Permissive expansion and homing of adoptively transferred T cells in tumor-bearing hosts.

abstract：:Microarray analysis of paired cultures of normal and cancerous urothelial cells revealed differences in cytokeratin and adhesion gene expression. Normal cells expressed autocrine growth factor genes more strongly whereas carcinoma cells were distinguished by concomitant expression of urothelial and epidermal different...

journal_title：International journal of cancer

authors： Dokun OY,Florl AR,Seifert HH,Wolff I,Schulz WA

更新日期：2008-12-15 00:00:00

abstract：:The impact of a human papillomavirus (HPV) vaccine on development of cervical intraepithelial neoplasia grade 2-3 or adenocarcinoma in situ (CIN2-3/AIS) in women with ongoing HPV16 or 18 infections prevaccination is reported. Seventeen thousand six-hundred and twenty-two women aged 16-26 were enrolled in 1 of 2 random...

journal_title：International journal of cancer

authors： Haupt RM,Wheeler CM,Brown DR,Garland SM,Ferris DG,Paavonen JA,Lehtinen MO,Steben M,Joura EA,Giacoletti KE,Radley DR,James MK,Saah AJ,Sings HL,FUTURE I and II Investigators.

更新日期：2011-12-01 00:00:00

abstract：:It has become axiomatic that critical windows of susceptibility to genotoxins exist and that genetic damage in utero may be a trigger for later life cancers. Data supporting this critical window hypothesis are remarkably few. This study provides a quantitative bridge between DNA damage by the liver carcinogen aflatoxi...

journal_title：International journal of cancer

authors： Chawanthayatham S,Thiantanawat A,Egner PA,Groopman JD,Wogan GN,Croy RG,Essigmann JM

更新日期：2015-03-15 00:00:00

abstract：:An important feature of cytochrome P450 (CYP) 2B1 is its high ability to convert the prodrug cyclophosphamide (CPA) to therapeutically cytotoxic metabolites, resulting in interstrand DNA-cross-linking and cell death. We have examined whether and how the phosphorylation of CYP2B1 influences CPA metabolic activation in ...

journal_title：International journal of cancer

authors： Oesch-Bartlomowicz B,Richter B,Becker R,Vogel S,Padma PR,Hengstler JG,Oesch F

更新日期：2001-12-01 00:00:00

abstract：:Epigenetic modification of gene expression plays an important role in the development of human cancers. The inactivation of SPARC through CpG island methylation was studied in colon cancers using oligonucleotide microarray analysis and methylation specific PCR (MSP). Gene expression of 7 colon cancer cell lines was ev...

journal_title：International journal of cancer

authors： Yang E,Kang HJ,Koh KH,Rhee H,Kim NK,Kim H

更新日期：2007-08-01 00:00:00

abstract：:Inbred rats were treated with extranuclear tumour membrane fractions or 3 M KCl-solubilized extracts of two antigenically distinct 3-methylcholanthrene-induced sarcomas, Mc7 and Mc57. The rats developed tumour-specific humoral antibody responses, but were not immune to tumour challenge. Moreover, they were unresponsiv...

journal_title：International journal of cancer

authors： Embleton MJ

更新日期：1976-11-15 00:00:00

abstract：:ErbB-2 and EGF receptors are often co-expressed in human tumors and have been shown to synergize in the transformation of cells in experimental model systems. Transactivation of ErbB-2 can occur via ligand-induced heterodimerization with EGF receptor or other members of the ErbB family of receptor tyrosine kinases. We...

journal_title：International journal of cancer

authors： Schmidt M,Hynes NE,Groner B,Wels W

更新日期：1996-02-08 00:00:00

abstract：:We evaluated promoter hypermethylation of a panel of tumor suppressor genes as a means to detect epigenetic alterations in oral squamous cell carcinomas (OSCC) of Indian-origin and compare with North-American head and neck squamous cell carcinomas (HNSCC). Quantitative-methylation-specific PCR was used to investigate ...

journal_title：International journal of cancer

authors： Kaur J,Demokan S,Tripathi SC,Macha MA,Begum S,Califano JA,Ralhan R

更新日期：2010-11-15 00:00:00

abstract：:India has the highest burden of cervical cancer in the world. To estimate the consequences of delaying implementation of organized cervical cancer screening, we projected the avertable burden of disease under different implementation scenarios of a screening program. We used an individual-based microsimulation model o...

journal_title：International journal of cancer

authors： Campos NG,Tsu V,Jeronimo J,Regan C,Resch S,Clark A,Sy S,Kim JJ

更新日期：2019-02-15 00:00:00

abstract：:An orang-utan (Pongo pygmaeus) suspension line, CP81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic N-alkaline phosphatase activity, and to release a B-cell-tropic herpesvirus. This herpesvirus, termed Herpesvirus pongo, had 30--40% DNA homology with EBV an...

