Establishment of primary cultures from human colonic tissue during tumor progression: vitamin-D responses and vitamin-D-receptor expression.

abstract：:It is well known that certain cancers have shown clustering in socioeconomic groups, but limited data are available on recent results and time trends in such clustering. We determined standardized incidence ratios (SIR) for cancer, adjusted for age, period, region, parity and age at first childbirth among men and wome...

journal_title：International journal of cancer

authors： Hemminki K,Zhang H,Czene K

更新日期：2003-07-10 00:00:00

abstract：:Mouse-transformed keratinocytes cultured in the presence of transforming growth factor beta1 (TGF-beta1) acquire an array of morphologic and functional properties that give rise to a migratory phenotype that expresses mesenchymal molecular markers. This cellular conversion involves activation of the Ras-ERK pathway, e...

journal_title：International journal of cancer

authors： Santibáñez JF,Olivares D,Guerrero J,Martínez J

更新日期：2003-12-10 00:00:00

abstract：:It has been established that the Hedgehog (Hh) and epithelial-mesenchymal transition (EMT) signals act on morphogenesis of embryonic and adult tissues. Recently, both signals have been involved in tumor malignancy. However, little is known as to whether Hh and EMT signals act on normal and malignant epithelial cells i...

journal_title：International journal of cancer

authors： Isohata N,Aoyagi K,Mabuchi T,Daiko H,Fukaya M,Ohta H,Ogawa K,Yoshida T,Sasaki H

更新日期：2009-09-01 00:00:00

abstract：:Fibroblast-like cells (F-cells) and epithelial-like (E-cells) derived from cultures of rabbit VX-2 carcinoma released collagenase in both active and latent forms in serum-free medium at a level higher than that of normal rabbit fibroblast cultures. The enhanced capacity of the F-cells to release the enzyme, however, c...

journal_title：International journal of cancer

authors： Dabbous MK,El-Torky M,Haney L,Brinkley SB,Sobhy N

更新日期：1983-03-15 00:00:00

abstract：:Germline mutation of the folliculin gene (BHD) at chromosome 17p11.2 is associated with the development of multiplex hamartomas of the hair follicles, chromophobe renal cell carcinomas (RCC) and renal oncocytomas (RO). We have analyzed the folliculin gene with sequencing for mutations and the chromosome 17p11.2 with m...

journal_title：International journal of cancer

authors： Nagy A,Zoubakov D,Stupar Z,Kovacs G

更新日期：2004-04-10 00:00:00

abstract：:The effect that polymorphonuclear leukocytes (PMN) may have on the metastatic colonization of tumor cells is controversial: some laboratories have reported that PMN can inhibit metastasis whereas others have shown an augmentation effect. We have exploited our finding that a particular fibrosarcoma (BMT-11) transplante...

journal_title：International journal of cancer

authors： Ishikawa M,Koga Y,Hosokawa M,Kobayashi H

更新日期：1986-06-15 00:00:00

abstract：:Data from a hospital-based matched case-control study with 531 male pairs were analyzed for risks of cancer of the lower urinary tract associated with previous employment and particular occupational exposures. Statistically significant odds ratios were obtained for ever-employment as mining workers (2.0), turners (2.3...

journal_title：International journal of cancer

authors： Claude JC,Frentzel-Beyme RR,Kunze E

更新日期：1988-03-15 00:00:00

abstract：:The human polyomaviruses JC virus (JCV) and BK virus (BKV) are oncogenic in experimental systems and commonly infect humans. JCV DNA has been reported to be present in human colon mucosa and in colorectal cancers. To investigate whether the risk for colorectal cancer is associated with JCV or BKV infection, we perform...

journal_title：International journal of cancer

authors： Lundstig A,Stattin P,Persson K,Sasnauskas K,Viscidi RP,Gislefoss RE,Dillner J

更新日期：2007-09-01 00:00:00

abstract：:A displacement assay with tamoxifen, based on the relative binding affinity of tamoxifen and estradiol for the estrogen receptor (ER), was proposed in 1990 as prognostic indicator for breast-cancer patients. Validation of its predictive results in relation to the outcome of 73 patients with ER+ tumors is analyzed. ER,...

journal_title：International journal of cancer

authors： Levin E,Actis AM,Caruso S,Gass H,Romero R,Qualeta N,Levin RW

更新日期：1997-11-14 00:00:00

abstract：:Somatic mutations in the E-cadherin (CDH1) gene have frequently been reported in cases with diffuse gastric and lobular breast cancers. Recently, germline mutations have been identified in families with diffuse gastric cancers. In families with hereditary prostate cancer (HPC), a significant association of prostate ca...

journal_title：International journal of cancer

authors： Jonsson BA,Bergh A,Stattin P,Emmanuelsson M,Grönberg H

更新日期：2002-04-20 00:00:00

abstract：:We have recently shown that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The aim of the present study was to determine the molecular mechanisms...

