Detection of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma cell lines: cell morphology and growth phenotype do not reflect presence of the virus.

abstract：:In low and middle income countries (LMIC), high-quality disease registration is difficult to achieve in the setting of inadequate healthcare infrastructure and political or economical instability. In this article, we explore the potential of geographic information systems (GIS) to add value to the understanding of chi...

journal_title：International journal of cancer

authors： Bailony MR,Hararah MK,Salhab AR,Ghannam I,Abdeen Z,Ghannam J

更新日期：2011-09-01 00:00:00

abstract：:Medulloblastoma is a primitive neuroectodermal tumor of the cerebellum with poorly understood pathogenesis. Previous studies have reported loss of heterozygosity (LOH) on chromosome arms 17p, 11p and 9q and cytogenetic abnormalities of chromosome 1 in medulloblastoma. We have used the polymerase chain reaction to ampl...

journal_title：International journal of cancer

authors： Kraus JA,Koch A,Albrecht S,Von Deimling A,Wiestler OD,Pietsch T

更新日期：1996-07-03 00:00:00

abstract：:Our previous studies demonstrate that introduction of a approximately 70 cM region (now estimated at 63.75 Mb by the Human Genome Project) of human chromosome 12 into the highly metastatic Dunning rat prostate cancer cell line AT6.1 results in >30-fold (>/=90%) reduction in the number of overt metastases in spontaneou...

journal_title：International journal of cancer

authors： Jaeger EB,Chekmareva MA,Tennant TR,Luu HH,Hickson JA,Chen SL,Samant RS,Sokoloff MH,Rinker-Schaeffer CW

更新日期：2004-01-01 00:00:00

abstract：:Mice transgenic for the carcinoembryonic (CEA) gene were used to study the biodistribution and tumor targeting of a radioiodinated monoclonal antibody (MAb), T84.66. The specificity of antibody uptake in tumors was assessed in mice bearing a CEA-transfected syngeneic tumor as well as the antigen-negative parental tumo...

journal_title：International journal of cancer

authors： Szalai G,Williams LE,Primus FJ

更新日期：2000-03-15 00:00:00

abstract：:Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253 participants of the European Pr...

journal_title：International journal of cancer

authors： Weikert C,Dietrich T,Boeing H,Bergmann MM,Boutron-Ruault MC,Clavel-Chapelon F,Allen N,Key T,Lund E,Olsen A,Tjønneland A,Overvad K,Rohrmann S,Linseisen J,Pischon T,Trichopoulou A,Weinehall L,Johansson I,Sánchez MJ,Ag

更新日期：2009-07-15 00:00:00

abstract：:We report the incidence of cervical intraepithelial neoplasia (CIN) among HIV-infected women who did not have any colposcopic or histopathological evidence of CIN at baseline. Of the 1,023 women without any CIN at baseline, 855 (83.6%) have been followed up to a maximum of 6.4 years contributing 2,875 person years of ...

journal_title：International journal of cancer

authors： Joshi S,Muwonge R,Kulkarni V,Deodhar K,Mandolkar M,Lucas E,Sankaranarayanan R

更新日期：2019-03-01 00:00:00

abstract：:Single-cell suspensions prepared from five human melanomas, grown serially as xenografts in athymic nude mice, were exposed in vitro to increasing concentrations of DTIC (Dacarbazine), CCNU (Lomustine), procarbazine, vinblastine, and the cancerostatic lectins abrin and ricin. The in vitro chemosensitivity of the cells...

journal_title：International journal of cancer

authors： Tveit KM,Fodstad O,Olsnes S,Pihl A

更新日期：1980-12-15 00:00:00

abstract：:Although tobacco smoking, pan chewing and alcohol drinking are important risk factors for head and neck cancer (HNC), the HNC risks conferred by products available in Nepal for these habits are unknown. We assessed the associations of tobacco smoking, chewing habits, and alcohol drinking with HNC risk in Nepal. A case...

journal_title：International journal of cancer

authors： Chang CP,Siwakoti B,Sapkota A,Gautam DK,Lee YA,Monroe M,Hashibe M

更新日期：2020-08-01 00:00:00

abstract：:Using a direct binding liquid competition radioimmunoassay, the amount of the ras oncogene protein product, p21, was quantitated in a variety of human tumors and adjacent apparently normal tissues. In 48 of 50 matched tumor and normal tissue biopsy specimens from 50 patients, more ras p21 was detected in the tumor tha...

journal_title：International journal of cancer

authors： De Biasi F,Del Sal G,Hand PH

更新日期：1989-03-15 00:00:00

abstract：:Cells from reticulum-cell sarcomas (RCS), tumors with a probable B-cell origin in the SJL/J mouse strain, induced a high degree of proliferation in O-bearing syngeneic lymph-node and thymus cells obtained from young non-tumours mice. Although of considerably lower magnitude, a proliferation of SJL/J thymus cells to sy...

