Association study of genetic variation in the autophagy lysosome pathway genes and risk of eight kinds of cancers.

abstract：:Intraductal papillary-mucinous carcinoma (IPMC) of the pancreas, a new entity of pancreatic cancer with a favorable prognosis, has shown a gradual increase in the number of reported cases. Patients with high-frequency microsatellite instability (MSI-H) tumors have been shown to survive longer than those with low-frequ...

journal_title：International journal of cancer

authors： Nakata B,Yashiro M,Nishioka N,Aya M,Yamada S,Takenaka C,Ohira M,Ishikawa T,Nishino H,Wakasa K,Seki S,Hirakawa K

更新日期：2002-12-20 00:00:00

abstract：:Folate-mediated one-carbon metabolism plays critical roles in DNA synthesis, repair and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate-metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of African ancestry. We co...

journal_title：International journal of cancer

authors： Gong Z,Yao S,Zirpoli G,David Cheng TY,Roberts M,Khoury T,Ciupak G,Davis W,Pawlish K,Jandorf L,Bovbjerg DH,Bandera EV,Ambrosone CB

更新日期：2015-08-01 00:00:00

abstract：:Therapeutic effectiveness against metastatic or even locally advanced pancreatic ductal adenocarcinoma (PDAC) is dismal, with 5-year survival less than 5%. Even in patients who undergo potentially curative resection, most patients' tumors recur in the liver. Improving therapies targeting or preventing liver metastases...

journal_title：International journal of cancer

authors： Kurahara H,Bohl C,Natsugoe S,Nishizono Y,Harihar S,Sharma R,Iwakuma T,Welch DR

更新日期：2016-08-01 00:00:00

abstract：:Isolated limb perfusion (ILP) with melphalan and tumor necrosis factor (TNF)-α is used to treat bulky, locally advanced melanoma and sarcoma. However, TNF toxicity suggests a need for better-tolerated drugs. Cilengitide (EMD 121974), a novel cyclic inhibitor of alpha-V integrins, has both anti-angiogenic and direct an...

journal_title：International journal of cancer

authors： Ten Hagen TL,Seynhaeve AL,de Wiel-Ambagtsheer Ga,de Bruijn EA,van Tiel ST,Ruegg C,Meyring M,Grell M,Goodman SL,Eggermont AM

更新日期：2013-06-01 00:00:00

abstract：:Freshly isolated human peripheral blood monocytes from healthy volunteers are not cytotoxic to allogeneic A375 melanoma cells, but they were rendered tumoricidal by incubation in vitro with either liposomes containing 5 micrograms/mumol phospholipid of muramyl tripeptide phosphatidylethanolamine (liposome-MTP-PE; opti...

journal_title：International journal of cancer

authors： Sone S,Tandon P,Utsugi T,Ogawara M,Shimizu E,Nii A,Ogura T

更新日期：1986-10-15 00:00:00

abstract：:Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also ...

journal_title：International journal of cancer

authors： Copeland BT,Bowman MJ,Boucheix C,Ashman LK

更新日期：2013-10-15 00:00:00

abstract：:NK cell recognition of tumor cells is mediated by a delicate balance of signals received by MHC class I-binding inhibitory NK cell receptors and activating NK cell receptors, which mainly bind to virus-, stress- or tumor-induced ligands. In addition, adhesion molecules such as the intercellular adhesion molecule-1 (IC...

journal_title：International journal of cancer

authors： Textor S,Accardi R,Havlova T,Hussain I,Sylla BS,Gissmann L,Cerwenka A

更新日期：2011-03-01 00:00:00

abstract：:Apoptin is a chicken anemia virus-derived, p53-independent, bcl-2-insensitive apoptotic protein with the ability to specifically induce apoptosis in tumor cells. To explore the use of the Apoptin gene in cancer gene therapy, we constructed a recombinant fowlpox virus expressing the Apoptin protein (vFV-Apoptin) and co...

journal_title：International journal of cancer

authors： Li X,Jin N,Mi Z,Lian H,Sun L,Li X,Zheng H

更新日期：2006-12-15 00:00:00

abstract：:T24 human bladder carcinoma cells reveal a high locomotor activity (70% locomoting cells) within a 3-dimensional collagen matrix. This high migratory activity is induced by an autocrine engagement of the interleukin-8 receptor A, as was shown by antibodies neutralizing the secreted interleukin-8. Treatment of the cell...

journal_title：International journal of cancer

authors： Lang K,Niggemann B,Zanker KS,Entschladen F

更新日期：2002-06-10 00:00:00

abstract：:This study investigates the role of tumor nitric oxide (NO) and vascular regulation in tumor ulceration following high-dose tumor necrosis factor-alpha (TNF) treatment. Using TNF-responsive (MethA) and nonresponsive (LL2) mouse tumors, tumor NO concentration was measured with an electrochemical sensor and tumor blood ...

