Humanization and characterization of the anti-HLA-DR antibody 1D10.

abstract：:The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of ...

journal_title：International journal of cancer

authors： Kang S,Kim JW,Kang GH,Lee S,Park NH,Song YS,Park SY,Kang SB,Lee HP

更新日期：2006-05-01 00:00:00

abstract：:Exposure of Chinese hamster cells to polyamines at an elevated temperature (42 degrees C) results in synergistic cell killing. The effectiveness of polyamines in potentiating thermal killing decreases in the following order: spermine greater than spermidine greater than cadaverine greater than putrescine. The magnitud...

journal_title：International journal of cancer

authors： Ben-Hur E,Prager A,Riklis E

更新日期：1978-11-15 00:00:00

abstract：:Telomerase plays a key role in carcinogenesis. It is activated in most immortal cell lines and human cancers, including cutaneous melanoma (CM). Increased cell proliferation and deregulation of the cell cycle occur in human cancers. Links between telomerase activity (TA), cell proliferation, cell death and expression ...

journal_title：International journal of cancer

authors： Miracco C,Pacenti L,Santopietro R,Biagioli M,Fimiani M,Perotti R,Rubegni P,Pirtoli L,Luzi P

更新日期：2000-11-01 00:00:00

abstract：:Src has been one of the most studied proto-oncogenes. The cellular Src (c-Src) holds a critical role in several human malignancies and has emerged as a key factor that promotes tumor progression during the multistep process of colorectal cancer (CRC) pathogenesis. The robust activation of Src in CRC of aggressive phen...

journal_title：International journal of cancer

authors： Gargalionis AN,Karamouzis MV,Papavassiliou AG

更新日期：2014-05-01 00:00:00

abstract：:We treated 72 patients with metastatic renal-cell cancer according to 2 protocols consisting of two 5-week induction cycles of continuous i.v. high-dose interleukin-2 (IL-2), i.m. interferon-alpha (IFN alpha) and ex vivo IL-2-activated lymphocytes, followed for patients with stable disease (SD), partial response (PR) ...

journal_title：International journal of cancer

authors： Gratama JW,Schmitz PI,Goey SH,Lamers CH,Stoter G,Bolhuis RL

更新日期：1996-01-17 00:00:00

abstract：:Cancer incidence rates are presented for the Nairobi Cancer Registry, a population-based cancer registry (PBCR) covering the population of the capital city of Kenya (3.2 million inhabitants in 2009). Case finding was by active methods, with standard and checks for accuracy and validity. During the period 2004-2008 a t...

journal_title：International journal of cancer

authors： Korir A,Okerosi N,Ronoh V,Mutuma G,Parkin M

更新日期：2015-11-01 00:00:00

abstract：:A population-based case-control study was conducted to examine the effect of ingestion of vitamin C, carotenoids and retinol on risk of pharyngeal cancer. Data were available from 166 cases of pharyngeal cancer or their next-of-kin, and from 547 controls similar in age and sex to the cases. Odds ratios (ORs) relating ...

journal_title：International journal of cancer

authors： Rossing MA,Vaughan TL,McKnight B

更新日期：1989-10-15 00:00:00

abstract：:We have shown that the loss of p53 function contributed to resistance of tumor cells to TNF-induced cytotoxicity. In the present study, we evaluated the effect of wild-type p53 (wt-p53) expression on TNF sensitivity, by introducing wt-p53 into MCF7/Adr cells in which p53 was deleted, via a recombinant adenovirus encod...

journal_title：International journal of cancer

authors： Shatrov VA,Ameyar M,Bouquet C,Cai Z,Stancou R,Haddada H,Chouaib S

更新日期：2000-01-01 00:00:00

abstract：:In order to evaluate whether the SCID mouse can provide the microenvironment for the growth of human immature T-cell leukemias and if in vivo growth alters their phenotype, we examined the behavior of 3 well-characterized T-cell acute lymphoblastic leukemia (T-ALL)-derived T-cell lines which are at different stages of...

journal_title：International journal of cancer

authors： Uittenbogaart CH,Anisman DJ,Tary-Lehmann M,Vollger LW,Breit TM,Van Dongen JJ,Saxon A

更新日期：1994-02-15 00:00:00

abstract：:Abnormal survivin expression has been reported to be involved in many types of cancer. A single-nucleotide polymorphism (SNP), C-31G, located in the promoter region of survivin reportedly may alter the mRNA level, while the significance of the nonsynonymous SNP A9194G in exon 4 has not yet been clarified. Here, the as...

journal_title：International journal of cancer

authors： Kawata N,Tsuchiya N,Horikawa Y,Inoue T,Tsuruta H,Maita S,Satoh S,Mitobe Y,Narita S,Habuchi T

更新日期：2011-10-15 00:00:00

abstract：:While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by poolin...

journal_title：International journal of cancer

authors： Jochems SHJ,Reulen RC,van Osch FHM,Witlox WJA,Goossens ME,Brinkman M,Giles GG,Milne RL,van den Brandt PA,White E,Weiderpass E,Huybrechts I,Hémon B,Agudo A,Bueno-de-Mesquita B,Cheng KK,van Schooten FJ,Bryan RT,Wesseliu

