当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CANCER期刊下所有文献 > Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation.

Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation.

Abstract：

:Azacytidine and decitabine are approved for treatment of acute myeloid leukemias and myelodysplastic syndromes. While clinical responses are attributed to epigenetic effects and induction of apoptosis in malignant cells, these azanucleosides also affect antitumor immune responses. NK cells as components of innate immunity may confine development and progression of cancer. Numerous therapeutic strategies presently aim to reinforce NK reactivity against hematopoietic malignancies. We here comparatively analyzed the effect of the two clinically available azanucleosides and report that NK cytotoxicity and IFN-γ production are significantly impaired by pharmacological concentrations of azacytidine but enhanced by decitabine. This was not due to alterations in the target cells but caused by direct effects on NK cells depending on the chemical modifications by which azanucleosides differ from their physiological analogues. Although azacytidine impaired mRNA synthesis and induced apoptosis in NK cells, decitabine did not per se alter NK cell viability or reactivity but enhanced responsiveness to activating stimuli by inducing transcription of genes involved in NK reactivity. Tantalizingly, these effects were independent of incorporation of the azanucleosides into DNA during cell division. While azacytidine impairs NK antitumor immunity, decitabine augments NK reactivity by yet unidentified mechanisms and may thus serve well in therapeutic strategies combining its effects on malignant cells with its ability to enhance NK functions.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Schmiedel BJ,Arélin V,Gruenebach F,Krusch M,Schmidt SM,Salih HR

doi

10.1002/ijc.25635

subject

Has Abstract

pub_date

2011-06-15 00:00:00

pages

2911-22

issue

12

eissn

0020-7136

issn

1097-0215

journal_volume

128

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CANCER文献大全
  • Urine estrogens and breast cancer risk factors among post-menopausal women.

    abstract：:Creatinine-adjusted levels of estrone, estradiol and estriol were determined in overnight urine specimens from 220 post-menopausal women, aged 54 to 66 years, from Boston (121 women) and Athens (99 women). The associations of individual and total estrogens with various characteristics of the women (age at menopause, y...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910400602

    authors： Trichopoulos D,Brown J,MacMahon B

    更新日期：1987-12-15 00:00:00

  • BYL719, a new α-specific PI3K inhibitor: single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma.

    abstract：:It has been established that disturbances in intracellular signaling pathways play a considerable part in the oncologic process. Phosphatidylinositol-3-kinase (PI3K) has become of key interest in cancer therapy because of its high mutation frequency and/or gain in function of its catalytic subunits in cancer cells. We...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.29040

    authors： Gobin B,Huin MB,Lamoureux F,Ory B,Charrier C,Lanel R,Battaglia S,Redini F,Lezot F,Blanchard F,Heymann D

    更新日期：2015-02-15 00:00:00

  • Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to gene-therapeutic overexpression of REIC/Dkk-3.

    abstract：:We have recently shown that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The aim of the present study was to determine the molecular mechanisms...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.24764

    authors： Tanimoto R,Sakaguchi M,Abarzua F,Kataoka K,Kurose K,Murata H,Nasu Y,Kumon H,Huh NH

    更新日期：2010-04-01 00:00:00

  • The growth inhibitory effect of actein on human breast cancer cells is associated with activation of stress response pathways.

    abstract：:Previous studies indicate that the triterpene glycoside actein from the herb black cohosh inhibits growth of human breast cancer cells. This study seeks to identify genes altered in human breast cancer cells by treatment with actein, using gene expression analysis. We treated MDA-MB-453 human breast cancer cells with ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.22897

    authors： Einbond LS,Su T,Wu HA,Friedman R,Wang X,Ramirez A,Kronenberg F,Weinstein IB

    更新日期：2007-11-01 00:00:00

  • Measurement of a pancreatic cancer-associated antigen (DU-PAN-2) detected by a monoclonal antibody in sera of patients with digestive cancers.

