A tumor-associated antigen expressed in melanoma cells with lower malignant potential.


:The antigen K-1-2, detectable by a MAb is found in nevi and melanomas. It is associated with melanoma cells of low invasive and metastatic potential as shown by immunoperoxidase studies with cell lines, biopsies and autopsies: K-1-2 occurs in melanoma cell line SK-Mel 25, but not in cell line A-375. A-375 has a higher malignant potential than SK-Mel 25 because, in contrast to SK-Mel 25, it produces plasminogen activator and grows in nude mice. K-1-2 was frequently strongly expressed (greater than or equal to 50% cells positive) in flat (less than 1.5 mm) and less frequently in medium and thick primary tumors. In thick primary melanomas K-1-2 positive cells were confined to the junctional zone or to marginal, flat areas of the tumor. Only rarely does K-1-2 occur in metastases. Strong expression of the K-1-2 antigen was found less often in primary melanomas, which develop early metastases, than in tumors that had not metastasized during an observation period of 18 months. In 5 patients with disseminated metastatic disease, metastases strongly expressing K-1-2 and those negative for this marker or containing only a minor percentage of K-1-2 positive cells were observed simultaneously or at different times. These findings suggest that a change from high malignancy to low malignancy--as observed in animal systems--may also occur in human melanoma.


Int J Cancer


Suter L,Brüggen J,Bröcker EB,Sorg C




Has Abstract


1985-06-15 00:00:00












  • Nevus density and melanoma risk in women: a pooled analysis to test the divergent pathway hypothesis.

    abstract::A "divergent pathway" model for the development of cutaneous melanoma has been proposed. The model hypothesizes that melanomas occurring in people with a low tendency to develop nevi will, on average, arise more commonly on habitually sun-exposed body sites such as the head and neck. In contrast, people with an inhere...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Olsen CM,Zens MS,Stukel TA,Sacerdote C,Chang YM,Armstrong BK,Bataille V,Berwick M,Elwood JM,Holly EA,Kirkpatrick C,Mack T,Bishop JN,Østerlind A,Swerdlow AJ,Zanetti R,Green AC,Karagas MR,Whiteman DC

    更新日期:2009-02-15 00:00:00

  • Prevalence and clinical impact of TP53 germline mutations in Chinese women with breast cancer.

    abstract::The prevalence and clinical relevance of TP53 germline mutations in a large unselected breast cancer series are largely unknown. Here, we determined TP53 germline mutations in a large cohort of 10,053 unselected breast cancer patients through multigene panel-based next-generation and/or Sanger sequencing assays. We fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sheng S,Xu Y,Guo Y,Yao L,Hu L,Ouyang T,Li J,Wang T,Fan Z,Fan T,Lin B,Xie Y

    更新日期:2020-01-15 00:00:00

  • Berberine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of nucleophosmin/B23 and telomerase activity.

    abstract::The steady-state level of nucleophosmin/B23 mRNA decreased during berberine-induced (25 microg/ml, 24 to 96 hr) apoptosis of human leukemia HL-60 cells. A decline in telomerase activity was also observed in HL-60 cells treated with berberine. A stable clone of nucleophosmin/B23 overexpressed in HL-60 cells was selecte...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wu HL,Hsu CY,Liu WH,Yung BY

    更新日期:1999-06-11 00:00:00

  • Lymphoma development from transplanted murine leukemia virus infected organ cultured thymuses: inhibitory effect of in vitro interferon treatment.

    abstract::Thymuses of 14-day-old AKR mouse embryos were infected with Gross murine leukemia virus (MuLV) and then maintained in organ culture for 3 weeks. When they were transplanted to 3-week-old (AKR X C3H)F1 mice, approximately 50% of these developed T lymphomas within 3-4 months. Most (22/23) tumors were of host, F1-hybrid,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Riesenfeld I,Tufveson G,Alm GV

    更新日期:1980-04-15 00:00:00

  • Population dynamics of serologically identified coinfections with human papillomavirus types 11, 16, 18 and 31 in fertile-aged Finnish women.