journal_title：International journal of cancer

authors： Lerman SP,Chapman JM,Carswell EA,Thorbecke GJ

更新日期：1974-12-15 00:00:00

abstract：:The targeted radiotherapy of neuroblastoma with 131l-labelled metaiodobenzyl guanidine (mIBG) is now the subject of several clinical studies. The precise intracellular localization of mIBG, necessary for nuclear microdosimetry, has not previously been described. We report the use of electron-energy-loss spectroscopy a...

journal_title：International journal of cancer

authors： Gaze MN,Huxham IM,Mairs RJ,Barrett A

更新日期：1991-04-01 00:00:00

abstract：:The high burden of cervical cancer and inadequate/suboptimal cytology screening in developing countries led to the evaluation of visual screening tests, like visual inspection with acetic acid (VIA) and Lugol's iodine (VILI). We describe the performance of VIA, VILI and cytology, carried out in a multinational project...

journal_title：International journal of cancer

authors： Deodhar K,Sankaranarayanan R,Jayant K,Jeronimo J,Thorat R,Hingmire S,Muwonge R,Chiwate A,Deshpande R,Ajit D,Kelkar R,Rekhi B,Ruben I,Malvi SG,Chinoy R,Jambhekar N,Nene BM

更新日期：2012-09-15 00:00:00

abstract：:In Bloom's syndrome (BS) the regulation of uracil-DNA glycosylase, an enzyme involved in the repair of DNA containing 5-FU, is altered. 5-FU induces higher levels of DNA fragmentation in BS cells than in non-BS cells. The increase in DNA fragmentation is connected to the cytotoxic mechanism where 5-FU is incorporated ...

journal_title：International journal of cancer

authors： Lönn U,Lönn S,Nylen U,Winblad G

更新日期：1990-03-15 00:00:00

abstract：:Small cell lung cancers (SCLCs) and extrapulmonary small cell cancers (SCCs) are very aggressive tumors arising de novo as primary small cell cancer with characteristic genetic lesions in RB1 and TP53. Based on murine models, neuroendocrine stem cells of the terminal bronchioli have been postulated as the cellular ori...

journal_title：International journal of cancer

authors： Meder L,König K,Ozretić L,Schultheis AM,Ueckeroth F,Ade CP,Albus K,Boehm D,Rommerscheidt-Fuss U,Florin A,Buhl T,Hartmann W,Wolf J,Merkelbach-Bruse S,Eilers M,Perner S,Heukamp LC,Buettner R

更新日期：2016-02-15 00:00:00

abstract：:Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...

journal_title：International journal of cancer

authors： Raguz S,Randle RA,Sharpe ER,Foekens JA,Sieuwerts AM,Meijer-van Gelder ME,Melo JV,Higgins CF,Yagüe E

更新日期：2008-03-01 00:00:00

abstract：:Recent genome-wide scans identified several novel breast cancer risk alleles, including variants of the FGFR2, MAP3K1 and LSP1 genes, and a study of associations between these alleles and characteristics of breast cancer patients reported a borderline significant correlation between the number of FGFR2 minor alleles a...

journal_title：International journal of cancer

authors： Gates MA,Tworoger SS,Terry KL,De Vivo I,Hunter DJ,Hankinson SE,Cramer DW

更新日期：2009-02-01 00:00:00

abstract：:Many studies have focused on global hypomethylation or hypermethylation of tumor suppressor genes, but less is known about the impact of promoter hypomethylation of oncogenes. We previously showed that promoter methylation may gradually increase or decrease during the transition from gastric mucosa (GM) to intestinal ...

journal_title：International journal of cancer

authors： Seo EH,Kim HJ,Kim JH,Lim B,Park JL,Kim SY,Lee SI,Jeong HY,Song KS,Kim YS

更新日期：2020-06-15 00:00:00

abstract：:The stability of a cloned murine tumor for sensitivity to NR was examined following growth in vivo in order to test the hypothesis that tumor progression proceeds through the generation and selection of variants. Clonal sensitivity to the [131I]-dUrd elimination assay of NR was assessed for the L5178Y-F9 tumor grown i...

journal_title：International journal of cancer

authors： Chow DA,Ray M,Greenberg AH

更新日期：1983-01-15 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumor, partially explained by mutations in the rearranged during transfection (RET) proto-oncogene. The nonsynonymous RET polymorphism G691S has been reported as associated with MTC, but findings are discordant. We sought to clarify the role of G691S in MTCs through in silic...

journal_title：International journal of cancer

authors： Lantieri F,Caroli F,Ceccherini I,Griseri P

更新日期：2013-06-15 00:00:00

abstract：:We assessed whether split dosing with the methylating agent DTIC is an effective strategy for inactivating the DNA repair protein O6-alkylguanine DNA-ATase in order to decrease tumour resistance to BCNU. ATase levels in PBMCs were used as a surrogate for tumour ATase depletion to determine whether this correlated with...