    abstract：:DU-PAN-2 is a high-molecular-weight glycoprotein defined by a murine monoclonal antibody (MAb) against a pancreatic ductal adenocarcinoma cell line. In order to evaluate the usefulness of this antigen as a tumor marker, we determined the serum level of the antigen by competitive inhibition radioimmunoassay in sera fro...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910370509

    authors： Sawabu N,Toya D,Takemori Y,Hattori N,Fukui M

    更新日期：1986-05-15 00:00:00

  • Migration and death from malignant melanoma.

    abstract：:The age-standardized mortality rates for malignant melanoma of the skin in immigrants to New Zealand were compared with those of New Zealand-born non-Maoris. Immigrants from European countries had mortality rates that were generally similar to those prevailing in their countries of origin, although, among immigrants f...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910360208

    authors： Cooke KR,Fraser J

    更新日期：1985-08-15 00:00:00

  • Randomized trial on the effect of radiotherapy in addition to 6 cycles CMF in node-positive breast-cancer patients. The German Breast-Cancer Study Group.

    abstract：:In 1984 the GBSG started a multicenter randomized trial to compare the effectiveness of 6 cycles of cyclophosphamide, methotrexate and fluorouracil (CMF) with or without radiotherapy (RT) as adjuvant treatment in node-positive breast-cancer patients treated by mastectomy. During 5 years, 199 patients were randomized. ...

    journal_title：International journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1002/(sici)1097-0215(20000501)86:3<408::aid-ijc

    authors： Schmoor C,Bastert G,Dunst J,Bojar H,Christmann D,Unbehaun V,Tümmers G,Bauer W,Sauerbrei W,Schumacher M

    更新日期：2000-05-01 00:00:00

  • Expression of Epstein-Barr virus latent infection genes and oncogenes in lymphoma cell lines derived from pyothorax-associated lymphoma.

    abstract：:Malignant lymphomas frequently develop in the pleural cavity of patients with long-standing pyothorax. The term pyothorax-associated lymphoma (PAL) has been proposed for this type of tumor. Most PALs are diffuse lymphomas of the B-cell type and contain Epstein-Barr virus (EBV) DNA. We have established 2 lymphoma cell ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(SICI)1097-0215(19960703)67:1<86::AID-IJC1

    authors： Kanno H,Yasunaga Y,Ohsawa M,Taniwaki M,Iuchi K,Naka N,Torikai K,Shimoyama M,Aozasa K

    更新日期：1996-07-03 00:00:00

  • GD2-mediated melanoma cell targeting and cytotoxicity of liposome-entrapped fenretinide.

    abstract：:Melanoma is a highly malignant and increasingly common neoplasm. Because metastatic melanoma remains incurable, new treatment approaches are needed. Immunoliposomes have been previously shown to enhance the selective localization of immunoliposome-entrapped drugs to solid tumors with improvements in the therapeutic in...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19990412)81:2<268::aid-ijc

    authors： Pagnan G,Montaldo PG,Pastorino F,Raffaghello L,Kirchmeier M,Allen TM,Ponzoni M

    更新日期：1999-04-12 00:00:00

  • A case-control study of diet and lung cancer in northeast China.

    abstract：:A case-control study involving interviews with 227 lung-cancer cases and 227 matched hospital controls was conducted in Heilongjiang Province in northeast China to examine the influence of dietary factors on the risk of developing lung cancer. Lung-cancer cases were all incident cases judged to be suitable candidates ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19970611)71:6<924::aid-ijc

    authors： Hu J,Johnson KC,Mao Y,Xu T,Lin Q,Wang C,Zhao F,Wang G,Chen Y,Yang Y

    更新日期：1997-06-11 00:00:00

  • Determining MDR1/P-glycoprotein expression in breast cancer.

