Cell-mediated mutagenesis in cultured Chinese hamster cells by polycyclic hydrocarbons: mutagenicity and DNA reaction related to carcinogenicity in a series of compounds.

abstract：:Sera from 526 Old-World monkeys and apes, representing 50 species and 20 genera and living in US zoos and vivaria, were screened for antibodies to HTLV-I, HTLV-III/LAV, and simian-AIDS retrovirus, type I (SRV-I). Sera were screened initially by ELISA, and ELISA-positive sera, as well as ELISA-negative sera from cage c...

journal_title：International journal of cancer

authors： Lowenstine LJ,Pedersen NC,Higgins J,Pallis KC,Uyeda A,Marx P,Lerche NW,Munn RJ,Gardner MB

更新日期：1986-10-15 00:00:00

abstract：:The aim of this study was to test the utility of AIMP3, an upstream regulator of DNA damage response following genotoxic stress, as a clinical biomarker in muscle-invasive bladder cancer (MIBC). AIMP3 was identified from a meta-analysis of a global gene-expression dataset. AIMP3 protein expression was determined by im...

journal_title：International journal of cancer

authors： Gurung PM,Veerakumarasivam A,Williamson M,Counsell N,Douglas J,Tan WS,Feber A,Crabb SJ,Short SC,Freeman A,Powles T,Hoskin PJ,West CM,Kelly JD

更新日期：2015-02-01 00:00:00

abstract：:There are few published estimates of the risk of developing breast or ovarian cancer in women with a strong family history of ovarian cancer. As these women commonly present to family cancer clinics, accurate cancer risk estimates are needed. We have estimated these risks in women from families with 2 or more confirme...

journal_title：International journal of cancer

authors： Sutcliffe S,Pharoah PD,Easton DF,Ponder BA

更新日期：2000-07-01 00:00:00

abstract：:We use the population-based Family-Cancer Database from Sweden to study familial breast cancer. The size of the population and the nation-wide registration of cancer offer unique possibilities for epidemiological studies of familial cancer, including complete and unbiased identification of cases in the probands and in...

journal_title：International journal of cancer

authors： Hemminki K,Vaittinen P

更新日期：1998-07-29 00:00:00

abstract：:A panel of monoclonal antibodies and other markers (e.g., terminal deoxynucleotidyl transferase, sheep erythrocyte rosettes, peanut agglutinin) have been used in conjunction with flow cytometry and biochemical analysis to monitor the induction of maturation in human thymic (T) leukaemic cell lines by phorbol ester (TP...

journal_title：International journal of cancer

authors： Delia D,Greaves MF,Newman RA,Sutherland DR,Minowada J,Kung P,Goldstein G

更新日期：1982-01-15 00:00:00

abstract：:Microtubule-targeted drugs are now indispensable for the therapy of various cancer types worldwide. In this article, we report MT119 [6-[2-(4-methoxyphenyl) -ethyl]-9-[(pyridine-3-ylmethyl)amino]pyrido[2',1':2,3]imida-zo[4,5-c]isoquinolin-5(6H)-one] as a new microtubule-targeted agent. MT119 inhibited tubulin polymeri...

journal_title：International journal of cancer

authors： Zhang Z,Meng T,Yang N,Wang W,Xiong B,Chen Y,Ma L,Shen J,Miao ZH,Ding J

更新日期：2011-07-01 00:00:00

abstract：:The influence of prolonged treatment with antilymphocyte globulin on tumour incidence in BN/a and BN/b mice was studied. One ALG sample appeared to be highly leukaemogenic in two independent experiments. All treated mice developed, after a short latency period, non-thymic lymphomas with involvement of abdominal lymph ...

journal_title：International journal of cancer

authors： Szkudlarek J,Radzikowski C,Czarnomska A,Dux K,Bartoszewicz W

更新日期：1976-12-15 00:00:00

abstract：:alpha beta+ TCR T cells recognize peptide fragments displayed by MHC-class I or -class II molecules. Recently, additional mechanisms of antigen recognition by T cells have been identified, including CD1-mediated presentation of nonpeptide antigens. Only a limited number of CD1 antigens is retained in the mouse, i.e., ...

journal_title：International journal of cancer

authors： Fiedler T,Walter W,Reichert TE,Maeurer MJ

更新日期：2002-03-20 00:00:00

abstract：:The intrauterine environment appears to play a role in the development of adult diseases, including several prominent cancers. Our study aims to characterize the relationship between birth weight, a measure of the intrauterine environment, and adult obesity. A population-based sample of women aged 50-79, living in the...

journal_title：International journal of cancer

authors： Leong NM,Mignone LI,Newcomb PA,Titus-Ernstoff L,Baron JA,Trentham-Dietz A,Stampfer MJ,Willett WC,Egan KM

更新日期：2003-03-01 00:00:00

abstract：:A segment of 712 bases coding for part of the human stearoyl-CoA desaturase gene was made by polymerase chain reaction (PCR) using primers based on published rat cDNA sequences. The human PCR product was confirmed by DNA sequencing. It was next cloned into a vector from which anti-sense, highly radioactive RNA transcr...