journal_title：International journal of cancer

authors： Tanimoto R,Sakaguchi M,Abarzua F,Kataoka K,Kurose K,Murata H,Nasu Y,Kumon H,Huh NH

更新日期：2010-04-01 00:00:00

abstract：:Thymidylate synthase (TYMS) is an important enzyme for 5-fluorouracil (5-FU) metabolism in metastatic colorectal cancer (mCRC) patients. The search for this enzyme in circulating tumor cells (CTCs) can be a powerful tool to follow-up cancer patients. mCRC patients were enrolled before the beginning of 5-FU-based chemo...

journal_title：International journal of cancer

authors： Abdallah EA,Fanelli MF,Buim ME,Machado Netto MC,Gasparini Junior JL,Souza E Silva V,Dettino AL,Mingues NB,Romero JV,Ocea LM,Rocha BM,Alves VS,Araújo DV,Chinen LT

更新日期：2015-09-15 00:00:00

abstract：:The synthetic retinoid fenretinide [N-(4-hydroxyphenyl)retinamide, 4-HPR] has demonstrated growth inhibition and induction of apoptosis of various malignant cells, including lung cancer cell lines. 4-HPR is now being investigated in several clinical trials. In our study, we show that 4-HPR inhibits growth on a broad p...

journal_title：International journal of cancer

authors： Ohlmann CH,Jung C,Jaques G

更新日期：2002-08-10 00:00:00

abstract：:In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis characterized by cell shrinkage and cell membrane scrambling. Eryptotic erythrocytes are rapidly cleared from circulating blood and may adhere to the vascular wall. Stimulation of eryptosis thus impairs microcirculation and leads to anemia as...

journal_title：International journal of cancer

authors： Lang E,Bissinger R,Qadri SM,Lang F

更新日期：2017-10-15 00:00:00

abstract：:This is a prospective study of lymphoid tissue showing benign reactive hyperplasia (18 lymph nodes and 2 tonsils), using cytogenetic analysis of cells stimulated with T- or B-cell mitogens. The reason for this study was the detection of an abnormal chromosomal population in cells from an enlarged lymph node excised fr...

journal_title：International journal of cancer

authors： Grace J,Hall BE,Lew M,Singh S,Pittman S,Palmer AA,Zbroja R,Wass J,Vincent PC

更新日期：1989-12-15 00:00:00

abstract：:Immunological studies are presented on a patient with a long clinical history suggesting the existence of a tumor-specific immune response. His tumor, first considered benign, progressed to a highly malignant osteosarcoma. Cell-mediated immune reactivity against biopsy cells and against tumor extract was detected in v...

journal_title：International journal of cancer

authors： Vanky F,Klein E,Cornain S,Bakács T,Stjernswärd J,Nilsonne U

更新日期：1976-09-15 00:00:00

abstract：:We sought to analyze utilization and survival outcomes of cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma (RCC) before and after introduction of targeted therapy. We identified patients with metastatic RCC between 1993 and 2010 in the SEER registry and examined temporal trends in utiliz...

journal_title：International journal of cancer

authors： Conti SL,Thomas IC,Hagedorn JC,Chung BI,Chertow GM,Wagner TH,Brooks JD,Srinivas S,Leppert JT

更新日期：2014-05-01 00:00:00

abstract：:We have separated subpopulations of macrophages from an immunogenic fibrosarcoma by the technique of unit gravity velocity sedimentation. The activation state of these subpopulations was determined by measurement of the Fc receptor avidity of adherent cells, and by their 5' nucleotidase and acid phosphatase activity. ...

journal_title：International journal of cancer

authors： Moore K,McBride WH

更新日期：1980-11-15 00:00:00

abstract：:Monoclonal antibody 38.13 was raised against the Burkitt lymphoma cell line Daudi and has been previously shown to recognize a globotriaosylceramide (Pk) determinant expressed selectively on Burkitt and a few other B-cell lymphomas. We report here that 38.13 binds to a subset of normal B lymphocytes in germinal centre...

journal_title：International journal of cancer

authors： Murray LJ,Habeshaw JA,Wiels J,Greaves MF

更新日期：1985-11-15 00:00:00

abstract：:It has been demonstrated that the chemopreventive agent N-(4-hydroxyphenyl)retinamide (4-HPR) induces apoptotic cell death, but recent data has suggested that late stage/recurrent tumours lose their response to 4-HPR-induced cell death by mechanisms that are unknown. Our study investigated the ability of 4-HPR to indu...

journal_title：International journal of cancer

authors： Davies M,Paterson IC,Ganapathy A,Prime SS

更新日期：2006-12-15 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are involved in the pathology of colorectal cancer (CRC). Current efforts to eradicate CRC predominantly focused on targeting the proliferation of rapidly growing cancer epithelial cells. This is largely ineffective with resistance arising in most tumors after exposure to chemotherapy. De...

