Abstract:
:The EBV-encoded membrane protein (LMP) and the nuclear antigen EBNA-1 were compared for their capacity to induce rejection of transfected murine mammary carcinoma cells in syngeneic hosts. The tumorigenic potential of stable LMP and EBNA-1 expressing sublines of the ACA (H-2f)-derived mammary carcinoma line S6C was tested in pre-immunized syngeneic and semi-syngeneic animals. LMP expressing S6C cells elicited a strong rejection response as demonstrated by the lower tumor take and slower growth in immunized vs. control mice. In contrast, EBNA-1-expressing cells were non-immunogenic in syngeneic hosts and in one semi-syngeneic F1-hybrid. Rejection in 2 additional F1-hybrids did not appear to be due to EBNA-1-specific immune responses. Our findings support the hypothesis that the escape of EBV carrying tumor cells from EBV-specific immune surveillance may be facilitated by the fact that viral gene expression is limited to EBNA-1.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Trivedi P,Masucci MG,Winberg G,Klein Gdoi
10.1002/ijc.2910480527keywords:
subject
Has Abstractpub_date
1991-07-09 00:00:00pages
794-800issue
5eissn
0020-7136issn
1097-0215journal_volume
48pub_type
杂志文章abstract::The Swedish Family-Cancer Database was used to analyze concordant (same site) and discordant (different site) second primary neoplasms in 633,964 cancer patients diagnosed from 1958 to 1996. Cases of second malignant neoplasms were extracted from the Database if the diagnosis date of the first and second cancer differ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1317
更新日期:2001-07-15 00:00:00
abstract::The roles of fibroblast growth factor-2 (FGF-2) in the hepatocellular carcinoma (HCC) development are still controversial. In this study, we investigated the expression of FGF-2 in chronic hepatitis (CH) type C patients with or without HCC and the immunoregulation of FGF-2 in NK sensitivity of HCC cells. The FGF-2 exp...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26003
更新日期:2012-01-15 00:00:00
abstract::Murine hepatocellular carcinoma cells were retrovirally transduced with the bacterial cytosine deaminase (CD) gene. CD-transduced cells exhibited more than 120-fold higher sensitivity to 5-fluorocytosine (5-FC) compared with parental cells. When syngeneic immunocompetent mice were inoculated s.c. with parental hepatoc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990517)81:4<592::aid-ijc
更新日期:1999-05-17 00:00:00
abstract::In 584 consecutive patients with no previous history of cancer or polypectomy, 769 adenomas were excised endoscopically and classified retrospectively according to the following parameters: macroscopic growth pattern, size, histological type, grade of dysplasia, anatomical site, presence of adenocarcinoma (ADK), numbe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490406
更新日期:1991-10-21 00:00:00
abstract::We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and up-regulated E-cadherin, an epi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24349
更新日期:2009-06-15 00:00:00
abstract::Desmoids represent the most important cause of death, after colorectal cancer, in patients affected with familial adenomatous polyposis (FAP), an inherited disease due to mutations in the APC gene. The aims of our study were to estimate the risk of developing desmoids in FAP patients and to evaluate the association be...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010320)95:2<102::aid-ijc1018>3
更新日期:2001-03-20 00:00:00
abstract::Chimeric bcr/abl fusion proteins are thought to be the molecular 'pathogen' of chronic myelogenous leukaemia (CML). Expression levels of the respective fusion RNAs reflect disease progression as well as remission upon therapeutic intervention in CML patients. However, there is no quick and reliable method that would a...
journal_title:International journal of cancer
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更新日期:2000-06-01 00:00:00
abstract::Thymidylate synthase (TYMS) is an important enzyme for 5-fluorouracil (5-FU) metabolism in metastatic colorectal cancer (mCRC) patients. The search for this enzyme in circulating tumor cells (CTCs) can be a powerful tool to follow-up cancer patients. mCRC patients were enrolled before the beginning of 5-FU-based chemo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29495
更新日期:2015-09-15 00:00:00
abstract::Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endocytic vesicles and exhibit a drug...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22098
更新日期:2006-12-01 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) receptors constitute a family of transmembrane proteins that bind TGF-beta ligands. In this study we assessed the growth responsiveness to TGF-beta 1 in pancreatic cancer cell lines and characterized the levels of expression of TGF-beta receptors in these cell lines and in hu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960717)67:2<283::AID-IJC
更新日期:1996-07-17 00:00:00
abstract::A long-term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210305
更新日期:1978-03-15 00:00:00
abstract::We have recently shown in the BDII rat model of human endometrial adenocarcinoma (EAC), rat chromosome 10 (RNO10) is frequently involved in chromosomal aberrations. In the present study, we investigated the association between RNO10 deletions, allelic imbalance (AI) at RNO10q24 and Tp53 mutation in 27 rat EAC tumors. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22533
更新日期:2007-04-01 00:00:00
abstract::We previously reported that exosomal nanoparticles secreted by human pancreatic tumoral cell lines decrease tumoral cell proliferation through the mitochondria-dependent apoptotic pathway, because of activation of pro-apoptotic phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and of glucose synthase kina...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24375
更新日期:2009-09-01 00:00:00
abstract::The clonotypic T-cell receptor (TCR) is a potential target antigen for specific immunotherapy of cutaneous T-cell lymphoma (CTCL). We identified T-cell epitopes from the rearranged TCR beta chain of the malignant T-cell population by the "reverse immunology" approach. Peptide-specific T-cell lines were generated again...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22113
更新日期:2006-11-15 00:00:00
abstract::Expression of the monocyte chemoattractant protein-1 (MCP-1) was examined in human central nervous system tumours (glioblastomas and astrocytomas) and normal human brain. Northern blot analysis demonstrated constitutive expression of MCP-1 mRNA in 6 of 12 glioblastoma cell lines. Expression could be stimulated by inte...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580216
更新日期:1994-07-15 00:00:00
abstract::Vascular endothelial growth factor-A (VEGF-A) plays an important role in tumour angiogenesis and cancer progression. VEGF gene variation may influence VEGF levels and therefore cancer susceptibility and progression. We studied the role of VEGF single nucleotide polymorphisms and haplotypes in breast cancer susceptibil...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22772
更新日期:2007-09-01 00:00:00
abstract::Patients with head-and-neck cancer commonly have immune defects. It was reported that these patients have raised serum IgA levels. We investigated whether IgA-anti-Fab autoantibodies, which occur in association with immune dysfunction, are present in patients with head-and-neck cancer. Sera of 101 patients with squamo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570109
更新日期:1994-04-01 00:00:00
abstract::Human leukocyte antigen (HLA)-G acts as negative regulator of the immune responses and its expression in tumor cells may enable them to escape immunosurveillance. The purpose of this study was to investigate the influence of HLA-G polymorphism on risk of high-grade cervical intraepithelial neoplasia (HG-CIN) and cervi...
