Optimum beam angles for the conformal treatment of lung cancer: a CT simulation study.

abstract：:Three polycyclic hydrocarbons, benz(a)anthracene, 3-methylcholanthrene and 7,12-dimethylbenz(a)anthracene, have been studied in a cell-mediated mutagenesis system using BHK 21 cells to metabolize the hydrocarbons and V-79 cells as targets for detecting induced cytotoxicity and mutation. In large-scale experiments, the...

journal_title：International journal of cancer

authors： Wigley CB,Newbold RF,Amos J,Brookes P

更新日期：1979-05-15 00:00:00

abstract：:The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing. We found that 1...

journal_title：International journal of cancer

authors： Bartel F,Meye A,Würl P,Kappler M,Bache M,Lautenschläger C,Grünbaum U,Schmidt H,Taubert H

更新日期：2001-05-20 00:00:00

abstract：:Experimental studies have suggested that the biosynthesis of arachidonic acid-derived eicosanoids such as prostaglandin E2 via the cyclo-oxygenase pathway may play a significant role in supporting cell proliferation in human prostate cancer cell lines. However, the aetiological significance of this for clinical prosta...

journal_title：International journal of cancer

authors： Norrish AE,Jackson RT,McRae CU

更新日期：1998-08-12 00:00:00

abstract：:The p16INK4a gene product acts as a negative regulator of the cell cycle by binding to cyclin-dependent kinases (CDKs) 4 and 6, thereby inhibiting the formation of an active CDK/cyclin D complex. Deletion of the p16 locus has been observed in tumor cell lines and, less frequently, in primary human neoplasms. We analyz...

journal_title：International journal of cancer

authors： Hegi ME,zur Hausen A,Rüedi D,Malin G,Kleihues P

更新日期：1997-09-26 00:00:00

abstract：:Co-injection of fibroblasts with human epithelial breast-tumor MCF7 cells in the presence of Matrigel enhances tumor growth in nude mice. While most of the matrix metalloproteinases (MMPs) have been shown to be produced by stromal cells, tumor cells such as MCF7 cells are unable to produce MMPs. We therefore, hypothes...

journal_title：International journal of cancer

authors： Noël A,Hajitou A,L'Hoir C,Maquoi E,Baramova E,Lewalle JM,Remacle A,Kebers F,Brown P,Calberg-Bacq CM,Foidart JM

更新日期：1998-04-13 00:00:00

abstract：:Vaccination strategies based on repeated injections of NY-ESO-1 protein formulated in ISCOMATRIX particles (NY-ESO-1 ISCOMATRIX) have shown to elicit combined NY-ESO-1 specific antibody and T cell responses. However, it remains unclear whether heterologous prime-boost strategies based on the combination with NY-ESO-1 ...

journal_title：International journal of cancer

authors： Chen JL,Dawoodji A,Tarlton A,Gnjatic S,Tajar A,Karydis I,Browning J,Pratap S,Verfaille C,Venhaus RR,Pan L,Altman DG,Cebon JS,Old LL,Nathan P,Ottensmeier C,Middleton M,Cerundolo V

更新日期：2015-03-15 00:00:00

abstract：:Malignant lymphomas frequently develop in the pleural cavity of patients with long-standing pyothorax. The term pyothorax-associated lymphoma (PAL) has been proposed for this type of tumor. Most PALs are diffuse lymphomas of the B-cell type and contain Epstein-Barr virus (EBV) DNA. We have established 2 lymphoma cell ...

journal_title：International journal of cancer

authors： Kanno H,Yasunaga Y,Ohsawa M,Taniwaki M,Iuchi K,Naka N,Torikai K,Shimoyama M,Aozasa K

更新日期：1996-07-03 00:00:00

abstract：:A population-based case-control study of incident primary brain tumors in adults was carried out in Adelaide, Australia in the period 1987 through 1990. It included 110 subjects with newly diagnosed primary glioma, 60 subjects with meningioma and 417 controls selected from the Australian Electoral Roll and frequency-m...

journal_title：International journal of cancer

authors： Ryan P,Lee MW,North B,McMichael AJ

更新日期：1992-04-22 00:00:00

abstract：:Insulin-like growth factor-binding protein 7 (IGFBP7) functions in several cellular processes including proliferation, senescence and apoptosis. This study analyzed IGFBP7 function in hepatocellular carcinoma (HCC) cells by gene manipulation and investigated the prognostic significance of IGFBP7 expression in clinical...

journal_title：International journal of cancer

authors： Tomimaru Y,Eguchi H,Wada H,Kobayashi S,Marubashi S,Tanemura M,Umeshita K,Kim T,Wakasa K,Doki Y,Mori M,Nagano H

