Abstract:
:An epithelioid cell line, started from a human pancreatic carcinoma of ductal cell origin, has been maintained in culture for over 2 years and has been subcultured more than 40 times. The PANC-1 cell line has a doubling time of 52 h and G6PD activity of the slow mobility of B type. Chromosome studies show a modal number of 63 with three distinct marker chromosomes and a small ring chromosome. The malignant nature of the PANC-1 cell line was verified by: (1) the ready growth of PANC-1 cells in soft agar and on top of a fibroblast monolayer; and (2) the formation of a progressively growing anaplastic carcinoma after injection of a nude-athymic mouse with PANC-1 cells.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Lieber M,Mazzetta J,Nelson-Rees W,Kaplan M,Todaro Gdoi
10.1002/ijc.2910150505keywords:
subject
Has Abstractpub_date
1975-05-15 00:00:00pages
741-7issue
5eissn
0020-7136issn
1097-0215journal_volume
15pub_type
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