Abstract:
:Freshly isolated human peripheral blood monocytes from healthy volunteers are not cytotoxic to allogeneic A375 melanoma cells, but they were rendered tumoricidal by incubation in vitro with either liposomes containing 5 micrograms/mumol phospholipid of muramyl tripeptide phosphatidylethanolamine (liposome-MTP-PE; optimal dose, 500 nmol/ml) or recombinant human interferon gamma (rIFN-gamma; optimal dose, 100 U/ml). A combination of sub-threshold concentrations of liposome-MTP-PE (50 nmol/ml) and rIFN-gamma (1 or 10 U/ml) also induced significant tumor-cell killing, indicating that the effects of rIFN-gamma and liposome-MTP-PE in monocyte activation are synergistic. In contrast to rIFN-gamma, recombinant IFN-alpha and IFN-beta had additive effects with liposome-MTP-PE in human monocyte activation. Since recombinant human IFN-gamma has a synergistic effect with liposome-MTP-PE in monocyte activation, unlike IFN-alpha or IFN-beta, and liposome-MTP-PE as well as rIFN-gamma is available at standardized concentrations, this combination could be of clinical value in the treatment of disseminated malignant disease.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Sone S,Tandon P,Utsugi T,Ogawara M,Shimizu E,Nii A,Ogura Tdoi
10.1002/ijc.2910380407subject
Has Abstractpub_date
1986-10-15 00:00:00pages
495-500issue
4eissn
0020-7136issn
1097-0215journal_volume
38pub_type
杂志文章abstract::Increasing use of heavy ions for cancer therapy and concerns from exposure to heavy charged particles in space necessitate the study of the basic biological mechanisms associated with exposure to heavy ions. As the most critical damage induced by ionizing radiation is DNA double strand break (DSB), this review focuses...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.26445
更新日期:2012-03-01 00:00:00
abstract::Alterations in TGF-beta signaling appear to be associated with an altered risk of developing cancer, including breast cancer. We carried out a case-control study on 8 polymorphisms, including 5 in the TGF-beta1 gene (G-800A, C-509T, Leu10-->Pro, Arg25-->Pro and Thr263-->Ile), a polyalanine polymorphism (9A-->6A) in th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20370
更新日期:2004-10-20 00:00:00
abstract::The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese populat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11332
更新日期:2003-10-10 00:00:00
abstract::A recent clinical trial found a protective role of niacinamide, a derivative of niacin, against skin cancer recurrence. However, there is no epidemiologic study to assess the association between niacin intake and risk of skin cancer [basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma]. We prospecti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30630
更新日期:2017-05-01 00:00:00
abstract::Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23774
更新日期:2008-11-15 00:00:00
abstract::Sperm protein 17 (Sp17) is an antigenic protein highly expressed in spermatozoa. Sp17 expression was demonstrated recently in multiple myeloma, suggesting that it may be a novel cancer-testis antigen. Expression of Sp17 mRNA and protein was examined in human ovarian tumors. Sp17 mRNA was evaluated by reverse transcrip...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11617
更新日期:2004-03-01 00:00:00
abstract::When sensitized leukocytes were re-exposed to EBV antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910200106
更新日期:1977-07-15 00:00:00
abstract::To examine the immunological mechanisms involved in cancer gene therapy using the herpes simplex virus thymidine kinase (HSV-tk) gene and ganciclovir (GCV), murine hepatocellular carcinoma (HCC) cells, BNL1ME A.7R.1, were transduced retrovirally with the HSV-tk gene. HSV-tk-transduced cells exhibited a more than 2,000...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19991029)83:3<374::aid-ijc
更新日期:1999-10-29 00:00:00
abstract::The antineoplastic effect of paclitaxel is mainly related to its ability to bind the beta subunit of tubulin, thus preventing tubulin chain depolarization and inducing apoptosis. The relevance of the Class I beta-tubulin characteristics have also been confirmed in the clinical setting where mutations of paclitaxel-bin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22557
更新日期:2007-05-15 00:00:00
abstract::Paclitaxel is widely used to treat cancer patients through the blocking of mitosis and result in formation of polyploidy giant cancer cells (PGCCs), which are generally believed to be nondividing cells or in mitotic catastrophe. Here, we showed that PGCCs following the treatment of paclitaxel of MCF-7 breast cancer ce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28319
更新日期:2014-02-01 00:00:00
abstract::In a previous study, human ZNF312b was identified as a cell proliferation-associated oncogene via the K-ras/extracellular signal-regulated kinase cascade in gastric cancer. However, the mechanism concerning its transcriptional activation remains unknown. Here, we show that DNA methylation and histone acetylation of th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25871
更新日期:2011-11-01 00:00:00
abstract::The effect on tumor progression produced by the injection of VCN-treated tumor cells in dogs with spontaneous mammary tumors was investigated. Untreated dogs of different races and different ages with at least two palpable spontaneous mammary tumors were selected. One of the tumors was left in the animal for further c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150307
更新日期:1975-03-15 00:00:00
abstract::Neuroendocrine gastrointestinal tumors take up, decarboxylate and store large amounts of monoamines. Radioactive-labeled monoamines like the norepinephrine analogue meta-iodobenzylguanidine (MIBG) have been used for the imaging of neuroendocrine tumors for many years. MIBG is selectively taken up via norepinephrine tr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10553
更新日期:2002-09-20 00:00:00
abstract::The aim of our study was to estimate uptake of prostate-specific antigen (PSA) testing in an entire country, including time trends and geographical differences. Data from the Swedish Cancer Register on prostate cancer incidence between 1980 and 2007 and published data from the Gothenburg branch of the European randomi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25846
更新日期:2011-10-15 00:00:00
abstract::We reported that tumor endothelial cells (TECs) differ from normal endothelial cells (NECs) in many aspects, such as gene expression profiles. Although CXCR7 is reportedly highly expressed in blood vessels of several tumors, its function in TECs is still unknown. To investigate this role, we isolated TECs from mouse t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29655
