Abstract:
:Common genetic variations in genes involved in DNA repair or response to genotoxic stress may influence both cancer susceptibility and treatment response individually or interactively. However, in acute myeloid leukemia (AML), the relevance of these genetic variations remains to be fully established. In this study, we analyzed 42 genetic variations among 15 candidate genes in 307 AML patients and 560 age-sex matched controls. Their associations with chemotherapy response were further evaluated in combination with other well-established prognostic factors. An increased risk of AML was found in individuals heterozygous for XPD 2251A>C (rs13181) with an odds ratio (OR) of 1.637 (95% confidence interval [CI]: 1.118-2.395), and the increased risk could be attributed to C allele (OR = 1.505, 95% CI: 1.061-2.134). Postchemotherapy response analysis revealed that AML patients heterozygous for ATM 4138C>T (rs3092856) or GG homozygous for TP53 215C>G (rs1042522) were independently linked to inferior treatment outcomes. These results uncover novel prognostic factors for AML patients treated with chemotherapy and may also indicate an etiological role of XPD in this disease.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Shi JY,Ren ZH,Jiao B,Xiao R,Yun HY,Chen B,Zhao WL,Zhu Q,Chen Z,Chen SJdoi
10.1002/ijc.25318subject
Has Abstractpub_date
2011-01-01 00:00:00pages
233-8issue
1eissn
0020-7136issn
1097-0215journal_volume
128pub_type
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