Abstract：
:The hypothesis has been advanced that deformation-induced lethal mechanical trauma, resulting in surface-membrane rupture, is inflicted on circulating cancer cells trapped in the microcirculation, and that this rapid cell-killing mechanism is a potentially important rate regulator for hematogenous metastasis. We describe and discuss an in vivo test of this hypothesis. Vital fluorescence microscopy was performed on the microcirculation of cremaster muscle preparations in mice, following retrograde injections into the femoral artery of acridine orange-stained sarcoma cells. Cancer cells having mean diameters of 16.5 microns in suspension, were deformed from spheres into cylinders having a mean length of 53 microns, in 7-microns diameter capillaries. Most of these cells were dead several minutes after injection. It was estimated that sphere-to-cylinder shape-transitions of this magnitude required an average increase of 52% in apparent cell surface area. Evidence is presented that most of this apparent increase was achieved by non-lethal surface "unfolding", utilizing membrane "excess". That cancer-cell deformation of the magnitude observed in vivo is the direct cause of lethal, surface-membrane rupture was indicated by the observed loss of membrane integrity in cells deformed from spherical to cylindrical shape in vitro, by aspiration into micropipettes of capillary dimensions. The experimental observations are therefore consistent with the hypothesis.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Weiss L,Nannmark U,Johansson BR,Bagge Udoi
10.1002/ijc.2910500121subject
Has Abstractpub_date
1992-01-02 00:00:00pages
103-7issue
1eissn
0020-7136issn
1097-0215journal_volume
50pub_type
杂志文章abstract：:The mRNA levels of the ras-related human rhoA, rhoB and rhoC genes were studied in human breast-cancer cell lines (HBCal), and in normal and immortalized mammary epithelial cells (HMEC) by Northern blot analysis and in situ hybridization. In contrast to the ubiquitous rhoA and rhoC gene expression, dramatic variations...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910590320
更新日期：1994-11-01 00:00:00
abstract：:Active oxygen (AO) is ubiquitous in nature and its many forms can act as natural carcinogens. Their effect on the transformation of a mouse myeloid progenitor cell line was studied using anchorage-independent colony formation in methylcellulose as the primary assay. Both cytotoxic and non-toxic concentrations of t-but...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910490519
更新日期：1991-11-11 00:00:00
abstract：:Previous studies indicate that the triterpene glycoside actein from the herb black cohosh inhibits growth of human breast cancer cells. This study seeks to identify genes altered in human breast cancer cells by treatment with actein, using gene expression analysis. We treated MDA-MB-453 human breast cancer cells with ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22897
更新日期：2007-11-01 00:00:00
abstract：:The mta1 gene is a recently identified novel candidate metastasis-associated gene. The deduced amino acid sequence contains an src homology-3 domain binding motif, a zinc finger motif and possible phosphorylation sites, suggesting that this gene is involved in signal transduction or regulation of gene expression. The ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970822)74:4<459::aid-ijc
更新日期：1997-08-22 00:00:00
abstract：:Previous studies indicate that the nonclassical class I HLA-G antigen, whose physiologic expression is mainly restricted to placenta, is upregulated in melanoma, renal carcinoma, lung carcinoma, glioblastoma and ovarian carcinoma, where its inhibitory effect on cytotoxic effector cells function is thought to participa...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11456
更新日期：2004-01-10 00:00:00
abstract：:Protectin (CD59) inhibits homologous complement-mediated cytolysis by preventing formation of the membrane attack complex at the point of insertion and polymerization of C9 into cell membranes. The present study investigated the expression and function of CD59 on human prostatic tumor cells in situ and on 5 human pros...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970611)71:6<1049::aid-ij
更新日期：1997-06-11 00:00:00
abstract：:Idiotypic protein (Id) produced by myeloma cells is clone-specific and may be a suitable tumor-specific antigen for immune targeting. Advances in dendritic cell (DC) technology suggest the opportunity for using this potent antigen presentation system to deliver myeloma Id to the autologous host to elicit anti-tumor im...
