Inhibition of prostate cancer metastatic colonization by approximately 4.2 Mb of human chromosome 12.

abstract：:DNA synthesis in heterokaryons of mouse peritoneal macrophages and various proliferating cultured cells was analyzed. Macrophages did not inhibit replication in the nuclei of non-immortalized and spontaneously immortalized cells (rat fibroblasts and macrophages, mouse pre-macrophages, NIH3T3 cells). On the contrary, t...

journal_title：International journal of cancer

authors： Prudovsky IA,Gumeniuk RR,Yegorov YE,Zelenin AV

更新日期：1989-12-15 00:00:00

abstract：:Colibactin-producing E. coli (CoPEC) are frequently detected in colorectal cancer (CRC) and exhibit procarcinogenic properties. Because increasing evidence show the role of immune environment and especially of antitumor T-cells in CRC development, we investigated the impact of CoPEC on these cells in human CRC and in ...

journal_title：International journal of cancer

authors： Lopès A,Billard E,Casse AH,Villéger R,Veziant J,Roche G,Carrier G,Sauvanet P,Briat A,Pagès F,Naimi S,Pezet D,Barnich N,Dumas B,Bonnet M

更新日期：2020-06-01 00:00:00

abstract：:Common genetic variations in genes involved in DNA repair or response to genotoxic stress may influence both cancer susceptibility and treatment response individually or interactively. However, in acute myeloid leukemia (AML), the relevance of these genetic variations remains to be fully established. In this study, we...

journal_title：International journal of cancer

authors： Shi JY,Ren ZH,Jiao B,Xiao R,Yun HY,Chen B,Zhao WL,Zhu Q,Chen Z,Chen SJ

更新日期：2011-01-01 00:00:00

abstract：:Infection with erbB-2 (E) of Ha-ras (H) oncogene-transfected cells has been previously shown to cooperatively induce anchorage-independent growth of the MCF10A human mammary epithelial cell line in vitro, but not to induce nude mouse tumorigenicity. Here we show that oncogene-transformed MCF10A are able to halt in the...

journal_title：International journal of cancer

authors： Giunciuglio D,Culty M,Fassina G,Masiello L,Melchiori A,Paglialunga G,Arand G,Ciardiello F,Basolo F,Thompson EW

更新日期：1995-12-11 00:00:00

abstract：:The levels of tumour-specific antigen, antibody and specific immune complexes in the sera of rats bearing lung nodules of a chemically induced rat hepatoma, produced by intravenous inoculation of viable tumour cells, have been examined and compared with the levels of serum factors in animals actively immunized by intr...

journal_title：International journal of cancer

authors： Bowen JG,Baldwin RW

更新日期：1976-02-15 00:00:00

abstract：:As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice. The present study was designed to investigate the combined effects of COX-1 and COX-2 selective inhibitors on spontaneous p...

journal_title：International journal of cancer

authors： Kitamura T,Itoh M,Noda T,Matsuura M,Wakabayashi K

更新日期：2004-04-20 00:00:00

abstract：:Antibodies directed against idiotypic determinants of the cell-surface IgM of a B lymphoma, 38c, were effective in delaying development of the tumor and in some instances in preventing its growth. The efficacity of the anti-idiotype antibodies was markedly increased when they were injected in combination with anti-neo...

journal_title：International journal of cancer

authors： Hurwitz E,Burowski D,Kashi R,Hollander N,Haimovich J

更新日期：1986-05-15 00:00:00

abstract：:Pancreatic cancer remains the fourth most common cause of cancer related death in the United States. Therefore, novel strategies for the prevention and treatment are urgently needed. Genistein is a prominent isoflavonoid found in soy products and has been proposed to be responsible for lowering the rate of pancreatic ...

journal_title：International journal of cancer

authors： Wang Z,Zhang Y,Banerjee S,Li Y,Sarkar FH

更新日期：2006-04-15 00:00:00

abstract：:An Epstein-Barr virus-related herpesvirus, termed Herpesvirus papio (HVP), was isolated from baboons (Papio hamadryas) at the Institute of Experimental Pathology and Therapy, Sukhumi, USSR, where there is a continuing outbreak of lymphoma. In the present study sera from diseased baboons and from age- and sex-matched c...

journal_title：International journal of cancer

authors： Neubauer RH,Rabin H,Strnad BC,Lapin BA,Yakovleva LA,Indzie E

更新日期：1979-02-01 00:00:00

abstract：:Malignant tumors are generally characterized by extensive local tissue invasion and destruction of ECM which may be due to increased constitutive expression and activity of secreted proteases. Moreover, a large number of diverse protease activities may be constitutively over-expressed in a simultaneous or co-ordinated...

journal_title：International journal of cancer

authors： Korczak B,Kerbel RS,Dennis J

更新日期：1991-06-19 00:00:00

abstract：:Cell populations resistant to high doses (30 microM) of 6-thioguanine (6-TG, 6-TG(r) cells) were selected from a human colon carcinoma cell line, LoVo. This cell line, which lacks hMSH2, a component of the human mismatch binding heterodimer hMutSalpha, is resistant to low doses of 6-TG. The level of activity of hypoxa...