journal_title:International journal of cancer
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doi:10.1002/ijc.27356
更新日期:2012-08-01 00:00:00
abstract::A PCR assay using capillary electrophoresis was designed for the detection of c-erbB-2 gene amplification in alcohol-formalin-acetic acid (AFA)-fixed, paraffin-embedded biopsies from 81 consecutive breast tumors. c-erbB-2 expression was analyzed in the same samples using immuno-histochemistry (IHC). In the competitive...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1097-0215(19991008)83:2<157::aid-ijc
更新日期:1999-10-08 00:00:00
abstract::Acquired chemoresistance is a critical issue for advanced bladder cancer patients during long-term treatment. Recent studies reveal that a fraction of tumor cells with enhanced tumor-initiating potential, or cancer stem-like cells (CSCs), may particularly contribute to acquired chemoresistance and recurrence. Thus, CS...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32505
更新日期:2020-02-15 00:00:00
abstract::Micro RNAs (miR) are master regulators of cellular transcriptome. We aimed to investigate the role of miR regulation on tumor radiosensitivity and development of local tumor recurrence by a novel large-scale in vivo loss of function screen. For stable miR silencing, human A431 tumor cells were transduced with lentivir...
journal_title:International journal of cancer
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更新日期:2019-06-01 00:00:00
abstract::The age-adjusted incidence rates of cutaneous melanoma in Queensland in 1987 have been analysed for 16 anatomic sites, taking into account their surface areas. In men, the incidence of invasive melanoma on the ears, a chronically sun-exposed site, was extraordinarily high with annual rates of over 200 per 10(5) units ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530210
更新日期:1993-01-21 00:00:00
abstract::Cultured murine hepatic tumor (HT) cells respond to the polar solvent dimethylsulfoxide (DMSO) with specific alterations in morphology, proliferative kinetics, and biochemical properties. These include entrance into a quiescent "Qi" substate (characterized by accumulation of cells in G1 phase and lowered cellular RNA ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420222
更新日期:1988-08-15 00:00:00
abstract::140.240, an IgG2a mouse monoclonal antibody raised against a cultured human melanoma cell line, was highly specific for melanoma cells as determined by direct and absorption analyses in a mixed hemadsorption assay. Supernatants of doubly cloned hybridomas producing antibody 140.240 reacted with all cultured and fresh ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300507
更新日期:1982-11-15 00:00:00
abstract::Radiation therapy (RT) continues to be a cornerstone in the treatment for many cancers. Unfortunately, not all individuals respond effectively to RT resulting clinically in two groups consisting of nonresponders (progressive disease) and responders (tumor control/cure). The mechanisms that govern the outcome of radiot...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28558
更新日期:2014-05-15 00:00:00
abstract::Aberrant activation of wingless (Wnt) signaling is involved in the pathogenesis of various cancers. Recent studies suggested a role of Wnt signaling in gliomas, the most common primary brain tumors. We investigated 70 gliomas of different malignancy grades for promoter hypermethylation in 8 genes encoding members of t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24981
更新日期:2010-06-01 00:00:00
abstract::Our aim was to identify plasma microRNA (miRNA)-based signatures to predict 3-year postoperative recurrence risk for patients with stage II and III gastric cancer (GC), so as to provide insights for individualized adjuvant therapy. Plasma miRNA expression was investigated in three phases, involving 407 patients recrui...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30895
更新日期:2017-11-15 00:00:00
abstract::The stability of a cloned murine tumor for sensitivity to NR was examined following growth in vivo in order to test the hypothesis that tumor progression proceeds through the generation and selection of variants. Clonal sensitivity to the [131I]-dUrd elimination assay of NR was assessed for the L5178Y-F9 tumor grown i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910310116
更新日期:1983-01-15 00:00:00
abstract::In advanced cancer patients, the oxidative stress could take place either at the onset of disease or as a function of disease progression. To test this hypothesis, the following parameters were investigated: the erythrocyte activity of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), the serum ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10143
更新日期:2002-03-01 00:00:00
abstract::Previous work from this laboratory established a large bank of human colon carcinoma cell lines in culture and classified them with respect to growth regulatory phenotypes based on several biological and biochemical characteristics. In the present report, Northern analysis indicates that addition of the maturational a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420113
更新日期:1988-07-15 00:00:00