Abstract:
:The E2F family of transcription factors plays a key role in the control of cell-cycle progression. Some family members may act as oncogenes, others as tumor-suppressor genes. The genetic changes and the expression of E2F-1 and -3 were examined in human gastric and colorectal carcinomas by Southern, Northern and Western blots. Gene amplification of E2F-1 was detected in 4% (1/23) of gastric carcinomas and 25% (3/12) of the colorectal carcinomas. Increased expression of E2F-1 mRNA was observed in 40% (12/30) of the gastric carcinomas and in 60% (3/5) of the colorectal carcinomas in comparison with the corresponding non-neoplastic mucosa. Over-expression of E2F-1 protein was confirmed in many of the gastric carcinomas. In contrast, expression levels of E2F-3 mRNA were lower in 70% (21/30) of the gastric carcinomas and in 20% (1/5) of the colorectal carcinomas than in their corresponding normal counterparts, while gross alteration of the E2F-3 gene was not detected. These results suggest that gene amplification and anomalous expression of the E2F gene may permit development of gastrointestinal carcinomas.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Suzuki T,Yasui W,Yokozaki H,Naka K,Ishikawa T,Tahara Edoi
10.1002/(sici)1097-0215(19990517)81:4<535::aid-ijckeywords:
subject
Has Abstractpub_date
1999-05-17 00:00:00pages
535-8issue
4eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19990517)81:4<535::AID-IJCjournal_volume
81pub_type
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