    abstract：:The mechanism of chemotherapy resistance in breast cancer is unresolved. MDR1/P-glycoprotein (P-Gp) over-expression confers multidrug resistance in vitro and might play a role in clinical breast cancer. Studies using clinical samples have yielded conflicting results. MDR1/P-Gp mRNA expression was determined relative t...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0215(20010701)93:1<114::aid-ijc1309>3

    authors： Faneyte IF,Kristel PM,van de Vijver MJ

    更新日期：2001-07-01 00:00:00

  • The bidirectional interaction of the gut microbiome and the innate immune system: Implications for chemotherapy-induced gastrointestinal toxicity.

    abstract：:Chemotherapy-induced gastrointestinal toxicity (CIGT) occurs in up to 80% of all patients undergoing cancer treatment, and leads to symptoms such as diarrhoea, abdominal bleeding and pain. There is currently limited understanding of how to predict an individual patient's risk of CIGT. It is believed the gut microbiome...

    journal_title：International journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1002/ijc.31836

    authors： Secombe KR,Coller JK,Gibson RJ,Wardill HR,Bowen JM

    更新日期：2019-05-15 00:00:00

  • Breast cancer risk in mothers of multiple births.

    abstract：:Data from an international case-control study of breast cancer that was conducted in the 1960s were used to examine whether multiple births affect the risk of breast cancer in the mother. Among 2821 parous breast-cancer patients, 88 had had one or more multiple births, whereas among 8882 controls 247 had had one or mo...

    journal_title：International journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1002/ijc.2910540114

    authors： Hsieh CC,Goldman M,Pavia M,Ekbom A,Petridou E,Adami HO,Trichopoulos D

    更新日期：1993-04-22 00:00:00

  • Beta-galactoside alpha2,6 sialyltransferase in human colon cancer: contribution of multiple transcripts to regulation of enzyme activity and reactivity with Sambucus nigra agglutinin.

    abstract：:Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0215(20001001)88:1<58::aid-ijc9>3.0.c

    authors： Dall'Olio F,Chiricolo M,Ceccarelli C,Minni F,Marrano D,Santini D

    更新日期：2000-10-01 00:00:00

  • The association between Epstein-Barr virus and Chinese Hodgkin's disease.

    abstract：:Epstein-Barr virus (EBV) can be detected in Hodgkin and Reed-Sternberg (HRS) cells in about one-half of cases of Hodgkin's disease (HD) in Western countries. To determine whether EBV is also associated with HD in a developing country such as China, we studied paraffin sections from 28 Chinese cases of HD for expressio...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910550303

    authors： Zhou XG,Hamilton-Dutoit SJ,Yan QH,Pallesen G

    更新日期：1993-09-30 00:00:00

  • Randomized phase II trial of TEGAFIRI (tegafur/uracil, oral leucovorin, irinotecan) compared with FOLFIRI (folinic acid, 5-fluorouracil, irinotecan) in patients with unresectable/recurrent colorectal cancer.

    abstract：:Irinotecan-based chemotherapy with bevacizumab is one of the first-line standard therapies for metastatic colorectal cancer (mCRC). TEGAFIRI (UFT/LV + irinotecan) is an irinotecan-based chemotherapy regimen. Currently, few clinical data regarding TEGAFIRI are available. This study evaluated the efficacy and safety of ...

    journal_title：International journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1002/ijc.30127

    authors： Shigeta K,Hasegawa H,Okabayashi K,Tsuruta M,Ishii Y,Endo T,Ochiai H,Kondo T,Kitagawa Y

    更新日期：2016-08-15 00:00:00

  • galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas.

    abstract：:Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage and in 5 normal uroth...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19990219)84:1<39::aid-ijc8

    authors： Cindolo L,Benvenuto G,Salvatore P,Pero R,Salvatore G,Mirone V,Prezioso D,Altieri V,Bruni CB,Chiariotti L

    更新日期：1999-02-19 00:00:00

  • The neu-oncogene protein as a predictive factor for haematogenous metastases in breast cancer patients.