journal_title：International journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1002/(sici)1097-0215(19991008)83:2<215::aid-ijc
更新日期：1999-10-08 00:00:00
abstract：:The stroma of ductal infiltrating carcinoma of the human breast shows characteristic and localized areas of collagen rarefaction and fragmentation. This finding has been correlated with a peculiar type of fibrillar damage, observed in a small percentage of collagen fibrils isolated in the native state from the tumour ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910390510
更新日期：1987-05-15 00:00:00
abstract：:A glycolipid extract was prepared from an SV40-transformed hamster cell line (EH-SV) according to the Folch partition procedure. The glycolipids from the aqueous layer were incorporated in liposomal membranes composed of lecithin/sphingomyelin/cholesterol (1:1:2 by weight). This liposomal preparation was inoculated in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910250616
更新日期：1980-06-15 00:00:00
abstract：:Some herds of miniature swine are genetically predisposed to cutaneous melanoma. To test if swine melanoma susceptibility could be linked to the CDKN2A gene, which is involved in a proportion of 9p21-linked human familial melanoma, we performed a genetic analysis of miniature pigs of the MeLiM strain. F(1) and backcro...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10871
更新日期：2003-02-20 00:00:00
abstract：:We examined the geospatial dimension of delays to diagnosis of breast cancer in a prospective study of 1541 women newly diagnosed in the African Breast Cancer - Disparities in Outcomes (ABC-DO) Study. Women were recruited at cancer treatment facilities in Namibia, Nigeria, Uganda, and Zambia. The baseline interview in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33400
更新日期：2020-11-16 00:00:00
abstract：:BRMS1 is regarded as a metastasis suppressor gene for its ability to reduce metastatic potential of human and murine breast cancer cells as well as human melanoma cells. However, BRMS1 association to human tumor progression is not clearly understood. In the present study we analyzed BRMS1 mRNA expression in tumor prog...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22379
更新日期：2007-03-15 00:00:00
abstract：:Carcinoma-associated fibroblasts (CAFs) play a key onco-supportive role during prostate cancer (PCa) development and progression. We previously reported that the reactive oxygen species (ROS)-producing enzyme NADPH oxidase 4 (Nox4) is essential for TGFβ1-mediated activation of primary prostate human fibroblasts to a C...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31316
更新日期：2018-07-15 00:00:00
abstract：:Histone deacetylase inhibitors, such as phenylbutyrate, are currently undergoing clinical trials as potential anticancer agents. Phenylbutyrate can induce cell differentiation and apoptosis in a number of cancer cell types and can act in synergy with ionizing radiation and chemotherapy to induce apoptosis. We used the...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10609
更新日期：2002-10-10 00:00:00
abstract：:Insulin-like growth factor-1 receptor (IGF-1R) and human epidermal growth factor receptor-2 (HER2) receptor expression has been found to be a key regulator of tumorigenesis. The purpose of our study was to establish the prognostic significance of IGF-1R in esophageal cancer and to determine the effect of IGF-1R and HE...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25196
更新日期：2010-10-15 00:00:00
abstract：:Polymorphisms in nucleotide oligomerization domain 2 gene (NOD2) have been associated with increased susceptibility to Crohn's disease. Recently, possible association of the NOD2 variants R702W, G908R and 3020insC with colorectal cancer (CRC) has been studied among Polish, Greek, Finnish and New Zealand Caucasian CRC ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22651
更新日期：2007-07-01 00:00:00
abstract：:Annamycin (Ann) is a non-cross-resistant lipophilic anthracycline antiobiotic optimally suited for liposome delivery. We studied how vesicle size and presence of phospholipids with a high phase transition temperature and monosialoganglioside (GM I) in the liposome bilayers affect the pharmacokinetics, tumor selectivit...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910610513
更新日期：1995-05-29 00:00:00
abstract：:In the 7th edition of the AJCC staging system, the mitotic rate criterion replaced Clark level to increase correct classification of high-risk thin melanoma patients (pT1B). Additionally, sentinel node biopsy (SNB) was recommended for nodal staging of pT1B melanomas. The aim of this article was to evaluate the effects...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.30607
更新日期：2017-04-15 00:00:00
abstract：:Two large-scale randomized screening trials, the Prostate, Lung, Colorectal and Ovary (PLCO) cancer trial in the USA and the European Randomized Screening for Prostate Cancer (ERSPC) trial in Europe are currently under way, aimed at assessing whether screening reduces prostate cancer mortality. Up to the end of 1998, ...
