Abstract:
:Studies of the MLTI were performed in a primary MSV-induced tumor system. Reactivity against mitomycin-C-treated RBL-5 cells could be detected during a limited period at about 14 days after virus injection. The degree of reactivity of MSV 14 spleen cells was quite variable; stimulation indices ranged from 2.2 to 9.4. Activity in the MLTI appeared to a great extent to be dependent on T-lymphocytes. A relatively broad spectrum of specificity was demonstrated in experiments using additional stimulating cells besides RBL-5. The kinetics of the MLTI correlated well with the kinetics of the primary cytotoxic response in the CRA against RBL-5 cells. However, positive results in the in vivo and in vitro secondary cytotoxicity assays could be detected between 21 and 100 days after MSV injection when the MLTI was negative. Transplantation resistance against challenge with RBL-5 tumor cells also persists for a long time after MSV inoculation. Our data therefore indicate that the MLTI, in contrast to the secondary cytotoxicity assays, does not correlate well with the status of in vivo immunity.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Kirchner H,Glaser M,Holden HT,Herberman RBdoi
10.1002/ijc.2910170313keywords:
subject
Has Abstractpub_date
1976-03-15 00:00:00pages
362-9issue
3eissn
0020-7136issn
1097-0215journal_volume
17pub_type
杂志文章abstract::A functional promoter polymorphism in the progesterone receptor (PR) gene previously has been associated with an increased risk of postmenopausal breast cancer. Whether the relationship between genetic variation in PR and risk of breast cancer is modified by postmenopausal hormone (PMH) use is unknown. Thus, we conduc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24477
更新日期:2009-10-01 00:00:00
abstract::A blood assay for detection of lung cancer biomarkers could significantly improve cancer patient prognosis and survival rates. Amplified fragment length polymorphism-differential display (AFLP-DD) was used to identify gene transcripts found in lung cancer tissue and the peripheral blood of lung cancer patients. The cl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10534
更新日期:2002-08-10 00:00:00
abstract::Nicotinic acetylcholine receptors (nAChR) are expressed on bronchial epithelial and non-small cell lung cancer cells and are involved in cell growth regulation. Nicotine (classical nAChR agonist) induced cell proliferation, whereas nAChR antagonists, d- tubocurarine or alpha-cobratoxin (alpha-CbT), induced cell death....
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24299
更新日期:2009-07-01 00:00:00
abstract::Coffee has been proposed to decrease the circulating insulin and estrogen levels, which are related to the development of endometrial cancer. However, few studies have prospectively assessed the association between coffee consumption and endometrial cancer. We conducted a population-based prospective cohort study in 5...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23760
更新日期:2008-11-15 00:00:00
abstract::The aim of this prospective study was to assess the uptake of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC) and its associations with sociodemographic and other factors, and long-term satisfaction with taking the test. The test was offered to all high-risk members (n = 446) of 36 Fi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-01-20 00:00:00
abstract::ECOG 1696 was a Phase II multi-center trial testing vaccination with melanoma peptides, gp100, MART-1 and tyrosinase delivered alone, with GM-CSF, IFN-α2b or both cytokines to HLA-A2(+) patients with metastatic melanoma. Here, the frequency of circulating CD8(+) tetramer(+) (tet(+) ) T cells and maturation stages of...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-08-15 00:00:00
abstract::Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines. CD59 expression had a low degree of intra- and intertumor heterogeneity. SDS-PA...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610420
更新日期:1995-05-16 00:00:00
abstract::Folate receptor-alpha (FR-alpha) is generally over-expressed in non-mucinous human ovarian carcinomas. The meaning of FR-alpha over-expression and its role in the 5-methyltetrahydrofolic acid (N5-CH3-H4PteGlu) transport in such tumors is not clear, especially compared with the reduced folate carrier (RFC), the other k...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980105)75:1<125::aid-ijc
更新日期:1998-01-05 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.1552
更新日期:2001-12-15 00:00:00
abstract::Oncostatin M is a leukocyte product that has been reported to have anti-proliferative effects directly on melanoma and other cancer cell lines in vitro. However, its function(s) in cancers in vivo appears complex and its roles in cancer growth in lungs are unknown. Here, we show that OSM promotes marked growth of tumo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29055
更新日期:2015-02-15 00:00:00
abstract::Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14, 15 and 18 are frequently deleted in primary ovarian cancers (OCs). Therefore we used microcell-mediated chromosome transfer (MMCT) to establish the functional effects of transferring normal copies of these chromosomes ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24058
更新日期:2009-03-01 00:00:00
abstract::The potential role of p16(INK4a) methylation in breast cancer is controversial whereas there are no data on fibroadenoma. To assess if inactivation of p16(INK4a) by promoter hypermethylation occurs in this hyperproliferative benign breast lesion or, on the contrary, it is strictly related to the carcinogenic process, ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20771
更新日期:2005-04-10 00:00:00
abstract::The epithelial ovarian carcinoma (EOC) is an aggressive malignant tumor, and is currently the leading cause of gynecologic cancer death. CA125 is the most commonly used serum marker for EOC, but shows a high-false-positive rate for several benign diseases such as endometriosis. The purpose of our study is therefore to...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29185
更新日期:2015-04-15 00:00:00