更新日期：2012-01-15 00:00:00

abstract：:Interleukin-10 (IL-10) is an inhibitory cytokine produced by various cell types. It exhibits strong sequence homology to BCRF-1 (viral IL-10, vIL-10), an open reading frame in the Epstein-Barr-virus (EBV) genome. Using in situ hybridization (ISH), polymerase chain reaction (PCR) and immunohistochemistry, we checked 41...

journal_title：International journal of cancer

authors： Yao M,Ohshima K,Suzumiya J,Kume T,Shiroshita T,Kikuchi M

更新日期：1997-07-29 00:00:00

abstract：:Peripheral or tonsil lymphocyte populations of EBV-seropositive donors give rise to EBV-carrying LCLs upon in vitro explantation. Such lines can arise either by a 2-step mechanism, namely release of virus from some of the explanted cells followed by infection of previously uninfected B cells, or by direct outgrowth of...

journal_title：International journal of cancer

authors： Lewin N,Aman P,Masucci MG,Klein E,Klein G,Oberg B,Strander H,Henle W,Henle G

更新日期：1987-04-15 00:00:00

abstract：:The nature of 15 immortal mouse liver epithelial cell (MLEC) lines established from normal C3H mice was investigated specifically in terms of ras oncogene activation. Neither transforming activity nor point mutation within codon 61 of c-H-ras could be demonstrated in any of the cell lines by DNA transfection in a NIH/...

journal_title：International journal of cancer

authors： Lee GH,Sakai R,Nagao M,Kitagawa T

更新日期：1991-01-02 00:00:00

abstract：:Studies were performed to characterize the effector cells responsible for natural cytotoxicity of mouse lymphoid cells against a variety of syngeneic and allogeneic tumor lines. Since spleen cells from normal nude mice were found to be highly cytotoxic, they were used for most of these experiments. Only a small propor...

journal_title：International journal of cancer

authors： Herberman RB,Nunn ME,Holden HT,Lavrin DH

更新日期：1975-08-15 00:00:00

abstract：:Clinical case reports have suggested that specific bacterial infections are associated with certain non-Hodgkin lymphoma (NHL) subtypes. Epidemiological case-control studies have been conducted using antibiotics as a proxy for bacterial infections, but with inconclusive results. The aim of this study was, in a cohort ...

journal_title：International journal of cancer

authors： Rasmussen ML,Hjalgrim H,Mølgaard-Nielsen D,Wohlfahrt J,Melbye M

更新日期：2012-10-01 00:00:00

abstract：:The purpose of this analysis was to correlate isotope selection with the urinary symptoms of patients who received a combination of external beam radiotherapy (EBRT) and a transperineal interstitial permanent prostate brachytherapy (TIPPB) boost with either a (103)palladium ((103)Pd) or a (125)iodine ((125)I) radioiso...

journal_title：International journal of cancer

authors： Chen CT,Waterman FM,Valicenti RK,Gomella LG,Strup SE,Dicker AP

更新日期：2001-01-01 00:00:00

abstract：:Several observational epidemiological studies have reported inconsistent results on the association between the use of benzodiazepine and the risk of cancer. We investigated the association by using a meta-analysis. We searched PubMed, EMBASE, and the bibliographies of relevant articles to locate additional publicatio...

journal_title：International journal of cancer

authors： Kim HB,Myung SK,Park YC,Park B

更新日期：2017-02-01 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B-cell malignancies. Notably, we found that the transgenic mice overexpressing AID developed lung adenocarcinoma and he...

journal_title：International journal of cancer

authors： Kou T,Marusawa H,Kinoshita K,Endo Y,Okazaki IM,Ueda Y,Kodama Y,Haga H,Ikai I,Chiba T

更新日期：2007-02-01 00:00:00

abstract：:Neuron-specific src mRNA, which is expressed in human brain tissue by alternative splicing, is associated with neural differentiation. Neuronal c-srcNI expression may be associated with the ability of neuroblastomas to mature; furthermore, c-srcN2 mRNA is induced in chemically differentiated neuroblastoma cells in vit...

journal_title：International journal of cancer

authors： Matsunaga T,Shirasawa H,Tanabe M,Ohnuma N,Kawamura K,Etoh T,Takahashi H,Simizu B

更新日期：1994-09-15 00:00:00

abstract：:MAGE genes are frequently expressed in several types of human malignancy and code for antigens recognized by cytotoxic T lymphocytes. We have previously described a monoclonal antibody (MAb), named 6C1, that recognizes the MAGE-1 protein and cross-reacts with a 72-kDa protein present in lysates of melanoma cells such ...

journal_title：International journal of cancer

authors： Rimoldi D,Salvi S,Reed D,Coulie P,Jongeneel VC,De Plaen E,Brasseur F,Rodriguez AM,Boon T,Cerottini JC

更新日期：1999-09-09 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is activated in a variety of human cancers, including ovarian cancer. The molecular mechanism by which the STAT3 is activated in cancer cells is poorly understood. We observed that human ovarian xenograft tumors (A2780) in mice were severely hypoxic (pO(2) app...