    abstract：:In a prospective study with a median follow-up of 13 months on a series of 71 breast cancer patients, 9 developed haematogenous metastases. The neu protein was found on the cell membranes in 27 of the 71 carcinomas (38%) by an immunohistochemical technique using a monoclonal antibody (MAb). Eight of the 9 patients wit...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910450112

    authors： De Potter CR,Beghin C,Makar AP,Vandekerckhove D,Roels HJ

    更新日期：1990-01-15 00:00:00

  • A cluster randomized controlled trial of visual, cytology and human papillomavirus screening for cancer of the cervix in rural India.

    abstract：:The impact of screening by visual inspection with acetic acid (VIA), cytology or HPV testing on cervical cancer incidence and mortality is investigated in a cluster randomized controlled trial in India. We report findings after the screening phase, when 52 clusters, with a total of 142,701 women aged 30-59 years in Os...

    journal_title：International journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1002/ijc.21050

    authors： Sankaranarayanan R,Nene BM,Dinshaw KA,Mahe C,Jayant K,Shastri SS,Malvi SG,Chinoy R,Kelkar R,Budukh AM,Keskar V,Rajeshwarker R,Muwonge R,Kane S,Parkin DM,Chauhan MK,Desai S,Fontaniere B,Frappart L,Kothari A,Lucas E

    更新日期：2005-09-10 00:00:00

  • The cell-specific anti-proliferative effect of reduced glutathione is mediated by gamma-glutamyl transpeptidase-dependent extracellular pro-oxidant reactions.

    abstract：:We have shown earlier that extracellular GSH can exert a cell-specific growth-inhibitory effect on human tumor cells. In the present study, 2 human ovarian carcinoma cell lines (A2780 and IGROV-1) were used to investigate the biochemical basis of the GSH growth-inhibitory effect. Whereas cells were resistant, A2780 ce...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19970410)71:2<246::aid-ijc

    authors： Perego P,Paolicchi A,Tongiani R,Pompella A,Tonarelli P,Carenini N,Romanelli S,Zunino F

    更新日期：1997-04-10 00:00:00

  • Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression.

    abstract：:Apigenin is a plant flavonoid that is thought to play a role in the prevention of carcinogenesis. However, its mechanism of action has not yet been elucidated. Because of the importance of angiogenesis in tumor growth, we investigated the effect of apigenin on endothelial and smooth-muscle cells in an in vitro model. ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(20000301)85:5<691::aid-ijc

    authors： Trochon V,Blot E,Cymbalista F,Engelmann C,Tang RP,Thomaïdis A,Vasse M,Soria J,Lu H,Soria C

    更新日期：2000-03-01 00:00:00

  • Germline APOBEC3B deletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype, PIK3CA mutations, and immune activation.

    abstract：:A 30-kb deletion that eliminates the coding region of APOBEC3B (A3B) is >5 times more common in women of Asian compared to European descent. This polymorphism creates a chimera with the APOBEC3A (A3A) coding region and A3B 3'UTR, and is associated with an increased risk for breast cancer in Asian women. Here, we explo...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.33463

    authors： Pan JW,Zabidi MMA,Chong BK,Meng MY,Ng PS,Hasan SN,Sandey B,Bahnu S,Rajadurai P,Yip CH,Rueda OM,Caldas C,Chin SF,Teo SH

    更新日期：2021-01-07 00:00:00

  • Erionite and asbestos differently cause transformation of human mesothelial cells.

    abstract：:Malignant mesothelioma (MM) is an aggressive tumor associated with environmental or occupational exposure to asbestos fibers. Erionite is a fibrous zeolite, morphologically similar to asbestos and it is assumed to be even more carcinogenic. Onset and progression of MM has been suggested as the result of the cooperatio...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.22687

    authors： Bertino P,Marconi A,Palumbo L,Bruni BM,Barbone D,Germano S,Dogan AU,Tassi GF,Porta C,Mutti L,Gaudino G

    更新日期：2007-07-01 00:00:00

  • Correlation of numerical and structural status of chromosome 16 with histological type and grade of non-invasive and invasive breast carcinomas.

