Evaluation of a displacement assay with tamoxifen as prognostic indicator in breast-cancer patients with estrogen-receptor-positive tumors.

abstract：:Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T-->G tr...

journal_title：International journal of cancer

authors： Terry PD,Umbach DM,Taylor JA

更新日期：2006-06-15 00:00:00

abstract：:Oncogenic activation of MYC occurs often in breast carcinoma and is associated with poor prognosis. Loss or inactivation of mechanisms that restrain MYC may therefore be involved in tumor progression. In this study, we show that the MYC-interacting adaptor protein BIN1 is frequently missing in malignant breast cells a...

journal_title：International journal of cancer

authors： Ge K,Duhadaway J,Sakamuro D,Wechsler-Reya R,Reynolds C,Prendergast GC

更新日期：2000-02-01 00:00:00

abstract：:Treatment of older mice with pyran copolymer, a known interferon-inducer, was found to result in a rapid boosting of cell-mediated cytolytic activity against YAC-1 tumor target cells. The effector cells were characterized as being non-adherent and were presumed to be natural killer (NK) cells. Augmentation occurred in...

journal_title：International journal of cancer

authors： Santoni A,Puccetti P,Riccardi C,Herberman RB,Bonmassar E

更新日期：1979-11-15 00:00:00

abstract：:The association between parity and hepatocellular carcinoma (HCC) was studied using a data-base generated by linking 2 Swedish nation-wide registries; the Cancer Registry and the Fertility Registry. Among women born between 1925 and 1960, 133 patients with HCC recorded in the Cancer Registry between 1958 and 1984 were...

journal_title：International journal of cancer

authors： Lambe M,Trichopoulos D,Hsieh CC,Ekbom A,Pavia M

更新日期：1993-11-11 00:00:00

abstract：:A subline of the murine P815 mastocytoma passaged for a long period of time in histoincompatible hosts was found to be deficient in surface MHC class-I antigens by serological and biochemical methods. In agreement with the lack of restriction elements, this variant cell line was no longer susceptible to killing by cyt...

journal_title：International journal of cancer

authors： Bertschmann M,Käsermann D,Keller R

更新日期：1990-10-15 00:00:00

abstract：:We examined the effects of acivicin, a specific inhibitor of the ectoenzyme gamma-glutamyltransferase (gamma-GT), on gamma-GT activity and apoptosis in 2 human T-lymphoblastoid CEM cell lines, CCRF and VBL-100. In both cell lines, acivicin was found to cause morphological and biochemical changes of apoptosis in a dose...

journal_title：International journal of cancer

authors： Graber R,Losa GA

更新日期：1995-08-09 00:00:00

abstract：:The effect of cyclic phosphatidic acid, a unique analogue of lysophosphatidic acid, on the induction of bombesin-enhanced peritoneal metastases from intestinal adenocarcinomas induced by azoxymethane was investigated in male Wistar rats. Rats were given 10 weekly injections of azoxymethane (7.4 mg/kg body weight, s.c....

journal_title：International journal of cancer

authors： Ishihara R,Tatsuta M,Iishi H,Baba M,Uedo N,Higashino K,Mukai M,Ishiguro S,Kobayashi S,Murakami-Murofushi K

更新日期：2004-06-10 00:00:00

abstract：:Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclea...

journal_title：International journal of cancer

authors： Ward HA,Murphy N,Weiderpass E,Leitzmann MF,Aglago E,Gunter MJ,Freisling H,Jenab M,Boutron-Ruault MC,Severi G,Carbonnel F,Kühn T,Kaaks R,Boeing H,Tjønneland A,Olsen A,Overvad K,Merino S,Zamora-Ros R,Rodríguez-Barranc

更新日期：2019-09-15 00:00:00

abstract：:Interleukin-10 (IL-10) is an inhibitory cytokine produced by various cell types. It exhibits strong sequence homology to BCRF-1 (viral IL-10, vIL-10), an open reading frame in the Epstein-Barr-virus (EBV) genome. Using in situ hybridization (ISH), polymerase chain reaction (PCR) and immunohistochemistry, we checked 41...

journal_title：International journal of cancer

authors： Yao M,Ohshima K,Suzumiya J,Kume T,Shiroshita T,Kikuchi M

更新日期：1997-07-29 00:00:00

abstract：:Tumor cells do not constitutively exhibit invasive activity, but rather, can be transiently induced to adhere and form lesions. We report here that the expression of seprase, a dominant EDTA-resistant gelatinase in malignant tumors, is dependent on tumor cell exposure to type I collagen gel (TICg). The induced seprase...

journal_title：International journal of cancer

authors： Kennedy A,Dong H,Chen D,Chen WT

更新日期：2009-01-01 00:00:00

abstract：:Cancer blood vessels consist of two interacting types of cells: inner lining endothelial cells (ECs) and surrounding perivascular cells (pericytes, vascular smooth muscle cells or mural cells). PDGFRbeta(CD140b)+ progenitor perivascular cells (PPC) can differentiate into pericytes and regulate vessel stability and vas...