journal_title：International journal of cancer

authors： Deng X,Ruan H,Zhang X,Xu X,Zhu Y,Peng H,Zhang X,Kong F,Guan M

更新日期：2020-03-15 00:00:00

abstract：:TP53 accumulation in human primary breast carcinomas was studied by a quantitative luminometric immunoassay (LIA), and TP53 gene alterations, exons 5-8, were examined by single-strand conformation polymorphism (SSCP) analysis. In 48 of 142 breast tumor samples, a TP53 gene alteration was identified. In tumor samples w...

journal_title：International journal of cancer

authors： de Witte HH,Foekens JA,Lennerstrand J,Smid M,Look MP,Klijn JG,Benraad TJ,Berns EM

更新日期：1996-04-22 00:00:00

abstract：:Suramin has been shown to have antiproliferative activity, either by blocking the binding of growth factors to their receptors or by inhibiting critical cellular enzymes. In 6 different cell lines from 5 tumour types (MCF-7, MCF-7/ADRR, PC3, HT-29, UM-SCC-11B and SW-1573/IR500), we studied the effect of scheduling of ...

journal_title：International journal of cancer

authors： Lopez Lopez R,Peters GJ,van Loenen AC,Pizao PE,van Rijswijk RE,Wagstaff J,Pinedo HM

更新日期：1992-07-30 00:00:00

abstract：:Trends in incidence rates of cutaneous malignant melanoma in Western Australia from 1975-76 to 1980-1981 have been examined with reference to age, sex, body site, presence or absence of dermal invasion, tumour thickness, histological type, socioeconomic status and occupation. The incidence rates of all melanomas incre...

journal_title：International journal of cancer

authors： English DR,Heenan PJ,Holman CD,Armstrong BK,Blackwell JB,Kelsall GR,Matz LR,Singh A,ten Seldam RE

更新日期：1986-02-15 00:00:00

abstract：:Benzene is considered a carcinogen, mostly based on evidence of causality for myeloid leukemia from high levels of exposure in occupational studies. We used United States Environmental Protection Agency National Ambient Toxics Assessment (NATA) estimates of low-level ambient benzene to examine potential associations f...

journal_title：International journal of cancer

authors： Teras LR,Diver WR,Deubler EL,Krewski D,Flowers CR,Switchenko JM,Gapstur SM

更新日期：2019-11-15 00:00:00

abstract：:Diabetes is a risk factor for many cancers; chronic hyperglycemia is hypothesized to be, in part, explanatory. We evaluated the association between glycated hemoglobin, a time-integrated glycemia measure, and cancer incidence and mortality in nondiabetic and diabetic men and women. We conducted a prospective study of ...

journal_title：International journal of cancer

authors： Joshu CE,Prizment AE,Dluzniewski PJ,Menke A,Folsom AR,Coresh J,Yeh HC,Brancati FL,Platz EA,Selvin E

更新日期：2012-10-01 00:00:00

abstract：:Paclitaxel has antiangiogenic properties, but the mechanisms for the enhanced sensitivity of endothelial cells (ECs) to this drug are not established. The aims of our study were to compare the distribution of paclitaxel into ECs with other cell types, to assess the effects of low doses of paclitaxel on Cox-2 expressio...

journal_title：International journal of cancer

authors： Merchan JR,Jayaram DR,Supko JG,He X,Bubley GJ,Sukhatme VP

更新日期：2005-01-20 00:00:00

abstract：:Evidence has accumulated that, in addition to the MDR1 gene-coded P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP) also mediates the multidrug resistance (MDR) of various human tumors. In the case of gastric cancer, there is little or no involvement of P-glycoprotein, and the mechanisms of MDR remai...

journal_title：International journal of cancer

authors： Endo K,Maehara Y,Kusumoto T,Ichiyoshi Y,Kuwano M,Sugimachi K

更新日期：1996-11-04 00:00:00

abstract：:A cDNA library specific for mRNA over-expressed in prostate cancer was generated by subtractive hybridization of transcripts originating from prostatic hyperplasia and cancer tissues. cDNA encoding ribosomal proteins L4, L5, L7a, L23a, L30, L37, S14 and S18 was found to be present among 100 analyzed clones. Levels of ...

journal_title：International journal of cancer

authors： Vaarala MH,Porvari KS,Kyllönen AP,Mustonen MV,Lukkarinen O,Vihko PT

更新日期：1998-09-25 00:00:00

abstract：:Ninety-eight cases of transitional-cell carcinoma (TCC) of the renal pelvis and ureter, including dysplastic lesions, were studied for tumor incorporation of human papillomavirus (HPV) type-16 and type-18 DNA by in situ hybridization (ISH) with DNA probes for each HPV viral type. Immunohistochemical analysis of p53 ex...

journal_title：International journal of cancer

authors： Furihata M,Yamasaki I,Ohtsuki Y,Sonobe H,Morioka M,Yamamoto A,Terao N,Kuwahara M,Fujisaki N

更新日期：1995-10-20 00:00:00