Abstract:
:Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of FOXO1 in neoplasms. This article may serve as a guide for future research and identify FOXO1 as a potent therapeutic target in neoplasms.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Jiang S,Li T,Yang Z,Hu W,Yang Ydoi
10.1002/ijc.31338subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1560-1568issue
7eissn
0020-7136issn
1097-0215journal_volume
143pub_type
杂志文章,评审abstract::Although menopausal hormone therapy (MHT) seemingly increases the risk of ovarian cancer, evidence is insufficient whether the risk varies between various MHT formulations, regimens and administration modes. With the aim of filling these knowledge gaps, we investigated the effect of different MHT treatment options on ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32706
更新日期:2020-07-01 00:00:00
abstract::The incidence of adult T-cell leukemia/lymphoma (ATL) and its impact on that of total non-Hodgkin lymphoma (NHL) were evaluated in Nagasaki, an area in southwestern Japan where human T-cell lymphotropic virus type I (HTLV-I) is endemic. The first study area comprised 4 towns located on the K Islands, which had a popul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000201)85:3<319::aid-ijc
更新日期:2000-02-01 00:00:00
abstract::Rabbits were immunized with extracts of primary or grafted intestinal adeno-carcinomas induced by carcinogenic drugs in inbred rats. After absorption with normal tissue extracts, the antisera were able to recognize three tumor-associated antigens. Two of them were glycoproteins, present in cancer cells but also, in tr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150117
更新日期:1975-01-15 00:00:00
abstract::Paraffin sections (n = 168, 27 benign, 16 low malignant potential [LMP] and 125 malignant tumours) from epithelial ovarian tumours were evaluated immunohistochemically for expression of retinoblastoma gene product (pRB) and p53 protein, and the relationship among pRB, p53 and cyclin-dependent kinase inhibitor 2 (CDKN2...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970822)74:4<407::aid-ijc
更新日期:1997-08-22 00:00:00
abstract::The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954) to a potent cytotoxic species that generates interstrand crosslinks in DNA. Nitroreductase therefore has potential as a "suicide enzyme" for cancer gene therapy, as cells that ex...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000615)86:6<848::aid-ijc
更新日期:2000-06-15 00:00:00
abstract::In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31524
更新日期:2018-09-15 00:00:00
abstract::A cDNA library specific for mRNA over-expressed in prostate cancer was generated by subtractive hybridization of transcripts originating from prostatic hyperplasia and cancer tissues. cDNA encoding ribosomal proteins L4, L5, L7a, L23a, L30, L37, S14 and S18 was found to be present among 100 analyzed clones. Levels of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980925)78:1<27::aid-ijc6
更新日期:1998-09-25 00:00:00
abstract::We present data on test positivity, relative sensitivity, rates of detection and relative specificity for primary human papillomavirus (HPV) testing with different cutoff levels for test positivity, in comparison to conventional cytology. In 2003-2004, 18,438 women were screened primarily with Hybrid Capture 2 (HC 2) ...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.23839
更新日期:2008-12-15 00:00:00
abstract::Several changes in smoking patterns over the past decades in Spain can be expected to result in a shift in lung-cancer mortality rates. We examined time trends in lung-cancer mortality from 1973-1997 using a log-linear Poisson age-period-cohort model. The standardized lung-cancer mortality rate for men almost doubled,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1575
更新日期:2002-01-01 00:00:00
abstract::Reverse-transcriptase polymerase chain reaction has been used to analyze the expression of 2 latent genes (EBNA-1 and LMP-1) and one replicative gene (BZLF-1) of Epstein-Barr virus in mononuclear cells from bone marrow and peripheral blood of healthy donors. EBV-gene transcription was detected in 8 out of 15 bone-marr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970304)70:5<524::aid-ijc
更新日期:1997-03-04 00:00:00
abstract::A series of 39 human brain tumors has been screened for the presence or absence of SV40-related T antigen by the direct and indirect immunoperoxidase methods. Two tumors of ependymal origin (malignant ependymoma, choroid plexus papilloma) revealed markedly positive nuclear staining for T antigen both in vivo and in vi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210104
更新日期:1978-01-15 00:00:00
abstract::In recent years, Akt signaling has gained recognition for its functional role in more aggressive, therapy-resistant malignancies. As it is frequently constitutively active in cancer cells, several drugs are being investigated for their ability to inhibit Akt signaling. The purpose of this study is to determine effect ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24419
更新日期:2009-08-15 00:00:00
abstract::Serum and tumor tissue from breast cancer patients were evaluated for the presence of alpha subunit of hCG, by means of the specific radioimmunoassay. Elevated serum levels occurred in 0/50 (0%) of normal female controls, 1/17 (6%) of patients with benign breast disease, 3/53 (6%) of patients with primary breast cance...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250508
更新日期:1980-05-15 00:00:00
abstract::We evaluated RS5444, a thiazolidinedione high affinity PPARgamma agonist, for the ability to inhibit colon carcinogenesis in azoxymethane (AOM)-treated mice. In our initial experiment, mice were treated with RS5444 during AOM treatment, and the drug was withdrawn 12 weeks after the last injection of AOM. RS5444 signif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23640
更新日期:2008-09-01 00:00:00
abstract::We quantified the expression of survivin, both as mRNA in real-time PCR and protein in immunohistochemistry, in tumor samples of 112 patients with esophageal cancer (56 squamous cell carcinomas and 56 adenocarcinomas). Overall survival of squamous cell carcinoma patients with high survivin mRNA levels was significantl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21923
更新日期:2006-10-01 00:00:00
abstract::Leukemia stem cells (LSCs) might originate from malignant transformation of normal hematopoietic stem cells (HSCs), or alternatively, of progenitors in which the acquired mutations have re-installed a dysregulated self-renewal program. LSCs are on top of a hierarchy and generate leukemia cells with more differentiated...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.26318
更新日期:2011-11-15 00:00:00
abstract::Anti-estrogen toremifene inhibits growth of the 7,12-dimethylbenz(a)anthracene(DMBA)-induced rat mammary carcinoma. The changes in proliferation and cell death were studied in detail. Proliferation was measured by counting mitotic figures in histologic sections, expressed by volume-corrected mitotic index (M/V INDEX)....