journal_title：International journal of cancer

authors： Mancuso P,Martin-Padura I,Calleri A,Marighetti P,Quarna J,Rabascio C,Braidotti P,Bertolini F

更新日期：2011-09-15 00:00:00

abstract：:The prevalence and clinical relevance of TP53 germline mutations in a large unselected breast cancer series are largely unknown. Here, we determined TP53 germline mutations in a large cohort of 10,053 unselected breast cancer patients through multigene panel-based next-generation and/or Sanger sequencing assays. We fo...

journal_title：International journal of cancer

authors： Sheng S,Xu Y,Guo Y,Yao L,Hu L,Ouyang T,Li J,Wang T,Fan Z,Fan T,Lin B,Xie Y

更新日期：2020-01-15 00:00:00

abstract：:In this review, we evaluate key molecular pathways and markers of muscle-invasive bladder cancer (MIBC). Overexpression and activation of EGFR, p63, and EMT genes are suggestive of basal MIBC subtype generally responsive to chemotherapy. Alterations in PPARγ, ERBB2/3, and FGFR3 gene products and their signaling along ...

journal_title：International journal of cancer

authors： Kiselyov A,Bunimovich-Mendrazitsky S,Startsev V

更新日期：2016-06-01 00:00:00

abstract：:The matrix metalloproteinase (MMP) family of proteins mediates various cellular pathways, including apoptosis and angiogenesis. Polymorphisms of MMP genes are associated with increased esophageal adenocarcinoma (EAC) risk. Gastroesophageal reflux disease (GERD) is an established EAC risk factor. We examined whether MM...

journal_title：International journal of cancer

authors： Cheung WY,Zhai R,Bradbury P,Hopkins J,Kulke MH,Heist RS,Asomaning K,Ma C,Xu W,Wang Z,Hooshmand S,Su L,Christiani DC,Liu G

更新日期：2012-12-01 00:00:00

abstract：:In the perspective of in vivo therapeutic applications, the monoclonal antibody (MAb) MOv18 was selected for its restricted reactivity with human ovarian carcinoma. Using the pH 2.8 desorption assay, we found that the antigen recognized by MOv18 had a high stability on the cell membrane and poor internalization. There...

journal_title：International journal of cancer

authors： Mezzanzanica D,Canevari S,Ménard S,Pupa SM,Tagliabue E,Lanzavecchia A,Colnaghi MI

更新日期：1988-04-15 00:00:00

abstract：:Promoter hypermethylation of various tumor-related genes is extremely frequent in gastric carcinoma (GC) associated with Epstein-Barr virus (EBV). To investigate the significance of the promoter methylation in this type of GC, we examined the methylation densities of the promoter regions of p14ARF and p16INK4A in EBV-...

journal_title：International journal of cancer

authors： Sakuma K,Chong JM,Sudo M,Ushiku T,Inoue Y,Shibahara J,Uozaki H,Nagai H,Fukayama M

更新日期：2004-11-01 00:00:00

abstract：:RB1 gene expression has been reported to be upregulated in colorectal carcinomas (CRC) at both the mRNA and protein levels when compared to normal colonic mucosa. However, allelic loss at the genomic level has been detected in CRC with widely differing frequencies ranging from 11.5% to 50%. To determine whether there ...

journal_title：International journal of cancer

authors： Lai PS,Cheah PY,Kadam P,Chua CL,Lie DK,Li HH,Eu KW,Seow-Choen F,Lee AS

更新日期：2006-09-01 00:00:00

abstract：:Chemotherapy with taxanes such as paclitaxel (PTX) is a key component of triple negative breast cancer (TNBC) treatment. PTX is used in combination with other drugs in both the adjuvant setting and in advanced breast cancer. Because a proportion of patients respond poorly to PTX or relapse after its use, a greater und...

journal_title：International journal of cancer

authors： Lasham A,Mehta SY,Fitzgerald SJ,Woolley AG,Hearn JI,Hurley DG,Ruza I,Algie M,Shelling AN,Braithwaite AW,Print CG

更新日期：2016-09-01 00:00:00

abstract：:The 1100delC mutation of the cell cycle checkpoint kinase 2 (CHEK2) gene confers an increased risk for breast cancer, but the clinical impact of other CHEK2 gene variants remains unclear. We determined the frequency of two functionally relevant CHEK2 gene mutations, I157T and IVS2+1G > A, in two large series of breast...

journal_title：International journal of cancer

authors： Bogdanova N,Enssen-Dubrowinskaja N,Feshchenko S,Lazjuk GI,Rogov YI,Dammann O,Bremer M,Karstens JH,Sohn C,Dörk T

更新日期：2005-08-20 00:00:00

abstract：:Mutations of the p53 tumor-suppressor gene universally occur on exons 5-8 in human cancer. We analyzed these mutations in esophageal cancer tissue from 207 patients in China using 2 methods, single-strand conformation polymorphism (SSCP), one of the most frequently used methods, and the recently developed denaturing h...