更新日期：2020-10-15 00:00:00

abstract：:Human T-cell leukemia virus type I (HTLV-I) is etiologically associated with adult T-cell leukemia/lymphoma (ATL). We cloned and sequenced host DNA adjacent to the long terminal repeats of HTLV-I from uncultured leukemic cells of 4 ATL patients. The region flanking the provirus was generally A/T-rich (60-64% A/T), and...

journal_title：International journal of cancer

authors： Chou KS,Okayama A,Su IJ,Lee TH,Essex M

更新日期：1996-01-03 00:00:00

abstract：:Southern blot analyses of surgical specimens of cervical carcinoma from Japanese patients showed that 3/9 samples contained human papillomavirus (HPV) type-16 DNA sequences, and 2 contained HPV type-18 DNA sequences. By Northern blot analyses, RNA transcripts of HPV DNA sequences were demonstrated in some of the tissu...

journal_title：International journal of cancer

authors： Tsunokawa Y,Takebe N,Nozawa S,Kasamatsu T,Gissmann L,zur Hausen H,Terada M,Sugimura T

更新日期：1986-04-15 00:00:00

abstract：:Dendritic cells (DCs) display an extraordinary capacity to induce T-cell responses providing the opportunity of DC-based cancer vaccination strategies. Additional findings indicate that DCs may also play a crucial role for the activation of natural killer (NK) cells, which are important effectors in innate antitumor i...

journal_title：International journal of cancer

authors： Wehner R,Löbel B,Bornhäuser M,Schäkel K,Cartellieri M,Bachmann M,Rieber EP,Schmitz M

更新日期：2009-01-15 00:00:00

abstract：:Tumorigenic clonal lines derived from soft agar colonies induced by DMBA-transformed feline embryo cells were isolated and characterized. The morphologically altered clonal cells formed large aggregates, growing in this aggregate form when suspended in liquid growth medium above an agar base and forming colonies in so...

journal_title：International journal of cancer

authors： Rhim JS,Koh KS,Chen A,Essex M

更新日期：1981-07-15 00:00:00

abstract：:Tissue recombinants (TRs) composed of mouse urogenital mesenchyme (mUGM) plus an immortalized nontumorigenic human prostatic epithelial cell line (BPH-1) were grown under the kidney capsule of male athymic nude mice under different hormonal conditions. The objectives were to determine temporal plasma concentrations of...

journal_title：International journal of cancer

authors： Ricke WA,Ishii K,Ricke EA,Simko J,Wang Y,Hayward SW,Cunha GR

更新日期：2006-05-01 00:00:00

abstract：:There is a great need to identify new and better prognostic and predictive biomarkers to stratify prostate cancer patients for optimal treatment. The aims of this study were to characterize the expression profile of pre-B cell leukemia homeobox (PBX) transcription factors in prostate cancer with an emphasis on investi...

journal_title：International journal of cancer

authors： Ramberg H,Grytli HH,Nygård S,Wang W,Ögren O,Zhao S,Løvf M,Katz B,Skotheim RI,Bjartell A,Eri LM,Berge V,Svindland A,Taskén KA

更新日期：2016-10-15 00:00:00

abstract：:In our previous study on hepatocellular carcinoma (HCC) susceptibility genes in chronic hepatitis patients, we identified the MHC class I polypeptide-related sequence A (MICA). Natural killer cells eliminate various cancer cells, including HCC, by suppressing MICA shedding. Therefore, we investigated MICA sheddases an...

journal_title：International journal of cancer

authors： Arai J,Goto K,Tanoue Y,Ito S,Muroyama R,Matsubara Y,Nakagawa R,Kaise Y,Lim LA,Yoshida H,Kato N

更新日期：2018-11-15 00:00:00

abstract：:In a case-control study of gastric cancer (GC) in high-risk and low-risk areas of Italy, 923 GCs were systematically categorized by one pathologist according to the Lauren classification distinguishing 2 main histologic types, intestinal (55%) and diffuse (23%). Intestinal types outnumbered diffuse types by a 3 to 1 m...

journal_title：International journal of cancer

authors： Buiatti E,Palli D,Bianchi S,Decarli A,Amadori D,Avellini C,Cipriani F,Cocco P,Giacosa A,Lorenzini L

更新日期：1991-05-30 00:00:00

abstract：:Androgen receptor (AR) mutations that modify both the ligand binding and the transactivation capacities of the AR represent one of the mechanisms involved in the transition of prostate cancer (PCa) from androgen-dependent to androgen-independent growth. We use a yeast-based functional assay to detect and analyze mutan...

journal_title：International journal of cancer

authors： Céraline J,Cruchant MD,Erdmann E,Erbs P,Kurtz JE,Duclos B,Jacqmin D,Chopin D,Bergerat JP