    abstract::Licensed human papillomavirus (HPV) vaccines are expected to prevent high-risk (hr) HPV-infections (most notably types 16 and 18). Whether HPV vaccination will change the distribution of hrHPVs at the population level is open, since competition between HPV types is not well understood. Two stratified random subcohorts...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kaasila M,Koskela P,Kirnbauer R,Pukkala E,Surcel HM,Lehtinen M

    更新日期:2009-11-01 00:00:00

  • Implementation of the 7th edition AJCC staging system: Effects on staging and survival for pT1 melanoma. A Dutch population based study.

    abstract::In the 7th edition of the AJCC staging system, the mitotic rate criterion replaced Clark level to increase correct classification of high-risk thin melanoma patients (pT1B). Additionally, sentinel node biopsy (SNB) was recommended for nodal staging of pT1B melanomas. The aim of this article was to evaluate the effects...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Oude Ophuis CM,Louwman MW,Grünhagen DJ,Verhoef K,van Akkooi AC

    更新日期:2017-04-15 00:00:00

  • Gold(III) porphyrin complex is more potent than cisplatin in inhibiting growth of nasopharyngeal carcinoma in vitro and in vivo.

    abstract::Nasopharyngeal carcinoma (NPC) is a common neoplasm in Southeastern Asia, and cisplatin-containing regimens for combinational chemotherapy are widely used for treating locally recurrent or metastatic diseases. However, resistance to cisplatin is not infrequently seen and its associated side effects may be life-threate...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: To YF,Sun RW,Chen Y,Chan VS,Yu WY,Tam PK,Che CM,Lin CL

    更新日期:2009-04-15 00:00:00

  • CXCL12-CXCR7 axis is important for tumor endothelial cell angiogenic property.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yamada K,Maishi N,Akiyama K,Towfik Alam M,Ohga N,Kawamoto T,Shindoh M,Takahashi N,Kamiyama T,Hida Y,Taketomi A,Hida K

    更新日期:2015-12-15 00:00:00

  • Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome-wide shRNA screen.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kurahara H,Bohl C,Natsugoe S,Nishizono Y,Harihar S,Sharma R,Iwakuma T,Welch DR

    更新日期:2016-08-01 00:00:00

  • Distribution of the transferrin receptor in normal human fibroblasts and fibrosarcoma cells.

    abstract::Transferrin is required for proliferation of most cells in culture. This effect is presumably mediated by the binding of transferrin to its receptor, a surface glycoprotein which is preferentially expressed by actively growing cells. Here we show that normal human fibroblasts cultured in serum, and other media contain...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ekblom P,Thesleff I,Lehto VP,Virtanen I

    更新日期:1983-01-15 00:00:00

  • Reproductive and menstrual factors and risk of differentiated thyroid carcinoma: the EPIC study.

    abstract::Differentiated thyroid carcinoma (TC) is threefold more common in women than in men and, therefore, a role of female hormones in the etiology of differentiated TC has been suggested. We assessed these hypotheses in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 345,157 women (mea...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zamora-Ros R,Rinaldi S,Biessy C,Tjønneland A,Halkjaer J,Fournier A,Boutron-Ruault MC,Mesrine S,Tikk K,Fortner RT,Boeing H,Förster J,Trichopoulou A,Trichopoulos D,Papatesta EM,Masala G,Tagliabue G,Panico S,Tumino R,P

    更新日期:2015-03-01 00:00:00

  • Suramin sodium: pronounced effects on methotrexate transport and anti-folate activity in cultured tumor cells.

    abstract::Suramin is an experimental anti-neoplastic agent which has shown promising activity against prostatic carcinoma and lymphoma in clinical trials. To elucidate its mechanism of action, suramin was examined for an effect on the transport of folate compounds by tumor cells. Influx of the anti-folate methotrexate via the r...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rideout DC,Bustamante A,Patel R,Henderson GB

    更新日期:1995-06-09 00:00:00

  • Incidence of childhood cancer in Cuba (1986-1990).

    abstract::Cancer is an infrequent disease in childhood. However, it is responsible for 13.06% of child deaths between 1 and 14 years in Cuba. The aim of our work was to describe the incidence of childhood cancer in the period 1986 to 1990 using data reported to the National Cancer Registry (NCR) of Cuba. All cancer cases betwee...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Martín AA,Alert JA,Renó JS,Lonchong M,Grueiro S