journal_title：International journal of cancer

authors： Yamanoshita O,Kubota T,Hou J,Ping YM,Zhang XL,Li XP,Li SS,Li XX,Zhu DC,Fukushima Y,Nakajima T

更新日期：2005-03-10 00:00:00

abstract：:The red bone marrow (BM) is an important indicator organ of hematogenous micrometastatic spread of carcinomas. Characterization of biological properties specific for BM micrometastatic cells, however, is technically challenging due to the limited number of target cells usually available for the purpose. This report pr...

journal_title：International journal of cancer

authors： Ree AH,Engebraaten O,Hovig E,Fodstad Ø

更新日期：2002-01-01 00:00:00

abstract：:To provide an up-to-date overview of recent trends in mortality from oral and pharyngeal cancer, we analyzed death certification data for 61 countries worldwide provided by the World Health Organization in 2010-2015, and, for selected most populous countries, over the period 1970-2016. For 12 largest countries, we ana...

journal_title：International journal of cancer

authors： Bosetti C,Carioli G,Santucci C,Bertuccio P,Gallus S,Garavello W,Negri E,La Vecchia C

更新日期：2020-08-15 00:00:00

abstract：:DNA-dependent protein kinase (DNA-PK) has been intensively investigated for its roles in the nonhomologous end-joining (NHEJ) pathway of DNA double-strand break repair and maintenance of genomic stability. Its catalytic subunit, DNA-PKcs, a serine/threonine protein kinase, has recently been reported to be overexpresse...

journal_title：International journal of cancer

authors： An J,Xu QZ,Sui JL,Bai B,Zhou PK

更新日期：2005-11-20 00:00:00

abstract：:While dietary antioxidants are emerging as potentially modifiable risk factors for esophageal adenocarcinoma (EAC), studies on dietary antioxidants and its precursor Barrett's esophagus (BE) are limited. The present study extends previous work on BE by investigating risks of nondysplastic BE, dysplastic BE and EAC ass...

journal_title：International journal of cancer

authors： Ibiebele TI,Hughes MC,Nagle CM,Bain CJ,Whiteman DC,Webb PM,Study of Digestive Health and Australian Cancer Study.

更新日期：2013-07-01 00:00:00

abstract：:Several lines of evidence suggest that long-term treatment with non-steroidal anti-inflammatory drugs may reduce the risk of colon cancer and the size and number of colonic polyps in patients with familial adenomatous polyposis. Aspirin has also been shown to inhibit cell proliferation in human tumor cell lines and to...

journal_title：International journal of cancer

authors： Ricchi P,Pignata S,Di Popolo A,Memoli A,Apicella A,Zarrilli R,Acquaviva AM

更新日期：1997-12-10 00:00:00

abstract：:The influence of prolonged treatment with antilymphocyte globulin on tumour incidence in BN/a and BN/b mice was studied. One ALG sample appeared to be highly leukaemogenic in two independent experiments. All treated mice developed, after a short latency period, non-thymic lymphomas with involvement of abdominal lymph ...

journal_title：International journal of cancer

authors： Szkudlarek J,Radzikowski C,Czarnomska A,Dux K,Bartoszewicz W

更新日期：1976-12-15 00:00:00

abstract：:This paper reports the results of 8 years of HLA typing of newly diagnosed nasopharyngeal carcinoma (NPC) patients among Chinese in Singapore, and compares the HLA profile of NPC cases with that of the normal Chinese population. Earlier results had indicated an association with A2 and BW46, but the heterogeneity of th...

journal_title：International journal of cancer

authors： Chan SH,Day NE,Kunaratnam N,Chia KB,Simons MJ

更新日期：1983-08-15 00:00:00

abstract：:The current paradigm stipulates that inhibition of histone deacetylase (HDAC) 6 is essential for the combinatorial effect of proteasome and HDAC inhibitors for the treatment of cancers. Our study aims to investigate the effect of combining different class I HDAC inhibitors (without HDAC6 action) with a proteasome inhi...

journal_title：International journal of cancer

authors： Hui KF,Chiang AK

更新日期：2014-12-15 00:00:00

abstract：:We have examined, in proliferating neoplastic cells, the effect on DNA of EGTA (a chelator of Ca2+) and W7 (an inhibitor of calmodulin). The treatment results in release of single-stranded DNA fragments (2-10 kb) from pre-labelled HMW DNA. When DNA from synchronized neoplastic cells in S phase is examined, almost all ...

journal_title：International journal of cancer

authors： Lönn U,Lönn S

更新日期：1986-06-15 00:00:00

abstract：:Signal transducer and activator of transcription 5b (STAT5b) is likely the relevant STAT5 isoform with respect to the process of malignant progression in gliomas. STAT5b is a latent cytoplasmic protein involved in cell signaling through the modulation of growth factors, apoptosis, and angiogenesis. Previous in vitro s...

journal_title：International journal of cancer

authors： Gressot LV,Doucette TA,Yang Y,Fuller GN,Heimberger AB,Bögler O,Rao A,Latha K,Rao G

更新日期：2015-05-01 00:00:00