    abstract：:Loss of heterozygosity on chromosome arm 16q frequently occurs in human breast carcinomas regardless of the histological grade or type. To reveal whether the status of chromosome 16 corresponds to the histology of breast carcinomas, we examined the signal number of 16cen, 16q breakpoints and 1;16 fusions in the interp...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19990820)84:4<381::aid-ijc

    authors： Tsuda H,Takarabe T,Hirohashi S

    更新日期：1999-08-20 00:00:00

  • Proteolytic imbalance is reversed after therapeutic surgery in breast cancer patients.

    abstract：:The occurrence of metastasis severely affects prognosis and survival of breast cancer patients. In order to metastasize, breast cancer cells need to cross the basement membrane (BM) tissue boundaries. Matrix metalloproteases (MMPs) are enzymes with proteolytic activity towards extracellular matrix components (ECM) of ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.20009

    authors： Giannelli G,Erriquez R,Fransvea E,Daniele A,Trerotoli P,Schittulli F,Grano M,Quaranta M,Antonaci S

    更新日期：2004-05-01 00:00:00

  • Topoisomerase-I inhibitors for human malignant glioma: differential modulation of p53, p21, bax and bcl-2 expression and of CD95-mediated apoptosis by camptothecin and beta-lapachone.

    abstract：:Beta-lapachone and camptothecin are structurally unrelated agents thought to inhibit topoisomerase-I activity through distinct mechanisms. We find that beta-lapachone is much more potent than camptothecin in inducing acute cytotoxic effects on human malignant glioma cells. Acute cytotoxicity induced by both drugs is a...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19971127)73:5<707::aid-ijc

    authors： Weller M,Winter S,Schmidt C,Esser P,Fontana A,Dichgans J,Groscurth P

    更新日期：1997-11-27 00:00:00

  • Amplification of the EGF receptor and c-myc genes in human esophageal cancers.

    abstract：:The incidence of esophageal cancer is extremely high in Linxian County and certain other regions of the People's Republic of China. Epidemiologic and laboratory studies suggest that N-nitroso carcinogens and other environmental factors play a causative role. In the present study, employing over 100 DNA samples obtaine...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910420406

    authors： Lu SH,Hsieh LL,Luo FC,Weinstein IB

    更新日期：1988-10-15 00:00:00

  • Management of the post-chemotherapy residual mass in patients with advanced stage non-seminomatous germ cell tumors (NSGCT).

    abstract：:Since it is difficult to predict the probability of persistent teratoma or of a viable tumor in patients with normalized tumor markers and a normal CT scan following chemotherapy for advanced stage testis cancer, recommendations regarding adjunctive surgery have ranged from observation to surgical exploration for all ...

    journal_title：International journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1002/(sici)1097-0215(19991210)83:6<852::aid-ijc

    authors： Kuczyk M,Machtens S,Stief C,Jonas U

    更新日期：1999-12-10 00:00:00

  • In vivo generation and selection of variants with altered sensitivity to natural resistance (NR): a model of tumor progression.

    abstract：:The stability of a cloned murine tumor for sensitivity to NR was examined following growth in vivo in order to test the hypothesis that tumor progression proceeds through the generation and selection of variants. Clonal sensitivity to the [131I]-dUrd elimination assay of NR was assessed for the L5178Y-F9 tumor grown i...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910310116

    authors： Chow DA,Ray M,Greenberg AH

    更新日期：1983-01-15 00:00:00

  • Copy number variations in DCC/18q and ERBB2/17q are associated with disease-free survival in microsatellite stable colon cancer.

    abstract：:We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in Stage II-III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ER...

    journal_title：International journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1002/ijc.30584

    authors： Sefrioui D,Vermeulin T,Blanchard F,Chapusot C,Beaussire L,Armengol-Debeir L,Sesboué R,Gangloff A,Hebbar M,Copin MC,Houivet E,Schwarz L,Clatot F,Tuech JJ,Bénichou J,Martin L,Bouvier AM,Sabourin JC,Sarafan-Vasseur N,F

    更新日期：2017-04-01 00:00:00