Urine estrogens and breast cancer risk factors among post-menopausal women.

abstract：:The protein C4.4A, a structural homologue of the urokinase-type plasminogen activator receptor, is a potential new biomarker in non-small cell lung cancer, with high levels of expression recently shown to correlate to poor survival of adenocarcinoma patients. In this study, C4.4A immunoreactivity in precursor lesions ...

journal_title：International journal of cancer

authors： Jacobsen B,Santoni-Rugiu E,Illemann M,Kriegbaum MC,Laerum OD,Ploug M

更新日期：2012-06-01 00:00:00

abstract：:The detection of CTCs prior to and during therapy is an independent and strong prognostic marker, and it is predictive of poor treatment outcome. A major challenge is that different technologies are available for isolation and characterization of CTCs in peripheral blood (PB). We compare the CellSearch system and Adna...

journal_title：International journal of cancer

authors： Andreopoulou E,Yang LY,Rangel KM,Reuben JM,Hsu L,Krishnamurthy S,Valero V,Fritsche HA,Cristofanilli M

更新日期：2012-04-01 00:00:00

abstract：:Prostate cancer incidence has increased during recent years, possibly linked to environmental exposures. Exposure to environmental carcinogens is unlikely to be evenly distributed geographically, which may give rise to variations in disease occurrence that is detectable in a spatial analysis. The aim of our study was ...

journal_title：International journal of cancer

authors： Jarup L,Best N,Toledano MB,Wakefield J,Elliott P

更新日期：2002-02-10 00:00:00

abstract：:Conjugates (immunotoxins) comprising ricin A-chain and monoclonal antibody 96.5, which is specific for human melanoma-associated antigen p97, inhibited protein synthesis and colony formation of cultured human melanoma cells that expressed more than 80,000 molecules of p97 per cell. Cells expressing fewer than 5,000 mo...

journal_title：International journal of cancer

authors： Casellas P,Brown JP,Gros O,Gros P,Hellström I,Jansen FK,Poncelet P,Roncucci R,Vidal H,Hellström KE

更新日期：1982-10-15 00:00:00

abstract：:The second most common target of prostate-cancer metastasis is bone, and the phenomenon of skeletal metastasis represents the incurable stage of disease. Histologically, skeletal metastasis from prostate cancer is distinctive due to its osteoblastic nature. The osteoblastic bone metastasis shows extensive new bone for...

journal_title：International journal of cancer

authors： Thomas R,True LD,Lange PH,Vessella RL

更新日期：2001-07-01 00:00:00

abstract：:Paraffin sections (n = 168, 27 benign, 16 low malignant potential [LMP] and 125 malignant tumours) from epithelial ovarian tumours were evaluated immunohistochemically for expression of retinoblastoma gene product (pRB) and p53 protein, and the relationship among pRB, p53 and cyclin-dependent kinase inhibitor 2 (CDKN2...

journal_title：International journal of cancer

authors： Dong Y,Walsh MD,McGuckin MA,Cummings MC,Gabrielli BG,Wright GR,Hurst T,Khoo SK,Parsons PG

更新日期：1997-08-22 00:00:00

abstract：:High epidermal growth factor (EGF) concentration (10(-8) M) induces inhibition of A431 cell proliferation, resulting in part from an apoptotic process. For some cells escaping this process, proliferation was associated with a decrease in apoptosis. Moreover, these surviving cells displayed marked morphological changes...

journal_title：International journal of cancer

authors： Smida Rezgui S,Honore S,Rognoni JB,Martin PM,Penel C

更新日期：2000-08-01 00:00:00

abstract：:We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...

journal_title：International journal of cancer

authors： Merlo A,Jermann E,Hausmann O,Chiquet-Ehrismann R,Probst A,Landolt H,Maecke HR,Mueller-Brand J,Gratzl O

更新日期：1997-05-29 00:00:00

abstract：:Although tobacco habits have been associated with the risk of oral leukoplakia, alcohol drinking and body mass index (BMI) as risk factors have not been well established. The purpose of this study is to evaluate the independent effects of drinking, BMI, tobacco chewing and smoking on the risk of oral leukoplakia. A ca...

journal_title：International journal of cancer

authors： Hashibe M,Sankaranarayanan R,Thomas G,Kuruvilla B,Mathew B,Somanathan T,Parkin DM,Zhang ZF

更新日期：2000-10-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is present in Reed-Sternberg (RS) cells of a substantial proportion of Hodgkin's lymphoma cases. Most EBV-positive cases are also MHC class I-positive, whereas the majority of EBV-negative cases lack detectable levels of MHC class I expression. Application of the SAGE technique has led to the ...

