Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas.

Abstract:

:An epithelioid cell line, started from a human pancreatic carcinoma of ductal cell origin, has been maintained in culture for over 2 years and has been subcultured more than 40 times. The PANC-1 cell line has a doubling time of 52 h and G6PD activity of the slow mobility of B type. Chromosome studies show a modal number of 63 with three distinct marker chromosomes and a small ring chromosome. The malignant nature of the PANC-1 cell line was verified by: (1) the ready growth of PANC-1 cells in soft agar and on top of a fibroblast monolayer; and (2) the formation of a progressively growing anaplastic carcinoma after injection of a nude-athymic mouse with PANC-1 cells.

journal_name

Int J Cancer

authors

Lieber M,Mazzetta J,Nelson-Rees W,Kaplan M,Todaro G

doi

10.1002/ijc.2910150505

keywords:

subject

Has Abstract

pub_date

1975-05-15 00:00:00

pages

741-7

issue

5

eissn

0020-7136

issn

1097-0215

journal_volume

15

pub_type

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