journal_title：International journal of cancer

authors： Menon C,Bauer TW,Kelley ST,Raz DJ,Bleier JI,Patel K,Steele K,Prabakaran I,Shifrin A,Buerk DG,Sehgal CM,Fraker DL

更新日期：2008-07-15 00:00:00

abstract：:We previously reported that ganglioside GD1a, which is highly expressed in poorly metastatic FBJ-S1 cells, inhibits the serum-induced motility of FBJ-LL cells and that the metastatic potential of FBJ-LL cells is completely suppressed by enforced GD1a expression (Hyuga et al., Int J Cancer 1999;83:685-91). We recently ...

journal_title：International journal of cancer

authors： Hyuga S,Kawasaki N,Hyuga M,Ohta M,Shibayama R,Kawanishi T,Yamagata S,Yamagata T,Hayakawa T

更新日期：2001-11-01 00:00:00

abstract：:A comparative case-referent study was conducted using data from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), with the aim of clarifying whether histologic subtypes of gastric cancer exhibit different risk-factor patterns of habitual smoking. Our study comprised 995 histologically...

journal_title：International journal of cancer

authors： Inoue M,Tajima K,Yamamura Y,Hamajima N,Hirose K,Nakamura S,Kodera Y,Kito T,Tominaga S

更新日期：1999-03-31 00:00:00

abstract：:Germline CDKN2A mutations are found in 5-20% of melanoma families. Numerous studies have shown that carriers of CDKN2A mutations have increased risks of non-melanoma cancers, but so far there have been no studies investigating cancer risks in CDKN2A wild type (wt) melanoma families. In this prospective cohort study, i...

journal_title：International journal of cancer

authors： Helgadottir H,Höiom V,Tuominen R,Jönsson G,Månsson-Brahme E,Olsson H,Hansson J

更新日期：2015-11-01 00:00:00

abstract：:Mortality rates for cancer of all sites combined and for 12 selected sites or site groups in Estonia from 1965 to 1989 were studied to assess overall progress in controlling cancer. Between 1965-1969 and 1985-1989, age-standardized mortality (world population) increased by 12.0% among males and decreased by 5.1% among...

journal_title：International journal of cancer

authors： Leinsalu M,Rahu M

更新日期：1993-04-01 00:00:00

abstract：:Liver cancers are strongly linked to hepatitis B virus (HBV) and hepatitis C virus (HCV). Egypt has the highest prevalence of HCV worldwide and has rising rates of hepatocellular carcinoma (HCC). Egypt's unique nature of liver disease presents questions regarding the distribution of HBV and HCV in the etiology of HCC....

journal_title：International journal of cancer

authors： Lehman EM,Wilson ML

更新日期：2009-02-01 00:00:00

abstract：:Antibodies to the 27 kDa heat shock protein (hsp27) are present in some women with ovarian and endometrial cancers but not in women with nonmalignant conditions or healthy women. The appearance of these antibodies suggests that the corresponding protein (hsp27) may be present in an extracellular form in gynecologic ca...

journal_title：International journal of cancer

authors： Korneeva I,Caputo TA,Witkin SS

更新日期：2002-12-10 00:00:00

abstract：:Six distinct cell surface antigens of human trophoblast and choriocarcinoma were defined with MAbs. The distribution of the antigens was determined by MHA assays on 150 tumor cell lines and normal cell cultures and by immunofluorescence tests with a wide range of normal adult and fetal tissues and a tumor panel. Antig...

journal_title：International journal of cancer

authors： Rettig WJ,Cordon-Cardo C,Koulos JP,Lewis JL Jr,Oettgen HF,Old LJ

更新日期：1985-04-15 00:00:00

abstract：:Hypoxia is known to play important roles in the development and progression of tumors. We previously demonstrated that S100A4, a critical molecule for metastasis, was upregulated in ovarian cancer cells. Therefore, we examined the mechanisms of the upregulation of S100A4 expression in ovarian carcinoma cells, with par...

journal_title：International journal of cancer

authors： Horiuchi A,Hayashi T,Kikuchi N,Hayashi A,Fuseya C,Shiozawa T,Konishi I

更新日期：2012-10-15 00:00:00

abstract：:Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 common single-nucleotide polymorphisms (SNPs) in 149 genes of the f...

journal_title：International journal of cancer

authors： Dai W,Liu H,Xu X,Ge J,Luo S,Zhu D,Amos CI,Fang S,Lee JE,Li X,Nan H,Li C,Wei Q

更新日期：2019-11-15 00:00:00

abstract：:Our previous clinicopathologic study revealed an inverse association of liver metastasis of colorectal cancer and stromal expression of matrix metalloproteinase-9 (MMP-9) or urokinase receptor (uPAR). This suggests that host cells, particularly macrophages, expressing matrix-degrading enzymes/factors could be protecti...

