Abstract:
:An immunopotentiating factor associated with spleen cells of C57BL/6J mice bearing the 3LL tumor is described. Supernatants of cultured spleen cells from tumor-bearing mice (TBM) augmented the generation of both 19S and 7S antibody-producing cells, when injected with sheep erythrocytes into syngeneic C57BL/6J mice. The enhancing supernatant acted both as a polyclonal activator, when injected in the absence of antigen, and as a potentiator of specific antigen-dependent humoral immune responses, when injected in the presence of antigen. It was found to augment induction of specific memory, but not memory expression. Concomitantly with their influence on humoral immune responses, TBM spleen cell supernatants enhanced tumor growth when injected, mixed with 3LL tumor cells, into syngeneic recipients. The secretion of a factor which augments antibody production was not confined to the 3LL tumor system. Spleen supernatants of C47BL mice carrying the B16 melanoma and those of C3H mice carrying the KHT sarcoma had a similar effect on antibody production. These findings suggest that an immunoregulatory factor(s) appears in spleen cells of TBM as a result of their interaction with the neoplastic tissue. This factor can potentiate production of antibodies, possibly also against tumor-associated antigens. The relevance of the immunopotentiating effects of such factor(s) to tumor growth is discussed.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Isakov N,Segal S,Hollander N,Feldman Mdoi
10.1002/ijc.2910220416subject
Has Abstractpub_date
1978-10-15 00:00:00pages
465-70issue
4eissn
0020-7136issn
1097-0215journal_volume
22pub_type
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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journal_title:International journal of cancer
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更新日期:1997-05-16 00:00:00
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更新日期:2012-06-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章,评审
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更新日期:2003-01-20 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150619
更新日期:1975-06-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28558
更新日期:2014-05-15 00:00:00
abstract::Ovarian cancer is the fourth most common cause of cancer deaths among females in the western world after cancer of the breast, colon and lung. The inability to control the disease within the peritoneal cavity is the major cause of treatment failure in patients with ovarian cancer. The majority of ovarian carcinomas ex...
journal_title:International journal of cancer
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doi:10.1002/ijc.22297
更新日期:2007-02-01 00:00:00
abstract::HER3 (ERBB3) is a catalytically inactive pseudokinase of the HER receptor tyrosine kinase family, frequently overexpressed in prostate and other cancers. Aberrant expression and mutations of 2 other members of the family, EGFR and HER2, are key carcinogenic events in several types of tumors, and both are well- validat...
journal_title:International journal of cancer
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更新日期:2009-12-01 00:00:00
abstract::Using a method optimized in hepatocellular carcinoma (HCC), we established patient-derived xenograft (PDX) models with an increased take rate (42.2%) and demonstrated that FBS +10% dimethyl sulfoxide exhibited the highest tumor take rate efficacy. Among 254 HCC patients, 103 stably transplantable xenograft lines that ...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2020-03-15 00:00:00
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journal_title:International journal of cancer
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更新日期:2000-07-01 00:00:00
abstract::A hamster lymphoid cell line, HCT-2, transformed by human T-cell leukemia virus type I (HTLV-I) was serially transplanted for 9 passages in newborn hamsters. A total of 34 newborn hamsters inoculated intraperitoneally (i.p.) with 0.2-2 X 10(7) HCT-2 cells developed fatal lymphomas with dissemination to various organs ...
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更新日期:1988-06-15 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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doi:10.1002/(sici)1097-0215(19990129)80:3<455::aid-ijc
更新日期:1999-01-29 00:00:00
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更新日期:2007-01-01 00:00:00
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abstract::Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients we...
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abstract::miRNAs have emerged as post-transcriptional regulators that are critically involved in the pathogenesis of a number of human cancers. Cdc42, one of the best characterized members of the Rho GTPase family, is found to be up-regulated in several types of human tumors and has been implicated in cancer initiation and prog...
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更新日期:2011-03-15 00:00:00