Abstract:
:Using a direct binding liquid competition radioimmunoassay, the amount of the ras oncogene protein product, p21, was quantitated in a variety of human tumors and adjacent apparently normal tissues. In 48 of 50 matched tumor and normal tissue biopsy specimens from 50 patients, more ras p21 was detected in the tumor than in its normal counterpart. Twenty-five of 28 breast tumors demonstrated more ras p21 than the average of the values obtained for fibroadenomas. Furthermore, in 17 of the 19 cases studied, over 20% more ras p21 was observed in breast carcinomas compared with their respective normal counterparts. More ras p21 was also demonstrated in the majority of tumors of the stomach, lung, colon and bladder compared with their respective adjacent normal tissues. Our data therefore indicate that ras p21 expression is quantitatively enhanced in many human tumors originating from several different tissue types.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
De Biasi F,Del Sal G,Hand PHdoi
10.1002/ijc.2910430315subject
Has Abstractpub_date
1989-03-15 00:00:00pages
431-5issue
3eissn
0020-7136issn
1097-0215journal_volume
43pub_type
杂志文章abstract::Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage and in 5 normal uroth...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990219)84:1<39::aid-ijc8
更新日期:1999-02-19 00:00:00
abstract::Breast cancer cells frequently metastasize to the skeleton, where they induce OCL formation and activity, resulting in extensive bone destruction. However, the mechanisms by which breast cancer cells mediate increased osteolysis remain unclear. To elucidate this point, we investigated how 3 human breast cancer cell li...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20056
更新日期:2004-05-01 00:00:00
abstract::Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high-grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermined significance (ASC...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11222
更新日期:2003-09-01 00:00:00
abstract::ECOG 1696 was a Phase II multi-center trial testing vaccination with melanoma peptides, gp100, MART-1 and tyrosinase delivered alone, with GM-CSF, IFN-α2b or both cytokines to HLA-A2(+) patients with metastatic melanoma. Here, the frequency of circulating CD8(+) tetramer(+) (tet(+) ) T cells and maturation stages of...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.26481
更新日期:2012-08-15 00:00:00
abstract::I-compounds are bulky indigenous DNA adducts that can be detected by (32)P-postlabeling. A subgroup, termed type II I-compounds, represents DNA lesions induced by oxidative stress. Several major type II I-compounds have been identified as dinucleotides containing 3'-terminal 8,5'-cyclo-2'-deoxyadenosine (cA). Levels o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20375
更新日期:2004-12-10 00:00:00
abstract::Angiogenesis and immunosuppression work hand-in-hand in the renal cell carcinoma (RCC) microenvironment. Tumor growth is associated with impaired antitumor immune response in RCC, which involves T cells, natural killer cells, dendritic cells (DCs) and macrophages. Vascular endothelial growth factor receptor (VEGFR), s...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28503
更新日期:2014-06-15 00:00:00
abstract::Combretastatin A4 (CA4) is a novel vascular disrupting agent that has promising clinical efficacy because of its ability to inhibit microtubule assembly and subsequently disrupt tumor blood flow. In this study, we demonstrate that mitogen-activated protein kinases (MAPKs) are critically involved in the cytotoxicity of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23262
更新日期:2008-04-15 00:00:00
abstract::Endometriosis is a common gynecologic disease, which generally follows a benign course. Notwithstanding, several clinical and histologic studies as well as molecular data show that endometriosis could be a precursor of sporadic endometrioid and clear cell carcinomas at extrauterine loci. Several reports have implicate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10715
更新日期:2002-12-01 00:00:00
abstract::PDT has been reported to induce cancer cell expression of cytokines, such as IL-6 and TNF-alpha, but it has been unclear whether cytokine expression by cancer cells is directly related to the antitumor effect of PDT. We treated Lewis lung carcinoma (LLC) cells with a new photosensitizer, mono-L-aspartyl chlorin e6 (NP...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1374
更新日期:2001-08-15 00:00:00
abstract::Two groups of rabbits were inoculated on the day of birth or at 4 weeks of age with a human T-cell leukemia virus type-I (HTLV-I)-infected and transformed rabbit cell line (Ra-I). Rabbits seroconverted to HTLV-I, as determined by indirect immunofluorescence, by 3 weeks after inoculation and remained persistently serop...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450123
更新日期:1990-01-15 00:00:00
abstract::In the perspective of in vivo therapeutic applications, the monoclonal antibody (MAb) MOv18 was selected for its restricted reactivity with human ovarian carcinoma. Using the pH 2.8 desorption assay, we found that the antigen recognized by MOv18 had a high stability on the cell membrane and poor internalization. There...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410422
更新日期:1988-04-15 00:00:00
abstract::Mantle cell lymphoma (MCL) is an aggressive and incurable malignant disease. Despite of general chemotherapy, relapse and mortality are common, highlighting the need for the development of novel targeted drugs or combination of therapeutic regimens. Recently, several drugs that target the B-cell receptor (BCR) signali...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31044
更新日期:2018-01-01 00:00:00
abstract::Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease characterized by early-onset colorectal tumors, primarily in the right colon, that are frequently associated with other cancers. In the absence of a reliable biomarker, clinical criteria for diagnosing HNPCC have been proposed by the I...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580608
更新日期:1994-09-15 00:00:00
abstract::Monoclonal antibody (MAb) K 112 was generated after a single intrasplenic immunization with a recurrent laryngeal squamous-cell carcinoma. The antibody detects a 43-kDa nuclear antigen, with a pI of 5.4, which is expressed only in cycling cells. Expression is typically seen in a granular pattern excluding the nucleoli...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460111
更新日期:1990-07-15 00:00:00
