Circadian organization of thymidylate synthase activity in normal tissues: a possible basis for 5-fluorouracil chronotherapeutic advantage.

abstract：:The effects of the tumor promoter -12-O-tetradecanoyl phorbol-13-acetate, its analogues, and other tumor promoters, on the proliferation of human skin fibroblasts (SF) have been investigated. We have previously shown (Kopelovich and Bias, 1979), that TPA caused a biphasic (upward concave) dose effect in the cloning ef...

journal_title：International journal of cancer

authors： Kopelovich L,Chou TC

更新日期：1984-12-15 00:00:00

abstract：:We have investigated the comparative initial DNA binding properties of 7 platinum-based anticancer drugs: 5 cis-oriented compounds, cisplatin, tetraplatin (Ormaplatin), JM118 [cis ammine dichloro (cyclohexylamine) platinum (II)], JM216 [bisacetato cis ammine dichloro (cyclohexylamine) platinum (IV)] and JM149 [cis amm...

journal_title：International journal of cancer

authors： Mellish KJ,Barnard CF,Murrer BA,Kelland LR

更新日期：1995-09-15 00:00:00

abstract：:Biopsies were obtained from 12 patients suspected of having nasopharyngeal carcinoma (NPC). A portion of the tissue was submitted for histopathology and another for Western blotting using a murine monoclonal antibody (MAb), MA6. Touch smears of the tissues were also prepared immediately prior to extraction and Western...

journal_title：International journal of cancer

authors： Yip TC,Chan KH,Choy D,Chan CW,Ng MH

更新日期：1987-04-15 00:00:00

abstract：:A recent 2-dimensional gel electrophoresis study revealed several polypeptide differences between a strongly metastatic and a weakly metastatic clone from a single chemically induced murine fibrosarcoma (Jellum et al., 1984). To exclude the possibility that this was merely coincidental, the study is extended here to 2...

journal_title：International journal of cancer

authors： Grimstad IA,Thorsrud AK,Varani J,Ward PA,Jellum E

更新日期：1988-04-15 00:00:00

abstract：:In STU mice bearing metastasizing SV40-transformed 51A-232B-M tumors, an immune response against a cellular 60kDa protein (p60) developed in about 50% of the tumor-bearing animals, in addition to the response against SV40 large T-antigen and cellular protein p53. The anti-p60 auto-immune response could be observed as ...

journal_title：International journal of cancer

authors： Manneck HE,Pfaff M,Anderer FA

更新日期：1988-12-15 00:00:00

abstract：:The causative role of human papillomaviruses (HPV) and HPV16 variants has been extensively studied in uterine cervix dysplastic lesions and invasive carcinoma; few such studies, however, have been performed in penile tumors. We have investigated HPV genotype and HPV16 variant distribution on 41 penile cancer biopsies ...

journal_title：International journal of cancer

authors： Tornesello ML,Duraturo ML,Losito S,Botti G,Pilotti S,Stefanon B,De Palo G,Gallo A,Buonaguro L,Buonaguro FM

更新日期：2008-01-01 00:00:00

abstract：:We assessed prospectively whether residual cervical intraepithelial neoplasia (CIN) after treatment for high-grade CIN can be predicted by genotype-specific high-risk HPV (HR-HPV) detection in follow-up cervical scrapes. A broad spectrum, highly sensitive SPF(10)-LiPA-PCR HPV detection technique was used on cervical s...

journal_title：International journal of cancer

authors： Bekkers RL,Melchers WJ,Bakkers JM,Hanselaar AG,Quint WG,Boonstra H,Massuger LF

更新日期：2002-11-10 00:00:00

abstract：:Phenotypic and functional characteristics of tumor-infiltrating lymphocytes (TIL) obtained from human primary and metastatic liver tumors were studied. Lymphocytes isolated from 18 tumors and autologous (A) peripheral blood (6 cases) were phenotyped by 2-color flow cytometry and cloned in a limiting dilution system, w...

journal_title：International journal of cancer

authors： Shimizu Y,Iwatsuki S,Herberman RB,Whiteside TL

更新日期：1990-11-15 00:00:00

abstract：:The objectives of this prospective multicentre international cohort study are to describe the characteristics of a cohort of HIV-1 positive women and determine the best management system by comparing cervical pathology according to results of cytology, colposcopy and human papillomavirus (HPV) testing at baseline and ...

journal_title：International journal of cancer

authors： Kitchener H,Nelson L,Adams J,Mesher D,Sasieni P,Cubie H,Moore C,Heard I,Agarossi A,Casolati E,Denny L,Bradbeer C,Lyons F,Beattie G,Niemiec T

更新日期：2007-12-01 00:00:00

abstract：:Carcinomatous meningitis is a devastating metastatic complication of systemic carcinoma, which may occur insidiously, accompanied by a confusing spectrum of clinical symptoms and signs. In the absence of reliable diagnostic tumour markers, the diagnosis is established by the demonstration of malignant cells within the...