journal_title：International journal of cancer

authors： Bemi V,Turchi G,Margotti E,Giorgelli F,Pesi R,Sgarrella F,Tozzi MG,Camici M

更新日期：1999-08-12 00:00:00

abstract：:Oncogene-transformed fibroblasts which expressed IL-1, spontaneously or after activation with conditioned medium (CM) and lipopolysaccharide (LPS), regressed in the syngeneic host. Since regression was significantly influenced by the immune competence of the host (see companion report), we speculated that regression w...

journal_title：International journal of cancer

authors： Zöller M,Douvdevani A,Segal S,Apte RN

更新日期：1992-02-01 00:00:00

abstract：:Chemokine receptors are known to regulate homing of lymphocytes into secondary lymphoid organs and may also be involved in the lymphatic spread of solid tumors. Therefore, the assessment of chemokine receptor expression on colorectal carcinomas could potentially improve the prediction of lymph node spread. This is of ...

journal_title：International journal of cancer

authors： Günther K,Leier J,Henning G,Dimmler A,Weissbach R,Hohenberger W,Förster R

更新日期：2005-09-20 00:00:00

abstract：:A randomized screening trial was started in Europe to show the effect of early detection and treatment of prostate cancer on mortality (European Study on Screening of Prostate Cancer). In one centre (Rotterdam), the screening protocol initially consisted of 3 screening tests for all men: prostate-specific antigen (PSA...

journal_title：International journal of cancer

authors： Beemsterboer PM,Kranse R,de Koning HJ,Habbema JD,Schröder FH

更新日期：1999-08-20 00:00:00

abstract：:In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis. In our study, we de...

journal_title：International journal of cancer

authors： Chen B,Liu X,Savell VH,Dilday BR,Johnson MW,Jenkins JJ,Parham DM

更新日期：1999-09-24 00:00:00

abstract：:The causative role of human papillomaviruses (HPV) and HPV16 variants has been extensively studied in uterine cervix dysplastic lesions and invasive carcinoma; few such studies, however, have been performed in penile tumors. We have investigated HPV genotype and HPV16 variant distribution on 41 penile cancer biopsies ...

journal_title：International journal of cancer

authors： Tornesello ML,Duraturo ML,Losito S,Botti G,Pilotti S,Stefanon B,De Palo G,Gallo A,Buonaguro L,Buonaguro FM

更新日期：2008-01-01 00:00:00

abstract：:We have recently shown that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The aim of the present study was to determine the molecular mechanisms...

journal_title：International journal of cancer

authors： Tanimoto R,Sakaguchi M,Abarzua F,Kataoka K,Kurose K,Murata H,Nasu Y,Kumon H,Huh NH

更新日期：2010-04-01 00:00:00

abstract：:We examined the effects of acivicin, a specific inhibitor of the ectoenzyme gamma-glutamyltransferase (gamma-GT), on gamma-GT activity and apoptosis in 2 human T-lymphoblastoid CEM cell lines, CCRF and VBL-100. In both cell lines, acivicin was found to cause morphological and biochemical changes of apoptosis in a dose...

journal_title：International journal of cancer

authors： Graber R,Losa GA

更新日期：1995-08-09 00:00:00

abstract：:The findings of mutations and the development of targeted therapies have improved lung cancer management. Still, the prognosis remains poor, and we need to know more about the genetic and epigenetic alterations in lung cancer. MicroRNAs are involved in crucial biological processes like carcinogenesis by regulating gen...

journal_title：International journal of cancer

authors： Bjaanaes MM,Halvorsen AR,Solberg S,Jørgensen L,Dragani TA,Galvan A,Colombo F,Anderlini M,Pastorino U,Kure E,Børresen-Dale AL,Brustugun OT,Helland A

更新日期：2014-10-15 00:00:00

abstract：:CD22 antibodies (Abs) bound to B-cell lymphomas are known to be internalized and catabolized rapidly. Therefore, it would be expected that use of CD22 as a target for radioimmunotherapy should be enhanced by the use of "residualizing" radiolabels, which are trapped within the cell after catabolism of the Ab to which t...

journal_title：International journal of cancer

authors： Mattes MJ,Shih LB,Govindan SV,Sharkey RM,Ong GL,Xuan H,Goldenberg DM

更新日期：1997-05-02 00:00:00

abstract：:Melanoma of unknown primary (MUP) may have a different biology to melanoma of known primary, but clinical trials of novel therapies (e.g., immune checkpoint or BRAF/MEK inhibitors) have not reported the outcomes in this population. We therefore evaluated the overall survival (OS) among patients with MUP in the era of ...