journal_title：International journal of cancer

authors： Clemons M,Ranson M,Margison JM,El Teraifi H,Griffiths A,Kelly J,Morris CQ,Howell A,Margison GP

更新日期：2003-02-20 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) inhibits epithelial cell proliferation. Inactivation of the TGF-beta signaling pathway is thought to play a role in tumorigenesis. Our purpose was to clarify the correlation between TGF-beta receptors or TGF-beta 1 expression and the clinicopathologic characteristics of patie...

journal_title：International journal of cancer

authors： Fukai Y,Fukuchi M,Masuda N,Osawa H,Kato H,Nakajima T,Kuwano H

更新日期：2003-03-20 00:00:00

abstract：:In a previous study, human ZNF312b was identified as a cell proliferation-associated oncogene via the K-ras/extracellular signal-regulated kinase cascade in gastric cancer. However, the mechanism concerning its transcriptional activation remains unknown. Here, we show that DNA methylation and histone acetylation of th...

journal_title：International journal of cancer

authors： Song IS,Ha GH,Kim JM,Jeong SY,Lee HC,Kim YS,Kim YJ,Kwon TK,Kim NS

更新日期：2011-11-01 00:00:00

abstract：:The expression of the recently described rap genes, closely related in the effector region to the ras proto-oncogenes, was examined by Northern blot analysis in 41 primary human tumors. The structural and in vitro biological properties of the rap gene products suggest their possible antagonistic action in the same eff...

journal_title：International journal of cancer

authors： Culine S,Olofsson B,Gosselin S,Honore N,Tavitian A

更新日期：1989-12-15 00:00:00

abstract：:Limited data are available on the carcinogenicity of smokeless tobacco products in organs other than the mouth. Snus is a smokeless tobacco product widely used in Norway. We studied 10,136 Norwegian men enrolled since 1966 in a prospective cohort study, 31.7% of whom were exposed to snus. The relative risk of pancreat...

journal_title：International journal of cancer

authors： Boffetta P,Aagnes B,Weiderpass E,Andersen A

更新日期：2005-05-10 00:00:00

abstract：:Experimental studies have suggested that the biosynthesis of arachidonic acid-derived eicosanoids such as prostaglandin E2 via the cyclo-oxygenase pathway may play a significant role in supporting cell proliferation in human prostate cancer cell lines. However, the aetiological significance of this for clinical prosta...

journal_title：International journal of cancer

authors： Norrish AE,Jackson RT,McRae CU

更新日期：1998-08-12 00:00:00

abstract：:Sexual behavior has been consistently identified as a major risk factor for cervical cancer. Population-based studies have demonstrated that risk related to sexual activity is mediated by human papillomavirus (HPV) infection. We conducted a case-control study of 199 cases with low-grade squamous intraepithelial lesion...

journal_title：International journal of cancer

authors： Kjaer SK,van den Brule AJ,Bock JE,Poll PA,Engholm G,Sherman ME,Walboomers JM,Meijer CJ

更新日期：1996-03-01 00:00:00

abstract：:The cis-2a,3-diol and the trans-4,5-, trans-7,8-, trans-9,10- and trans-11,12-dihydrodiols of 3-methylcholanthrene and the trans-3,4, trans-5,6-, trans-8,9. and trans-10,11- dihydrodiols of 7,12-dimethylbenz[a]anthrancene have been tested, in comparison with the parent hydrocarbons, for their abilities to initiate sk...

journal_title：International journal of cancer

authors： Chouroulinkov I,Gentil A,Tierney B,Grover PL,Sims P

更新日期：1979-10-15 00:00:00

abstract：:Studies of the MLTI were performed in a primary MSV-induced tumor system. Reactivity against mitomycin-C-treated RBL-5 cells could be detected during a limited period at about 14 days after virus injection. The degree of reactivity of MSV 14 spleen cells was quite variable; stimulation indices ranged from 2.2 to 9.4. ...

journal_title：International journal of cancer

authors： Kirchner H,Glaser M,Holden HT,Herberman RB

更新日期：1976-03-15 00:00:00

abstract：:The tumor-suppressor genes p14(ARF), p16(INK4a) and Tp53 are commonly inactivated in many tumors. We investigated their role in the pathogenesis of 9 bile tract cancer cell lines and 21 primary sporadic extrahepatic bile duct carcinomas. p53 and p16 protein expression was examined by Western blot analysis and immunohi...

journal_title：International journal of cancer

authors： Caca K,Feisthammel J,Klee K,Tannapfel A,Witzigmann H,Wittekind C,Mössner J,Berr F

更新日期：2002-02-01 00:00:00

abstract：:Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution multimodal imaging approach assessing in vivo the metabolism of i...

journal_title：International journal of cancer

authors： Lai M,Vassallo I,Lanz B,Poitry-Yamate C,Hamou MF,Cudalbu C,Gruetter R,Hegi ME

更新日期：2018-07-01 00:00:00