journal_title：International journal of cancer

authors： Li J,Ding SF,Habib NA,Fermor BF,Wood CB,Gilmour RS

更新日期：1994-05-01 00:00:00

abstract：:Specific estrogen, progesterone and androgen receptors were determined in 19 well-characterized squamous-cell carcinoma (SCC) cell lines. Ten of the lines were derived from patients with SCC of the larynx and nine were from patients with SCC originating in other areas of the head and neck. Estrogen receptors (ER) were...

journal_title：International journal of cancer

authors： Virolainen E,Vanharanta R,Carey TE

更新日期：1984-01-15 00:00:00

abstract：:A case-control study involving interviews with 227 lung-cancer cases and 227 matched hospital controls was conducted in Heilongjiang Province in northeast China to examine the influence of dietary factors on the risk of developing lung cancer. Lung-cancer cases were all incident cases judged to be suitable candidates ...

journal_title：International journal of cancer

authors： Hu J,Johnson KC,Mao Y,Xu T,Lin Q,Wang C,Zhao F,Wang G,Chen Y,Yang Y

更新日期：1997-06-11 00:00:00

abstract：:Human papillomavirus (HPV)-associated penile lesions in men may increase the risk of HPV transmission to their female partners. Risk factor data on HPV-associated penile lesions are needed from regions with a high burden of cervical cancer. Visual inspection of the penis was conducted using a colposcope at the 24-mont...

journal_title：International journal of cancer

authors： Backes DM,Bleeker MC,Meijer CJ,Hudgens MG,Agot K,Bailey RC,Ndinya-Achola JO,Hayombe J,Hogewoning CJ,Moses S,Snijders PJ,Smith JS

更新日期：2012-04-15 00:00:00

abstract：:We have studied the clonal heterogeneity of 2 spontaneously metastasizing mammary carcinomas which recently arose spontaneously in C3H/He female retired breeders. Cells of early (2nd to 5th) transplant generations of these tumors were cloned by a combination of semi-solid agarose colony formation and limiting dilution...

journal_title：International journal of cancer

authors： Brodt P,Parhar R,Sankar P,Lala PK

更新日期：1985-02-15 00:00:00

abstract：:The majority of intermediate-risk rhabdomyosarcoma (RMS) patients have gross residual disease (Group III) after their first operative procedure. It is currently not known if local control rates can be maintained when, following induction chemotherapy, the radiation therapy (RT) dose is decreased after a delayed primar...

journal_title：International journal of cancer

authors： Rodeberg DA,Wharam MD,Lyden ER,Stoner JA,Brown K,Wolden SL,Paidas CN,Donaldson SS,Hawkins DS,Spunt SL,Arndt CA

更新日期：2015-07-01 00:00:00

abstract：:Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the leading causes of death among women in Brazil. In our study, we determined the frequency and the pattern of TP53 mutations in malignant breast tumors from 120 pati...

journal_title：International journal of cancer

authors： Simão TA,Ribeiro FS,Amorim LM,Albano RM,Andrada-Serpa MJ,Cardoso LE,Mendonça GA,de Moura-Gallo CV

更新日期：2002-09-01 00:00:00

abstract：:Active oxygen (AO) is ubiquitous in nature and its many forms can act as natural carcinogens. Their effect on the transformation of a mouse myeloid progenitor cell line was studied using anchorage-independent colony formation in methylcellulose as the primary assay. Both cytotoxic and non-toxic concentrations of t-but...

journal_title：International journal of cancer

authors： Crawford DR,Greenberger JS

更新日期：1991-11-11 00:00:00

abstract：:A hospital-based case-control study of renal-cell carcinoma was conducted in France from 1987 to 1991. A total of 196 histologically confirmed cases (138 males and 58 females) and 347 controls (235 males and 112 females), matched for sex, age at interview, hospital and interviewer, were included. The risk of renal-cel...

journal_title：International journal of cancer

authors： Benhamou S,Lenfant MH,Ory-Paoletti C,Flamant R

更新日期：1993-08-19 00:00:00

abstract：:Bcl-2 expression is up-regulated in prostate cancer cells after androgen ablation and associated with development of androgen independence and chemoresistance. We recently reported that antisense Bcl-2 oligodeoxynucleotides (ODNs) delay progression to androgen independence in the androgen-dependent (AD) human LNCaP pr...

journal_title：International journal of cancer

authors： Leung S,Miyake H,Zellweger T,Tolcher A,Gleave ME

更新日期：2001-03-15 00:00:00

abstract：:The incidence of esophageal cancer is extremely high in Linxian County and certain other regions of the People's Republic of China. Epidemiologic and laboratory studies suggest that N-nitroso carcinogens and other environmental factors play a causative role. In the present study, employing over 100 DNA samples obtaine...

