Abstract:
:A postal survey addressed to 2,083 general practitioners of childhood cancer survivors of reproductive age has revealed that females having undergone direct abdominal irradiation (exposed), particularly for Wilms' tumour, have an increased risk of several adverse pregnancy outcomes as compared with female survivors of the same types of tumour who had not undergone direct abdominal irradiation (unexposed). Among female survivors, 22% of those exposed and 41% of those unexposed have children. The percentages of first pregnancies reported as ending in spontaneous abortion were 9/40 = 22% (exposed mothers) and 11/174 = 6% (unexposed mothers). The mean birth-weight of first singleton children born to exposed mothers was over 300 g less than the corresponding value for unexposed mothers. We conclude that radiation is probably involved in the mechanism producing these effects. The findings have implications for counselling survivors, monitoring their pregnancies and treating future patients.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Hawkins MM,Smith RAdoi
10.1002/ijc.2910430309subject
Has Abstractpub_date
1989-03-15 00:00:00pages
399-402issue
3eissn
0020-7136issn
1097-0215journal_volume
43pub_type
杂志文章abstract::The distance of nerve invasion is an important prognostic factor in pancreatic cancer. The extracellular matrix (ECM) of nerve, mainly composed of laminin, collagen IV and anchoring fibrils, might affect nerve invasion. However, this relationship has not been demonstrated. Our study aimed at discovering the promoting ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25104
更新日期:2010-08-15 00:00:00
abstract::Monocytes from the peripheral blood of 10 normal adult human donors were tested for their cytolytic activity on untransformed or SV40-transformed, early passage, human fibroblasts. Two pairs of human fibroblast lines (2303 and SV40-2303, 2931 and SV40-2931) were used and lysis was assessed in terms of release of [3H]t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230106
更新日期:1979-01-15 00:00:00
abstract::Intestinal mucositis is a common side effect of chemotherapy leading to diarrhea, abdominal pain and increased risk of infections. The intestinal microbiota has been recognized as a key regulator of mucosal immune responses. Therefore, we hypothesized that intestinal microbial changes would be associated with enterocy...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32942
更新日期:2020-10-01 00:00:00
abstract::Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution multimodal imaging approach assessing in vivo the metabolism of i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31299
更新日期:2018-07-01 00:00:00
abstract::Targeting of T lymphocytes against epidermal growth-factor-receptor (EGF-R)+ tumor cells was achieved by constructing a hybrid hybridoma which secretes an anti-EGF-R/anti-CD3 bispecific monoclonal antibody (biMAb) of hybrid isotype (IgG1/IgG2a). Purification of biMAb molecules from parental anti-EGF-R and anti-CD3 MAb...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550610
更新日期:1993-12-02 00:00:00
abstract::DT-diaphorase (DTD) is a flavoprotein which catalyzes obligate two-electron reduction of a diverse group of substrates. We have reported previously that non-tumorigenic mouse lung alveolar type-II pneumocytes have high DTD activity, while cell lines derived from lung tumors do not. In contrast, other investigators, us...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490126
更新日期:1991-08-19 00:00:00
abstract::Medullary thyroid carcinoma (MTC) is a rare tumor, partially explained by mutations in the rearranged during transfection (RET) proto-oncogene. The nonsynonymous RET polymorphism G691S has been reported as associated with MTC, but findings are discordant. We sought to clarify the role of G691S in MTCs through in silic...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
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更新日期:2013-06-15 00:00:00
abstract::Angiogenesis in pancreatic ductal adenocarcinomas depends on the presence of angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and is thought to be stimulated by hypoxia. We tested the angiogenic potential of 9 cell lines of pancreatic ductal carcinoma origi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10753
更新日期:2002-12-20 00:00:00
abstract::This population-based cohort study investigated the occurrence of familial astrocytoma among first-degree relatives of patients with astrocytoma diagnosed between 1985 and 1993 in the northern region of Sweden. The 432 cases received a questionnaire. They were asked to provide names and cancer diagnoses of first-degre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990505)81:3<366::aid-ijc
更新日期:1999-05-05 00:00:00
abstract::Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25272
更新日期:2010-12-01 00:00:00
abstract::A human revertant cell line, derived from non-producer human osteosarcoma cells (NP/KHOS) induced by Kirsten murine sarcoma virus, was treated in vitro with various levels of polycyclic aromatic hydrocarbons (3-methylcholanthrene, 7,12-dimethylbenz(alpha)anthracene, and benzo(alpha)pyrene [BP] or dimethyl sulfoxide (c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210106
更新日期:1978-01-15 00:00:00
abstract::Lethal phenotypes of human prostate cancer are characterized by progression to androgen-independence and metastasis. For want of a clinically relevant animal model, mechanisms behind this progression remain unclear. Our study used an in vivo model of androgen-sensitive LNCaP human prostate cancer cell xenografts in ma...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20206
更新日期:2004-07-20 00:00:00
abstract::Prostate stem cell antigen (PSCA) and prostate-specific antigen (PSA) are overexpressed in most prostate cancers. PSCA- and PSA-derived, HLA-A2 binding peptides are specific targets for T-cell responses in vitro. A phase I/II trial was performed to demonstrate feasibility, safety and induction of antigen-specific immu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22097
更新日期:2006-11-15 00:00:00