abstract::A challenging task of the immune system is to fight cancer cells. However, a variety of human cancers educate immune cells to become tumor supportive. This is exemplified for tumor-associated macrophages (TAMs), which are polarized towards an anti-inflammatory and cancer promoting phenotype. Mechanistic explanations, ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24594
更新日期:2009-11-01 00:00:00
abstract::We examined the effects of acivicin, a specific inhibitor of the ectoenzyme gamma-glutamyltransferase (gamma-GT), on gamma-GT activity and apoptosis in 2 human T-lymphoblastoid CEM cell lines, CCRF and VBL-100. In both cell lines, acivicin was found to cause morphological and biochemical changes of apoptosis in a dose...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620414
更新日期:1995-08-09 00:00:00
abstract::The effects of galanin on pancreatic carcinogenesis induced by azaserine and on the norepinephrine concentration in the pancreas were investigated in male Wistar rats. Rats were given weekly injections of 10 mg/kg body weight of azaserine for 25 weeks and 8 microg/kg body weight of galanin in depot form every other da...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980130)75:3<396::aid-ijc
更新日期:1998-01-30 00:00:00
abstract::Recent suggestions that tumor-cell targeting of elastin-rich tissues (e.g., lung) correlates with the presence of surface elastin receptors have been investigated. Receptors for insoluble (fibrous) elastin and for soluble elastin peptides have been implemented in these correlations. A rapid assay for binding of insolu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530520
更新日期:1993-03-12 00:00:00
abstract::5-Fluorouracil (5-FU) is the major chemotherapeutic component for colorectal cancer (CRC) and other types of solid tumours. Resistance of cancer cells to 5-FU is considered the major obstacle for successful chemotherapy. NF-kappaB is a transcription factor. Cancer cells with high NF-kappaB nuclear activity demonstrate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10972
更新日期:2003-04-20 00:00:00
abstract::The hedgehog (Hh) signaling pathway is essential for the development of tissues and organs. Hyperactive Hh signaling has been implicated in many gastric cancers, including esophageal cancer. However, the interaction between the Hh pathway and other potential signaling pathways in primary esophageal tumorigenesis has n...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25673
更新日期:2011-07-15 00:00:00
abstract::Multiple myeloma (MM) is the second most common hematologic malignancy characterized by the clonal expansion of plasma cells. Despite continuing advances, novel biomarkers are needed for diagnosis and prognosis of MM. In our study, we characterized the diagnostic and prognostic potential of circulating microRNAs (miRN...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29199
更新日期:2015-04-15 00:00:00
abstract::We conducted a retrospective cohort study to investigate the colorectal cancer (CRC) incidence and mortality prevention achievable in clinical practice with an optimized colonoscopy protocol targeting near-complete polyp clearance. The protocol consisted of: (i) telephonic reinforcement of bowel preparation instructio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29228
更新日期:2015-03-15 00:00:00
abstract::Risk of Hodgkin's disease (HD) in young adults has frequently been associated with limited access to social contact in childhood and related correlates of childhood social class. In addition, case clustering has sometimes been associated with influxes of population into relatively isolated communities. To investigate ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480103
更新日期:1991-04-22 00:00:00
abstract::Some herds of miniature swine are genetically predisposed to cutaneous melanoma. To test if swine melanoma susceptibility could be linked to the CDKN2A gene, which is involved in a proportion of 9p21-linked human familial melanoma, we performed a genetic analysis of miniature pigs of the MeLiM strain. F(1) and backcro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10871
更新日期:2003-02-20 00:00:00
abstract::Emerging evidence suggests that diffusion-weighted magnetic resonance imaging (DW MRI) could be useful for tumor detection with N and M staging of lung cancer in place of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). DW MRI at 3.0 T and FDG PET/CT were performed before t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28394
更新日期:2014-02-01 00:00:00
abstract::The activity of ecto-nucleotidases has been determined on intact cells from Burkitt lymphoma (BL) and lymphoblastoid cell lines established in vitro (LCLs). BL cells never express ecto-5'-nucleotidase (5'-N) and exhibit only low levels of ecto-ATPase activity, whereas LCL-cells usually express both enzymes to varying ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410321
更新日期:1988-03-15 00:00:00
abstract::The prognostic impact of distinct KRAS mutations in colorectal carcinomas is not fully characterized. We hypothesized that the prognostic impact of KRAS mutations is modulated by KRAS mutant allele-specific imbalance (MASI). KRAS MASI was assessed by sequencing electropherograms in KRAS-mutated colorectal carcinomas (...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27461
更新日期:2012-10-15 00:00:00
abstract::Prostate cancer incidence has increased during recent years, possibly linked to environmental exposures. Exposure to environmental carcinogens is unlikely to be evenly distributed geographically, which may give rise to variations in disease occurrence that is detectable in a spatial analysis. The aim of our study was ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10113
更新日期:2002-02-10 00:00:00
abstract::The incidence of adult T-cell leukemia/lymphoma (ATL) and its impact on that of total non-Hodgkin lymphoma (NHL) were evaluated in Nagasaki, an area in southwestern Japan where human T-cell lymphotropic virus type I (HTLV-I) is endemic. The first study area comprised 4 towns located on the K Islands, which had a popul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000201)85:3<319::aid-ijc
更新日期:2000-02-01 00:00:00
abstract::Fibronectin in human solid tumors was studied by indirect immunofluorescence staining of biopsy material. Altogether 73 tumors were examined, comprising 12 sarcomas, 3 melanomas 1 reticulum cell sarcoma, 39 carcinomas, 6 benign soft-tissue tumors and 12 benign epithelial tumors. In all sarcomas the individual tumor ce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270403
更新日期:1981-01-01 00:00:00