journal_title：International journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1002/ijc.1588
更新日期：2002-01-10 00:00:00
abstract：:The major obstacle preventing effective treatment of melanoma is the biological heterogeneity of tumor cells. This study was performed to determine clonal genetic heterogeneity within primary melanoma and the evolution of these heterogeneous sub-clones during disease progression. DNA samples were obtained from 44 morp...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：
更新日期：2000-02-15 00:00:00
abstract：:Paclitaxel has antiangiogenic properties, but the mechanisms for the enhanced sensitivity of endothelial cells (ECs) to this drug are not established. The aims of our study were to compare the distribution of paclitaxel into ECs with other cell types, to assess the effects of low doses of paclitaxel on Cox-2 expressio...
journal_title：International journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1002/ijc.20595
更新日期：2005-01-20 00:00:00
abstract：:In vivo TSTA induction in Syrian hamsters was studied with the use of SV40 ts mutants (A, B, C, BC and D). The ts A30, TS A239 and possibly also the ts BC210 mutants were defective in resistance-inducing activity in hamsters in contrast to wild type SV40 and other ts mutnats. At the permissive temperature ts A30 and t...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910200420
更新日期：1977-10-15 00:00:00
abstract：:Tumor angiogenesis plays a critical role in colorectal cancer progression. Recent randomized clinical trials have revealed the additive effect of bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF)-A, to conventional chemotherapy in the improved survival of patients with meta...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.28686
更新日期：2014-07-15 00:00:00
abstract：:Chicken anemia virus viral protein 3 (VP3 or apoptin) localizes more efficiently in the nucleus of transformed than nontransformed cells. Although previous studies implicate the C-terminus of apoptin as being responsible, the molecular basis is controversial, and the extent to which altered nuclear transport efficienc...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23884
更新日期：2008-12-15 00:00:00
abstract：:We investigated whether the concentration of fibronectin (FN) in the cerebrospinal fluid (CSF) could be used for identifying patients with subclinical blast-cell infiltration in the central nervous system (CNS) and an increased risk of CNS relapse later in the course of their leukemia. Our series comprised 36 children...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910430108
更新日期：1989-01-15 00:00:00
abstract：:G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32588
更新日期：2020-03-15 00:00:00
abstract：:Angiogenesis is essential for tumor growth and metastasis. In the process of angiogenesis, the interaction between adhesive proteins of endothelial cells and extracellular matrix components plays an important role by mediating cell attachment, which is indispensable for their motility, and by transmitting the regulato...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19960529)66:5<664::AID-IJC
更新日期：1996-05-29 00:00:00
abstract：:Cancers of the stomach, pancreas, colon and rectum are increasingly regarded as being diet-influenced. Migrants to Australia from England, Scotland, Ireland, Poland, Yugoslavia, Greece, and Italy have come from countries with varied dietary backgrounds and gastrointestinal cancer risks. Age-standardized cancer death r...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910250402
更新日期：1980-04-15 00:00:00
abstract：:The melanosomal protein TRP2 expressed by melanocytes and most melanoma cells is an attractive, clinically relevant model antigen for the experimental development of melanoma immunotherapy in mice. A peptide shared by murine and human TRP2 can be recognized by melanoma-reactive CTL in C57BL/6 mice, as well as in human...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(20000401)86:1<89::aid-ijc1
更新日期：2000-04-01 00:00:00
abstract：:To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Can...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33369
更新日期：2020-10-31 00:00:00
