210 leukemia cell (L1210/LN-1) for generation of tumor immunity has been obtained from culture of L1210 cells originally fused with human Lesch-Nyhan fibroblasts. In L1210/LN-1 cells, no human chromosomes were identified and chromosomes M1 and No. 1 carried by the parent L1...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kawashima K,Nagura E,Watanabe E,Mizoguchi K,Saga S,Isobe K,Nakashima I,Yamada K,Oikawa T,Kojima K

    更新日期:1983-10-15 00:00:00

  • Arsenic trioxide sensitizes CD95/Fas-induced apoptosis through ROS-mediated upregulation of CD95/Fas by NF-kappaB activation.

    abstract::CD95/Fas is a cell surface protein that belongs to the tumor necrosis factor receptor family. Signals through CD95/Fas are able to induce apoptosis in sensitive cells. Therefore, modalities to regulate the CD95/Fas expression level in tumor cells are called for. In the present study, we show that sublethal doses of ar...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Woo SH,Park IC,Park MJ,An S,Lee HC,Jin HO,Park SA,Cho H,Lee SJ,Gwak HS,Hong YJ,Hong SI,Rhee CH

    更新日期:2004-11-20 00:00:00

  • Cardiac mortality after radiotherapy, chemotherapy and endocrine therapy for breast cancer: Cohort study of 2 million women from 57 cancer registries in 22 countries.

    abstract::Comparisons of patients receiving different cancer treatments reflect the effects of both treatment and patient selection. In breast cancer, however, if radiotherapy decisions are unrelated to laterality, comparisons of left-sided and right-sided cancers can demonstrate the causal effects of higher-versus-lower cardia...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Henson KE,McGale P,Darby SC,Parkin M,Wang Y,Taylor CW

    更新日期:2020-09-01 00:00:00

  • Wnt2 as a new therapeutic target in malignant pleural mesothelioma.

    abstract::Malignant mesothelioma of the pleura (MPM) is a highly aggressive neoplasm with a poor prognosis and limited treatment options. A better understanding of its pathogenesis is essential to developing alternative therapeutic strategies. We previously demonstrated that the Wnt signaling pathway is activated in MPM through...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mazieres J,You L,He B,Xu Z,Twogood S,Lee AY,Reguart N,Batra S,Mikami I,Jablons DM

    更新日期:2005-11-01 00:00:00

  • Basal biomarkers nestin and INPP4B predict gemcitabine benefit in metastatic breast cancer: Samples from the phase III SBG0102 clinical trial.

    abstract::In a formal prospective-retrospective analysis of the phase III SBG0102 clinical trial randomizing metastatic breast cancer patients to gemcitabine-docetaxel or to single agent docetaxel, patients with basal-like tumors by PAM50 gene expression had significantly better overall survival in the gemcitabine arm. By immun...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Asleh K,Lyck Carstensen S,Tykjaer Jørgensen CL,Burugu S,Gao D,Won JR,Jensen MB,Balslev E,Laenkholm AV,Nielsen DL,Ejlertsen B,Nielsen TO

    更新日期:2019-05-15 00:00:00