    更新日期:1997-08-07 00:00:00

  • Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome.

    abstract::CDKN2A (p16) disruption is reported as a frequent event in head and neck squamous cell carcinomas that confers poor prognosis. We investigated the frequency of different potential mechanisms of CDKN2A inactivation in oral tongue squamous cell carcinomas (OTSCC) and their impact on patient outcome. From a cohort of 153...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lim AM,Do H,Young RJ,Wong SQ,Angel C,Collins M,Takano EA,Corry J,Wiesenfeld D,Kleid S,Sigston E,Lyons B,Fox SB,Rischin D,Dobrovic A,Solomon B

    更新日期:2014-08-15 00:00:00

  • Tube leukocyte adherence inhibition assay for the detection of anti-tumour immunity. II. Monocyte reacts with tumour antigen via cytophilic anti-tumour antibody.

    abstract::The peripheral blood monocyte is the reactive cell in the tube LAI assay. The monocyte loses its properties of adherence to glass upon exposure to specific antigen. Two different experiments to determine if lymphocytes, when they reacted with tumour, released mediators that were responsible for inhibiting monocyte gla...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Marti JH,Grosser N,Thomson DM

    更新日期:1976-07-15 00:00:00

  • Specific glycolipid antigen(s) in SV40-transformed cell membranes.

    abstract::A glycolipid extract was prepared from an SV40-transformed hamster cell line (EH-SV) according to the Folch partition procedure. The glycolipids from the aqueous layer were incorporated in liposomal membranes composed of lecithin/sphingomyelin/cholesterol (1:1:2 by weight). This liposomal preparation was inoculated in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ansel S,Huet C

    更新日期:1980-06-15 00:00:00

  • Epidemiology of hepatitis viruses among hepatocellular carcinoma cases and healthy people in Egypt: a systematic review and meta-analysis.

    abstract::Liver cancers are strongly linked to hepatitis B virus (HBV) and hepatitis C virus (HCV). Egypt has the highest prevalence of HCV worldwide and has rising rates of hepatocellular carcinoma (HCC). Egypt's unique nature of liver disease presents questions regarding the distribution of HBV and HCV in the etiology of HCC....

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Lehman EM,Wilson ML

    更新日期:2009-02-01 00:00:00

  • Pigmentary characteristics, sun sensitivity and non-Hodgkin lymphoma.

    abstract::We report on pigmentary characteristics, sun sensitivity and some other possible risk factors for non-Hodgkin lymphoma (NHL) in people 20-74 years of age. A statewide case-control study was conducted in New South Wales, Australia, with population-based sampling of cases (n = 704) and controls (n = 694). Risk of NHL wa...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hughes AM,Armstrong BK,Vajdic CM,Turner J,Grulich A,Fritschi L,Milliken S,Kaldor J,Benke G,Kricker A

    更新日期:2004-06-20 00:00:00

  • ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5.

    abstract::Many studies have focused on global hypomethylation or hypermethylation of tumor suppressor genes, but less is known about the impact of promoter hypomethylation of oncogenes. We previously showed that promoter methylation may gradually increase or decrease during the transition from gastric mucosa (GM) to intestinal ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Seo EH,Kim HJ,Kim JH,Lim B,Park JL,Kim SY,Lee SI,Jeong HY,Song KS,Kim YS

    更新日期:2020-06-15 00:00:00

  • Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes.

    abstract::A subgroup of medulloblastomas shows constitutive activation of the Sonic hedgehog pathway with expression of GLI1. We identified the subset of GLI1 transforming target genes specifically expressed in medulloblastomas by comparing GLI1 targets in RK3E cells transformed by GLI1 with the gene expression profile of Sonic...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yoon JW,Gilbertson R,Iannaccone S,Iannaccone P,Walterhouse D

    更新日期:2009-01-01 00:00:00

  • Fetal myofibroblast-like cells isolated from post-radiation fibrosis in human breast cancer.