journal_title：International journal of cancer

authors： Moseley RP,Oge K,Shafqat S,Moseley CM,Sullivan NM,Badley RA,Burchell J,Taylor-Papadimitriou J,Coakham HB

更新日期：1989-09-15 00:00:00

abstract：:Dimethylarsinic acid (DMA) is a major metabolite of inorganic arsenicals, which are epidemiologically significant chemicals in relation to liver cancer in mammals. The present study was conducted to determine the promoting effects of organic arsenicals related to DMA [monomethylarsonic acid (MMA) and trimethylarsine o...

journal_title：International journal of cancer

authors： Nishikawa T,Wanibuchi H,Ogawa M,Kinoshita A,Morimura K,Hiroi T,Funae Y,Kishida H,Nakae D,Fukushima S

更新日期：2002-07-10 00:00:00

abstract：:Telomerase appears to be an important factor for the control of cellular proliferation capacity and for tumorigenesis. Enzyme activity is highly increased in almost all human tumors and distinguishes them from benign lesions. Besides its diagnostic value, telomerase activity appears to be associated with tumor progres...

journal_title：International journal of cancer

authors： Hoos A,Hepp HH,Kaul S,Ahlert T,Bastert G,Wallwiener D

更新日期：1998-02-20 00:00:00

abstract：:CD30 is selectively expressed on the tumor cells of a variety of malignant disorders of the immune system and can therefore be used as a target for an anti-CD30 antibody-based immunotherapy. However, CD30 is cleaved at the cell surface by tumor necrosis factor-alpha converting enzyme (TACE). This metalloproteinase rel...

journal_title：International journal of cancer

authors： Hansen HP,Matthey B,Barth S,Kisseleva T,Mokros T,Davies SJ,Beckett RP,Foelster-Holst R,Lange HH,Engert A,Lemke H

更新日期：2002-03-10 00:00:00

abstract：:Gastric cancer is the second most common cause of cancer deaths worldwide. The identification of molecular genetic parameters that are associated with response to chemotherapy and prognosis is of utmost interest. We examined methylation of the apoptosis-related genes, TMS1 and DAPK, in 81 primary gastric cancers using...

journal_title：International journal of cancer

authors： Kato K,Iida S,Uetake H,Takagi Y,Yamashita T,Inokuchi M,Yamada H,Kojima K,Sugihara K

更新日期：2008-02-01 00:00:00

abstract：:The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cance...

journal_title：International journal of cancer

authors： Hemminki K,Jiang Y,Dong C

更新日期：2001-07-15 00:00:00

abstract：:A postal survey addressed to 2,083 general practitioners of childhood cancer survivors of reproductive age has revealed that females having undergone direct abdominal irradiation (exposed), particularly for Wilms' tumour, have an increased risk of several adverse pregnancy outcomes as compared with female survivors of...

journal_title：International journal of cancer

authors： Hawkins MM,Smith RA

更新日期：1989-03-15 00:00:00

abstract：:Evidence has accumulated that, in addition to the MDR1 gene-coded P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP) also mediates the multidrug resistance (MDR) of various human tumors. In the case of gastric cancer, there is little or no involvement of P-glycoprotein, and the mechanisms of MDR remai...

journal_title：International journal of cancer

authors： Endo K,Maehara Y,Kusumoto T,Ichiyoshi Y,Kuwano M,Sugimachi K

更新日期：1996-11-04 00:00:00

abstract：:Loss of heterozygosity (LOH) at chromosome 3p21 is frequent in cervical cancers. The candidate tumor suppressor gene, RASSF1A located at 3p21.3, is found to be inactivated in several major human cancers, implicating its significance in carcinogenesis. We aimed to investigate the status of RASSF1A in cervical cancers. ...

journal_title：International journal of cancer

authors： Yu MY,Tong JH,Chan PK,Lee TL,Chan MW,Chan AW,Lo KW,To KF

更新日期：2003-06-10 00:00:00

abstract：:We examined the geospatial dimension of delays to diagnosis of breast cancer in a prospective study of 1541 women newly diagnosed in the African Breast Cancer - Disparities in Outcomes (ABC-DO) Study. Women were recruited at cancer treatment facilities in Namibia, Nigeria, Uganda, and Zambia. The baseline interview in...

journal_title：International journal of cancer

authors： Togawa K,Anderson BO,Foerster M,Galukande M,Zietsman A,Pontac J,Anele A,Adisa C,Parham G,Pinder LF,McKenzie F,Schüz J,Dos-Santos-Silva I,McCormack V

更新日期：2020-11-16 00:00:00

abstract：:A human papillomavirus (HPV) was cloned from a patient with multiple squamous cell carcinomas (SCCs) and identified as HPV88, recently categorized into a new species within the genus Gamma. The HPV88 viral load in an SCC of the index patient exceeded 1 million copies/cell. By contrast, a survey of 447 skin lesions (79...

