Abstract:
:We have induced plasmacytomas (MPC) in BALB/c radiochimeras (RCh) repopulated with syngeneic hemopoietic cells carrying distinctive chromosomal markers. A group of 38 RCh that received 0.5 ml pristane, followed by Abelson virus infection 2-3 weeks later, developed 7 tumors (18.5%) of donor origin after a relatively short latency period (X = 83 +/- 8.3 days). In contrast, only 3 (2%) MPCs were observed in 149 RChs that received 0.5 ml pristane 3 times at monthly intervals. Two of them originated from host cells. Pristane-treated RChs developed a less extensive oil granuloma (OG), compared with pristane-treated intact mice. This may explain the low incidence of MPC in the former. Our findings also suggest that Abelson virus can overcome the postulated deficiency of OG. MPC induction in the pristane + Abelson-virus-treated RCh system will facilitate the further characterization of the MPC precursor cell and the localization of genetic resistance vs. susceptibility factors at the donor vs. host level.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Silva S,Babonits M,Wiener F,Klein Gdoi
10.1002/ijc.2910440225subject
Has Abstractpub_date
1989-08-15 00:00:00pages
337-42issue
2eissn
0020-7136issn
1097-0215journal_volume
44pub_type
杂志文章abstract::A panel of eight conditionally immortal lines derived by infection of human breast epithelial cells with an amphotropic retrovirus transducing a ts mutant of SV40 large T-antigen was analyzed with respect to individual retroviral integration patterns. Each line contained multiple integration sites which were clonal an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570616
更新日期:1994-06-15 00:00:00
abstract::History of diabetes may be associated with decreased prostate cancer (PCa) risk. Published studies have not always accounted for time since diabetes diagnosis or confounding and effect modification by lifestyle factors. The authors investigated the relationship between diabetes and PCa risk in men in the Health Profes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24044
更新日期:2009-03-15 00:00:00
abstract::NY-ESO-1 antigen is a prototype of a class of cancer/testis antigens. We carried out a clinical trial using NY-ESO-1 whole protein as a cancer vaccine for 13 advanced cancer patients. We have recently reported that vaccine elicited humoral and cellular immune responses in 9 cancer patients including 4 esophageal cance...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23810
更新日期:2008-11-15 00:00:00
abstract::We have reported the establishment of a mitomycin-C (MMC)-resistant non-small-cell lung-cancer cell line, PC-9/MC4. As determined by an MTT assay, this resistant cell line was found to be 4 times more sensitive to adriamycin (ADM) than was the parental PC-9. There were no significant differences in sensitivity to etop...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1994-10-15 00:00:00
abstract::Recurrent deletions of chromosome fragments observed in neoplasms are thought to participate in tumor development through the inactivation of tumor-suppressor genes. In gliomas, the most frequent deletions involve chromosome arms 9p, 10q, 17p, 19q and 22q. We have analysed deletions of chromosome 22 in gliomas by stud...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1995-02-08 00:00:00
abstract::Gastric cancer is the second most common cause of cancer deaths worldwide. The identification of molecular genetic parameters that are associated with response to chemotherapy and prognosis is of utmost interest. We examined methylation of the apoptosis-related genes, TMS1 and DAPK, in 81 primary gastric cancers using...
journal_title:International journal of cancer
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更新日期:2008-02-01 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:2015-04-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2010-04-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
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更新日期:2009-02-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1998-03-16 00:00:00
abstract::Oxaliplatin, which is widely used as chemotherapy for certain solid cancers, frequently causes peripheral neuropathy. Commonly described neuropathic symptoms include aberrant sensations such as mechanical allodynia (hypersensitivity to normally innocuous stimuli). Although oxaliplatin neuropathy is a dose-limiting tox...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32043
更新日期:2019-10-15 00:00:00
abstract::By means of a chemical extraction procedure and confocal laser scanning microscopy, we investigated the kinetic patterns of uptake and biolocalization of 5-aminolevulinic acid (ALA)-induced porphyrins in s.c. transplanted tumors, adjacent normal skin and muscle, and liver of mice bearing mammary carcinoma, after i.p. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520318
更新日期:1992-09-30 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30039
更新日期:2016-07-15 00:00:00
abstract::The autophagy lysosome pathway is essential to maintain cell viability and homeostasis in response to many stressful environments, which is reported to play a vital role in cancer development and therapy. However, the association of genetic alterations of this pathway with risk of cancer remains unclear. Based on geno...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31288
更新日期:2018-07-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1219
更新日期:2001-05-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23962
更新日期:2009-01-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29055
更新日期:2015-02-15 00:00:00
abstract::Numerous reports suggest that interleukin-6 (IL-6) promotes survival and proliferation of tumor cells through the phosphorylation of a cell-signaling protein, signal-transducer-and-activator-of-transcription-3 (STAT3). Constitutive activation of STAT3 in head and neck squamous cell carcinoma (HNSCC) and its role in pr...
journal_title:International journal of cancer
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更新日期:2006-09-15 00:00:00
abstract::Several changes in smoking patterns over the past decades in Spain can be expected to result in a shift in lung-cancer mortality rates. We examined time trends in lung-cancer mortality from 1973-1997 using a log-linear Poisson age-period-cohort model. The standardized lung-cancer mortality rate for men almost doubled,...
journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1995-10-20 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2002-02-10 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2002-05-20 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1997-03-04 00:00:00
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journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1980-06-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260110
更新日期:1980-07-15 00:00:00