    abstract::Cells were isolated from post-radiation fibrosis biopsies of patients with recurrent breast carcinoma. These cells were identified as fibroblasts and compared with fibroblasts from normal breast tissues for their proliferative activities, chromosome number and for the presence of various components of the extracellula...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Brouty-Boyé D,Raux H,Azzarone B,Tamboise A,Tamboise E,Béranger S,Magnien V,Pihan I,Zardi L,Israël L

    更新日期:1991-03-12 00:00:00

  • Comparative biological responses of rabbits infected with human T-lymphotropic virus type I isolates from patients with lymphoproliferative and neurodegenerative disease.

    abstract::An experimental rabbit model was used to determine host responses to infection by various human T-lymphotropic virus type-I (HTLV-I) strains. Seven groups of 4 to 5 rabbits each were inoculated with lethally-irradiated HTLV-I-infected cell lines derived from patients with adult T-cell leukemia/lymphoma or from patient...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lairmore MD,Roberts B,Frank D,Rovnak J,Weiser MG,Cockerell GL

    更新日期:1992-01-02 00:00:00

  • Screening for familial and hereditary prostate cancer.

    abstract::Prostate cancer (PC) has the highest degree of genetic transmission of any form of malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal dominance trait. We reviewed the known predisposing genetic markers to assess possible strategies for screening of families at risk. We carried o...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Lynch HT,Kosoko-Lasaki O,Leslie SW,Rendell M,Shaw T,Snyder C,D'Amico AV,Buxbaum S,Isaacs WB,Loeb S,Moul JW,Powell I

    更新日期:2016-06-01 00:00:00

  • RACK1 regulates Ki-Ras-mediated signaling and morphological transformation of NIH 3T3 cells.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bjørndal B,Myklebust LM,Rosendal KR,Myromslien FD,Lorens JB,Nolan G,Bruland O,Lillehaug JR

    更新日期:2007-03-01 00:00:00

  • Second malignant tumors after elective end of therapy for a first cancer in childhood: a multicenter study in Italy.

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    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Rosso P,Terracini B,Fears TR,Jankovic M,Fossati Bellani F,Arrighini A,Carli M,Cordero di Montezemolo L,Garrè ML,Guazzelli C

    更新日期:1994-11-15 00:00:00

  • Cardiac mortality after radiotherapy, chemotherapy and endocrine therapy for breast cancer: Cohort study of 2 million women from 57 cancer registries in 22 countries.

    abstract::Comparisons of patients receiving different cancer treatments reflect the effects of both treatment and patient selection. In breast cancer, however, if radiotherapy decisions are unrelated to laterality, comparisons of left-sided and right-sided cancers can demonstrate the causal effects of higher-versus-lower cardia...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Henson KE,McGale P,Darby SC,Parkin M,Wang Y,Taylor CW

    更新日期:2020-09-01 00:00:00

  • HPV-associated flat penile lesions in men of a non-STD hospital population: less frequent and smaller in size than in male sexual partners of women with CIN.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bleeker MC,Hogewoning CJ,Voorhorst FJ,van den Brule AJ,Berkhof J,Hesselink AT,Lettink M,Starink TM,Stoof TJ,Snijders PJ,Meijer CJ

    更新日期:2005-01-01 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hamilton WB,Helling F,Lloyd KO,Livingston PO

    更新日期:1993-02-20 00:00:00

  • Resistance to verapamil sensitization of multidrug-resistant cells grown as multicellular spheroids.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sakata K,Kwok TT,Gordon GR,Waleh NS,Sutherland RM

    更新日期:1994-10-15 00:00:00

  • Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis.

    abstract::The prognostic role of inflammation index like neutrophil-to-lymphocyte ratio (NLR) in colorectal cancer (CRC) remains controversial. We conduct a meta-analysis to determine the predictable value of NLR in the clinical outcome of CRC patients. The analysis was carried out based on the data from 16 studies (19 cohorts)...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Li MX,Liu XM,Zhang XF,Zhang JF,Wang WL,Zhu Y,Dong J,Cheng JW,Liu ZW,Ma L,Lv Y

    更新日期:2014-05-15 00:00:00