journal_title：International journal of cancer

authors： Van den Berg A,Visser L,Eberwine J,Dadvand L,Poppema S

更新日期：2000-05-15 00:00:00

abstract：:In order to establish the role of human papillomavirus (HPV) in carcinogenesis of epidermodysplasia verruciformis (EV), the presence, the molecular characteristics and the physical state of HPV DNA in a benign lesion, a primary carcinoma and a metastatic carcinoma developing in the same EV patient were studied and com...

journal_title：International journal of cancer

authors： Yabe Y,Tanimura Y,Sakai A,Hitsumoto T,Nohara N

更新日期：1989-06-15 00:00:00

abstract：:Up to 2016, low- and middle-income countries mostly introduced routine human papillomavirus (HPV) vaccination for just a single age-cohort of girls each year. However, high-income countries have reported large reductions in HPV prevalence following "catch-up" vaccination of multiple age-cohorts in the year of HPV vacc...

journal_title：International journal of cancer

authors： Jit M,Brisson M

更新日期：2018-07-15 00:00:00

abstract：:Variability in the expression of enzymes metabolizing carcinogens derived from cigarette smoke may contribute to individual susceptibility to pulmonary carcinogenesis. This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize...

journal_title：International journal of cancer

authors： Piipari R,Savela K,Nurminen T,Hukkanen J,Raunio H,Hakkola J,Mäntylä T,Beaune P,Edwards RJ,Boobis AR,Anttila S

更新日期：2000-06-01 00:00:00

abstract：:TP53 accumulation in human primary breast carcinomas was studied by a quantitative luminometric immunoassay (LIA), and TP53 gene alterations, exons 5-8, were examined by single-strand conformation polymorphism (SSCP) analysis. In 48 of 142 breast tumor samples, a TP53 gene alteration was identified. In tumor samples w...

journal_title：International journal of cancer

authors： de Witte HH,Foekens JA,Lennerstrand J,Smid M,Look MP,Klijn JG,Benraad TJ,Berns EM

更新日期：1996-04-22 00:00:00

abstract：:Germline mutation of the folliculin gene (BHD) at chromosome 17p11.2 is associated with the development of multiplex hamartomas of the hair follicles, chromophobe renal cell carcinomas (RCC) and renal oncocytomas (RO). We have analyzed the folliculin gene with sequencing for mutations and the chromosome 17p11.2 with m...

journal_title：International journal of cancer

authors： Nagy A,Zoubakov D,Stupar Z,Kovacs G

更新日期：2004-04-10 00:00:00

abstract：:Under the aegis of EUROCARE, a European Union project to assemble survival data from population-based cancer registries and analyze them according to standardized procedures, we have investigated and compared colon-cancer survival in 10 European countries. We analyzed 68,283 colon-cancer cases diagnosed between 1978 a...

journal_title：International journal of cancer

authors： Sant M,Capocaccia R,Verdecchia A,Gatta G,Micheli A,Mariotto A,Hakulinen T,Berrino F

更新日期：1995-09-27 00:00:00

abstract：:CD16 surface antigens represent activatory molecules in CD3-16+ NK cells. In order to target NK cells against relatively NK-resistant ovarian carcinomas, we used an anti-CD16 monoclonal antibody (MAb) (VD4), together with an anti-ovarian carcinoma-associated antigen (MOV19), to construct biMAbs. To this end, hybrid hy...

journal_title：International journal of cancer

authors： Ferrini S,Prigione I,Miotti S,Ciccone E,Cantoni C,Chen Q,Colnaghi MI,Moretta L

更新日期：1991-05-10 00:00:00

abstract：:We, and others, have recently shown that recombinant feline leukaemia viruses (FeLV) containing the myc gene (FeLV-myc) occur in up to 30% of naturally occurring cases of T-cell lymphosarcoma. Investigation of the disease spectrum of two FeLV-myc isolates showed that they induced clonal or oligoclonal T-cell tumours a...

journal_title：International journal of cancer

authors： Onions D,Lees G,Forrest D,Neil J

更新日期：1987-07-15 00:00:00

abstract：:Prostate cancer is the most common malignancy in men, and patients with metastatic disease have poor outcome even with the most advanced therapeutic approaches. Most cancer therapies target the bulk tumor cells, but may leave intact a small population of tumor-initiating cells (TICs), which are believed to be responsi...

journal_title：International journal of cancer

authors： Marian CO,Wright WE,Shay JW

更新日期：2010-07-15 00:00:00

abstract：:The monoclonal antibody (MAb) K1 recognizes an approximate 40 kDa glycoprotein, mesothelin, that is present on the surface of human mesothelial cells, mesotheliomas and ovarian cancers. We have cloned the cDNAs encoding the variable regions of MAb K1 and constructed plasmids for expression of recombinant K1(FAb). Reco...

journal_title：International journal of cancer

authors： Brinkmann U,Webber K,Di Carlo A,Beers R,Chowdhury P,Chang K,Chaudhary V,Gallo M,Pastan I

