Abstract:
:Although human NK cells lyse a wide spectrum of target cells, the precise target structure recognized by NK cells has not yet been elucidated. In order to define a possible relationship between gangliosides on human target cells and susceptibility to NK lysis, 14 human leukemia and lymphoma cell lines were studied. A significant correlation was observed between the quantity of ganglioside GM2 on the target cells and sensitivity to NK lysis. In a single-cell binding assay purified GM2 specifically inhibited human NK cell binding to K562 target cells while other gangliosides did not inhibit binding. The competitive inhibition of NK cells by GM2 was restricted to the source of tissue from which GM2 was isolated. These results indicate that GM2 is a strong candidate as a target recognition structure for human NK cells.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ando I,Hoon DS,Suzuki Y,Saxton RE,Golub SH,Irie RFdoi
10.1002/ijc.2910400104subject
Has Abstractpub_date
1987-07-15 00:00:00pages
12-7issue
1eissn
0020-7136issn
1097-0215journal_volume
40pub_type
杂志文章abstract::Interleukin (IL)-2 has been approved for treatment of metastatic renal cancer and malignant melanoma. However, its unfavorable pharmacologic properties, severe side effects and the negative role of IL-2 in maintaining T regulatory cells are severe drawbacks. It has been shown that immunocomplexes of IL-2 and certain a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25859
更新日期:2011-10-15 00:00:00
abstract::Major etiologic factors associated with human hepatocellular carcinomas (HCCs) include infection with hepatitis C (HCV) and hepatitis B virus (HBV), excess alcohol intake and aflatoxin B(1) exposure. While the G-->T p53 mutation at codon 249 has been identified as a genetic hallmark of HCC caused by aflatoxin B(1), th...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.11254
更新日期:2003-09-01 00:00:00
abstract::I-compounds are bulky indigenous DNA adducts that can be detected by (32)P-postlabeling. A subgroup, termed type II I-compounds, represents DNA lesions induced by oxidative stress. Several major type II I-compounds have been identified as dinucleotides containing 3'-terminal 8,5'-cyclo-2'-deoxyadenosine (cA). Levels o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20375
更新日期:2004-12-10 00:00:00
abstract::A new antigan has been revealed by means of antisera against Rauscher virus in mice with Rauscher virus-induced leukemia. This antigen appears to be different from both Rauscher type-specific antigen and MULV-gs-1 (p-30), as shown by studies of electrophoretic mobility and immunochemical specificity. Except in leukemi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170617
更新日期:1976-06-15 00:00:00
abstract::The influence of viremia on hepatic injury in patients infected with hepatitis C virus was examined by analysis of the relationship between alanine aminotransferase activity and the amount of hepatitis C virus RNA in sequential serum samples from I untreated patient with acute hepatitis C and 3 untreated patients with...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520510
更新日期:1992-11-11 00:00:00
abstract::Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone EO9 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase may be involved in the metabolic activation of EO9 and mitomycin C in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560124
更新日期:1994-01-02 00:00:00
abstract::A panel of 24 healthy seropositive donors have been followed prospectively over a period of 15 months and monitored (1) for the level of EB virus shedding in the throat by means of a sensitive cord-blood transformation assay; (2) for the level of virus-infected B cells in the blood via a new in vitro protocol where "s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350107
更新日期:1985-01-15 00:00:00
abstract::Tobacco smoking and alcohol drinking histories were obtained from 194 patients with hepatocellular carcinoma (HCC) and 456 hospital controls, and the results were analysed in conjunction with the results of serological determinations of hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs) and antibody to ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390109
更新日期:1987-01-15 00:00:00
abstract::We examined pp60c-src protein kinase activity in human gastric carcinoma cell lines and gastric carcinoma tissues as well as normal mucosa. pp60c-src kinase activity was detected in all 5 carcinoma cell lines at various levels. Of 16 gastric carcinoma tissues, 8 showed higher pp60c-src kinase activity in tumor tissues...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450510
更新日期:1990-05-15 00:00:00
abstract::Multifocal occurrence and frequent recurrence are characteristic features of urothelial carcinomas of both the urinary bladder and the upper urinary tract. To describe the clonal nature of these tumors, 2 theories have been proposed. The monoclonality hypothesis describes the multiple tumors as descendants of a single...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.10544
更新日期:2002-09-01 00:00:00
abstract::It is increasingly appreciated that host factors within the tumor center and microenvironment play a key role in dictating colorectal cancer (CRC) outcomes. As a result, the metastatic process has now been defined as a result of epithelial-mesenchymal transition (EMT). Establishment of the role of EMT within the tumor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31739
更新日期:2019-01-01 00:00:00
abstract::To investigate whether addition of local therapy to EGFR-TKIs could provide survival benefit than EGFR-TKIs alone in EGFR-mutant NSCLC patients with oligometastatic or oligoprogressive liver metastases (LM). Patients with EGFR-mutant NSCLC and oligometastatic or oligoprogressive LM who met inclusion criteria were retr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31962
更新日期:2019-05-15 00:00:00
abstract::The aim of this study was to examine the cellular distribution of osteopontin (OPN) protein [by immunohistochemical (IHC) analysis] and mRNA [by in situ hybridization (ISH)] in the primary tumors of lymph node negative (LNN) breast cancer patients and to determine whether the level of immunodetectable OPN may be assoc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19981023)79:5<502::aid-ijc
更新日期:1998-10-23 00:00:00
abstract::During the course of a mechanism-based screening program aimed at identifying new antimitotic agents, a novel microtubule depolymerizing piperazine derivative, 1-(5-chloro-2-methoxybenzoyl)-4-(3-chlorophenyl) piperazine, was identified. The compound, designated CB694, caused inhibition of proliferation of a wide range...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21424
更新日期:2006-02-15 00:00:00
abstract::We have obtained a novel multidrug resistant cell line, derived from HT29 G(+) human colon carcinoma cells, by selection with gradually increasing concentrations of the anti-mitotic, microtubule-disrupting agent colchicine. This HT29(col) cell line displayed a 25-fold increase in colchicine resistance and exhibited cr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000715)87:2<172::aid-ijc3>3.0.