journal_title：International journal of cancer

authors： Selvendiran K,Bratasz A,Kuppusamy ML,Tazi MF,Rivera BK,Kuppusamy P

更新日期：2009-11-01 00:00:00

abstract：:Integrins are extracellular matrix receptors involved in tumour invasion and angiogenesis. Although there is evidence that inhibiting integrins might enhance the efficiency of radiotherapy, little is known about the exact mechanisms involved in the integrin-dependent modulation of tumor radiosensitivity. The purpose o...

journal_title：International journal of cancer

authors： Monferran S,Skuli N,Delmas C,Favre G,Bonnet J,Cohen-Jonathan-Moyal E,Toulas C

更新日期：2008-07-15 00:00:00

abstract：:The survival experience of 284 patients with cancer of the cervix uteri registered by the population-based Zimbabwe National Cancer Registry in 1995-1997 is described. The vital status of these subjects was established by linkage with death registration and by retrieval of patient files from medical records department...

journal_title：International journal of cancer

authors： Chokunonga E,Ramanakumar AV,Nyakabau AM,Borok MZ,Chirenje ZM,Sankila R,Parkin DM

更新日期：2004-03-20 00:00:00

abstract：:More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective populat...

journal_title：International journal of cancer

authors： Jung AY,Hüsing A,Behrens S,Krzykalla J,Obi N,Becher H,Chang-Claude J

更新日期：2021-01-01 00:00:00

abstract：:Ninety-seven Japanese patients with so-called primary non-Hodgkin's lymphoma of the central nervous system (CNS-NHL), unrelated to the acquired immunodeficiency syndrome (AIDS) or organ transplantation, were reviewed. The patients' ages ranged from 1 to 87 years (median: 58 years) with a male to female ratio of 1.77:1...

journal_title：International journal of cancer

authors： Aozasa K,Ohsawa M,Yamabe H,Shima N,Kirimoto K,Yamane T,Tsujimoto M,Kobayashi Y,Kurata A,Osada H

更新日期：1990-04-15 00:00:00

abstract：:The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a protein that plays a critical role in tumor suppression, in part by modulating bioavailability of a potent mitogen, insulin-like growth factor-2 (IGF2). We tested the hypothesis that the common nonsynonymous genetic variants in M6P/IGF...

journal_title：International journal of cancer

authors： Hoyo C,Schildkraut JM,Murphy SK,Chow WH,Vaughan TL,Risch H,Marks JR,Jirtle RL,Calingaert B,Mayne S,Fraumeni J Jr,Gammon MD

更新日期：2009-12-01 00:00:00

abstract：:IL-15 is an immunostimulatory cytokine with IL-2-like activities. To exploit the potential role of IL-15 in cancer immuno-/gene therapy, we engineered murine TS/A cells with different IL-15 cDNA constructs. Significant IL-15 secretion was achieved only by the use of a modified cDNA encoding for an IL-15 pre-protein be...

journal_title：International journal of cancer

authors： Meazza R,Lollini PL,Nanni P,De Giovanni C,Gaggero A,Comes A,Cilli M,Di Carlo E,Ferrini S,Musiani P

更新日期：2000-08-15 00:00:00

abstract：:The expression of the recently described rap genes, closely related in the effector region to the ras proto-oncogenes, was examined by Northern blot analysis in 41 primary human tumors. The structural and in vitro biological properties of the rap gene products suggest their possible antagonistic action in the same eff...

journal_title：International journal of cancer

authors： Culine S,Olofsson B,Gosselin S,Honore N,Tavitian A

更新日期：1989-12-15 00:00:00

abstract：:Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide. Owing to late diagnosis and limited treatment options, the prognosis for cholangiocarcinoma remains dismal, compelling a search for new treatments. As aspirin exhibits a well-supported chemopreventive effect on comm...

journal_title：International journal of cancer

authors： Shen X,Shen X

更新日期：2021-03-15 00:00:00

abstract：:Fecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all FOBT-positive persons have screen-detected adenomas. Despite removal of these, patients with large/multiple adenomas have increased risk of later developing new advanced adenomas and CRC....

journal_title：International journal of cancer

authors： Bjerrum A,Lindebjerg J,Andersen O,Fischer A,Lynge E

更新日期：2020-08-15 00:00:00

abstract：:Breast cancer incidence increases considerably in women who migrate from Japan to the United States. Based on the hypothesis that mammographic density in healthy mammograms reflects differences in breast cancer risk, we compared mammographic density in 3 groups of women at different levels of risk: Caucasian and Japan...

journal_title：International journal of cancer

authors： Maskarinec G,Nagata C,Shimizu H,Kashiki Y

更新日期：2002-11-01 00:00:00