journal_title：International journal of cancer

authors： Kullander J,Handisurya A,Forslund O,Geusau A,Kirnbauer R,Dillner J

更新日期：2008-01-15 00:00:00

abstract：:The effects of combined administration of bombesin (40 micrograms/kg body weight) and the ornithine decarboxylase (ODC) inhibitor, 1,3-diaminopropane (DAP), on the development of large and small intestinal tumors and the incidence of their metastasis to the peritoneum induced by azoxymethane (AOM, 7.4 mg/kg body weigh...

journal_title：International journal of cancer

authors： Iishi H,Tatsuta M,Baba M,Uehara H,Nakaizumi A

更新日期：1994-08-15 00:00:00

abstract：:In Bloom's syndrome (BS) the regulation of uracil-DNA glycosylase, an enzyme involved in the repair of DNA containing 5-FU, is altered. 5-FU induces higher levels of DNA fragmentation in BS cells than in non-BS cells. The increase in DNA fragmentation is connected to the cytotoxic mechanism where 5-FU is incorporated ...

journal_title：International journal of cancer

authors： Lönn U,Lönn S,Nylen U,Winblad G

更新日期：1990-03-15 00:00:00

abstract：:We aimed to identify risk factors for Kaposi's sarcoma (KS) among HIV-positive patients and behaviors associated with human Herpesvirus 8 (HHV-8) infection, as well as to assess KS incidence and mortality rates longitudinally. To fulfill the first objective, a European case-control study was designed in the early 1990...

journal_title：International journal of cancer

authors： Martró E,Esteve A,Schulz TF,Sheldon J,Gambús G,Muñoz R,Whitby D,Casabona J,Euro-Shaks study group.

更新日期：2007-03-01 00:00:00

abstract：:Although childhood exposure to ionizing radiation is a well-established risk factor for thyroid cancer, the risk associated with adulthood exposure remains unclear. We prospectively examined the association between cumulative, low-to-moderate dose occupational radiation exposure to the thyroid and thyroid cancer incid...

journal_title：International journal of cancer

authors： Kitahara CM,Preston DL,Neta G,Little MP,Doody MM,Simon SL,Sigurdson AJ,Alexander BH,Linet MS

更新日期：2018-11-01 00:00:00

abstract：:1D10 is a previously described antibody that binds to cells from a majority of B-cell malignancies. The current studies were designed to further evaluate the antigen specificity of 1D10 and its potential as an immunotherapeutic agent. Studies with transfectants and immunoprecipitation demonstrated that 1D10 recognizes...

journal_title：International journal of cancer

authors： Kostelny SA,Link BK,Tso JY,Vasquez M,Jorgensen BH,Wang H,Hall WC,Weiner GJ

更新日期：2001-08-15 00:00:00

abstract：:From C57BL mouse melanoma B-16 cells, variant clones were selected in vitro which were resistant to the lectins wheat-germ agglutinin and ricin. Cells were also selected which survived toxic concentrations of concanavalin A. Four different in vivo assays using intradermal, intravenous, intraperitoneal and intramuscula...

journal_title：International journal of cancer

authors： Tao TW,Burger MM

更新日期：1982-04-15 00:00:00

abstract：:Interaction between CD40 and its ligand, CD154, has a key function in immune regulation. Recent experimental data support a role of deregulated CD40 signalling in lymphomagenesis. Data from earlier studies that are part of this pooling study implicate a functional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene en...

journal_title：International journal of cancer

authors： Nieters A,Bracci PM,de Sanjosé S,Becker N,Maynadié M,Benavente Y,Foretova L,Cocco P,Staines A,Holly EA,Boffetta P,Brennan P,Skibola CF

更新日期：2011-03-15 00:00:00

abstract：:Meningioma, the most frequent tumor in the central nervous system, has few recognized risk factors. We explored the role of allergies in a population-based case-control consortium study of meningioma in five geographic areas. We also studied serum levels of a marker of atopic allergy (IgE) in a subset of study partici...

journal_title：International journal of cancer

authors： Wiemels JL,Wrensch M,Sison JD,Zhou M,Bondy M,Calvocoressi L,Black PM,Yu H,Schildkraut JM,Claus EB

更新日期：2011-10-15 00:00:00

abstract：:Female residents of six counties in Washington and Utah in whom a diagnosis of ovarian cancer was made during 1975-79 were interviewed concerning prior use of oral contraceptives. Interviews with a random sample of women drawn from these same counties were obtained for comparison. A smaller proportion of women with ep...

journal_title：International journal of cancer

authors： Weiss NS,Lyon JL,Liff JM,Vollmer WM,Daling JR

更新日期：1981-12-01 00:00:00

abstract：:Lethally X-irradiated LEW rats reconstituted with syngeneic bone marrow and given low-dose Cyclosporine A (CyA) for 5 weeks develop, after withdrawal of CyA, symptoms of disease resembling graft-vs.-host disease (GVHD) as seen after allogeneic bone-marrow transplantation. Symptoms of disease may include acute dermatit...

journal_title：International journal of cancer

authors： Wodzig KW,Beijleveld LJ,Damoiseaux JG,Arends JW,van Breda Vriesman PJ

更新日期：1997-07-29 00:00:00