journal_title：International journal of cancer

authors： Rabin H,Neubauer RH,Hopkins RF 3rd,Nonoyama M

更新日期：1978-06-15 00:00:00

abstract：:We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and up-regulated E-cadherin, an epi...

journal_title：International journal of cancer

authors： Kabashima A,Higuchi H,Takaishi H,Matsuzaki Y,Suzuki S,Izumiya M,Iizuka H,Sakai G,Hozawa S,Azuma T,Hibi T

更新日期：2009-06-15 00:00:00

abstract：:Therapeutic effectiveness against metastatic or even locally advanced pancreatic ductal adenocarcinoma (PDAC) is dismal, with 5-year survival less than 5%. Even in patients who undergo potentially curative resection, most patients' tumors recur in the liver. Improving therapies targeting or preventing liver metastases...

journal_title：International journal of cancer

authors： Kurahara H,Bohl C,Natsugoe S,Nishizono Y,Harihar S,Sharma R,Iwakuma T,Welch DR

更新日期：2016-08-01 00:00:00

abstract：:Several lines of evidence have demonstrated that IFNs could be relevant in the treatment of certain neoplastic diseases such as carcinomas. In particular, IFN-alpha, in addition to the anti-proliferative and cytostatic effects, was demonstrated to be capable of inducing cell death by apoptosis both in vivo and in vitr...

journal_title：International journal of cancer

authors： Matarrese P,Giandomenico V,Fiorucci G,Rivabene R,Straface E,Romeo G,Affabris E,Malorni W

更新日期：1998-05-18 00:00:00

abstract：:Therapies targeted to human epidermal growth factor receptor 2 (HER2) have proven effective against tumors positive for HER2 amplification, but there is an unmet clinical need for the treatment of tumors that express HER2 protein in the absence of HER2 amplification. [fam-] trastuzumab deruxtecan (DS-8201a) is a novel...

journal_title：International journal of cancer

authors： Takegawa N,Tsurutani J,Kawakami H,Yonesaka K,Kato R,Haratani K,Hayashi H,Takeda M,Nonagase Y,Maenishi O,Nakagawa K

更新日期：2019-12-15 00:00:00

abstract：:Cancer is well established as an age-associated disease, and there is substantial overlap in the molecular, cellular and physiological changes observed with both ageing and the progression of cancer. Age-specific declines in resilience mechanisms such as DNA repair or epigenetic maintenance may contribute to the devel...

journal_title：International journal of cancer

authors： Lau CE,Robinson O

更新日期：2021-01-04 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an important role in stress-responsive gene expression. Although primarily sensitive to hypoxia, HIF-1 signaling can be regulated by a number of stress factors including metabolic stress, growth factors and molecules present in the extracellular matrix (ECM). Degradation of ECM...

journal_title：International journal of cancer

authors： Surazynski A,Donald SP,Cooper SK,Whiteside MA,Salnikow K,Liu Y,Phang JM

更新日期：2008-03-15 00:00:00

abstract：:Sera from 450 individuals between the age of 1 and 80 years, representing the general population of the Czech Republic, were tested for the presence of antibodies to human-papillomavirus(HPV)-derived antigens. The following antigens were used: (i) HPV1 virions; (ii) HPV16, -18 and -33-virus-like particles (VLP); (iii)...

journal_title：International journal of cancer

authors： Hamsíková E,Ludvíková V,Smahel M,Sapp M,Vonka V

更新日期：1998-08-31 00:00:00

abstract：:We have surveyed the incidence of adult T-cell leukemia/lymphoma (ATLL) in an endemic area of 290,464 inhabitants for 7 years. We now revise our previous results on the basis of additional findings and estimate the age- and sex-specific cumulative rate for HTLV-I carriers, the adoption of which is recommended by curre...

journal_title：International journal of cancer

authors： Kondo T,Kono H,Miyamoto N,Yoshida R,Toki H,Matsumoto I,Hara M,Inoue H,Inatsuki A,Funatsu T

更新日期：1989-06-15 00:00:00

abstract：:The tumor microenvironment consists of an immunosuppressive niche created by the complex interactions between cancer cells and surrounding stromal cells. A critical component of this environment are myeloid-derived suppressor cells (MDSCs), a heterogeneous group of immature myeloid cells arrested at different stages o...

journal_title：International journal of cancer

authors： Pyzer AR,Cole L,Rosenblatt J,Avigan DE

更新日期：2016-11-01 00:00:00

abstract：:The age-adjusted lung cancer incidence rates among Japanese, Chinese and Hawaiian women in Hawaii do not correlate to their respective cigarette smoking exposures. We conducted a case-control study to determine the lung cancer risk associated with smoking among these three ethnic groups of women by reviewing the medic...