更新日期：1997-05-16 00:00:00

abstract：:Conversion of solid sarcomas and carcinomas into ascites tumors depends on the in vivo selection of phenotypically altered tumor cell variants that can grow in the dissociated form. Once selected, they retain this property even after prolonged s.c. growth as solid tumors. From an s.c.-passaged subline of an ascites-co...

journal_title：International journal of cancer

authors： Minarovits J,Steinitz M,Boldog F,Imreh S,Wirschubsky Z,Ingvarsson S,Hedenskog M,Minarovits-Kormuta S,Klein G

更新日期：1990-03-15 00:00:00

abstract：:Studies of colon cancer risk in males have reported strong positive associations with obesity, particularly with central adiposity. The association has been weaker and less consistent for women. In a prospective cohort study of women, body measurements were taken directly; fat mass and fat-free mass being estimated by...

journal_title：International journal of cancer

authors： MacInnis RJ,English DR,Hopper JL,Gertig DM,Haydon AM,Giles GG

更新日期：2006-03-15 00:00:00

abstract：:Overuse of antibiotic drugs alters the composition of gut microbiota and has detrimental effects on the host. In our study, we investigated association of gut flora and antibiotics in the prognosis of patients with liver cancer who have undergone chemotherapy by analyzing two independent clinical studies. We retrospec...

journal_title：International journal of cancer

authors： Iida N,Mizukoshi E,Yamashita T,Terashima T,Arai K,Seishima J,Kaneko S

更新日期：2019-11-15 00:00:00

abstract：:A case-control study of 374 patients with primary epithelial cancers of the oral cavity, oro- and hypopharynx, and larynx is reported, the controls being patients with selected other cancers, matched for age and sex. Of all eligible patients, 93% were interviewed. Increased risks were seen with alcohol consumption and...

journal_title：International journal of cancer

authors： Elwood JM,Pearson JC,Skippen DH,Jackson SM

更新日期：1984-11-15 00:00:00

abstract：:Murine monoclonal antibody HRS-4 (Ab1), which defines the cell-bound and soluble CD30 antigen associated with Hodgkin's lymphoma, was used to generate monoclonal anti-idiotypic antibodies (Ab2) in syngeneic BALB/c mice. Murine monoclonal Ab2 14G9 and Ab2 9G10 directed against HRS-4 were shown to be anti-idiotypic Ab2 ...

journal_title：International journal of cancer

authors： Pohl C,Renner C,Schwonzen M,Sieber M,Lorenz P,Pfreundschuh M,Diehl V

更新日期：1992-04-01 00:00:00

abstract：:The incidence of non-Hodgkin's lymphoma (NHL) has markedly increased in the US and other westernized countries in recent years and presents a considerable clinical challenge. NHL is divided into subtypes that follow an aggressive or indolent course. Follicular lymphoma (FL), the most common indolent subtype, and mantl...

journal_title：International journal of cancer

authors： Leonard JP,Furman RR,Coleman M

更新日期：2006-09-01 00:00:00

abstract：:Although surgical resection is considered the adequate treatment in early stages of nonsmall cell lung cancer, long-term survival is not satisfactory and recurrence rate is high. We previously showed that postoperative chemotherapy at stage IB reduces recurrences and prolongs overall survival. We extended size and obs...

journal_title：International journal of cancer

authors： Roselli M,Mariotti S,Ferroni P,Laudisi A,Mineo D,Pompeo E,Ambrogi V,Mineo TC

更新日期：2006-08-15 00:00:00

abstract：:Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras e...

journal_title：International journal of cancer

authors： Unver N,Delgado O,Zeleke K,Cumpian A,Tang X,Caetano MS,Wang H,Katayama H,Yu H,Szabo E,Wistuba II,Moghaddam SJ,Hanash SM,Ostrin EJ

更新日期：2018-04-01 00:00:00

abstract：:Tobacco-related carcinogens cause a variety of DNA damage that is repaired by different enzymatic pathways, suggesting that DNA repair plays an important role in tobacco-induced carcinogenesis. In a large hospital-based case-control study, we investigated DNA repair capacity (DRC) as a biomarker for susceptibility to ...

journal_title：International journal of cancer

authors： Shen H,Spitz MR,Qiao Y,Guo Z,Wang LE,Bosken CH,Amos CI,Wei Q

更新日期：2003-10-20 00:00:00

abstract：:A panel of 24 healthy seropositive donors have been followed prospectively over a period of 15 months and monitored (1) for the level of EB virus shedding in the throat by means of a sensitive cord-blood transformation assay; (2) for the level of virus-infected B cells in the blood via a new in vitro protocol where "s...

journal_title：International journal of cancer

authors： Yao QY,Rickinson AB,Epstein MA

更新日期：1985-01-15 00:00:00