abstract::Although new treatments have been widely studied to improve the survival of patients with metastatic breast cancer (BC), prognosis continues to be poor with an average survival time no longer than 3 years. We carried on a population-based study with the purpose of evaluating the outcome of metastatic breast cancer in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29503
更新日期:2015-09-15 00:00:00
abstract::The present study was undertaken to define the gene(s) of importance on the long arm of chromosome 18 (chromosome 18q) in endometrial carcinomas. We analyzed loss of heterozygosity (LOH) at 3 loci on chromosome 18q and DCC gene expression by the reverse-transcriptase/polymerase chain reaction (RT-PCR) method. Among 61...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570407
更新日期:1994-05-15 00:00:00
abstract::The mechanism of tumor cell killing by OXI4503 was investigated by studying vascular functional and morphological changes post drug administration. SCID mice bearing MHEC5-T hemangioendothelioma were given a single dose of OXI4503 at 100 mg/kg. Tumor blood flow, measured by microsphere fluorescence, was reduced by 50%...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20297
更新日期:2004-09-10 00:00:00
abstract::With metastatic disease at diagnosis for 70% of patients, ovarian cancer represents the most lethal gynecological malignancy. Ovarian carcinomas are aggressive malignancies that can evade immune surveillance and frequently develop into metastases. The tumor microenvironment is decisive for preventing immune attack but...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24881
更新日期:2010-05-01 00:00:00
abstract::The nature of 15 immortal mouse liver epithelial cell (MLEC) lines established from normal C3H mice was investigated specifically in terms of ras oncogene activation. Neither transforming activity nor point mutation within codon 61 of c-H-ras could be demonstrated in any of the cell lines by DNA transfection in a NIH/...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470112
更新日期:1991-01-02 00:00:00
abstract::Using individual subject data from 10 case-control studies, comprising over 3000 cases and almost 4000 controls, we have estimated the relative risk of melanoma associated with aspects of complexion, namely, hair, eye and skin colour and freckling in adulthood, and have examined the relationships between these factors...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620402
更新日期:1995-08-09 00:00:00
abstract::To better understand the molecular basis of radiation-induced osteosarcoma (OS), we performed global gene expression profiling of rat OS tumors induced by the bone-seeking alpha emitter (238)Pu, and the expression profiles were compared with those of normal osteoblasts (OB). The expressions of 72 genes were significan...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24392
更新日期:2009-08-01 00:00:00
abstract::The alpha 5 beta 1 integrin (CD49e/CD29), a heterodimeric membrane protein, is the "classical" fibronectin receptor on many cell types. During B-cell ontogeny, expression of the alpha 5-subunit is developmentally regulated. The alpha 5 beta 1 is decisive for migration on fibronectin substrate and very likely cooperate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600623
更新日期:1995-03-16 00:00:00
abstract::Increases in the incidence of childhood acute lymphoblastic leukemia (ALL) have been reported in some countries, while other reports from similar geographical regions have indicated stable rates. The reasons for the discrepancies have been debated in the literature, with the focus on whether the observed increases are...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23226
更新日期:2008-03-01 00:00:00
abstract::Renewed interest in the use of therapeutic enzymes combined with an improved knowledge of cancer cell metabolism, has led to the translation of several arginine depletion strategies into early phase clinical trials. Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginos...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30051
更新日期:2016-08-01 00:00:00
abstract::It has been established that disturbances in intracellular signaling pathways play a considerable part in the oncologic process. Phosphatidylinositol-3-kinase (PI3K) has become of key interest in cancer therapy because of its high mutation frequency and/or gain in function of its catalytic subunits in cancer cells. We...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29040
更新日期:2015-02-15 00:00:00
abstract::Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endocytic vesicles and exhibit a drug...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22098
更新日期:2006-12-01 00:00:00
abstract::Liquid-based cytology (LBC) has replaced conventional cytology (CC) for cervical cancer screening in some countries. However, it remains unclear whether LBC is superior to CC. A randomized controlled trial was conducted between August 2007 and March 2009 in Germany to compare LBC, alone and in combination with compute...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.27955
更新日期:2013-06-15 00:00:00
abstract::In 584 consecutive patients with no previous history of cancer or polypectomy, 769 adenomas were excised endoscopically and classified retrospectively according to the following parameters: macroscopic growth pattern, size, histological type, grade of dysplasia, anatomical site, presence of adenocarcinoma (ADK), numbe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490406
更新日期:1991-10-21 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410321
更新日期:1988-03-15 00:00:00
abstract::Genome-wide association studies (GWAS) have identified several loci contributing to lung cancer and COPD risk independently; however, inflammation-related pathways likely harbor additional lung cancer risk-associated variants in biologically relevant immune genes that differ dependent on COPD. We selected single nucle...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32780
更新日期:2020-08-01 00:00:00
abstract::The effects of a new metalloproteinase inhibitor, BE16627B [L-N-(N-hydroxy-2-isobutylsuccinynamoyl)-seryl-L-valine, MW: 375.2] isolated from microbial cultures, on human tumor cell growth in nude mice were investigated. BE16627B inhibited metalloproteinases in enzyme assays, as well as gelatinolysis and collagenolysis...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580518
更新日期:1994-09-01 00:00:00