journal_title：International journal of cancer

authors： Saito K,Takeha S,Shiba K,Matsuno S,Sorsa T,Nagura H,Ohtani H

更新日期：2000-04-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) is frequently expressed in triple-negative breast cancer (TNBC) and is a marker of poor prognosis in this patient population. Because activating mutations in this kinase are very rare events in breast cancer, we screened breast tumor gene expression profiles to examine the d...

journal_title：International journal of cancer

authors： Giricz O,Calvo V,Peterson EA,Abouzeid CM,Kenny PA

更新日期：2013-12-01 00:00:00

abstract：:Professional antigen-presenting cells (APC), e.g. dendritic cells, express immuno-proteasome components and process proteins for MHC presentation differently from non-immune cells. Thus, they induce reactivities against sets of peptides that do not overlap with those generated by non-professional APC, i.e., tumor cell...

journal_title：International journal of cancer

authors： Mangino G,Grazia Capri M,Barnaba V,Alberti S

更新日期：2002-10-01 00:00:00

abstract：:CD4(+) Th cells that are restricted by MHC class II molecules play an important role in the induction of antitumor immune responses. We have established a stable CD4(+) Th cell clone (Th35-1A) from the PBMCs of a patient with primary cutaneous melanoma. The Th cell clone is noncytolytic and proliferates specifically i...

journal_title：International journal of cancer

authors： Somasundaram R,Swoboda R,Caputo L,Lee A,Jackson N,Marincola FM,Guerry D,Herlyn D

更新日期：2003-04-10 00:00:00

abstract：:Smoking is indisputably linked to lung cancer, yet only a small fraction of smokers develops this disease. Although previously tobacco-derived carcinogens and enzyme polymorphisms have been identified to increase the risk for smokers, recent epidemiological data suggest even sex-specificity as a new and additional fac...

journal_title：International journal of cancer

authors： Stapelfeld C,Dammann C,Maser E

更新日期：2020-05-01 00:00:00

abstract：:A PCR assay using capillary electrophoresis was designed for the detection of c-erbB-2 gene amplification in alcohol-formalin-acetic acid (AFA)-fixed, paraffin-embedded biopsies from 81 consecutive breast tumors. c-erbB-2 expression was analyzed in the same samples using immuno-histochemistry (IHC). In the competitive...

journal_title：International journal of cancer

authors： de Cremoux P,Martin EC,Vincent-Salomon A,Dieras V,Barbaroux C,Liva S,Pouillart P,Sastre-Garau X,Magdelenat H

更新日期：1999-10-08 00:00:00

abstract：:Breast cancer incidence increases considerably in women who migrate from Japan to the United States. Based on the hypothesis that mammographic density in healthy mammograms reflects differences in breast cancer risk, we compared mammographic density in 3 groups of women at different levels of risk: Caucasian and Japan...

journal_title：International journal of cancer

authors： Maskarinec G,Nagata C,Shimizu H,Kashiki Y

更新日期：2002-11-01 00:00:00

abstract：:Prostate cancer is the most common malignancy in men, and patients with metastatic disease have poor outcome even with the most advanced therapeutic approaches. Most cancer therapies target the bulk tumor cells, but may leave intact a small population of tumor-initiating cells (TICs), which are believed to be responsi...

journal_title：International journal of cancer

authors： Marian CO,Wright WE,Shay JW

更新日期：2010-07-15 00:00:00

abstract：:Although aneuploidy is commonly observed in human cancers, the molecular mechanism underlying aneuploidization remains unclear. We used multiploid cancer model that had diploid and aneuploid cancer cells within the same cancerous tissue and attempted to detect specific epigenetic alterations associated with tumor cell...

journal_title：International journal of cancer

authors： Habano W,Sugai T,Jiao YF,Nakamura S

更新日期：2007-10-01 00:00:00

abstract：:We found that rhabdomyosarcoma (RMS) subcellular membranes contain sialyltransferase activities for LcOse4Cer and GgOse4Cer acceptors. Chromatographic analyses and neuraminidase lability of the sialyltransferase products indicated that the principal site of sialylation was the non-reducing terminal galactosyl moiety. ...

journal_title：International journal of cancer

authors： Liepkans VA

更新日期：1990-05-15 00:00:00

abstract：:To generate non-small cell lung cancer (NSCLC)-reactive lymphocytes, we transfected an HLA-A2-expressing human NSCLC line (1355) with the cDNA encoding the lymphocyte co-stimulatory molecule CD80. Following selection in G418, 1355.7 demonstrated stable cell-surface expression of CD80. Allogeneic mixed lymphocyte tumor...

journal_title：International journal of cancer

authors： Bixby DL,Yannelli JR

更新日期：1998-12-09 00:00:00