journal_title：International journal of cancer

authors： Lu SH,Hsieh LL,Luo FC,Weinstein IB

更新日期：1988-10-15 00:00:00

abstract：:Mammalian LIM kinase 1 (LIMK1) phosphorylates and inactivates the actin-binding and -depolymerizing factor cofilin and induces actin cytoskeletal changes. LIMK1 is reported to play an important role in cell motility, but the mechanism of induction of cell motility and the role of LIMK1 in tumor growth, angiogenesis an...

journal_title：International journal of cancer

authors： Bagheri-Yarmand R,Mazumdar A,Sahin AA,Kumar R

更新日期：2006-06-01 00:00:00

abstract：:A population-based case-control study of esophageal cancer was conducted in urban Shanghai involving interviews with 902 cases and 1,552 controls. Risk of esophageal cancer was increased among tobacco smokers and alcohol drinkers. Odds ratios (OR) for smoking were 2.1 and 1.6 for men and women, respectively, and incre...

journal_title：International journal of cancer

authors： Gao YT,McLaughlin JK,Blot WJ,Ji BT,Benichou J,Dai Q,Fraumeni JF Jr

更新日期：1994-07-15 00:00:00

abstract：:To evaluate renal pelvis and ureter (RPU) cancer risk in relation to lifetime use of analgesics, a population-based case-control study was carried out in 3 areas of the United States. Among 502 cases and 496 controls diagnosed and interviewed during 1983-1986, no significant increases in risk were found for any of the...

journal_title：International journal of cancer

authors： Linet MS,Chow WH,McLaughlin JK,Wacholder S,Yu MC,Schoenberg JB,Lynch C,Fraumeni JF Jr

更新日期：1995-07-04 00:00:00

abstract：:To investigate whether addition of local therapy to EGFR-TKIs could provide survival benefit than EGFR-TKIs alone in EGFR-mutant NSCLC patients with oligometastatic or oligoprogressive liver metastases (LM). Patients with EGFR-mutant NSCLC and oligometastatic or oligoprogressive LM who met inclusion criteria were retr...

journal_title：International journal of cancer

authors： Jiang T,Chu Q,Wang H,Zhou F,Gao G,Chen X,Li X,Zhao C,Xu Q,Li W,Wu F,Xiong A,Zhao J,Xu Y,Su C,Ren S,Zhou C,Hirsch FR

更新日期：2019-05-15 00:00:00

abstract：:The sister chromatid exchange (SCE) rates of cell lines derived from patients with different malignant and premalignant disease were studied before and after intracerebral inoculation into nude mice and were compared to the SCE frequencies of cell lines from healthy controls. Lymphoma lines characterized by chromosoma...

journal_title：International journal of cancer

authors： Fonatsch C,Kirchner HH,Schaadt M,Günzel M,Diehl V

更新日期：1981-10-15 00:00:00

abstract：:The majority of small-cell lung cancers (SCLCs) express p16 but not pRb. Given our previous study showing loss of pRb in Merkel cell carcinoma (MCC)/neuroendocrine carcinoma of the skin and the clinicopathological similarities between SCLC and MCC, we wished to determine if this was also the case in MCC. Twenty-nine M...

journal_title：International journal of cancer

authors： Cook AL,Pollock PM,Welch J,Walsh MD,Bowman RV,Baumann KC,Hayward NK,Leonard JH

更新日期：2001-08-01 00:00:00

abstract：:The incidence of breast cancer among women in Shanghai, a traditionally low-risk population, has increased substantially over the past 20 years. To evaluate the association of menstrual and reproductive factors with breast cancer risk and the influence of these factors on the temporal trend of breast cancer incidence,...

journal_title：International journal of cancer

authors： Gao YT,Shu XO,Dai Q,Potter JD,Brinton LA,Wen W,Sellers TA,Kushi LH,Ruan Z,Bostick RM,Jin F,Zheng W

更新日期：2000-07-15 00:00:00

abstract：:The E2F family of transcription factors plays a key role in the control of cell-cycle progression. Some family members may act as oncogenes, others as tumor-suppressor genes. The genetic changes and the expression of E2F-1 and -3 were examined in human gastric and colorectal carcinomas by Southern, Northern and Wester...

journal_title：International journal of cancer

authors： Suzuki T,Yasui W,Yokozaki H,Naka K,Ishikawa T,Tahara E

更新日期：1999-05-17 00:00:00

abstract：:Epstein-Barr virus (EBV) can be detected in Hodgkin and Reed-Sternberg (HRS) cells in about one-half of cases of Hodgkin's disease (HD) in Western countries. To determine whether EBV is also associated with HD in a developing country such as China, we studied paraffin sections from 28 Chinese cases of HD for expressio...

journal_title：International journal of cancer

authors： Zhou XG,Hamilton-Dutoit SJ,Yan QH,Pallesen G

更新日期：1993-09-30 00:00:00

abstract：:The independent effects of parity and age at first birth on breast cancer incidence are investigated in a 1% sample of women aged 16 to 59 from the 1971 Census of England and Wales. Over the period 1971-81, 1,003 breast cancer cases occurred in the cohort of 113,263 women who were either married, widowed or divorced a...

journal_title：International journal of cancer

authors： Leon DA

更新日期：1989-06-15 00:00:00