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550429
更新日期:1993-10-21 00:00:00
abstract::We present a pilot study that aims to examine the possibility to easily and noninvasively detect and discriminate females with ovarian cancer (OC) from females that have no tumor(s) and from females that have benign genital tract neoplasia, using exhaled breath samples. The study is based on clinical samples and data ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29166
更新日期:2015-03-15 00:00:00
abstract::We used a cross-sectional survey to examine short-term anxiety and distress in women receiving different results following routine human papillomavirus (HPV) primary testing at cervical screening. Participants were women aged 24-65 (n = 1,127) who had attended screening at one of five sites piloting HPV primary screen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32540
更新日期:2020-04-15 00:00:00
abstract::Folate-mediated one-carbon metabolism plays critical roles in DNA synthesis, repair and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate-metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of African ancestry. We co...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29434
更新日期:2015-08-01 00:00:00
abstract::While platelet-derived growth factor, PDGF, is not regularly expressed in mesenchymal tissues, PDGF B mRNA is often found in tumors derived from these tissues. PDGF B protein is also present, but the protein levels in individual tumors do not appear to correlate well with those of the mRNA. PDGF B is homologous to the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-01-15 00:00:00
abstract::The survival experience of 284 patients with cancer of the cervix uteri registered by the population-based Zimbabwe National Cancer Registry in 1995-1997 is described. The vital status of these subjects was established by linkage with death registration and by retrieval of patient files from medical records department...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11670
更新日期:2004-03-20 00:00:00
abstract::Human papillomavirus (HPV) infection is the pathogenesis of anogenital cancers and genital warts in both men and women, whereas there is a scarcity of large studies focused on HPV prevalence in different anogenital sites of both sexes in the same population. From May to July 2014, 2,309 men and 2,378 women aged 18-55 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31128
更新日期:2018-03-15 00:00:00
abstract::Seven human ocular melanoma cell lines were established in vitro and 3 of these, GU-4, LLN-40 and its subline C17-11, were characterized. Mice were immunized with these ocular melanoma cell lines, and 2 hybridomas producing monoclonal IgG1 antibodies (MAb) were produced. MAb 2/10SN recognizes a 44-kDa monomeric protei...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510510
更新日期:1992-07-09 00:00:00
abstract::The loss of E-cadherin expression and the translocation of beta-catenin to the nucleus are frequently associated with the metastatic conversion of epithelial cells. In the nucleus, beta-catenin binds to the TCF/LEF-1 (T-cell factor/ lymphoid enhancer factor) transcription factor family resulting in the activation of s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21291
更新日期:2006-01-01 00:00:00
abstract::Studies in human, animal and cellular systems suggest that phenols from virgin olive oil are capable of inhibiting several stages in carcinogenesis, including metastasis. The invasion cascade comprises cell attachment to extracellular matrix components or basement membrane, degradation of basement membrane by proteoly...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23148
更新日期:2008-02-01 00:00:00
abstract::A population-based case-control study of gastric cancer was conducted in areas with contrasting incidence rates in Sweden. Face-to-face interviews were carried out with 338 (74.1%) of all eligible cases and 679 (77.3%) of the selected controls. Consumption of selected nutrients during adolescence and 20 years prior to...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570505
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journal_title:International journal of cancer
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更新日期:2003-06-20 00:00:00
abstract::Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910500605
更新日期:1992-04-01 00:00:00
abstract::Human mammary carcinoma cell lines (MCF-7) were analysed for their hormone sensitivity before and after transfection with a v-Ha-ras oncogene or with a neomycin-resistance gene followed by selection in vitro or in vivo. Our aim was to test how the expression of the ras oncogene would influence the estradiol sensitivit...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1990-09-15 00:00:00