abstract::Recent studies suggest a potential role of lipid lowering drugs, fibrates and statins, in anticancer treatment. One candidate for tumor chemoprevention is fenofibrate, which is a potent agonist of peroxisome proliferator activated receptor alpha (PPARalpha). Our results demonstrate elevated expression of PPARalpha in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23588
更新日期:2008-09-01 00:00:00
abstract::A general concern exists that cervical cancer screening using human papillomavirus (HPV) testing may lead to considerable overtreatment. We evaluated the trade-off between benefits and overtreatment among different screening strategies differing by primary tests (cytology, p16/Ki-67, HPV alone or in combinations), int...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32849
更新日期:2020-08-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500623
更新日期:1992-04-01 00:00:00
abstract::Paracrine motogenic cytokines secreted by normal cells can stimulate metastatic cell invasion. For example, human fibroblasts secrete hepatocyte growth factor/scatter factor (HGF/SF), which stimulates paracrine migration of epithelial and certain carcinoma cells, and migration-stimulating factor (MSF), which stimulate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620516
更新日期:1995-09-04 00:00:00
abstract::The Insulin-like growth factor (IGF)/IGF-receptor pathway with its scaffolding proteins Insulin Receptor Substrate (IRS)1 and IRS2 are crucial regulators of metabolism and progression in metastatic colorectal cancer (mCRC). The goal of the study was the identification of predictive and prognostic markers among IRS1, I...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.30715
更新日期:2017-07-15 00:00:00
abstract::Telomerase, the enzyme responsible for maintenance of the telomeres, is absent from the vast majority of somatic cells but is present in most tumours. Little is known about how telomerase is activated in cancer, although it is thought vital for immortalisation to occur. The aim of our study was to identify genetic cha...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19991022)84:5<516::aid-ijc
更新日期:1999-10-22 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600409
更新日期:1995-02-08 00:00:00
abstract::Cytological screening for cervical cancer is hampered by high false negative rates. Inter-observer reproducibility needs optimizing. The potential of p16(INK4a) as a biomarker for cervical lesions was examined in a study of liquid-based cytology (LBC), HPV DNA testing by MY09/MY11 consensus PCR and type-specific PCRs ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11589
更新日期:2004-03-01 00:00:00
abstract::Deletions on chromosomes 1p and 19q are associated with favorable prognosis in patients with oligodendroglial tumors. The aim of our study was to identify additional genomic aberrations linked to patient survival. We performed a genome-wide screen for genomic imbalances by comparative genomic hybridization on tumors f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22574
更新日期:2007-06-01 00:00:00
abstract::It has been proposed that oxidative stress develops in tumors, with important consequences for growth and progression. To investigate this hypothesis, we measured low m.w. thiols, disulfides, protein-mixed disulfides and a pool of major anti-oxidant enzymes in renal-cortex as well as renal-cell carcinoma (RCC) specime...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010101)91:1<55::aid-ijc1006>3.
更新日期:2001-01-01 00:00:00
abstract::Effects of 12-O-tetradecanoyl phorbol 13-acetate (TPA) and the hepatic peroxisome proliferators (HPPs) clofibrate, methyl clofenapate (MCP), di(2-ethylhexyl)phthalate (DEHP) and mono(2-ethylhexyl)phthalate (MEHP) were studied in 2 gap junctional intercellular communication (GJIC) systems, metabolic cooperation in V79 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971009)73:2<240::aid-ijc
更新日期:1997-10-09 00:00:00
abstract::Alcohol consumption is associated with a modest increased risk of colon cancer, but its relationship with colon cancer survival has not been elucidated. Using data from a phase III randomized adjuvant trial, we assessed the association of alcohol consumption with colon cancer outcomes. Patients completed a risk factor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30135
更新日期:2016-09-01 00:00:00
abstract::Human papillomavirus (HPV) vaccination of a birth cohort of girls in the 9-13 age range is recommended as a priority, but decreases in HPV vaccine cost may make catch-up of a few additional cohorts more attractive not only in high-income countries. We assessed the reduction in HPV16 and 18 infections that could be ach...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28197
更新日期:2013-10-15 00:00:00
abstract::Human oocytes in different stages of maturation were obtained by follicular aspiration from women given Clomovid and Gonadex. Particles similar to type-C virus were observed in three out of 16 oocytes. The particles were irregularly distributed along the oocyte membrane. They were seen both in a state of budding and l...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280504
更新日期:1981-11-15 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.28638
更新日期:2014-06-15 00:00:00
abstract::Nitrogen-containing bisphosphonates (N-BPs) are effective antiosteolytic agents in patients with multiple myeloma. Preclinical studies have also demonstrated that these agents have direct antitumor effects in vitro and can reduce tumor burden in a variety of animal models, although it is not clear whether such effects...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24758
更新日期:2010-01-01 00:00:00
abstract::We recently reported that hormone therapy induces antigen-specific autoantibody responses in prostate cancer patients. However, the contribution of autoantibody responses to clinical outcomes is unknown. We used an animal model to test the hypothesis that hormone therapy-induced immune responses may be associated with...
journal_title:International journal of cancer
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doi:10.1002/ijc.24673
更新日期:2009-12-15 00:00:00