更新日期：2004-01-01 00:00:00

abstract：:CD43 is a leukocyte-associated sialoglycoprotein which is also expressed in human colon adenoma and carcinoma. To obtain monoclonal antibodies (MAbs) that would react with CD43 in a glycosylation-independent way, antibodies were raised against a peptide corresponding to a portion of the CD43 cytoplasmic domain. Hybrid...

journal_title：International journal of cancer

authors： Sikut R,Andersson CX,Sikut A,Fernandez-Rodriguez J,Karlsson NG,Hansson GC

更新日期：1999-07-02 00:00:00

abstract：:We describe a new, spontaneously occurring BALB/c-derived murine T-cell leukemia. The leukemic cells, designated LB, grow rapidly and progressively in the syngeneic host with no signs of effective immunological resistance. LB cells expressed the Thy-1+, Lyt-2+, L3T4-, CD3- class-I+, CD25+ (IL-2 receptor, IL-2R), class...

journal_title：International journal of cancer

authors： Lugasi H,Hajos S,Murphy JR,Strom TB,Nichols J,Peñarroja C,Naor D

更新日期：1990-01-15 00:00:00

abstract：:The glycoprotein 90K was originally described as a tumor-secreted antigen and subsequently found to have immunostimulatory activity as well as other possible functions. This protein interacts with an endogenous lectin, galectin-3, and may play a role in tumor metastasis through this interaction. Because 90K is heavily...

journal_title：International journal of cancer

authors： Tinari N,Kuwabara I,Huflejt ME,Shen PF,Iacobelli S,Liu FT

更新日期：2001-01-15 00:00:00

abstract：:Some ovarian cancer cells in vivo are in a reversible quiescent state where they can contribute to cancer spread under favorable growth conditions. The serine/threonine kinase Mirk/dyrk1B was expressed in each of seven ovarian cancer cell lines and in 21 of 28 resected human ovarian cancers, and upregulated in 60% of ...

journal_title：International journal of cancer

authors： Hu J,Nakhla H,Friedman E

更新日期：2011-07-15 00:00:00

abstract：:A group of 83 Spanish BC/OC families were analysed for BRCA1 germ-line mutations. Analysis of the entire coding sequence was carried out by SSCP and PTT. We identified 5 frameshift mutations: 185delAG (2 times), 189insTGTC, 1241delAC, and 5537delA and 3 missense mutations in BRCA1: 330A > G, 1240C > T, and 5263G > A. ...

journal_title：International journal of cancer

authors： Díez O,Cortés J,Domènech M,Brunet J,Del Río E,Pericay C,Sanz J,Alonso C,Baiget M

更新日期：1999-11-12 00:00:00

abstract：:Permanent cell lines have been established in vitro from lymphoid tumors induced in C57BH/Ka mice by fractionated X-irradiation or by inoculation of the radiation leukemia virus (RadOV). The cultured cells are lymphoblastic, replicate rapidly in vitro, and are tumorigenic in vivo. The cell surface markers Thy 1, Ly 1,...

journal_title：International journal of cancer

authors： Lieberman M,Declève A,Ricciardi-Castagnoli P,Boniver J,Finn OJ,Kaplan HS

更新日期：1979-08-01 00:00:00

abstract：:We previously reported that ganglioside GD1a, which is highly expressed in poorly metastatic FBJ-S1 cells, inhibits the serum-induced motility of FBJ-LL cells and that the metastatic potential of FBJ-LL cells is completely suppressed by enforced GD1a expression (Hyuga et al., Int J Cancer 1999;83:685-91). We recently ...

journal_title：International journal of cancer

authors： Hyuga S,Kawasaki N,Hyuga M,Ohta M,Shibayama R,Kawanishi T,Yamagata S,Yamagata T,Hayakawa T

更新日期：2001-11-01 00:00:00

abstract：:Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human ...

journal_title：International journal of cancer

authors： Vajdic CM,van Leeuwen MT,Turner JJ,McDonald AM,Webster AC,McDonald SP,Chapman JR,Kaldor JM,Grulich AE

更新日期：2010-12-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are involved in the pathology of colorectal cancer (CRC). Current efforts to eradicate CRC predominantly focused on targeting the proliferation of rapidly growing cancer epithelial cells. This is largely ineffective with resistance arising in most tumors after exposure to chemotherapy. De...

journal_title：International journal of cancer

authors： Deng X,Ruan H,Zhang X,Xu X,Zhu Y,Peng H,Zhang X,Kong F,Guan M

更新日期：2020-03-15 00:00:00

abstract：:Epstein-Barr virus genome-positive Burkitt's lymphoma is endemic in Africa and Papua New Guinea and in both countries the tumour is restricted to regions with holoendemic malaria. The present work has compared groups of healthy indigenous individuals living in malarious and non-malarious regions of Papua New Guinea fo...

journal_title：International journal of cancer

authors： Moss DJ,Burrows SR,Castelino DJ,Kane RG,Pope JH,Rickinson AB,Alpers MP,Heywood PF

更新日期：1983-06-15 00:00:00