更新日期:2015-12-15 00:00:00
abstract::The incidence of testicular cancer was examined in the Nordic and Baltic countries, Poland and Germany by collaboration among 10 cancer registries. Population-based registers were used to analyze a total of 34,309 cases, diagnosed from the start of registration (varying from 1943 in Denmark to 1980 in Latvia and Lithu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910590108
更新日期:1994-10-01 00:00:00
abstract::The macrophage electrophoretic mobility (MEM) test was performed on guinea-pig macrophages treated with the interaction products of encephalitogenic protein and peripheral lymphocytes from 44 patients with colorectal cancer and 33 "healthy" controls. In 54/60 tests involving patients, statistically significant reducti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910190407
更新日期:1977-04-15 00:00:00
abstract::In a formal prospective-retrospective analysis of the phase III SBG0102 clinical trial randomizing metastatic breast cancer patients to gemcitabine-docetaxel or to single agent docetaxel, patients with basal-like tumors by PAM50 gene expression had significantly better overall survival in the gemcitabine arm. By immun...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2019-05-15 00:00:00
abstract::Obesity is a well-known risk factor for postmenopausal breast cancer. In contrast, the relationship between obesity and stage of breast cancer at diagnosis is less clear. We hypothesized that increased breast size in obese women may delay discovery of breast tumors. Thus, the purpose of our study was to examine whethe...
journal_title:International journal of cancer
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abstract::Classical Hodgkin lymphoma (HL) is characterized by the presence of Hodgkin and Reed-Sternberg cells (H&RS) and a prominent lymphocytic infiltration. We previously reported Hodgkin-like adult T-cell leukemia/lymphoma (HL-like ATLL) (new WHO classification). Various CXC and CC chemokines are expressed on H&RS cells and...
journal_title:International journal of cancer
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abstract::We have established a number of cell lines from Merkel cell carcinoma (MCC) of the skin. In many respects these cell lines resemble those established from small cell lung cancer (SCLC) and it is difficult to differentiate between metastatic MCC and SCLC on morphological or histochemical criteria. Both are thought to b...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580223
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abstract::Specific estrogen, progesterone and androgen receptors were determined in 19 well-characterized squamous-cell carcinoma (SCC) cell lines. Ten of the lines were derived from patients with SCC of the larynx and nine were from patients with SCC originating in other areas of the head and neck. Estrogen receptors (ER) were...
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pub_type: 杂志文章
doi:10.1002/ijc.2910330105
更新日期:1984-01-15 00:00:00
abstract::In an attempt to obtain cell lines from the different components found in primary breast cancers, we used a low-calcium medium to culture epithelial cells of mixed phenotype and a recombinant T antigen containing retrovirus to immortalize cells found in these cultures. In each case, the histology of the sample used fo...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910510417
更新日期:1992-06-19 00:00:00
abstract::Multiple myeloma (MM) is characterized by accumulation of monoclonal plasma cells in the bone marrow and progression of lytic bone lesions. The mechanisms of enhanced bone resorption in patients with myeloma are not fully defined. We have previously identified the role of brain-derived neurotrophic factor (BDNF) in pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26059
更新日期:2012-02-15 00:00:00
abstract::Because renal-cell carcinoma (RCC) is considered relatively resistant to radio- and chemotherapy, RCC patients may benefit from new treatment modalities, e.g. immunotherapy. In vitro and in vivo studies suggest that combinations of cytokines such as interferon gamma or interferon alpha (IFN-gamma, IFN-alpha) and tumor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560220
更新日期:1994-01-15 00:00:00
abstract::When effector cells from most individuals are tested directly against a number of target cells for cell-mediated cytotoxicity, most of the reactivity is non-selective. This apparent non-selectiveness is a result of specific activity against multiple antigens on target cells by each effector suspension. The specific re...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910190603
更新日期:1977-06-15 00:00:00
abstract::Human papillomavirus (HPV) causes oropharyngeal squamous cell carcinoma (OPSCC), although strongly divergent results have been reported regarding the prevalence of HPV16 in different countries, whether this represents important differences in etiology remains unclear. Applying rigorous protocols for sample processing,...
journal_title:International journal of cancer
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更新日期:2017-05-01 00:00:00
abstract::An Epstein-Barr virus-related herpesvirus, termed Herpesvirus papio (HVP), was isolated from baboons (Papio hamadryas) at the Institute of Experimental Pathology and Therapy, Sukhumi, USSR, where there is a continuing outbreak of lymphoma. In the present study sera from diseased baboons and from age- and sex-matched c...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910230208
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abstract::Tyrosine kinase inhibitors are effective treatments for cancers. Knowing the specific kinase mutants that drive the underlying cancers predict therapeutic response to these inhibitors. Thus, the current protocol for personalized cancer therapy involves genotyping tumors in search of various driver mutations and subseq...
journal_title:International journal of cancer
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abstract::We have previously described an inverse relationship between Cu-Zn superoxide dismutase (SOD) activity and invasiveness of a clone of human tongue cancer cells. In these cells, suppression of Cu-Zn SOD activity by transfection with anti-sense cDNA enhanced motility in vitro. The present studies were undertaken to dete...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1997-10-09 00:00:00