Abstract:
:We describe a new, spontaneously occurring BALB/c-derived murine T-cell leukemia. The leukemic cells, designated LB, grow rapidly and progressively in the syngeneic host with no signs of effective immunological resistance. LB cells expressed the Thy-1+, Lyt-2+, L3T4-, CD3- class-I+, CD25+ (IL-2 receptor, IL-2R), class-II-, gp70- phenotype. As LB cells express IL-2, as indicated by staining with 2 distinct anti-CD25 IL-2R monoclonal antibodies (MAbs), the therapeutic efficacy of IL-2-diphtheria toxin-related protein was tested on this leukemic model. IL-2-diphtheria toxin, but not diphtheria toxin, efficiently inhibited the proliferation of LB cells. The proliferation of a murine myeloma cell line, which does not express IL-2R, was not inhibited by IL-2-diphtheria toxin. The possible implantation of this animal model in fundamental and practical studies is discussed.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Lugasi H,Hajos S,Murphy JR,Strom TB,Nichols J,Peñarroja C,Naor Ddoi
10.1002/ijc.2910450129subject
Has Abstractpub_date
1990-01-15 00:00:00pages
163-7issue
1eissn
0020-7136issn
1097-0215journal_volume
45pub_type
杂志文章abstract::We conducted a case-control study of adenocarcinoma of the lung and exposure to environmental tobacco smoke (ETS) in 7 countries. We interviewed 70 cases of adenocarcinoma of the lung and 178 population or hospital controls. All subjects had smoked fewer than 400 cigarettes in their lifetimes. Ever exposure to ETS fro...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
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journal_title:International journal of cancer
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更新日期:2009-01-15 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2012-08-01 00:00:00
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journal_title:International journal of cancer
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