更新日期:2000-07-15 00:00:00
abstract::Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines. CD59 expression had a low degree of intra- and intertumor heterogeneity. SDS-PA...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610420
更新日期:1995-05-16 00:00:00
abstract::Human papillomavirus (HPV) has been identified as a causative agent of cervical cancer and oropharyngeal cancer (OPC). Intriguingly, estrogen and HPV were shown to play synergistic roles in cervical carcinogenesis. We recently demonstrated that the apolipoprotein B mRNA-editing catalytic polypeptide 3 (APOBEC3, A3) fa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32500
更新日期:2019-09-15 00:00:00
abstract::Examination of the effect of the farnesylprotein transferase (FPTase) inhibitor UCF1-C/manumycin on NIH3T3 cells transfected with a normal N-ras gene and expressing high levels of the corresponding p21-ras protein showed that 10 microm UCF1-C immediately and reversibly inhibited growth in these cells, without modifyin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980518)76:4<601::aid-ijc
更新日期:1998-05-18 00:00:00
abstract::CD44 is a transmembrane glycoprotein that binds hyaluronan, extracellular matrix proteins and growth factors. Multiple isoforms of CD44 are generated by alternative splicing of 10 separate exons (V1-V10). Expression of the variable exons has been correlated with tumour progression and metastasis in a range of cell typ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960516)66:4<457::AID-IJC
更新日期:1996-05-16 00:00:00
abstract::The potential of the novel insulin-like growth factor receptor (IGF-IR) inhibitor NVP-AEW541 as an antiproliferative agent in human neuroblastoma was investigated. Proliferation of a panel of neuroblastoma cell lines was inhibited by NVP-AEW541 with IC(50) values ranging from 0.15 to 5 microM. Experiments using an IGF...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22126
更新日期:2006-12-01 00:00:00
abstract::A novel non-phorbol-ester-like tumor promoter, okadaic acid (OA) has been shown to be an inhibitor of protein phosphatase I and IIA and, thus, to cause an "apparent activation" of protein kinase C (PKC). We previously showed that cis-diamminedichloroplatinum(II) (CDDP)-resistant cells, PC-9/CDDP, were cross-resistant ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500319
更新日期:1992-02-01 00:00:00
abstract::UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme which catalyses not only the glucuronidation of tobacco smoke carcinogens like benzopyrene, but also of the endogenous substrate bilirubin. Bilirubin for a long time was considered to be only a toxic waste product of hemoglobin degradation, but recent findings have...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25296
更新日期:2010-12-15 00:00:00
abstract::In a formal prospective-retrospective analysis of the phase III SBG0102 clinical trial randomizing metastatic breast cancer patients to gemcitabine-docetaxel or to single agent docetaxel, patients with basal-like tumors by PAM50 gene expression had significantly better overall survival in the gemcitabine arm. By immun...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31969
更新日期:2019-05-15 00:00:00
abstract::Under the aegis of EUROCARE, a European Union project to assemble survival data from population-based cancer registries and analyze them according to standardized procedures, we have investigated and compared colon-cancer survival in 10 European countries. We analyzed 68,283 colon-cancer cases diagnosed between 1978 a...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910630109
更新日期:1995-09-27 00:00:00
abstract::We have established a number of cell lines from Merkel cell carcinoma (MCC) of the skin. In many respects these cell lines resemble those established from small cell lung cancer (SCLC) and it is difficult to differentiate between metastatic MCC and SCLC on morphological or histochemical criteria. Both are thought to b...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580223
更新日期:1994-07-15 00:00:00
abstract::Folate-mediated one-carbon metabolism plays critical roles in DNA synthesis, repair and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate-metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of African ancestry. We co...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29434
更新日期:2015-08-01 00:00:00
abstract::The results from the population-based cancer registry for the city of Ho Chi Minh in 1995-1996 represent the first information on the incidence of cancer in southern Viet Nam. A total of 4,080 cancer cases in males and 4,338 in females were registered, corresponding to age-standardized incidence rates (ASRs) of 130.9 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980518)76:4<472::aid-ijc
更新日期:1998-05-18 00:00:00
abstract::Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesized that the transcriptomic profile might reveal molecular subgroups which could help to define the tumor origin and behavior beyond anatomical location. The...
journal_title:International journal of cancer
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doi:10.1002/ijc.32384
更新日期:2019-12-15 00:00:00
abstract::Peripheral blood leukocytes from patients with confirmed pulmonary neoplasia were tested for cytotoxicity against cultured cells derived from lung tumours of various histological types, foetal and normal adult lung tissue and tumours arising in organs other than the lung. Leukocytes from 73 percent of patients were cy...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150216
更新日期:1975-02-15 00:00:00
abstract::It is thought that TIL can be activated in vitro by rIL-2 and acquire specific anti-tumor activity. In this study, we investigated this possibility, using lymphocytes isolated from primary lung cancer tissues. In a first series of experiments, TILs and autologous PBLs from 16 patients were cultured in rIL-2 from 7 to ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430414
更新日期:1989-04-15 00:00:00