journal_title：International journal of cancer

authors： Verver D,van der Veldt A,van Akkooi A,Verhoef C,Grünhagen DJ,Louwman WJ

更新日期：2020-01-01 00:00:00

abstract：:Farnesyl transferase inhibitors (FTIs) were shown to be effective in modulating tumor growth in Ras-transformed tumor cells. Recent studies have focused on Rho GTPases as putative targets of FTI action. Previously, we demonstrated that FTIs were effective in inhibiting the growth and invasiveness of RhoC GTPase-overex...

journal_title：International journal of cancer

authors： Chatterjee M,van Golen KL

更新日期：2011-07-01 00:00:00

abstract：:We have recently reported that glioblastoma (GB)-initiating cells (GIC) with low expression and/or mutation of TP53 and high expression of PI3K ("responder" genetic profile) can be effectively and safely radiosensitized by the ATM inhibitor KU60019. We report here on drug's diffusion and elimination from the animal bo...

journal_title：International journal of cancer

authors： Vecchio D,Daga A,Carra E,Marubbi D,Raso A,Mascelli S,Nozza P,Garrè ML,Pitto F,Ravetti JL,Vagge S,Corvò R,Profumo A,Baio G,Marcello D,Frosina G

更新日期：2015-03-15 00:00:00

abstract：:Socioeconomic status (SES) is a determinant of outcome in various types of cancer. The aim of this study is to analyze the impact of the SES in Hodgkin's lymphoma (HL). From 2001 to 2005, 194 consecutive patients were prospectively followed in 5 institutions. Patients answered a questionnaire with a set of items used ...

journal_title：International journal of cancer

authors： Soares A,Biasoli I,Scheliga A,Luiz RR,Costa MA,Land M,Romano S,Morais JC,Spector N

更新日期：2007-02-15 00:00:00

abstract：:miRNAs have emerged as post-transcriptional regulators that are critically involved in the pathogenesis of a number of human cancers. Cdc42, one of the best characterized members of the Rho GTPase family, is found to be up-regulated in several types of human tumors and has been implicated in cancer initiation and prog...

journal_title：International journal of cancer

authors： Liu M,Lang N,Qiu M,Xu F,Li Q,Tang Q,Chen J,Chen X,Zhang S,Liu Z,Zhou J,Zhu Y,Deng Y,Zheng Y,Bi F

更新日期：2011-03-15 00:00:00

abstract：:The purpose of this study is to help clarify the use of prostate size as a selection factor for prostate brachytherapy. From 1997 to 1998, 33 patients with a TRUS-based prostate volume greater than 50 cc were treated at the University of Washington by I-125 (144 Gy) or Pd-103 (115 Gy) implantation for prostatic carcin...

journal_title：International journal of cancer

authors： Wang H,Wallner K,Sutlief S,Blasko J,Russell K,Ellis W

更新日期：2000-08-20 00:00:00

abstract：:We studied the effect of retinoids on the growth and differentiation of a cell line (U 343 MG-A) derived from a human malignant astrocytoma. Cultures treated with all-trans or 13-cis retinoic acid showed a dose-dependent inhibition of proliferation and a marked reduction in the mean cell number at the plateau phase of...

journal_title：International journal of cancer

authors： Rutka JT,De Armond SJ,Giblin J,McCulloch JR,Wilson CB,Rosenblum ML

更新日期：1988-09-15 00:00:00

abstract：:The acyclic nucleoside phosphonate analogue cidofovir is a broad-spectrum anti-DNA virus agent, which also possesses potent inhibitory activity against various tumors associated with papillomaviruses in animal models and patients. Moreover, we recently described the potent inhibition of polyomavirus (PyV)-induced hema...

journal_title：International journal of cancer

authors： Liekens S,Verbeken E,De Clercq E,Neyts J

更新日期：2001-04-15 00:00:00

abstract：:NY-ESO-1 antigen is a prototype of a class of cancer/testis antigens. We carried out a clinical trial using NY-ESO-1 whole protein as a cancer vaccine for 13 advanced cancer patients. We have recently reported that vaccine elicited humoral and cellular immune responses in 9 cancer patients including 4 esophageal cance...

journal_title：International journal of cancer

authors： Wada H,Sato E,Uenaka A,Isobe M,Kawabata R,Nakamura Y,Iwae S,Yonezawa K,Yamasaki M,Miyata H,Doki Y,Shiku H,Jungbluth AA,Ritter G,Murphy R,Hoffman EW,Old LJ,Monden M,Nakayama E

更新日期：2008-11-15 00:00:00

abstract：:Interleukin-12 (IL-12) is a disulfide-linked p40-p35 heterodimeric cytokine and plays a key role in linking innate cellular immunity to an adaptive Th1 response against pathogens and tumor cells and in counteracting a Th2 immune response. The pathogenesis of Hodgkin's disease (HD) is partially attributed to a Th2 domi...

journal_title：International journal of cancer

authors： Heuser C,Diehl V,Abken H,Hombach A

更新日期：2003-09-10 00:00:00