journal_title：International journal of cancer

authors： Hinds MW,Stemmermann GN,Yang HY,Kolonel LN,Lee J,Wegner E

更新日期：1981-03-15 00:00:00

abstract：:There is strong evidence of a protection of high consumption of plant foods against squamous cell carcinoma of the oesophagus, but the respective role of fruits and vegetables is not well elucidated. In the time period 1996-2003, a case-control study designed in order to address this question was conducted in Uruguay....

journal_title：International journal of cancer

authors： De Stefani E,Boffetta P,Deneo-Pellegrini H,Ronco AL,Correa P,Mendilaharsu M

更新日期：2005-08-10 00:00:00

abstract：:BRCA1 and BRCA2 play essential roles in maintaining the genome stability. Pathogenic germline mutations in these two genes disrupt their function, lead to genome instability and increase the risk of developing breast and ovarian cancers. BRCA mutations have been extensively screened in Caucasian populations, and the r...

journal_title：International journal of cancer

authors： Bhaskaran SP,Chandratre K,Gupta H,Zhang L,Wang X,Cui J,Kim YC,Sinha S,Jiang L,Lu B,Wu X,Qin Z,Huang T,Wang SM

更新日期：2019-08-15 00:00:00

abstract：:The effects of three monoclonal antibodies (B3/25, 43/31, and 42/6) reactive with human transferrin (Tf) receptors on growth of normal and malignant myeloid cells were examined using in vitro culture techniques. When added directly to cultures, all three antibodies caused dose-dependent inhibition of normal granulocyt...

journal_title：International journal of cancer

authors： Taetle R,Honeysett JM,Trowbridge I

更新日期：1983-09-15 00:00:00

abstract：:Malignant cells possess a high degree of proteolytic activity in which the plasminogen activator system plays an important role. An increased expression of urokinase type plasminogen activator (uPA) is of significance for degradation of the extracellular tumor matrix, facilitating invasiveness and growth. Inhibition o...

journal_title：International journal of cancer

authors： Billström A,Hartley-Asp B,Lecander I,Batra S,Astedt B

更新日期：1995-05-16 00:00:00

abstract：:B-cell chronic lymphocytic leukaemia (B-CLL) cells fail to undergo apoptosis. The mechanism underlying this resistance to cell death is still largely unknown. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) effectively kills tumour cells but not normal cells, and thus represents an attractive tool for...

journal_title：International journal of cancer

authors： Garofalo M,Romano G,Quintavalle C,Romano MF,Chiurazzi F,Zanca C,Condorelli G

更新日期：2007-03-15 00:00:00

abstract：:Microsatellite instability (MSI) has been reported to occur in a wide variety of sporadic tumours, such as colorectal and gastric cancers. MSI positivity has been associated with a particular clinico-pathologic profile, including the presence of abundant lymphoid infiltration, poor differentiation and a relatively goo...

journal_title：International journal of cancer

authors： Schmitt FC,Soares R,Gobbi H,Milanezzi F,Santos-Silva F,Cirnes L,Costa C,Seruca R

更新日期：1999-08-27 00:00:00

abstract：:The results from the population-based cancer registry for the city of Ho Chi Minh in 1995-1996 represent the first information on the incidence of cancer in southern Viet Nam. A total of 4,080 cancer cases in males and 4,338 in females were registered, corresponding to age-standardized incidence rates (ASRs) of 130.9 ...

journal_title：International journal of cancer

authors： Nguyen QM,Nguyen HC,Parkin DM

更新日期：1998-05-18 00:00:00

abstract：:Pancreatic adenocarcinoma (PDAC) is known to have a poor prognosis partly because of lack of effective biomarkers. In the test set, we investigated dysbindin (DTNBP1) as a potential biomarker for PDAC by comparing preoperative and postoperative serum mass spectrometry (MS) proteomic profilings. Of the included 50 PDAC...

journal_title：International journal of cancer

authors： Guo X,Lv X,Fang C,Lv X,Wang F,Wang D,Zhao J,Ma Y,Xue Y,Bai Q,Yao X,Chen Y

更新日期：2016-10-15 00:00:00

abstract：:The independent effects of parity and age at first birth on breast cancer incidence are investigated in a 1% sample of women aged 16 to 59 from the 1971 Census of England and Wales. Over the period 1971-81, 1,003 breast cancer cases occurred in the cohort of 113,263 women who were either married, widowed or divorced a...

journal_title：International journal of cancer

authors： Leon DA

更新日期：1989-06-15 00:00:00

abstract：:The suppressive activity of regulatory T cells (Treg) has been implicated as an important factor limiting immune mediated destruction of tumor cells. However, not much is known about the presence and function of Treg within tumors. Here we show in a syngeneic murine glioma model a time-dependent accumulation of CD4+Fo...

journal_title：International journal of cancer

authors： Grauer OM,Nierkens S,Bennink E,Toonen LW,Boon L,Wesseling P,Sutmuller RP,Adema GJ

更新日期：2007-07-01 00:00:00